WO2007146427A3 - Méthode de traitement de complications vasculaires diabétiques - Google Patents

Méthode de traitement de complications vasculaires diabétiques Download PDF

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Publication number
WO2007146427A3
WO2007146427A3 PCT/US2007/014089 US2007014089W WO2007146427A3 WO 2007146427 A3 WO2007146427 A3 WO 2007146427A3 US 2007014089 W US2007014089 W US 2007014089W WO 2007146427 A3 WO2007146427 A3 WO 2007146427A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating diabetic
vascular complications
diabetic vascular
extract
soluble fraction
Prior art date
Application number
PCT/US2007/014089
Other languages
English (en)
Other versions
WO2007146427A2 (fr
Inventor
Rong-Tsun Wu
Original Assignee
Univ Nat Yang Ming
Jiang Tsung Shann
Rong-Tsun Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nat Yang Ming, Jiang Tsung Shann, Rong-Tsun Wu filed Critical Univ Nat Yang Ming
Priority to EP07796179A priority Critical patent/EP2051722B1/fr
Priority to AT07796179T priority patent/ATE497773T1/de
Priority to DE602007012442T priority patent/DE602007012442D1/de
Priority to CA2656185A priority patent/CA2656185C/fr
Priority to KR1020097000750A priority patent/KR101101253B1/ko
Priority to JP2009515518A priority patent/JP5068314B2/ja
Priority to CN2007800302156A priority patent/CN101500586B/zh
Priority to AU2007258202A priority patent/AU2007258202B2/en
Publication of WO2007146427A2 publication Critical patent/WO2007146427A2/fr
Publication of WO2007146427A3 publication Critical patent/WO2007146427A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne une méthode de traitement de complications vasculaires diabétiques qui comprend l'administration à un sujet le nécessitant d'une quantité thérapeutiquement active d'un produit extrait d'un membre de l'espèce Dioscorea. Le produit extrait est préférentiellement élaboré par un procédé qui implique (a) l'extraction depuis un tubercule de l'espèce Dioscorea à l'aide d'un solvant à base d'alcool en présence d'une solution d'acide acétique pour former une préparation d'extrait, (b) la soumission d'un produit résultant obtenu dans l'étape (a) pour obtenir une fraction soluble, et (c) l'élimination du solvant de la fraction soluble obtenue dans l'étape (b) pour obtenir le produit extrait.
PCT/US2007/014089 2006-06-14 2007-06-14 Méthode de traitement de complications vasculaires diabétiques WO2007146427A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP07796179A EP2051722B1 (fr) 2006-06-14 2007-06-14 Méthode de traitement de complications vasculaires diabétiques
AT07796179T ATE497773T1 (de) 2006-06-14 2007-06-14 Verfahren zur behandlung von diabetischen vaskulären komplikationen
DE602007012442T DE602007012442D1 (de) 2006-06-14 2007-06-14 En komplikationen
CA2656185A CA2656185C (fr) 2006-06-14 2007-06-14 Methode de traitement de complications vasculaires diabetiques
KR1020097000750A KR101101253B1 (ko) 2006-06-14 2007-06-14 당뇨병 혈관성 합병증 치료방법
JP2009515518A JP5068314B2 (ja) 2006-06-14 2007-06-14 糖尿病性血管合併症の治療方法
CN2007800302156A CN101500586B (zh) 2006-06-14 2007-06-14 用于治疗糖尿病血管并发症的方法
AU2007258202A AU2007258202B2 (en) 2006-06-14 2007-06-14 Method for treating diabetic vascular complications

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80465606P 2006-06-14 2006-06-14
US60/804,656 2006-06-14
US11/582,894 US7645463B2 (en) 2006-06-14 2006-10-18 Method for treating diabetic vascular complications
US11/582,894 2006-10-18

Publications (2)

Publication Number Publication Date
WO2007146427A2 WO2007146427A2 (fr) 2007-12-21
WO2007146427A3 true WO2007146427A3 (fr) 2008-02-14

Family

ID=38832568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/014089 WO2007146427A2 (fr) 2006-06-14 2007-06-14 Méthode de traitement de complications vasculaires diabétiques

Country Status (9)

Country Link
US (1) US7645463B2 (fr)
EP (1) EP2051722B1 (fr)
JP (1) JP5068314B2 (fr)
KR (1) KR101101253B1 (fr)
AT (1) ATE497773T1 (fr)
AU (1) AU2007258202B2 (fr)
CA (1) CA2656185C (fr)
DE (1) DE602007012442D1 (fr)
WO (1) WO2007146427A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8668908B2 (en) * 2002-12-31 2014-03-11 National Yang-Ming University Method for alleviating chemotherapy side effects using extract of Dioscorea sp
US20060068036A1 (en) * 2002-12-31 2006-03-30 National Yang-Ming University Extract of Dioscorea sp. and the medical uses thereof
FR2961400B1 (fr) * 2010-06-18 2013-08-16 Ass F Zabana Phuna Composition pharmaceutique ou dietetique utilisee comme antidiabetique
RU2741715C1 (ru) * 2020-03-20 2021-01-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации Способ прогнозирования формирования микрососудистых осложнений сахарного диабета 2 типа

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040182A1 (fr) * 2003-10-24 2005-05-06 Meiji Seika Kaisha, Ltd. Nouvel inhibiteur de formation de produit terminal de glycation avancee et inhibiteur d'aldose reductase
US20060068036A1 (en) * 2002-12-31 2006-03-30 National Yang-Ming University Extract of Dioscorea sp. and the medical uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019580A (en) * 1989-12-19 1991-05-28 Shaman Pharmaceuticals, Inc. Dioscoretine and its use as a hypoglycemic agent
US20040126447A1 (en) * 2002-12-31 2004-07-01 Rong-Tsun Wu Extract of Dioscorea sp. and the medical uses thereof
JPWO2005082391A1 (ja) * 2004-03-01 2007-10-25 株式会社カネカ ヒトβ３アドレナリン受容体アゴニスト剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060068036A1 (en) * 2002-12-31 2006-03-30 National Yang-Ming University Extract of Dioscorea sp. and the medical uses thereof
WO2005040182A1 (fr) * 2003-10-24 2005-05-06 Meiji Seika Kaisha, Ltd. Nouvel inhibiteur de formation de produit terminal de glycation avancee et inhibiteur d'aldose reductase
US20070060533A1 (en) * 2003-10-24 2007-03-15 Meiji Seika Kaisha Ltd. Novel inhibitor of the formation of advanced glycation end product and aldose reductase inhibitor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIMENIBO-UADIA: "Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber", TROP. J. PHARM. RES., vol. 2, no. 1, June 2003 (2003-06-01), pages 183 - 189 *

Also Published As

Publication number Publication date
US7645463B2 (en) 2010-01-12
CA2656185C (fr) 2012-06-19
AU2007258202A8 (en) 2009-03-19
AU2007258202A1 (en) 2007-12-21
KR101101253B1 (ko) 2012-01-04
AU2007258202B2 (en) 2010-12-16
KR20090040888A (ko) 2009-04-27
WO2007146427A2 (fr) 2007-12-21
JP5068314B2 (ja) 2012-11-07
DE602007012442D1 (de) 2011-03-24
JP2009540002A (ja) 2009-11-19
CA2656185A1 (fr) 2007-12-21
EP2051722B1 (fr) 2011-02-09
EP2051722A4 (fr) 2010-04-21
US20080008775A1 (en) 2008-01-10
ATE497773T1 (de) 2011-02-15
EP2051722A2 (fr) 2009-04-29

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