WO2007135693A3 - Intermédiaires utiles pour la préparation d'un dérivé de la pipéridine antihistaminique - Google Patents

Intermédiaires utiles pour la préparation d'un dérivé de la pipéridine antihistaminique Download PDF

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Publication number
WO2007135693A3
WO2007135693A3 PCT/IN2007/000201 IN2007000201W WO2007135693A3 WO 2007135693 A3 WO2007135693 A3 WO 2007135693A3 IN 2007000201 W IN2007000201 W IN 2007000201W WO 2007135693 A3 WO2007135693 A3 WO 2007135693A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidine derivative
preparation
intermediates useful
antihistaminic piperidine
antihistaminic
Prior art date
Application number
PCT/IN2007/000201
Other languages
English (en)
Other versions
WO2007135693A2 (fr
Inventor
Chidambaram Venkate Srinivasan
Perminder Singh Johar
Lalit Wadhwa
Original Assignee
Ind Swift Lab Ltd
Chidambaram Venkate Srinivasan
Perminder Singh Johar
Lalit Wadhwa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Swift Lab Ltd, Chidambaram Venkate Srinivasan, Perminder Singh Johar, Lalit Wadhwa filed Critical Ind Swift Lab Ltd
Publication of WO2007135693A2 publication Critical patent/WO2007135693A2/fr
Publication of WO2007135693A3 publication Critical patent/WO2007135693A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation d'un dérivé de la pipéridine antihistaminique, notamment la fexofénadine et ses sels pharmaceutiquement acceptables, par l'utilisation de nouveaux intermédiaires synthétiques de formule (I) suivante, où R représente un alkyle inférieur ; R2 représente H, un cyclopropyle, R1 représente un alkyle, la 4-(hydroxy-diphényl-méthyl)-pipéridin-1-yle.
PCT/IN2007/000201 2006-05-18 2007-05-18 Intermédiaires utiles pour la préparation d'un dérivé de la pipéridine antihistaminique WO2007135693A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1219/DEL/2006 2006-05-18
IN1219DE2006 2006-05-18

Publications (2)

Publication Number Publication Date
WO2007135693A2 WO2007135693A2 (fr) 2007-11-29
WO2007135693A3 true WO2007135693A3 (fr) 2009-06-11

Family

ID=38723705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000201 WO2007135693A2 (fr) 2006-05-18 2007-05-18 Intermédiaires utiles pour la préparation d'un dérivé de la pipéridine antihistaminique

Country Status (1)

Country Link
WO (1) WO2007135693A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE03757471T1 (de) 2002-06-10 2005-09-01 Teva Pharmaceutical Industries Ltd. Polymorphe form xvi von fexofenadin-hydrochlorid
CN102757382B (zh) * 2012-07-06 2013-11-27 启东东岳药业有限公司 非索非那定中间体的纯化方法
HUE047669T2 (hu) 2015-10-22 2020-05-28 Sanofi Aventis Deutschland Eljárás fexofenadin és az eljárásban használt köztitermékek elõállítására

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750703A (en) * 1993-06-24 1998-05-12 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
US6147217A (en) * 1997-02-04 2000-11-14 Sepracor Inc. Synthesis of terfenadine and derivatives
WO2002102776A1 (fr) * 2001-06-15 2002-12-27 Aventis Pharma Deutschland Gmbh Procede de production du derive fexofenadine de piperidine
WO2004054955A1 (fr) * 2002-12-16 2004-07-01 Ranbaxy Laboratories Limited Procede de preparation de la fexofenadine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750703A (en) * 1993-06-24 1998-05-12 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
US6147217A (en) * 1997-02-04 2000-11-14 Sepracor Inc. Synthesis of terfenadine and derivatives
WO2002102776A1 (fr) * 2001-06-15 2002-12-27 Aventis Pharma Deutschland Gmbh Procede de production du derive fexofenadine de piperidine
WO2004054955A1 (fr) * 2002-12-16 2004-07-01 Ranbaxy Laboratories Limited Procede de preparation de la fexofenadine

Also Published As

Publication number Publication date
WO2007135693A2 (fr) 2007-11-29

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