WO2008029879A1 - agent HYDRATANT, ACTIVATEUR cellulaire et antioxydant - Google Patents

agent HYDRATANT, ACTIVATEUR cellulaire et antioxydant Download PDF

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Publication number
WO2008029879A1
WO2008029879A1 PCT/JP2007/067405 JP2007067405W WO2008029879A1 WO 2008029879 A1 WO2008029879 A1 WO 2008029879A1 JP 2007067405 W JP2007067405 W JP 2007067405W WO 2008029879 A1 WO2008029879 A1 WO 2008029879A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
pomegranate
plant
antioxidant
skin
Prior art date
Application number
PCT/JP2007/067405
Other languages
English (en)
Japanese (ja)
Inventor
Akira Hatani
Yumiko Okumura
Hayami Maeda
Original Assignee
Noevir Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noevir Co., Ltd. filed Critical Noevir Co., Ltd.
Publication of WO2008029879A1 publication Critical patent/WO2008029879A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a humectant, a cell activator, and an antioxidant containing a naturally derived ingredient as an active ingredient. More specifically, the present invention relates to the use of a plant of the genus Pomegranate or its extract. Background art
  • a humectant, a cell activator, and an antioxidant containing one or more plants selected from Pomegranate plants or an extract thereof as active ingredients there is provided a composition containing one or more plants selected from the genus Pomegranate or two or more extracts thereof.
  • the plant of the genus Pomegranate ( ⁇ 2 ⁇ 1 ⁇ ), which is a plant used as a raw material of the present invention, is an annual plant belonging to the family Pomegranate, and is widely distributed in Honshu, Shikoku and Kyushu.
  • Pomegranate plant Mollueo Oentaphvlla
  • Knoremanano Mollugo verticillata
  • the pomegranate plant or its extract contains so many kinds of ingredients that it cannot be analyzed. It is presumed that the various effects of the present invention can be obtained by acting comprehensively.
  • the plant used as a raw material is not particularly limited as long as it is a plant belonging to the genus Pomegranate, but it is particularly preferable to use pomegranate since it is relatively easy to obtain and effective. Multiple species of the genus Pomegranate can also be used in combination.
  • any part such as leaves, flowers, seeds, roots, stems, buds, etc., with no particular restrictions can be used. You can use multiple parts in combination. For easy use, use whole grass.
  • any of the above-mentioned parts of the plant of the genus Pomegranate may be used, or an extract may be obtained using a plurality of parts. You can also use a mixture of two or more extracts extracted using different solvents.
  • the plant may be used as it is, but considering the extraction efficiency, it is preferable to carry out the extraction after processing such as shredding, drying, and grinding.
  • Extraction methods include room temperature, cooling or warming, extraction by immersing in an arbitrary extraction solvent for a predetermined time, extraction using a distillation method such as steam distillation, or from raw plants
  • a distillation method such as steam distillation
  • Examples of the pressing method include pressing to obtain an extract. Any of these methods can be used alone or in combination of two or more.
  • extraction can be performed using a supercritical fluid or a subcritical fluid. Agitation to increase extraction efficiency Or may be homogenized in an extraction solvent. It is also possible to extract under a caloric pressure using an autoclave.
  • the extraction temperature is suitably about 5 ° C to the boiling point of the extraction solvent.
  • the extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it for about 1 hour to 14 days.
  • the ratio of the plant and the solvent during the extraction is not particularly limited, but is preferably 0.5 to 5 times the solvent for the plant 1; Preferably 100 times by mass.
  • Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethyl ether and propyl ether Solvents such as ethers such as butyl acetate, butyl acetate, ethyl acetate, and the like; ketones such as acetone, ethylmethylol ketone, and the like can be used. These may be used alone or in combination of any two or more. Saline, phosphate buffer, phosphate buffered saline and the like may be used. In addition, one or more supercritical liquids and subcritical liquids such as water, carbon dioxide, ethylene, propylene, ethanol, methanol, and ammonia may be used.
  • lower alcohols such as methanol, ethanol, propanol and isopropanol
  • the extract of the above-mentioned plant of the genus Pomegranate can be used as it is, but it may be left to mature for a certain period of time, or may be used after being concentrated and dried to water or a polar solvent. It can also be used by dissolving. Alternatively, it may be used after performing purification treatment such as decolorization, deodorization, desalting, etc., or fractionation treatment by column chromatography or the like within a range not impairing these physiological functions.
  • the above-mentioned extract of the genus Pomegranate, the treated product and fraction thereof can be freeze-dried after each treatment and fractionation, and dissolved in a solvent before use. It can also be used by encapsulating in vesicles such as ribosomes or microcapsules.
  • a plant of the genus Pomegranate or an extract thereof has excellent moisturizing action, cell activation action, and antioxidant action, and can be preferably used as a moisturizing agent, cell activator, and antioxidant.
  • each of these agents contains a pomegranate plant or an extract thereof as an active ingredient, its form and the presence or absence of other ingredients are not limited at all.
  • any form such as liquid, paste, gel, solid, powder, etc. can be selected according to its use etc., and the vehicle (excipient), solvent, Other general additives (antioxidants, colorants, dispersants, etc.) can optionally be included.
  • the amount of the pomegranate plant or extract thereof, which is an active ingredient in each agent, is adjusted with respect to the total amount from the viewpoint of power effect and stability that can be adjusted according to the type of agent and the purpose of use. , 0. 00001 ⁇ in terms of solid content; preferably from 100 mass 0/0 force Mashigu ⁇ is 0. 001-5 0 mass%.
  • a moisturizing agent comprising a pomegranate plant or an extract thereof as an active ingredient exerts an excellent moisturizing action on the skin and hair, and particularly has a high moisturizing effect on the skin.
  • a cell activator comprising a pomegranate plant or an extract thereof as an active ingredient exhibits an excellent activation action on various cells, and particularly exhibits an excellent effect on dermal fibroblasts.
  • An antioxidant comprising a pomegranate plant or an extract thereof as an active ingredient exhibits an excellent antioxidant action, but particularly exhibits an excellent free radical scavenging action.
  • each of these agents can be used for hair and the like as well as applied externally to the skin, and can be applied to various compositions such as an external composition and an oral composition.
  • the composition for external use is not limited to any one category such as cosmetics, external preparations for skin, quasi-drugs, external medicines, etc., but any combination for external use on skin or hair. Means an adult.
  • oral composition means any composition that can be taken orally, regardless of the type of drug, food, beverage, etc.
  • the dosage form of the composition for external use is arbitrary, and can be provided as, for example, a solubilizing system such as lotion, a dispersion system such as calamine mouth lotion, or an emulsifying system such as cream or emulsion.
  • a solubilizing system such as lotion
  • a dispersion system such as calamine mouth lotion
  • an emulsifying system such as cream or emulsion.
  • it can be provided in various dosage forms such as aerosol forms, ointments, and poultices filled with propellants.
  • emulsions creams, lotions, lotions, packs, serums, cleaning agents, lips
  • Various types of cosmetics such as ticks, makeup cosmetics and foundations; various forms of quasi-drugs such as liquids, ointments, powders, granules, aerosols, patches, poultices, and external medicines can be exemplified.
  • the form of the oral composition is also arbitrary, and is in a liquid form such as a liquid, syrup, or extract, or a solid such as a granule, tablet, powder, capsule, or glaze, or a jelly, It can be processed and used in various forms such as gummi and gum, and is not particularly limited.
  • Specific examples include general foods including beverages, health foods (supplements), functional foods, nutritional supplements, oral medicines, and quasi drugs.
  • a pomegranate plant or an extract thereof to an external preparation for skin including, for example, cosmetics, external medicines, quasi-drugs, etc. It is possible to obtain a composition for external use that exhibits an excellent effect on the prevention and improvement of various skin symptoms such as dullness, dullness, dryness, and fine wrinkles, and a skin external preparation for moisturizing, a skin external preparation for whitening, or an external skin for improving aging prevention. It can be used as an agent. In particular, it is preferably used as a skin external preparation for improving anti-aging containing pomegranate plant or an extract thereof.
  • pomegranate plant or its extract can also be used in foods and drinks, health foods (supplements), quasi-drugs, functional foods, etc. for the purpose of beauty, health maintenance or nutrition. Monkey.
  • the composition for external use or oral use, etc. in addition to its use and necessity, usually skin cosmetics, hair cosmetics, pharmaceutical parts
  • skin cosmetics in addition to its use and necessity, usually skin cosmetics, hair cosmetics, pharmaceutical parts
  • Optional components used in preparations such as external products and pharmaceuticals are included.
  • Such components include water, oils (oil-based ingredients), alcohols, excipients, binders, extenders, disintegrants, corrigents, dyes, colorants, emulsifiers, solubilizers, dispersants, gelling agents.
  • Agent plasticizer, cleaning agent, UV absorber, thickener, pH adjuster, buffer agent, surfactant, lubricant, chelating agent, drug (medicinal component), fragrance, resin, coating agent
  • plasticizer plasticizer
  • cleaning agent UV absorber
  • thickener thickener
  • pH adjuster buffer agent
  • surfactant surfactant
  • lubricant chelating agent
  • drug drug (medicinal component)
  • fragrance resin
  • coating agent examples include fungicides, preservatives, preservatives, antioxidants, and pH adjusters.
  • other moisturizers, cell activators, antioxidants, or plants other than the pomegranate plant or extracts thereof can be used as long as the effects of the present invention are not impaired.
  • the combination with various ingredients used in food is not particularly limited.
  • the dosage form of food is arbitrary, and can be provided in various dosage forms such as powders, granules, capsules, liquids, etc.
  • it can be used in combination with other humectants, cell activators, or antioxidants as long as the effects of the present invention are not impaired.
  • the amount of the pomegranate plant or its extract in the composition for external use or oral composition can be adjusted according to the kind of composition, purpose of use, etc. in view of sex, based on the total amount, 0.1 in terms of solid content 00001-50. 0 wt% Ca, more preferably, 0.5 0001- 25. 0 mass 0/0. Furthermore, 0. 0001- 10 mass 0/0 Ca, more preferably 0.000;! A ⁇ 5 mass 0/0, more preferably 0.001 to 5 wt%, more preferably 0. 0;! To 5% by mass, particularly preferably 0 .;! To 5% by mass.
  • the whole pomegranate plant was put into a supercritical extractor and extracted using a supercritical fluid of carbon dioxide at 40 ° C under 15 MPa pressure. The extract was recovered to obtain extract 4 of whole pomegranate plant.
  • the dermal fibroblast activation effect was evaluated as follows.
  • DMEM Dulbecco's modified Eagle medium
  • FBS urchin fetal serum
  • the sample solution was adjusted so that each sample concentration shown in Table 2 was obtained, and 100 / j l was added to a 96-well microphone opening plate. Thereto, 0.2 mM of 1,1-diphenyl-2-picrylhydrazyl (DPPH) ethanol solution was added in increments of 1001 and mixed well, and allowed to stand at room temperature for 24 hours. Finally, the absorbance at 516 nm derived from DPPH radical was measured.
  • DPPH 1,1-diphenyl-2-picrylhydrazyl
  • the extinction rate of the DPPH radical was calculated from the following equation, where (A) is the absorbance when no sample is added and (B) is the absorbance when the sample is added.
  • Radical scavenging rate ⁇ 1— (B) / (A) ⁇ X 100
  • Carboxyvinyl polymer (1% by weight aqueous solution) 1 5. 0
  • Extract of Zaku mouth sow plant 1 1.0 Production method: Mix the water phase components of (1) to (6) and dissolve by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Start cooling after emulsification and add (15) at 50 ° C. Cool to 40 ° C and add (16) to mix evenly. Match.
  • Extract of Zaku mouth sow plant 4 1.0 Production method: Mix the oil phase components of (1) to 1 ⁇ 2) and dissolve by heating at 75 ° C. On the other hand, (7) to (10) The aqueous phase components are mixed, dissolved by heating at 75 ° C, and the pigments (11) to (15) are added thereto and dispersed uniformly with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after emulsification, and components (16) and (17) are added sequentially at 40 ° C and mixed uniformly.
  • Fragrance 12.0 Production method (1) to (3) were respectively sieved and mixed, then (4) to (5) were added and mixed. Thereafter, tableting was performed by a conventional method to obtain a tablet having a total amount of 600 mg.
  • Table 4 shows the number of panelists that obtained each evaluation.
  • a moisturizer, a cell activator, and an antioxidant having excellent effects can be provided by using a pomegranate plant or an extract thereof as an active ingredient. Furthermore, by blending pomegranate plant or its extract into skin preparations (or compositions for external use) such as cosmetics, external medicines, or oral compositions such as foods, wrinkles, tarmi, skin firmness or skin It is possible to provide various compositions that exhibit an excellent effect in preventing and improving various dermatological conditions such as low elasticity of the skin, spots, dullness, dryness, and fine wrinkles.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Toxicology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention a pour objet un agent hydratant, un agent activateur cellulaire et un antioxydant contenant en tant que principe actif un ou plusieurs types de plantes du genre Molluginaceae ou un extrait. L'invention concerne également diverses compositions contenant une plante du genre Molluginaceae ou un extrait.
PCT/JP2007/067405 2006-09-06 2007-09-06 agent HYDRATANT, ACTIVATEUR cellulaire et antioxydant WO2008029879A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006242157A JP4515423B2 (ja) 2006-09-06 2006-09-06 保湿剤、細胞賦活剤、及び抗酸化剤
JP2006-242157 2006-09-06

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Publication Number Publication Date
WO2008029879A1 true WO2008029879A1 (fr) 2008-03-13

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PCT/JP2007/067405 WO2008029879A1 (fr) 2006-09-06 2007-09-06 agent HYDRATANT, ACTIVATEUR cellulaire et antioxydant

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JP (1) JP4515423B2 (fr)
WO (1) WO2008029879A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012232976A (ja) * 2011-04-18 2012-11-29 Toyo Shinyaku Co Ltd 美白用組成物、それを含む皮膚外用剤及び飲食品、並びにその美白用組成物の生産方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF CHINESE MEDICINE, vol. 30, no. 2-3, 2002, pages 225 - 234 *
AMERICAN JOURNAL OF CHINESE MEDICINE, vol. 32, no. 3, 2004, pages 339 - 349 *
DATABASE BIOSIS [online] FERREIRA A.P. ET AL.: "Immunomodulatory activity of Mollugo verticillata L., Phytomedicine (Jena)", XP003024685, Database accession no. (PREV200300318178) *
DATABASE BIOSIS [online] LIN C.-C. ET AL.: "Anti-inflammatory and hepatoprotective activity of peh-hue-juwa-chi-cao in male rats, peh-hue-juwa-chi-cao in male rats", XP003024684, Database accession no. (PREV200200594481) *
DATABASE BIOSIS [online] LIN C.-C. ET AL.: "Antioxidant activity of extracts of Peh-Hue-Juwa-Chi-Cao in a cell free system", XP003024683, Database accession no. (PREV200400415849) *
PHYTOMEDICINA (JENA), vol. 10, no. 2-3, 2003, pages 154 - 158 *
YANG J.-J.: "Comparative Study on the Immunocompetent Activity of Three Different Kinds of Peh-Hue-Juwa-Chi-Cao, Hedyotis diffusa, H.corymbosa and Mollugo pentaphylla after Sublethal Whole Body X-Irradiation", PHYTOTHER. RES., vol. 11, no. 6, 1997, pages 428 - 432, XP003024686 *

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JP2008063273A (ja) 2008-03-21
JP4515423B2 (ja) 2010-07-28

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