WO2008055047A2 - Devices and methods to simulate an ocular environment - Google Patents

Devices and methods to simulate an ocular environment Download PDF

Info

Publication number
WO2008055047A2
WO2008055047A2 PCT/US2007/082584 US2007082584W WO2008055047A2 WO 2008055047 A2 WO2008055047 A2 WO 2008055047A2 US 2007082584 W US2007082584 W US 2007082584W WO 2008055047 A2 WO2008055047 A2 WO 2008055047A2
Authority
WO
WIPO (PCT)
Prior art keywords
testing surface
male
female
concave
testing
Prior art date
Application number
PCT/US2007/082584
Other languages
English (en)
French (fr)
Other versions
WO2008055047A3 (en
Inventor
Dharmesh K. Dubey
Lauren May
Original Assignee
Johnson & Johnson Vision Care, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Vision Care, Inc. filed Critical Johnson & Johnson Vision Care, Inc.
Priority to AU2007313797A priority Critical patent/AU2007313797A1/en
Priority to EP07854430.1A priority patent/EP2078186B1/en
Priority to CA2668296A priority patent/CA2668296C/en
Priority to CN2007800489590A priority patent/CN101573604B/zh
Priority to JP2009535401A priority patent/JP2010508562A/ja
Priority to BRPI0718298-8A priority patent/BRPI0718298A2/pt
Publication of WO2008055047A2 publication Critical patent/WO2008055047A2/en
Publication of WO2008055047A3 publication Critical patent/WO2008055047A3/en
Priority to HK09111019.5A priority patent/HK1133297A1/zh
Priority to HK10104340.7A priority patent/HK1138640A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M11/00—Testing of optical apparatus; Testing structures by optical methods not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44—Resins; Plastics; Rubber; Leather
    • G01N33/442—Resins; Plastics

Definitions

  • This invention related to devices and methods simulate an ocular environment to enable the testing of ophthalmic lens.
  • BACKGROUND Most diseases of the eye are treated with topical ophthalmic solutions containing pharmaceutical agents. It has been postulated that delivery and efficacy of these agents would be greatly increased if the agents were incorporated in ophthalmic lenses and those lenses were used as drug delivery devices. These agents may be added to the ophthalmic lenses by a variety of methods including soaking the agent into a formed lens, adding the agent to the formulation of the lens prior to its formation and the like. Others have postulated methods of testing the uptake and discharge rates of such pharmaceutical agents to and from the ophthalmic lenses. These methods include placing ophthalmic lenses in solutions and monitoring the concentration of the pharmaceutical agent over time. Even though these methods work, due to the volume of solution used in the test, the conditions do not mimic the conditions that an ophthalmic lens is exposed to when inserted into an ocular environment.
  • Fig. 1 illustrates a perspective drawing of a male mold.
  • Fig. 2 illustrates a perspective drawing of a female mold.
  • Fig. 3 illustrates a close up cross-sectional drawing of the mated apparatus.
  • Fig. 4 illustrates a perspective drawing of a male mold.
  • Fig. 5 illustrates a perspective drawing of a female mold.
  • Fig. 6 illustrates a cross-sectional drawing of the mated apparatus.
  • Fig. 7 illustrates a close up cross-sectional drawing of the mated apparatus.
  • This invention includes an apparatus for testing an ophthalmic lens comprising a male mold and a female mold, wherein said male mold comprises a convex testing surface, an outer male surface, male seating ridge extending from the perimeter of the convex testing surface, and an aperture extending from said outer male surface to said convex testing surface,
  • said female mold comprises an outer female surface a concave testing surface, female seating ridge extending from the perimeter of the concave testing surface, and an aperture extending from said concave testing surface to said outer female surface,
  • the male seating ridge sits on the female seating ridge and creates a testing area between the male convex testing surface and the female concave testing surface.
  • Fig. 1 a perspective drawing of a male mold 100, contains convex testing surface 120, aperture 160, and, male seating ridge 180.
  • Fig. 2 a perspective drawing of a female mold 200, contains concave testing surface 220, aperture 260, and female seating ridge 280.
  • Fig. 3 a close up cross section of mated apparatus, where the mated convex testing surface 120 and concave testing surface 220, define the testing area 300 between those surfaces.
  • the convex and concave testing surfaces are of a size and shape to mimic the shape of the eye and an eyelid. Testing area 300 is large enough to hold an ophthalmic lens (not shown) and a volume of solution.
  • the testing area be sized to house an ophthalmic lens and about 50 ⁇ l_ to about 500 ⁇ l_ of solution, more preferably, about 100 ⁇ l_ to about 400 ⁇ l_ of solution, most preferably about 200 ⁇ l_ of solution.
  • the convex or concave testing surfaces of the apparatus may contain grooves that provide pathways for the small volumes of solutions to pass over the surfaces of ophthalmic lenses contained in the testing area. These grooves may be in any number or orientation, but preferably a convex or concave testing surface contains at least one latitudinal groove and one radial groove. It is preferred that such grooves intersect at a point on the convex or concave testing surface.
  • both the concave and the convex surfaces contain radial and latitudinal grooves.
  • Fig. 4 a perspective drawing of a male mold 10, contains convex testing surface Yl, four radial grooves 14, aperture 16, male seating ridge 18, and six concentric latitudinal grooves 19.
  • Fig. 5, a perspective drawing of a female mold 20, contains concave testing surface 22, four radial grooves, 24, aperture 26, female seating ridge 28, and nine concentric latitudinal grooves 29.
  • the radial grooves on the convex testing surface intersect with the latitudinal grooves so as to allow solutions that flow through the apertures, to more easily flow to the entire convex testing surface.
  • each testing surface may contain the same or different numbers of radial grooves. It is preferred that each testing surface contain contains at least two radial grooves, more preferably three radial grooves, most preferably four radial grooves. With respect to latitudinal grooves, the number of these grooves on each testing surface may be the same or different. It is preferred that each testing surface contain contains at least four latitudinal grooves, more preferably at least five latitudinal grooves, most preferably at least eight latitudinal grooves.
  • the outer male and female surfaces may be the same or different shapes. In one embodiment of the invention (not illustrated) the outer male surface is concave and the outer female surface is convex.
  • the convex and concave testing surfaces are of a size and shape to mimics the shape of an eye and an eyelid.
  • Fig. 6 a cross section of the mated apparatus, with male mold 10, female mold 20, male outer surface 13, female outer surface 23, male seating ridge 18, and female seating ridge 28.
  • aperture 16 extends from male outer surface 13 to the convex testing surface 12 to the testing area not shown.
  • aperture 26 extends from concave testing surface 22 to outer female surface 23.
  • Fig. 7 a close up cross section of mated apparatus, where the mated convex testing surface Y ⁇ and concave testing surface 22, define the testing area 30 those surfaces.
  • Testing area 30 is large enough to hold an ophthalmic lens (not shown) and a volume of solution. It is preferred that the testing area be sized to house an ophthalmic lens and about 50 ⁇ l_ to about 500 ⁇ l_ of solution, more preferably, about 100 ⁇ l_ to about 400 ⁇ l_ of solution, most preferably about 200 ⁇ l_ of solution.
  • the apparatus of the invention may be prepared from durable thermoplastic materials, such as thermoplastic resins, polyolefins, and thermoplastic polyesters.
  • durable thermoplastic materials such as thermoplastic resins, polyolefins, and thermoplastic polyesters.
  • thermoplastic resins such as thermoplastic resins, polyolefins, and thermoplastic polyesters.
  • materials include but are not limited to low medium, medium and high density polypropylene, polyethylene and co-polymers thereof, poly-4-methylpentene, fluorinated ethylene propylene copolymers, ethylene fluoroethylene copolymers, polyacetal resins, polacrylether, polyarylether sulfones, nylons, and the like.
  • the apparatus may be prepared by injection molding thermoforming and the like.
  • the invention includes a method of testing the diffusion rate of an ophthalmic device comprising a pharmaceutical agent, wherein the method comprises the steps of (a) placing an ophthalmic lens comprising a pharmaceutical agent in the testing area of an apparatus comprising a male mold and a female mold,
  • said male mold comprises a convex testing surface an outer male surface, male seating ridge extending from the perimeter of the convex testing surface, and an aperture extending from said outer male surface to said convex testing surface,
  • said female mold comprises an outer female surface a concave testing surface, female seating ridge extending from the perimeter of the concave testing surface, and an aperture extending from said concave testing surface to said outer female surface,
  • the male seating ridge sits on the female seating ridge and creates a testing area between the male convex testing surface and the female concave testing surface.
  • male mold female mold, radial groove, latitudinal groove, testing area convex testing surface, and concave testing surface are as described above.
  • pharmaceutical agents refers to pharmaceutical or nutraceutical compounds used to treat conditions of the eye, and such compound degrade in the presence of oxygen and certain transition metals.
  • pharmaceutical compounds include antihistamines, antibiotics, antibacterial agents, antiviral agents, antifungal agents, analgesics, anesthetics, antiallergeneic agents, mast cell stabilizers, steroidal and nonsteroidal anti-inflammatory agents, angiogenesis inhibitors; antimetabolites, fibrinolytics, neuroprotective drugs, angiostatic steroids, mydriatics, cyclopegic mydriatics; miotics; vasoconstrictors; vasodilators, anticlotting agents; anticancer agents, antisense agents, immunomodulatory agents, carbonic anhydrase inhibitors, integhn antabonistsl; cyclooxygenase inhibitors, VEGF antagonists; immunosuppressant agents and the like.
  • examples of pharmaceutical compounds include but are not limited to achvastine, antazoline, astemizole, azatadine, azelastine, buclizine, bupivacaine, cetirizine, clemastine, cyclizine, cyproheptadine, ebastine, emedastine, ephedrine, eucatropine, fexofenadine, homatropine, hydroxyzine, ketotifen, levocabastine, levoceterizine, lomefloxacin, meclizine, mepivacaine, mequitazine, methdilazine, methapyrilene, mianserin, naphazoline norastemizole, norebastine, ofloxacin, oxymetazoline, pheniramine, phenylephrine, physostigmine, picumast, promethazine, scopolamine, terfen
  • Preferred pharmaceutical compounds include achvatine, antazoline, astemizole, azatadine, azelastine, clemastine, cyproheptadine, ebastine, emedastine, eucatropine, fexofenadine, homatropine, hydroxyzine, ketotife, levocabastine, levoceterizine, meclizine, mequitazine, methdialazine, methapyrilene, norastemizole, norebastine, oxymetazoline, physootigmine, picumast, promethazine, scopolamine, terfenadine, tetrahyerozoline, fimilol, trimeprazine, triprolidine, and pharmaceutically acceptable salts thereof.
  • Particularly preferred pharmaceutical compounds include phenarimine, ketotifen, ketotifen fumarate nor ketotifen fumarate, 11 -dihydro-11 -(1 -methyl-4-piperidinylidene)- 5H-imidazo[2,1 -b][3]benzazepine-3-carboxaldehyde (CAS# 147084-10-4), olapatadine and mixtures thereof. More particularly preferred pharmaceutical compounds include ketotifen fumarate, 11 -dihydro-11 -(1 -methyl-4- pipehdinylidene)-5H-imidazo[2,1 -b][3]benzazepine-3-carboxaldehyde (CAS# 147084-10-4) and mixtures thereof.
  • nutraceutical compounds include vitamins and supplements such as vitamins A, D, E, lutein, zeaxanthin, lipoic acid, flavonoids, ophthalmicially compatible fatty acids, such as omega 3 and omega 6 fatty acids, combinations thereof, combinations with pharmaceutical compounds and the like.
  • the methods of the invention may be used to detect the discharge rate (or uptake rate) of ophthalmic lenses containing about 8 ⁇ g or more of pharmaceutical agent.
  • the discharge rate for ophthalmic lenses that contain about 8 ⁇ g to about 90 ⁇ g, more preferably about 10 ⁇ g to about 40 ⁇ g, more preferably about 10 ⁇ g to about 25 ⁇ g may be determined by the methods of this invention.
  • Ophthalmic lens refers to a device that resides in or on the eye. These devices can provide optical correction or may be cosmetic. Ophthalmic lenses include but are not limited to soft contact lenses, intraocular lenses, overlay lenses, ocular inserts, and optical inserts.
  • the preferred lenses of the invention are soft contact lenses made from silicone elastomers or hydrogels, which include but are not limited to silicone hydrogels, and fluorohydrogels.
  • Soft contact lens formulations are disclosed in US Patent No. 5,710,302, WO 9421698, EP 406161 , JP 2000016905, U.S. Pat. No. 5,998,498, U.S. Patent No. 6,087,415, U.S. Pat. No. 5,760,100, U.S. Pat.
  • the particularly preferred ophthalmic lenses of the inventions are known by the United States Approved Names of acofilcon A, alofilcon A, alphafilcon A, amifilcon A, astifilcon A, atalafilcon A, balafilcon A, bisfilcon A, bufilcon A, comfilcon, crofilcon A, cyclofilcon A,balilcon A, deltafilcon A, deltafilcon B, dimefilcon A, drooxifilcon A, epsifilcon A, esterifilcon A, etafilcon A, focofilcon A, genfilcon A, govafilcon A, hefilcon A, hefilcon B, hefilcon D, hilafilcon A, hilafilcon B, hioxifilcon B, hioxifilcon C, hixoifilcon A, hydrofilcon A, lenefilcon A, licryfilcon A, licryfilcon B, lidofilcon A, lidofil
  • More particularly preferred ophthalmic lenses of the invention are genfilcon A, lenefilcon A, comfilcon, lotrafilcon A, lotraifilcon B, and balafilcon A.
  • the most preferred lenses include etafilcon A, nelfilcon A, hilafilcon, vifilcon, and polymacon.
  • solutions that are used in methods of this invention may be water- based solutions. Solutions that mimic natural tear film are preferred. Typical solutions include, without limitation, saline solutions, other buffered solutions, and deionized water.
  • the preferred aqueous solution is deioinized water or saline solution containing salts including, without limitation, sodium chloride, sodium borate, sodium phosphate, sodium hydrogenphosphate, sodium dihydrogenphosphate, or the corresponding potassium salts of the same.
  • salts including, without limitation, sodium chloride, sodium borate, sodium phosphate, sodium hydrogenphosphate, sodium dihydrogenphosphate, or the corresponding potassium salts of the same.
  • the buffered solutions may additionally include 2-(N-morpholino)ethanesulfonic acid (MES), sodium hydroxide, 2,2-bis(hydroxymethyl)-2,2',2"-nitnlothethanol, n-tris(hydroxynnethyl)nnethyl-2-anninoethanesulfonic acid, citric acid, sodium citrate, sodium carbonate, sodium bicarbonate, acetic acid, sodium acetate, ethylenediamine tetraacetic acid and the like and combinations thereof.
  • MES 2-(N-morpholino)ethanesulfonic acid
  • sodium hydroxide 2,2-bis(hydroxymethyl)-2,2',2"-nitnlothethanol
  • n-tris(hydroxynnethyl)nnethyl-2-anninoethanesulfonic acid citric acid, sodium citrate, sodium carbonate, sodium bicarbonate, acetic acid, sodium acetate, ethylenediamine tetraacetic acid and the like
  • monitoring refers to methods of analyzing the solution to determine the concentration of pharmaceutical agent in the solution. Examples of such detecting methods include but are not limited to HPLC, UV Spectormeters and the like. Still further the invention includes, a method of measuring the uptake rate of a pharmaceutical agent to an ophthalmic lens, wherein the method comprises the steps of
  • said female mold comprises an outer female surface a concave testing surface, female seating ridge extending from the perimeter of the concave testing surface, and an aperture extending from said concave testing surface to said outer female surface,
  • the male seating ridge sits on the female seating ridge and creates a testing area between the male convex testing surface and the female concave testing surface.
  • male mold female mold, radial groove, latitudinal groove, testing area convex testing surface, concave testing surface, pharmaceutical agent, ophthalmic lens, solution and monitoring are as described above.
  • this invention includes a method of measuring the uptake rate of an eyecare solution component to an ophthalmic lens, wherein the method comprises the steps of
  • said female mold comprises an outer female surface a concave testing surface, female seating ridge extending from the perimeter of the concave testing surface, and an aperture extending from said concave testing surface to said outer female surface,
  • the male seating ridge sits on the female seating ridge and creates a testing area between the male convex testing surface and the female concave testing surface, (b) adding a solution comprising eyecare solution components to the aperture of the male mold from the outer male surface, and (c) monitoring the solution that emerges from the aperture of the outer female surface to determine the presence or absence of the eyecare solution component.
  • male mold female mold, radial groove, latitudinal groove, testing area convex testing surface, concave testing surface, eyecare solution component, ophthalmic lens, solution and monitoring are as described above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Eyeglasses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eye Examination Apparatus (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Instructional Devices (AREA)
  • Prostheses (AREA)
PCT/US2007/082584 2006-10-31 2007-10-26 Devices and methods to simulate an ocular environment WO2008055047A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2007313797A AU2007313797A1 (en) 2006-10-31 2007-10-26 Devices and methods to simulate an ocular environment
EP07854430.1A EP2078186B1 (en) 2006-10-31 2007-10-26 Devices and methods to simulate an ocular environment
CA2668296A CA2668296C (en) 2006-10-31 2007-10-26 Devices and methods to simulate an ocular environment
CN2007800489590A CN101573604B (zh) 2006-10-31 2007-10-26 模拟眼环境的装置和方法
JP2009535401A JP2010508562A (ja) 2006-10-31 2007-10-26 眼環境をシミュレーションするための装置および方法
BRPI0718298-8A BRPI0718298A2 (pt) 2006-10-31 2007-10-26 Dispositivos e métodos para simular um ambiente ocular
HK09111019.5A HK1133297A1 (zh) 2006-10-31 2009-11-25 模擬眼環境的裝置和方法
HK10104340.7A HK1138640A1 (zh) 2006-10-31 2010-05-03 模擬眼環境的裝置和方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85543306P 2006-10-31 2006-10-31
US60/855,433 2006-10-31

Publications (2)

Publication Number Publication Date
WO2008055047A2 true WO2008055047A2 (en) 2008-05-08
WO2008055047A3 WO2008055047A3 (en) 2008-06-26

Family

ID=39154017

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/082584 WO2008055047A2 (en) 2006-10-31 2007-10-26 Devices and methods to simulate an ocular environment

Country Status (13)

Country Link
US (2) US7793535B2 (zh)
EP (1) EP2078186B1 (zh)
JP (1) JP2010508562A (zh)
KR (1) KR20090094816A (zh)
CN (1) CN101573604B (zh)
AR (1) AR063753A1 (zh)
AU (1) AU2007313797A1 (zh)
BR (1) BRPI0718298A2 (zh)
CA (1) CA2668296C (zh)
HK (2) HK1133297A1 (zh)
RU (1) RU2443999C2 (zh)
TW (1) TWI460417B (zh)
WO (1) WO2008055047A2 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2083793A2 (en) * 2006-10-31 2009-08-05 Johnson and Johnson Vision Care, Inc. Methods and devices to test diffusion rates of ocular drug delivery systems
US7968018B2 (en) * 2007-04-18 2011-06-28 Coopervision International Holding Company, Lp Use of surfactants in extraction procedures for silicone hydrogel ophthalmic lenses
US8295684B2 (en) * 2007-10-08 2012-10-23 Sony Computer Entertainment America Inc. Method and system for scaling content for playback with variable duration
US9827250B2 (en) 2012-07-31 2017-11-28 Johnson & Johnson Vision Care, Inc. Lens incorporating myopia control optics and muscarinic agents
US9069186B2 (en) * 2013-03-15 2015-06-30 Johnson & Johnson Vision Care, Inc. Thermoformed ophthalmic insert devices
KR20200048825A (ko) * 2018-10-30 2020-05-08 부산대학교 산학협력단 가상현실 기반의 백내장 수술 시뮬레이터 시스템

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406161A2 (en) 1989-06-20 1991-01-02 Ciba-Geigy Ag Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymers and contact lenses thereof
WO1994021698A1 (en) 1993-03-15 1994-09-29 Bausch & Lomb Incorporated Novel fumarate and fumaramide siloxane hydrogel compositions
US5710302A (en) 1995-12-07 1998-01-20 Bausch & Lomb Incorporated Monomeric units useful for reducing the modules of silicone hydrogels
US5760100A (en) 1994-09-06 1998-06-02 Ciba Vision Corporation Extended wear ophthalmic lens
US5776999A (en) 1994-09-06 1998-07-07 Ciba Vision Corporation Methods of using and screening extended wear ophthalmic lenses
US5817924A (en) 1998-01-21 1998-10-06 Modern Controls, Inc. Method and apparatus for measuring oxygen transmission through contact lenses
US5998498A (en) 1998-03-02 1999-12-07 Johnson & Johnson Vision Products, Inc. Soft contact lenses
JP2000016905A (ja) 1998-07-01 2000-01-18 Tokuriki Kagaku Kenkyusho:Kk 抗菌抗かび剤および抗菌抗かび材料
US6087415A (en) 1998-06-11 2000-07-11 Johnson & Johnson Vision Care, Inc. Biomedical devices with hydrophilic coatings

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601967D0 (en) * 1986-01-28 1986-03-05 Coopervision Optics Manufacturing contact lenses
US4782946A (en) * 1987-09-17 1988-11-08 Allergan, Inc. Soft contact lens hydration device and kit
TW325744U (en) * 1993-07-21 1998-01-21 Ciba Geigy Ag Two-sided contact lens mold
US5490415A (en) * 1994-04-15 1996-02-13 Pharmetrix Corporation Diffusion test apparatus and method
JP3813667B2 (ja) 1996-09-24 2006-08-23 株式会社トーメー コンタクトレンズ用洗浄・消毒用具及びそれを用いたコンタクトレンズの消毒方法
US6450014B1 (en) * 1999-12-28 2002-09-17 Eastman Kodak Company Method and apparatus for measuring osmotic pressure
ATE310634T1 (de) * 2001-05-23 2005-12-15 Novartis Pharma Gmbh Aufnahmekorb für eine ophtalmische linse
US6909503B2 (en) * 2001-08-17 2005-06-21 Novartis Ag Cuvette for lens inspection
DE60326597D1 (de) 2002-06-05 2009-04-23 Univ Florida Ophthalmisches arzneimittelabgabesystem
US6981403B2 (en) * 2003-10-31 2006-01-03 Mocon, Inc. Method and apparatus for measuring gas transmission rates of deformable or brittle materials
CA2597219C (en) * 2005-02-04 2014-04-15 Auburn University Contact drug delivery system
SG177132A1 (en) * 2005-02-14 2012-01-30 Johnson & Johnson Vision Care A comfortable ophthalmic device and methods of its production
EP2083793A2 (en) * 2006-10-31 2009-08-05 Johnson and Johnson Vision Care, Inc. Methods and devices to test diffusion rates of ocular drug delivery systems

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406161A2 (en) 1989-06-20 1991-01-02 Ciba-Geigy Ag Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymers and contact lenses thereof
WO1994021698A1 (en) 1993-03-15 1994-09-29 Bausch & Lomb Incorporated Novel fumarate and fumaramide siloxane hydrogel compositions
US5965631A (en) 1994-09-06 1999-10-12 Ciba Vision Corporation Extended wear ophthalmic lens
US5849811B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corporatin Extended wear ophthalmic lens
US5776999A (en) 1994-09-06 1998-07-07 Ciba Vision Corporation Methods of using and screening extended wear ophthalmic lenses
US5789461A (en) 1994-09-06 1998-08-04 Ciba Vision Corporation Methods of forming an extended wear ophthalmic lens having a hydrophilic surface
US5760100A (en) 1994-09-06 1998-06-02 Ciba Vision Corporation Extended wear ophthalmic lens
US5849811A (en) 1994-09-06 1998-12-15 Ciba Vision Corporation Extended wear ophthalmic lens
US5776999B1 (en) 1994-09-06 2000-11-21 Ciba Vision Corp Methods of using and screening extended wear opthalmic lenses
US5789461B1 (en) 1994-09-06 2000-11-21 Ciba Vision Corp Methods of forming an extended wear ophthalmic lens having a hydrophilic surface
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
US5710302A (en) 1995-12-07 1998-01-20 Bausch & Lomb Incorporated Monomeric units useful for reducing the modules of silicone hydrogels
US5817924A (en) 1998-01-21 1998-10-06 Modern Controls, Inc. Method and apparatus for measuring oxygen transmission through contact lenses
US5998498A (en) 1998-03-02 1999-12-07 Johnson & Johnson Vision Products, Inc. Soft contact lenses
US6087415A (en) 1998-06-11 2000-07-11 Johnson & Johnson Vision Care, Inc. Biomedical devices with hydrophilic coatings
JP2000016905A (ja) 1998-07-01 2000-01-18 Tokuriki Kagaku Kenkyusho:Kk 抗菌抗かび剤および抗菌抗かび材料

Also Published As

Publication number Publication date
BRPI0718298A2 (pt) 2013-12-03
KR20090094816A (ko) 2009-09-08
TW200837342A (en) 2008-09-16
HK1138640A1 (zh) 2010-08-27
AR063753A1 (es) 2009-02-18
US7793535B2 (en) 2010-09-14
US20100300182A1 (en) 2010-12-02
EP2078186B1 (en) 2014-05-07
RU2009120559A (ru) 2010-12-10
CA2668296C (en) 2015-12-29
CN101573604B (zh) 2013-12-04
CA2668296A1 (en) 2008-05-08
RU2443999C2 (ru) 2012-02-27
HK1133297A1 (zh) 2010-03-19
EP2078186A2 (en) 2009-07-15
TWI460417B (zh) 2014-11-11
CN101573604A (zh) 2009-11-04
AU2007313797A1 (en) 2008-05-08
JP2010508562A (ja) 2010-03-18
WO2008055047A3 (en) 2008-06-26
US20080100795A1 (en) 2008-05-01

Similar Documents

Publication Publication Date Title
US20100300182A1 (en) Devices and methods to simulate an ocular environment
US10045975B2 (en) Methods and ophthalmic devices used in the treatment of ocular allergies
CN101573102B (zh) 测试眼部药物递送系统扩散率的方法和装置
AU2007305205B2 (en) Methods and ophthalmic devices used in the treatment of ocular allergies

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780048959.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07854430

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2007313797

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2009535401

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2668296

Country of ref document: CA

Ref document number: 1625/KOLNP/2009

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007854430

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2007313797

Country of ref document: AU

Date of ref document: 20071026

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020097011210

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2009120559

Country of ref document: RU

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: PI0718298

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090430