WO2008044957A1 - Procédé d'analyse différentielle de protéomes - Google Patents

Procédé d'analyse différentielle de protéomes Download PDF

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Publication number
WO2008044957A1
WO2008044957A1 PCT/RU2006/000522 RU2006000522W WO2008044957A1 WO 2008044957 A1 WO2008044957 A1 WO 2008044957A1 RU 2006000522 W RU2006000522 W RU 2006000522W WO 2008044957 A1 WO2008044957 A1 WO 2008044957A1
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WO
WIPO (PCT)
Prior art keywords
cells
differential
transcripts
type
proteins
Prior art date
Application number
PCT/RU2006/000522
Other languages
English (en)
Russian (ru)
Inventor
Evgeny Davidovich Sverdlov
Galina Sergeevna Monastyrskaya
Tatyana Viktorovna Vinogradova
Lyudmila Lvovna Zavalova
Alexandr Sergeevich Spirin
Evgeny Pavlovich Kopantsev
Original Assignee
Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) filed Critical Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran)
Priority to PCT/RU2006/000522 priority Critical patent/WO2008044957A1/fr
Priority to EA200701996A priority patent/EA010352B1/ru
Publication of WO2008044957A1 publication Critical patent/WO2008044957A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Physiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention relève du domaine de biologie moléculaire, en particulier de la génomique et de la protéomique, se rapporte à une technique polyvalente permettant de détecter des gènes exprimés, ainsi que des transcrits et des protéines codés par lesdits gènes, qui sont présents de manière différentielle dans divers types de cellules d'un organisme, y compris dans des cellules normales et des cellules transformées par diverses pathologies génétiques ou acquises, notamment par transformation tumorale, ou dans des cellules homogènes mais dans des conditions différentes. Des agents protéiques et nucléotidiques synthétisés à l'aide de la technique selon l'invention peuvent servir de médicaments thérapeutiques ou prophylactiques. L'invention concerne également des procédés de diagnostic, qui peuvent être utilisés en médecine pour l'évaluation semi-quantitative rapide du contenu de transcrits de gènes d'expression différentielle et des protéines différentielles correspondantes dans diverses cellules, ce qui permet de déterminer l'état de santé d'un patient, de pronostiquer l'évolution d'une maladie et de donner des recommandations relatives aux méthodes de traitement.
PCT/RU2006/000522 2006-10-09 2006-10-09 Procédé d'analyse différentielle de protéomes WO2008044957A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/RU2006/000522 WO2008044957A1 (fr) 2006-10-09 2006-10-09 Procédé d'analyse différentielle de protéomes
EA200701996A EA010352B1 (ru) 2006-10-09 2006-10-09 Способ дифференциального анализа протеомов

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2006/000522 WO2008044957A1 (fr) 2006-10-09 2006-10-09 Procédé d'analyse différentielle de protéomes

Publications (1)

Publication Number Publication Date
WO2008044957A1 true WO2008044957A1 (fr) 2008-04-17

Family

ID=39283082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2006/000522 WO2008044957A1 (fr) 2006-10-09 2006-10-09 Procédé d'analyse différentielle de protéomes

Country Status (2)

Country Link
EA (1) EA010352B1 (fr)
WO (1) WO2008044957A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2709815C1 (ru) * 2019-05-14 2019-12-23 Федеральное бюджетное учреждение науки "Нижегородский научно-исследовательский институт эпидемиологии и микробиологии им. академика И.Н. Блохиной" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ поиска молекулярных маркеров патологического процесса для дифференциальной диагностики, мониторинга и таргетной терапии

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036420A2 (fr) * 1998-12-11 2000-06-22 Ludwig Institute For Cancer Research Expression differentielle dans le cas du cancer primaire du sein
US20050136403A1 (en) * 2001-08-16 2005-06-23 Mariana Nacht Molecular characterists of non-small cell lung cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036420A2 (fr) * 1998-12-11 2000-06-22 Ludwig Institute For Cancer Research Expression differentielle dans le cas du cancer primaire du sein
US20050136403A1 (en) * 2001-08-16 2005-06-23 Mariana Nacht Molecular characterists of non-small cell lung cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANAL. BIOCHEM., vol. 319, no. 2, 15 August 2003 (2003-08-15), pages 244 - 250 *
DATABASE MEDLINE [online] MCCAULEY T.G. ET AL.: "Aptamer-based biosensor arrays for detection and quantification of biological macromolecules", accession no. NCBI Database accession no. (12871718) *
LUDA DIATCHENKO ET AL.: "Suppression subtractive hybridization: A versatile method for identifying differentially expressed genes", METHODS ENZYMOL., vol. 303, 1999, pages 349 - 380 *
TROY D.R. ET AL.: "J chain syntheses and secretion of hexameric JgM is differentially regulated by lipopolysaccharide and interleukin 5", PROC. NATL. ACAD. SCI. USA, vol. 89, no. 3, 1992, pages 962 - 966 *

Also Published As

Publication number Publication date
EA010352B1 (ru) 2008-08-29
EA200701996A1 (ru) 2008-04-28

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