WO2008012440A3 - Composes pyridaziniques et pyrroliques, procedes d'obtention et applications - Google Patents

Composes pyridaziniques et pyrroliques, procedes d'obtention et applications Download PDF

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Publication number
WO2008012440A3
WO2008012440A3 PCT/FR2007/001287 FR2007001287W WO2008012440A3 WO 2008012440 A3 WO2008012440 A3 WO 2008012440A3 FR 2007001287 W FR2007001287 W FR 2007001287W WO 2008012440 A3 WO2008012440 A3 WO 2008012440A3
Authority
WO
WIPO (PCT)
Prior art keywords
obtaining
processes
pyridazine
pyrrole compounds
relates
Prior art date
Application number
PCT/FR2007/001287
Other languages
English (en)
Other versions
WO2008012440A2 (fr
Inventor
Didier Max Dubreuil
Muriel Genevieve Pipelier
Jean Paul Pradere
Hicham Bakkali
Patrice Lepape
Thierry Delaunay
Alexandra Tabatchnik
Original Assignee
Centre Nat Rech Scient
Didier Max Dubreuil
Muriel Genevieve Pipelier
Jean Paul Pradere
Hicham Bakkali
Patrice Lepape
Thierry Delaunay
Alexandra Tabatchnik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Didier Max Dubreuil, Muriel Genevieve Pipelier, Jean Paul Pradere, Hicham Bakkali, Patrice Lepape, Thierry Delaunay, Alexandra Tabatchnik filed Critical Centre Nat Rech Scient
Priority to JP2009521300A priority Critical patent/JP5564252B2/ja
Priority to CA002658624A priority patent/CA2658624A1/fr
Priority to EP07823344A priority patent/EP2069345A2/fr
Priority to US12/309,585 priority patent/US9034873B2/en
Publication of WO2008012440A2 publication Critical patent/WO2008012440A2/fr
Publication of WO2008012440A3 publication Critical patent/WO2008012440A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/10—Metal complexes of organic compounds not being dyes in uncomplexed form

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention est relative à des composés oligopyridaziniques non linéaires, à leurs procédés d'obtention, à leurs applications, ainsi qu'à leur régression en oligopyrroles et aux applications des composés pyridazinyl-pyrroliques et oligopyrroliques obtenus. L'invention vise en particulier les applications en tant que médicaments, notamment pour traiter des pathologies telles que le cancer, les infections bactériennes ou parasitaires, ainsi que les applications dans le domaine des matériaux, de l'environnement de l'électronique et de l'optique.
PCT/FR2007/001287 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications WO2008012440A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009521300A JP5564252B2 (ja) 2006-07-26 2007-07-26 ピリダジンおよびピロール化合物、それらを得るための方法および使用
CA002658624A CA2658624A1 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications
EP07823344A EP2069345A2 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications
US12/309,585 US9034873B2 (en) 2006-07-26 2007-07-26 Pyridazine and pyrrole compounds, processes for obtaining them and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606842 2006-07-26
FR0606842A FR2904315B1 (fr) 2006-07-26 2006-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications

Publications (2)

Publication Number Publication Date
WO2008012440A2 WO2008012440A2 (fr) 2008-01-31
WO2008012440A3 true WO2008012440A3 (fr) 2008-05-29

Family

ID=37763892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001287 WO2008012440A2 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications

Country Status (6)

Country Link
US (1) US9034873B2 (fr)
EP (1) EP2069345A2 (fr)
JP (1) JP5564252B2 (fr)
CA (1) CA2658624A1 (fr)
FR (1) FR2904315B1 (fr)
WO (1) WO2008012440A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2186810A1 (fr) * 2008-10-31 2010-05-19 Institut Curie Dérivés de poly-hétéroaryle pour le traitement de cancer
US8906850B2 (en) 2009-01-28 2014-12-09 Smartcells, Inc. Crystalline insulin-conjugates
EP2391217A4 (fr) 2009-01-28 2015-05-20 Smartcells Inc Conjugués synthétiques et leurs utilisations
ES2791683T3 (es) 2009-01-28 2020-11-05 Smartcells Inc Sistemas a base de conjugados para la administración controlada de fármacos
US8846103B2 (en) 2009-01-28 2014-09-30 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010107519A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués fonctionnalisés aux extrémités et leurs utilisations
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
JP6125742B2 (ja) * 2009-10-30 2017-05-10 住友化学株式会社 含窒素芳香族化合物及び金属錯体
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
EP2598527A4 (fr) 2010-07-28 2014-01-08 Smartcells Inc Polypeptides d'insuline exprimés de façon recombinante et utilisations de ceux-ci
CA2805902A1 (fr) 2010-07-28 2012-02-02 Smartcells, Inc. Lectines recombinees, lectines a site de liaison modifie et leurs utilisations
JP2014156402A (ja) * 2011-05-27 2014-08-28 Nippon Soda Co Ltd ビピリジン化合物および殺菌剤
WO2013033018A2 (fr) 2011-08-30 2013-03-07 Drexel University Complexes de dihydroxybipyridine de ruthénium et d'iridium destinés à l'oxydation de l'eau et à l'hydrogénation
WO2014158943A1 (fr) * 2013-03-13 2014-10-02 Avon Products, Inc Inhibiteurs de tyrosinase
WO2014164200A1 (fr) 2013-03-13 2014-10-09 Avon Products, Inc Inhibiteurs de la tyrosinase
WO2014164195A1 (fr) 2013-03-13 2014-10-09 Avon Products, Inc Inhibiteurs de tyrosinase
AU2014329567B2 (en) 2013-10-04 2019-07-25 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
US10130625B2 (en) 2014-07-22 2018-11-20 University Of Maryland, College Park Linked diaryl compounds with anticancer properties and methods of using the same
JP7063231B2 (ja) * 2018-10-26 2022-05-09 住友化学株式会社 ジピリダジニルエーテル化合物及びその用途
CN110437206B (zh) * 2019-03-13 2022-06-10 上海大学 吡啶-吡咯交替的分子折叠体及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186288A1 (en) * 2001-05-08 2004-09-23 Martin Kruger 3,5-Diamino-1,2,4-triazoles as kinase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3889065B2 (ja) * 1994-03-15 2007-03-07 株式会社東芝 有機非線形光学材料

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20040186288A1 (en) * 2001-05-08 2004-09-23 Martin Kruger 3,5-Diamino-1,2,4-triazoles as kinase inhibitors

Non-Patent Citations (3)

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Title
BAXTER P N ET AL: "Self-assembly and structure of interconverting multinuclear inorganic arrays: a [4X5]-Ag(I)20 grid and an Ag(I)10 quadruple helicate", CHEMISTRY - A EUROPEAN JOURNAL, vol. 6, no. 24, 15 December 2000 (2000-12-15), pages 4510 - 4517, XP002422690 *
COATES W J ET AL: "1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl) benzene analogs: potent phosphodiesterase inhibitors and inodilators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 6, 1990, pages 1735 - 1741, XP002119282 *
JONES R A ET AL: "Extended heterocyclic systems 1. The synthesis and characterisation of pyrrolylpyridines, alternating pyrrole:pyridine oligomers and polymers, and related systems", TETRAHEDRON, vol. 52, no. 26, June 1996 (1996-06-01), pages 8707 - 8724, XP004103814 *

Also Published As

Publication number Publication date
CA2658624A1 (fr) 2008-01-31
WO2008012440A2 (fr) 2008-01-31
US9034873B2 (en) 2015-05-19
FR2904315B1 (fr) 2012-12-14
JP5564252B2 (ja) 2014-07-30
JP2009544671A (ja) 2009-12-17
FR2904315A1 (fr) 2008-02-01
US20100298562A1 (en) 2010-11-25
EP2069345A2 (fr) 2009-06-17

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