WO2008059466A1 - Production de compactine au moyen d'une nouvelle souche mutante de penicillium citrinum atcc 38065 - Google Patents

Production de compactine au moyen d'une nouvelle souche mutante de penicillium citrinum atcc 38065 Download PDF

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Publication number
WO2008059466A1
WO2008059466A1 PCT/IB2007/054699 IB2007054699W WO2008059466A1 WO 2008059466 A1 WO2008059466 A1 WO 2008059466A1 IB 2007054699 W IB2007054699 W IB 2007054699W WO 2008059466 A1 WO2008059466 A1 WO 2008059466A1
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WO
WIPO (PCT)
Prior art keywords
compactin
mutant strain
process according
mtcc
fermentation medium
Prior art date
Application number
PCT/IB2007/054699
Other languages
English (en)
Inventor
Parveen Kumar
Bupinder Kumar Chowdhary
Vivek Kumar Jain
Original Assignee
Ranbaxy Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited
Publication of WO2008059466A1 publication Critical patent/WO2008059466A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Abstract

L'invention concerne une nouvelle souche mutante de Penicillium citrinum ATCC 38065 ainsi qu'un procédé pour produire de la compactine de formule (1) au moyen d'une nouvelle souche mutante de Penicillium citrinum ATCC 38065.
PCT/IB2007/054699 2006-11-17 2007-11-19 Production de compactine au moyen d'une nouvelle souche mutante de penicillium citrinum atcc 38065 WO2008059466A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2487/DEL/2006 2006-11-17
IN2487DE2006 2006-11-17

Publications (1)

Publication Number Publication Date
WO2008059466A1 true WO2008059466A1 (fr) 2008-05-22

Family

ID=39171408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/054699 WO2008059466A1 (fr) 2006-11-17 2007-11-19 Production de compactine au moyen d'une nouvelle souche mutante de penicillium citrinum atcc 38065

Country Status (1)

Country Link
WO (1) WO2008059466A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827123A (zh) * 2012-08-02 2012-12-19 丽珠集团新北江制药股份有限公司 美伐他汀的分离提取工艺

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2524355A1 (de) * 1974-06-07 1975-12-18 Sankyo Co Physiologisch aktive verbindungen und verfahren zu ihrer herstellung
US5691173A (en) * 1995-09-21 1997-11-25 Apotex, Inc. Fermentation process for preparation of compactin
WO1998006867A1 (fr) * 1996-08-09 1998-02-19 Yungjin Pharmaceutical Ind. Co., Ltd. Nouveau procede de production du precurseur de la pravastatine, ml-236b
US6323021B1 (en) * 1999-01-15 2001-11-27 Industrial Technology Research Institute Mutant strain of penicillium citrinum and use thereof for preparation of compactin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2524355A1 (de) * 1974-06-07 1975-12-18 Sankyo Co Physiologisch aktive verbindungen und verfahren zu ihrer herstellung
US5691173A (en) * 1995-09-21 1997-11-25 Apotex, Inc. Fermentation process for preparation of compactin
WO1998006867A1 (fr) * 1996-08-09 1998-02-19 Yungjin Pharmaceutical Ind. Co., Ltd. Nouveau procede de production du precurseur de la pravastatine, ml-236b
US6323021B1 (en) * 1999-01-15 2001-11-27 Industrial Technology Research Institute Mutant strain of penicillium citrinum and use thereof for preparation of compactin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABE Y ET AL: "Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum", JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, XX, XX, vol. 50, no. 3, 2004, pages 169 - 176, XP002400774 *
CHAKRAVARTI R ET AL: "Compactin - a review", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 64, no. 5, 19 March 2004 (2004-03-19), pages 618 - 624, XP002400772, ISSN: 0175-7598 *
HOSOBUCHI M ET AL: "PRODUCTION OF ML-236B, AND INHIBITOR OF 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE, BY PENICILLIUM CITRINUM: IMPROVEMENTS OF STRAIN AND CULTURE CONDITIONS", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM, TOKYO, JP, vol. 57, no. 9, 1993, pages 1414 - 1419, XP002036624, ISSN: 0916-8451 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102827123A (zh) * 2012-08-02 2012-12-19 丽珠集团新北江制药股份有限公司 美伐他汀的分离提取工艺
CN102827123B (zh) * 2012-08-02 2015-04-22 丽珠集团新北江制药股份有限公司 美伐他汀的分离提取工艺

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