WO2008061400A1 - Inhibiteurs de synthase d'acide gras et utilisations médicales - Google Patents

Inhibiteurs de synthase d'acide gras et utilisations médicales Download PDF

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Publication number
WO2008061400A1
WO2008061400A1 PCT/CN2006/003403 CN2006003403W WO2008061400A1 WO 2008061400 A1 WO2008061400 A1 WO 2008061400A1 CN 2006003403 W CN2006003403 W CN 2006003403W WO 2008061400 A1 WO2008061400 A1 WO 2008061400A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzyloxy
dichloro
furan
oxo
carboxylic acid
Prior art date
Application number
PCT/CN2006/003403
Other languages
English (en)
Chinese (zh)
Inventor
Song Li
Hong Yu
Xuehui Zhang
Lili Wang
Junhai Xiao
Zhibing Zheng
Wu Zhong
Original Assignee
Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. filed Critical Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A.
Publication of WO2008061400A1 publication Critical patent/WO2008061400A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de formule (I) et leurs sels ou solvates pharmaceutiquement acceptables ayant un effet inhibiteur de synthase d'acide gras (FabH), sachant que les définitions des substituants de cette formule sont telles que mentionnées dans la description. Également, procédés d'élaboration de ce type de composé, compositions pharmaceutiques renfermant les composés, et utilisations des composés dans l'élaboration de tels inhibiteurs. Les composés peuvent être utilisés dans le traitement d'infections bactériennes.
PCT/CN2006/003403 2006-11-23 2006-12-13 Inhibiteurs de synthase d'acide gras et utilisations médicales WO2008061400A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610114792.0 2006-11-23
CNA2006101147920A CN101190904A (zh) 2006-11-23 2006-11-23 脂肪酸合成酶抑制剂及其制药用途

Publications (1)

Publication Number Publication Date
WO2008061400A1 true WO2008061400A1 (fr) 2008-05-29

Family

ID=39429368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2006/003403 WO2008061400A1 (fr) 2006-11-23 2006-12-13 Inhibiteurs de synthase d'acide gras et utilisations médicales

Country Status (2)

Country Link
CN (1) CN101190904A (fr)
WO (1) WO2008061400A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1370158A (zh) * 1999-08-23 2002-09-18 史密丝克莱恩比彻姆公司 脂肪酸合成酶抑制剂
CN1580054A (zh) * 2003-07-31 2005-02-16 中国人民解放军军事医学科学院毒物药物研究所 五元硫杂环类化合物及其用于制备治疗和预防肥胖相关疾病的药物的用途
CN1705478A (zh) * 2002-07-01 2005-12-07 法斯根有限责任公司 新化合物、包含该化合物的药物组合物及该化合物的应用方法
CN1724525A (zh) * 2005-06-24 2006-01-25 山东大学 γ－丁内酯衍生物及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1370158A (zh) * 1999-08-23 2002-09-18 史密丝克莱恩比彻姆公司 脂肪酸合成酶抑制剂
CN1705478A (zh) * 2002-07-01 2005-12-07 法斯根有限责任公司 新化合物、包含该化合物的药物组合物及该化合物的应用方法
CN1580054A (zh) * 2003-07-31 2005-02-16 中国人民解放军军事医学科学院毒物药物研究所 五元硫杂环类化合物及其用于制备治疗和预防肥胖相关疾病的药物的用途
CN1724525A (zh) * 2005-06-24 2006-01-25 山东大学 γ－丁内酯衍生物及其制备方法

Also Published As

Publication number Publication date
CN101190904A (zh) 2008-06-04

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