WO2007129487A1

WO2007129487A1 - Livestock feed

Info

Publication number: WO2007129487A1
Application number: PCT/JP2007/052245
Authority: WO
Inventors: Shinji Ito; Motoshi Suzuki
Original assignee: Idemitsu Kosan Co., Ltd.
Priority date: 2006-05-01
Filing date: 2007-02-08
Publication date: 2007-11-15
Also published as: JP2007319156A; TW200742552A; JP5346433B2

Abstract

Disclosed is a safe and simple means for increasing the amount of milk in a mammal. Also disclosed is a means for stabilizing the calcium concentration in milk when the amount of the milk is increased. Trehalose is added to a feed, and the feed is used to breed a mammal.

Description

Specification

Livestock feed

Technical field

[0001] The present invention relates to a milk yield increasing agent for mammals and a feed containing the same. The present invention also relates to a calcium absorption promoter for livestock belonging to mammals, a calcium extender in milk, and a feed containing the same.

Background art

[0002] In mammals (excluding humans), especially in animals where milk is a commodity, such as cattle, goats, and sheep, poor milk production and decreased milk yield due to illness are serious economic problems for dairy farmers. Also, even if the animal is in good condition, increasing the milk yield per head is preferable because it will increase the income of dairymen.

[0003] Methods for increasing milk yield include adding maltose, sucrose, starch, etc. to the feed to increase the amount of energy intake, controlling the type of amino acid to be administered and the timing of administration (Patent Documents 1 to 3) is known. However, there is a problem that the method of administering saccharides and starch cannot obtain a sufficient effect, resulting in poor feed efficiency, and the method of administering amino acid is very complicated to adjust the addition timing. There was a problem.

[0004] Trehalose is a non-reducing disaccharide having glucose as a structural unit, and is widely distributed in mold, yeast, red algae, lichens, and many insects. Trehalose is known to have an anti-aging effect on starch, an anti-denaturation effect on proteins, and an anti-fouling effect on lipids, and is widely used for the purpose of improving the storage stability of foods.

In addition, a technique for improving the storage stability of animal feed using the above-mentioned effects of trehalose has been reported (Patent Documents 4 and 5). In these feeds, specifically, trehalose is used for the purpose of improving the stability of contained components, such as increasing the residual rate of feed enzymes by utilizing the protein denaturation preventing effect. It has also been reported that trehalose is used as a sweetener to impart palatability (Patent Document 6). However, the administration of trehalose to mammals to increase milk yield should be studied.

[0005] In addition, as the amount of milk seen in the late lactation period decreased, the calcium concentration in the milk changed, There is a problem that the quality of On the other hand, when the milk yield is increased, there is a concern that calcium in the blood is deficient and the calcium concentration in the milk is lowered. It is also predicted that if milk production is increased in older livestock, the likelihood of developing hypocalcemia is increased. The development of hypocalcemia is a very serious problem for dairymen, which can cause inability to stand.

As a method for increasing the absorption rate of calcium, a method of administering vitamin D is known. However, since vitamin D has side effects such as promoting the deposition of blood vessel walls and calcium when taken too much, it must be used under strict control.

On the other hand, trehalose is known to interact with calcium and suppress the formation of insoluble salts such as calcium phosphate (Non-patent Document 1). In mice, it is also known that when trehalose is orally administered simultaneously with calcium chloride, the calcium concentration in blood increases! / Non-patent document 2).

[0006] Patent Document 1: Japanese Patent Application Laid-Open No. 5-92093

Patent Document 2: JP-A-6-237701

Patent Document 3: Japanese Patent Laid-Open No. 2001-86940

Patent Document 4: Japanese Translation of Special Publication 2002-536005

Patent Document 5: JP-A-6-217716

Patent Document 6: Japanese Unexamined Patent Application Publication No. 2004-210795

Non-Patent Document 1: Ikuo Sawaya, “Interaction between trehalose and minerals”, 5th Treha Symposium, p. 41 -48, 2001

Non-Patent Document 2: Naruyuki Arai et al., “Trehalose and Osteoporosis”, The 3rd Treha Symposium Collection, p.

Disclosure of the invention

[0007] An object of the present invention is to provide a safe and simple means for increasing the milk yield of a mammal. It is another object of the present invention to provide a safe and simple means for stably maintaining the calcium concentration of milk even when the amount of milk is increased.

[0008] As a result of studies on substances that have the effect of increasing the milk yield of mammals to solve the above problems and effective amounts thereof, the present inventors have added trehalose to feed. It has been found that there is an effect of increasing the milk yield of livestock such as cattle, goats, sheep and so on. Furthermore, it was found that adjusting the dosage of trehalose is more effective in increasing milk yield. Further, the inventors have found that when the milk yield is increased using trehalose, the calcium concentration in the milk is stable over the lactation period, and the present invention has been completed.

That is, the present invention is as follows.

(1) A mammalian milk yield increasing agent containing trehalose as an active ingredient.

(2) The milk yield increasing agent according to (1), wherein the mammal is a cow, goat or sheep.

(3) A feed containing the milk yield increasing agent according to (1) or (2).

(4) The feed according to (3), wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry matter.

(5) A method for raising a mammal, comprising supplying the feed according to (3) or (4) to a lactating mammal.

(6) A calcium absorption promoter for livestock belonging to mammals containing trehalose as an active ingredient.

(7) A calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient.

(8) The calcium absorption enhancer or the calcium extender in milk according to (6) or (7), wherein the domestic animals are cattle, goats and sheep.

(9) A feed containing the calcium absorption promoter according to any one of (6) to (8) or the calcium extender in milk.

(10) The feed according to (9), wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry substance amount.

(11) A method for raising livestock belonging to mammals, comprising supplying the feed according to (9) or (10) to livestock belonging to lactating mammals.

Brief Description of Drawings

FIG. 1 is a graph showing changes in milk yield of dairy cows.

FIG. 2 is a graph showing the total amount of calcium contained in milk. BEST MODE FOR CARRYING OUT THE INVENTION

[0010] The milk yield increasing agent of the present invention is characterized by containing trehalose as an active ingredient.

The trehalose contained in the milk yield increasing agent of the present invention may be any of α, α-trehalose, a, j8-trehalose, β, β-trehalose, but preferably a, a-trenorose. is there. Further, the production method, origin and form of trehalose are not limited. For example, trehalose found in nature such as trehalose derived from yeast may be used, and trehalose produced by maltose starch may be used. It is also possible to use trehalose sold on the market.

[0011] The concentration of trehalose in the milk yield increasing agent of the present invention can be adjusted as appropriate depending on the type of feed to be added, etc. Trehalose is 0.02 to 1. Og per kg body weight per day, preferably It is preferable that the concentration is suitable for giving 0.02 to 0.40 g or that the trehalose content of the feed is 10 to 1000 ppm by mass per dry substance.

[0012] The dosage form of the milk yield increasing agent of the present invention is not particularly limited, and may be any form such as powder, liquid, tablet, and the like. The method for producing the milk yield-increasing agent of the present invention is not particularly limited, and for example, it can be produced by mixing trehalose and, if necessary, optional ingredients and preparing a formulation.

[0013] The milk yield increasing agent of the present invention may further contain optional components such as a component effective for increasing milk yield and a component for improving storage stability.

Optional ingredients include, for example, viable agents such as Enterococcus, Bacillus, and Bifidobacteria, enzymes such as amylase and lipase, vitamins such as L-corsorbic acid, salt 匕 choline, inositol, and folic acid, saltミネラル Minerals such as potassium, iron citrate, magnesium oxide, phosphates, amino acids such as DL-alanine, DL-methionine, L-lysine, organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and their salts, Antioxidants such as ethoxyquin and dibutylhydroxytoluene, fungicides such as calcium propionate, binders such as carboxymethylcellulose, sodium caseinate and sodium polyacrylate, emulsifiers such as glycerin fatty acid ester and sorbitan fatty acid ester, fasta xanthine, Canthaxanthin Which dyes, esters, ethers, such as ketones Examples include flavoring agents, monosaccharides such as glucose, lactose, and raffinose, and oligosaccharides.

[0014] Further, the milk yield increasing agent containing trehalose of the present invention as an active ingredient is mixed with other feed ingredients used for mammal feed, pet food, and supplements for pets (hereinafter referred to as feed). It can be used as a feed for increasing the milk yield of mammals. There are no particular restrictions on the type and ingredients of the feed. Further, the feed of the present invention may be prepared by adding an optional ingredient that can be added to the milk yield increasing agent! /.

The trehalose content in the feed of the present invention can be adjusted as appropriate according to the type of animal to be fed, the composition of the feed, age, weight, time, etc., and is not particularly limited, but is 10 mass ppm to 10000 mass ppm per dry matter amount. Preferably there is.

[0015] The milk yield increasing agent of the present invention may be added to the feed ingredients as they are and mixed. Carrot supplementation can be performed by sprinkling the top of the feed. In addition, when a powdery or solid milk increasing agent is added and mixed, it can be used in liquid or gel form for easy mixing with feed. In this case, water, vegetable oils such as soybean oil, rapeseed oil and corn oil, liquid animal oils, water-soluble polymer compounds such as polybulal alcohol, polybulurpyrrolidone and polyacrylic acid can be used as the liquid carrier. It is also preferable to add water-soluble polysaccharides such as alginic acid, sodium alginate, xanthan gum, sodium caseinate, gum arabic, guar gum, tamarind seed polysaccharide to maintain the homogeneity of trehalose in the feed.

[0016] The animal that provides the feed of the present invention is a lactating mammal. The lactation period varies depending on the animal species, but is usually about 12 months after delivery. As a kind of mammal, it can use for pets, such as livestock, a dog, and a cat, for example. Among these, it can be suitably used for livestock, particularly cattle, goats and sheep. Furthermore, among these, it can be particularly suitably used for raising dairy cows. The amount of feed to be fed can be adjusted as appropriate according to the type of animal, body weight, age, health condition, ingredients of the feed, etc. Can be given in the range of 0.02g to 0.4g. For example, in the case of dairy cows, the dosage of trehalose is preferably 10 to 50 Og per head per day. Moreover, the time when the feed of the present invention is supplied is not particularly limited, and it is particularly effective when used after 2 months after delivery when the amount of 1S milk starts to decrease. Also keep The fee will be provided in the usual way.

[0017] The milk yield-increasing agent of the present invention can be added to and dissolved in water and provided to lactating mammals. Among these, it is preferable to provide it as drinking water to livestock, particularly cattle, goats and sheep. In this case, the amount of milk added to the milk yield increasing agent can be adjusted so that the dosage of trehalose falls within the above range, as in the case of feed. Moreover, the method for providing drinking water is not particularly limited, and may be, for example, free intake.

[0018] The calcium absorption promoter of the present invention is characterized by containing trehalose as an active ingredient. The trehalose contained in the calcium absorption promoter of the present invention is the same as the above-mentioned milk yield increasing agent.

[0019] The concentration of trehalose in the calcium absorption enhancer of the present invention, the dosage form of the calcium absorption enhancer, and the optional components contained therein can be appropriately selected in the same manner as the milk yield increasing agent described above.

[0020] In addition, the calcium absorption promoter of the present invention can be mixed with other feed ingredients used in livestock feed to make a feed for promoting calcium absorption. There are no particular restrictions on the type and ingredients of the feed. Further, the feed of the present invention may be prepared by adding the above-mentioned optional components that can be added to the milk yield increasing agent of the present invention. Also preferred is a combination with calcium supplements.

The trehalose content in the feed for promoting calcium absorption according to the present invention can be adjusted as appropriate as in the case of the milk yield increasing agent.

[0021] Further, the animal that supplies the feed containing the calcium absorption enhancer of the present invention is a livestock belonging to a mammal. Among these, it can use suitably with respect to a cow, a goat, and a sheep. The method for supplying the feed of the present invention is not particularly limited, and can be performed in the same manner as the feed containing the milk yield increasing agent.

[0022] The calcium extender in milk of the present invention is characterized by containing trehalose as an active ingredient. The calcium extender of the present invention has the action of increasing the milk yield of livestock belonging to mammals and maintaining the calcium concentration in the milk. As a result, the total amount of calcium used for milk production is increased. The concentration of trehalose in the calcium extender of the present invention, the dosage form of the calcium absorption promoter, and the optional ingredients contained therein are as described above. It can be appropriately selected in the same manner as the milk yield increasing agent and calcium absorption promoter.

In addition, the calcium extender in milk of the present invention is mixed with other feed ingredients used in livestock feed to increase the milk yield and serve as a feed for maintaining the calcium concentration in the milk. Can do. The trehalose content, the type and ingredients of the feed are not particularly limited, and can be prepared in the same manner as the feed containing the milk yield-increasing agent and calcium absorption promoter of the present invention. Moreover, the form combined with a calcium supplement etc. is also preferable.

Also, the feed supply method is not particularly limited, and can be performed in the same manner as the feed supply containing a milk yield increasing agent or a calcium absorption promoter.

Example

[0023] Breeding tests of dairy cows (Holstein, 2-3 months after parturition) using a feed containing trehalose were conducted as follows.

Use 15 healthy dairy cows with no abnormalities in the findings before the start of the study, and make sure that the milk yield does not vary. It was. For the three groups, trehalose (made by Wako Pure Chemical Industries, Ltd.) and 10g, 50g, and 2OOg supplements each day were fed to dairy cattle feed (Haiday Valky 72, Nippon Agricultural Industry Co., Ltd.) Feed 50g maltose (manufactured by Wako Pure Chemical Industries, Ltd.) instead of trehalose for one group, and feed for another group without adding trehalose. Was provided. Trehalose and maltose were sprinkled on the top of the feed. The milk yield during the breeding period was measured, and the average milk yield of each group was determined. Figure 1 shows changes in milk yield.

[0024] As can be seen from Fig. 1, milk yield tends to decrease gradually in the group bred with no trehalose-added feed, but overall milk yield is higher in the group bred with trehalose-added feed. In addition, the decrease in milk yield was also low. In particular, the increase in milk yield was significant in the group administered trehalose at a daily dose of 50 g or 200 g. On the other hand, in the group to which maltose was added, an increase in milk yield was not confirmed.

[0025] Milk was sampled every week during the test period, and the calcium concentration in the milk was measured by atomic absorption spectrophotometry. The measurement results (average values) are shown in Table 1 and Fig. 2.

[0026] [Table 1] Japan Patent Office 05.3.2007

In groups fed with trehalose-free diet and maltose-added diet, it was confirmed that the calcium concentration in milk increased over time with a significant decrease in milk yield. (Calculate the mass with the specific gravity of milk as 1))

It decreased. On the other hand, in the group fed with 10g trehalose supplemented feed, the amount of milk was not changed. With a slight decrease, a trend of increasing calcium concentration in milk was confirmed, and the total calcium content also increased slightly. In the group fed with trehalose 50g and 200g supplemented feed, milk yield increased significantly and calcium concentration was maintained. That is, it can be seen that the total calcium content has increased significantly.

From the above, it was found that feeding with trehalose added increased the milk yield and also promoted calcium absorption, resulting in maintaining the calcium concentration in the milk. It also contributed to the increase in total calcium used for milk production. Industrial applicability

By administering a feed containing trehalose to a mammal, the milk yield of the mammal is increased and stabilized. In addition, even if the absorption of calcium by mammals is promoted and the milk yield is increased, a certain quality can be maintained without lowering the calcium concentration in milk. As a result, the total amount of calcium utilized for the production of mammalian milk is increased. The feed containing the milk yield increasing agent and the feed containing the calcium absorption enhancer of the present invention are particularly suitable for feeding to cattle, goats and sheep.

Claims

The scope of the claims

[I] A milk yield increasing agent for mammals containing trehalose as an active ingredient.

[2] The milk yield increasing agent according to claim 1, wherein the mammal is cow, goat or sheep.

[3] A feed comprising the milk yield increasing agent according to claim 1 or 2.

[4] The feed according to claim 3, wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry matter amount.

[5] A method for raising a mammal, comprising supplying the feed according to claim 3 or 4 to a lactating mammal.

[6] A calcium absorption promoter for domestic animals belonging to mammals containing trehalose as an active ingredient.

[7] A calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient.

[8] The calcium absorption enhancer or the calcium extender in milk according to claim 6 or 7, wherein the livestock is cow, goat or sheep.

[9] A feed comprising the calcium absorption enhancer according to any one of claims 6 to 8 or a calcium extender in milk.

[10] The feed according to claim 9, wherein the trehalose content is 10 ppm by mass to 10,000 ppm by mass per dry substance.

[II] A method for raising livestock belonging to mammals, comprising supplying the feed according to claim 9 or 10 to livestock belonging to lactating mammals.