WO2007129487A1 - Livestock feed - Google Patents
Livestock feed Download PDFInfo
- Publication number
- WO2007129487A1 WO2007129487A1 PCT/JP2007/052245 JP2007052245W WO2007129487A1 WO 2007129487 A1 WO2007129487 A1 WO 2007129487A1 JP 2007052245 W JP2007052245 W JP 2007052245W WO 2007129487 A1 WO2007129487 A1 WO 2007129487A1
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- WO
- WIPO (PCT)
- Prior art keywords
- feed
- milk
- trehalose
- calcium
- milk yield
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
Definitions
- the present invention relates to a milk yield increasing agent for mammals and a feed containing the same.
- the present invention also relates to a calcium absorption promoter for livestock belonging to mammals, a calcium extender in milk, and a feed containing the same.
- Methods for increasing milk yield include adding maltose, sucrose, starch, etc. to the feed to increase the amount of energy intake, controlling the type of amino acid to be administered and the timing of administration (Patent Documents 1 to 3) is known.
- Patent Documents 1 to 3 there is a problem that the method of administering saccharides and starch cannot obtain a sufficient effect, resulting in poor feed efficiency, and the method of administering amino acid is very complicated to adjust the addition timing. There was a problem.
- Trehalose is a non-reducing disaccharide having glucose as a structural unit, and is widely distributed in mold, yeast, red algae, lichens, and many insects. Trehalose is known to have an anti-aging effect on starch, an anti-denaturation effect on proteins, and an anti-fouling effect on lipids, and is widely used for the purpose of improving the storage stability of foods.
- Patent Documents 4 and 5 a technique for improving the storage stability of animal feed using the above-mentioned effects of trehalose has been reported.
- trehalose is used for the purpose of improving the stability of contained components, such as increasing the residual rate of feed enzymes by utilizing the protein denaturation preventing effect.
- trehalose is used as a sweetener to impart palatability (Patent Document 6).
- the administration of trehalose to mammals to increase milk yield should be studied.
- vitamin D As a method for increasing the absorption rate of calcium, a method of administering vitamin D is known. However, since vitamin D has side effects such as promoting the deposition of blood vessel walls and calcium when taken too much, it must be used under strict control.
- Non-patent Document 1 trehalose is known to interact with calcium and suppress the formation of insoluble salts such as calcium phosphate.
- insoluble salts such as calcium phosphate
- mice it is also known that when trehalose is orally administered simultaneously with calcium chloride, the calcium concentration in blood increases! / Non-patent document 2).
- Patent Document 1 Japanese Patent Application Laid-Open No. 5-92093
- Patent Document 2 JP-A-6-237701
- Patent Document 3 Japanese Patent Laid-Open No. 2001-86940
- Patent Document 4 Japanese Translation of Special Publication 2002-536005
- Patent Document 5 JP-A-6-217716
- Patent Document 6 Japanese Unexamined Patent Application Publication No. 2004-210795
- Non-Patent Document 1 Ikuo Sawaya, “Interaction between trehalose and minerals”, 5th Treha Symposium, p. 41 -48, 2001
- Non-Patent Document 2 Naruyuki Arai et al., “Trehalose and Osteoporosis”, The 3rd Treha Symposium Collection, p.
- An object of the present invention is to provide a safe and simple means for increasing the milk yield of a mammal. It is another object of the present invention to provide a safe and simple means for stably maintaining the calcium concentration of milk even when the amount of milk is increased.
- the present invention is as follows.
- a mammalian milk yield increasing agent containing trehalose as an active ingredient containing trehalose as an active ingredient.
- a method for raising a mammal comprising supplying the feed according to (3) or (4) to a lactating mammal.
- a calcium absorption promoter for livestock belonging to mammals containing trehalose as an active ingredient (6) A calcium absorption promoter for livestock belonging to mammals containing trehalose as an active ingredient.
- a calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient is a calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient.
- a method for raising livestock belonging to mammals comprising supplying the feed according to (9) or (10) to livestock belonging to lactating mammals.
- FIG. 1 is a graph showing changes in milk yield of dairy cows.
- FIG. 2 is a graph showing the total amount of calcium contained in milk.
- the milk yield increasing agent of the present invention is characterized by containing trehalose as an active ingredient.
- the trehalose contained in the milk yield increasing agent of the present invention may be any of ⁇ , ⁇ -trehalose, a, j8-trehalose, ⁇ , ⁇ -trehalose, but preferably a, a-trenorose. is there.
- the production method, origin and form of trehalose are not limited.
- trehalose found in nature such as trehalose derived from yeast may be used, and trehalose produced by maltose starch may be used. It is also possible to use trehalose sold on the market.
- the concentration of trehalose in the milk yield increasing agent of the present invention can be adjusted as appropriate depending on the type of feed to be added, etc.
- Trehalose is 0.02 to 1. Og per kg body weight per day, preferably It is preferable that the concentration is suitable for giving 0.02 to 0.40 g or that the trehalose content of the feed is 10 to 1000 ppm by mass per dry substance.
- the dosage form of the milk yield increasing agent of the present invention is not particularly limited, and may be any form such as powder, liquid, tablet, and the like.
- the method for producing the milk yield-increasing agent of the present invention is not particularly limited, and for example, it can be produced by mixing trehalose and, if necessary, optional ingredients and preparing a formulation.
- the milk yield increasing agent of the present invention may further contain optional components such as a component effective for increasing milk yield and a component for improving storage stability.
- Optional ingredients include, for example, viable agents such as Enterococcus, Bacillus, and Bifidobacteria, enzymes such as amylase and lipase, vitamins such as L-corsorbic acid, salt ⁇ choline, inositol, and folic acid, salt ⁇ ⁇ ⁇ ⁇ Minerals such as potassium, iron citrate, magnesium oxide, phosphates, amino acids such as DL-alanine, DL-methionine, L-lysine, organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and their salts, Antioxidants such as ethoxyquin and dibutylhydroxytoluene, fungicides such as calcium propionate, binders such as carboxymethylcellulose, sodium caseinate and sodium polyacrylate, emulsifiers such as glycerin fatty acid ester and sorbitan fatty acid ester, fasta xanthine, Canthaxanthin Which dyes, est
- the milk yield increasing agent containing trehalose of the present invention as an active ingredient is mixed with other feed ingredients used for mammal feed, pet food, and supplements for pets (hereinafter referred to as feed). It can be used as a feed for increasing the milk yield of mammals. There are no particular restrictions on the type and ingredients of the feed. Further, the feed of the present invention may be prepared by adding an optional ingredient that can be added to the milk yield increasing agent! /.
- the trehalose content in the feed of the present invention can be adjusted as appropriate according to the type of animal to be fed, the composition of the feed, age, weight, time, etc., and is not particularly limited, but is 10 mass ppm to 10000 mass ppm per dry matter amount. Preferably there is.
- the milk yield increasing agent of the present invention may be added to the feed ingredients as they are and mixed. Carrot supplementation can be performed by sprinkling the top of the feed.
- a powdery or solid milk increasing agent when added and mixed, it can be used in liquid or gel form for easy mixing with feed.
- water, vegetable oils such as soybean oil, rapeseed oil and corn oil, liquid animal oils, water-soluble polymer compounds such as polybulal alcohol, polybulurpyrrolidone and polyacrylic acid can be used as the liquid carrier.
- water-soluble polysaccharides such as alginic acid, sodium alginate, xanthan gum, sodium caseinate, gum arabic, guar gum, tamarind seed polysaccharide to maintain the homogeneity of trehalose in the feed.
- the animal that provides the feed of the present invention is a lactating mammal.
- the lactation period varies depending on the animal species, but is usually about 12 months after delivery.
- it can use for pets, such as livestock, a dog, and a cat, for example.
- livestock particularly cattle, goats and sheep.
- livestock particularly cattle, goats and sheep.
- livestock particularly cattle, goats and sheep.
- dairy cows among these, it can be particularly suitably used for raising dairy cows.
- the amount of feed to be fed can be adjusted as appropriate according to the type of animal, body weight, age, health condition, ingredients of the feed, etc. Can be given in the range of 0.02g to 0.4g.
- the dosage of trehalose is preferably 10 to 50 Og per head per day.
- the time when the feed of the present invention is supplied is not particularly limited, and it is particularly effective when used after 2 months after delivery when the amount of 1S milk starts to decrease. Also keep The fee will be provided in the usual way.
- the milk yield-increasing agent of the present invention can be added to and dissolved in water and provided to lactating mammals. Among these, it is preferable to provide it as drinking water to livestock, particularly cattle, goats and sheep. In this case, the amount of milk added to the milk yield increasing agent can be adjusted so that the dosage of trehalose falls within the above range, as in the case of feed. Moreover, the method for providing drinking water is not particularly limited, and may be, for example, free intake.
- the calcium absorption promoter of the present invention is characterized by containing trehalose as an active ingredient.
- the trehalose contained in the calcium absorption promoter of the present invention is the same as the above-mentioned milk yield increasing agent.
- concentration of trehalose in the calcium absorption enhancer of the present invention, the dosage form of the calcium absorption enhancer, and the optional components contained therein can be appropriately selected in the same manner as the milk yield increasing agent described above.
- the calcium absorption promoter of the present invention can be mixed with other feed ingredients used in livestock feed to make a feed for promoting calcium absorption.
- feed ingredients used in livestock feed to make a feed for promoting calcium absorption.
- the feed of the present invention may be prepared by adding the above-mentioned optional components that can be added to the milk yield increasing agent of the present invention. Also preferred is a combination with calcium supplements.
- the trehalose content in the feed for promoting calcium absorption according to the present invention can be adjusted as appropriate as in the case of the milk yield increasing agent.
- the animal that supplies the feed containing the calcium absorption enhancer of the present invention is a livestock belonging to a mammal. Among these, it can use suitably with respect to a cow, a goat, and a sheep.
- the method for supplying the feed of the present invention is not particularly limited, and can be performed in the same manner as the feed containing the milk yield increasing agent.
- the calcium extender in milk of the present invention is characterized by containing trehalose as an active ingredient.
- the calcium extender of the present invention has the action of increasing the milk yield of livestock belonging to mammals and maintaining the calcium concentration in the milk. As a result, the total amount of calcium used for milk production is increased.
- the concentration of trehalose in the calcium extender of the present invention, the dosage form of the calcium absorption promoter, and the optional ingredients contained therein are as described above. It can be appropriately selected in the same manner as the milk yield increasing agent and calcium absorption promoter.
- the calcium extender in milk of the present invention is mixed with other feed ingredients used in livestock feed to increase the milk yield and serve as a feed for maintaining the calcium concentration in the milk.
- the trehalose content, the type and ingredients of the feed are not particularly limited, and can be prepared in the same manner as the feed containing the milk yield-increasing agent and calcium absorption promoter of the present invention.
- the form combined with a calcium supplement etc. is also preferable.
- the feed supply method is not particularly limited, and can be performed in the same manner as the feed supply containing a milk yield increasing agent or a calcium absorption promoter.
- milk yield tends to decrease gradually in the group bred with no trehalose-added feed, but overall milk yield is higher in the group bred with trehalose-added feed. In addition, the decrease in milk yield was also low. In particular, the increase in milk yield was significant in the group administered trehalose at a daily dose of 50 g or 200 g. On the other hand, in the group to which maltose was added, an increase in milk yield was not confirmed.
- the milk yield of the mammal is increased and stabilized.
- the absorption of calcium by mammals is promoted and the milk yield is increased, a certain quality can be maintained without lowering the calcium concentration in milk.
- the total amount of calcium utilized for the production of mammalian milk is increased.
- the feed containing the milk yield increasing agent and the feed containing the calcium absorption enhancer of the present invention are particularly suitable for feeding to cattle, goats and sheep.
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Abstract
Disclosed is a safe and simple means for increasing the amount of milk in a mammal. Also disclosed is a means for stabilizing the calcium concentration in milk when the amount of the milk is increased. Trehalose is added to a feed, and the feed is used to breed a mammal.
Description
明 細 書 Specification
家畜用飼料 Livestock feed
技術分野 Technical field
[0001] 本発明は、哺乳動物の乳量増加剤及びこれを含有する飼料に関する。また、本発 明は、哺乳動物に属する家畜用のカルシウム吸収促進剤、乳中のカルシウム増量剤 及びこれを含有する飼料に関する。 [0001] The present invention relates to a milk yield increasing agent for mammals and a feed containing the same. The present invention also relates to a calcium absorption promoter for livestock belonging to mammals, a calcium extender in milk, and a feed containing the same.
背景技術 Background art
[0002] 哺乳動物 (ヒトを除く。)、特に牛、山羊、羊のように乳が商品となる動物においては 、体調不良や病気による乳量低下は、酪農農家にとって深刻な経済問題である。ま た、動物の体調が良好な場合であっても、一頭当たりの乳量が増加すれば、酪農家 の収入増加につながるため好ま 、。 [0002] In mammals (excluding humans), especially in animals where milk is a commodity, such as cattle, goats, and sheep, poor milk production and decreased milk yield due to illness are serious economic problems for dairy farmers. Also, even if the animal is in good condition, increasing the milk yield per head is preferable because it will increase the income of dairymen.
[0003] 乳量を増大させる方法としては、マルトース、スクロース、澱粉などを飼料に添加し、 摂取エネルギー量を増やすこと、投与するアミノ酸の種類や投与のタイミングを制御 することなど (特許文献 1〜3)が知られている。しかしながら、糖類や澱粉を投与する 方法では十分な効果が得られず、結果的に飼料効率が悪くなるという問題があり、ァ ミノ酸を投与する方法は、添加時期の調節が非常に煩雑であるという問題があった。 [0003] Methods for increasing milk yield include adding maltose, sucrose, starch, etc. to the feed to increase the amount of energy intake, controlling the type of amino acid to be administered and the timing of administration (Patent Documents 1 to 3) is known. However, there is a problem that the method of administering saccharides and starch cannot obtain a sufficient effect, resulting in poor feed efficiency, and the method of administering amino acid is very complicated to adjust the addition timing. There was a problem.
[0004] トレハロースはグルコースを構成単位とする非還元性の二糖類でありカビ、酵母、紅 藻、地衣、多くの昆虫に広く分布している。トレハロースにはデンプンの老化防止効 果、タンパク質の変性防止効果、脂質の変敗抑制効果があることが知られており、食 品の保存性を高める目的で広く用いられている。 [0004] Trehalose is a non-reducing disaccharide having glucose as a structural unit, and is widely distributed in mold, yeast, red algae, lichens, and many insects. Trehalose is known to have an anti-aging effect on starch, an anti-denaturation effect on proteins, and an anti-fouling effect on lipids, and is widely used for the purpose of improving the storage stability of foods.
また、トレハロースの上記の効果を利用して、動物の飼料の保存性を高める技術も 報告されている(特許文献 4、 5)。これらの飼料においては、具体的にトレハロースは 、タンパク質の変性防止効果を利用して飼料酵素の残存率を高めるなど、含有成分 の安定性を向上させる目的で用いられている。また、嗜好性を付与するためにトレハ ロースを甘味料として用いることも報告されている(特許文献 6)。し力しながら、トレハ ロースを哺乳動物に投与して乳量を増加させることにつ 、ては検討されて ヽな 、。 In addition, a technique for improving the storage stability of animal feed using the above-mentioned effects of trehalose has been reported (Patent Documents 4 and 5). In these feeds, specifically, trehalose is used for the purpose of improving the stability of contained components, such as increasing the residual rate of feed enzymes by utilizing the protein denaturation preventing effect. It has also been reported that trehalose is used as a sweetener to impart palatability (Patent Document 6). However, the administration of trehalose to mammals to increase milk yield should be studied.
[0005] また、泌乳後期に見られる乳量の減少に伴い、乳中のカルシウム濃度が変化し、乳
の品質が安定しないという問題が存在する。一方、乳量を増加させた場合には、血 中のカルシウムが欠乏し、乳中のカルシウム濃度が低下することが懸念される。また、 高齢の家畜において生産乳量を増加させる場合には、低カルシウム血症の発症の 可能性が高くなることも予測される。低カルシウム血症の発症は、起立不能を引き起 こすこともあり、酪農家にとって極めて深刻な問題である。 [0005] In addition, as the amount of milk seen in the late lactation period decreased, the calcium concentration in the milk changed, There is a problem that the quality of On the other hand, when the milk yield is increased, there is a concern that calcium in the blood is deficient and the calcium concentration in the milk is lowered. It is also predicted that if milk production is increased in older livestock, the likelihood of developing hypocalcemia is increased. The development of hypocalcemia is a very serious problem for dairymen, which can cause inability to stand.
カルシウムの吸収率を高める方法としては、ビタミン Dを投与する方法が知られてい る。し力しながら、ビタミン Dは、摂取しすぎると血管壁やカルシウムの沈着を促すなど の副作用があるため、厳密な管理下での使用が必要である。 As a method for increasing the absorption rate of calcium, a method of administering vitamin D is known. However, since vitamin D has side effects such as promoting the deposition of blood vessel walls and calcium when taken too much, it must be used under strict control.
一方、トレハロースはカルシウムと相互作用を行い、リン酸カルシウムなどの不溶性 の塩類の生成を抑制することが知られている(非特許文献 1)。また、マウスにおいて 、塩化カルシウムと同時にトレハロースを経口投与すると、血中のカルシウム濃度が 増加することも知られて!/ゝる (非特許文献 2)。 On the other hand, trehalose is known to interact with calcium and suppress the formation of insoluble salts such as calcium phosphate (Non-patent Document 1). In mice, it is also known that when trehalose is orally administered simultaneously with calcium chloride, the calcium concentration in blood increases! / Non-patent document 2).
[0006] 特許文献 1 :特開平 5— 192093号公報 [0006] Patent Document 1: Japanese Patent Application Laid-Open No. 5-92093
特許文献 2:特開平 6 - 237701号公報 Patent Document 2: JP-A-6-237701
特許文献 3:特開 2001— 86940号公報 Patent Document 3: Japanese Patent Laid-Open No. 2001-86940
特許文献 4:特表 2002— 536005号公報 Patent Document 4: Japanese Translation of Special Publication 2002-536005
特許文献 5:特開平 6— 217716号公報 Patent Document 5: JP-A-6-217716
特許文献 6:特開 2004— 210795号公報 Patent Document 6: Japanese Unexamined Patent Application Publication No. 2004-210795
非特許文献 1 :澤谷郁夫、「トレハロースとミネラルの相互作用」、第 5回トレハシンポ 記録集、 p. 41 -48, 2001年 Non-Patent Document 1: Ikuo Sawaya, “Interaction between trehalose and minerals”, 5th Treha Symposium, p. 41 -48, 2001
非特許文献 2 :新井成之ら、「トレハロースと骨粗鬆症」、第 3回トレハシンポ記録集、 p . 51— 56、 2000年 Non-Patent Document 2: Naruyuki Arai et al., “Trehalose and Osteoporosis”, The 3rd Treha Symposium Collection, p.
発明の開示 Disclosure of the invention
[0007] 本発明は、哺乳動物の乳量を増加させる安全かつ簡便な手段を提供することを課 題とする。さらに、乳量を増加させた場合でも、乳のカルシウム濃度を安定的に維持 する安全かつ簡便な手段を提供することを課題とする。 [0007] An object of the present invention is to provide a safe and simple means for increasing the milk yield of a mammal. It is another object of the present invention to provide a safe and simple means for stably maintaining the calcium concentration of milk even when the amount of milk is increased.
[0008] 本発明者らは、前記課題を解決すベぐ哺乳動物の乳量を増加させる作用を有す る物質やその有効量などについて研究を行った結果、トレハロースを飼料に添加す
ることにより、牛、山羊、羊などの家畜の乳量を増加させ、安定ィ匕する効果があること を知見した。さらに、トレハロースの投与量を調節することにより、乳量増加の効果が より優れることを知見した。また、トレハロースを用いて乳量を増加させた場合には、 泌乳期に渡り、乳中のカルシウム濃度が安定することを知見し、本発明を完成するに 至った。 [0008] As a result of studies on substances that have the effect of increasing the milk yield of mammals to solve the above problems and effective amounts thereof, the present inventors have added trehalose to feed. It has been found that there is an effect of increasing the milk yield of livestock such as cattle, goats, sheep and so on. Furthermore, it was found that adjusting the dosage of trehalose is more effective in increasing milk yield. Further, the inventors have found that when the milk yield is increased using trehalose, the calcium concentration in the milk is stable over the lactation period, and the present invention has been completed.
すなわち、本発明は以下のとおりである。 That is, the present invention is as follows.
(1)トレハロースを有効成分として含有する哺乳動物の乳量増加剤。 (1) A mammalian milk yield increasing agent containing trehalose as an active ingredient.
(2)上記哺乳動物が牛、山羊、羊である(1)に記載の乳量増加剤。 (2) The milk yield increasing agent according to (1), wherein the mammal is a cow, goat or sheep.
(3) (1)又は(2)に記載の乳量増加剤を含有する飼料。 (3) A feed containing the milk yield increasing agent according to (1) or (2).
(4)トレハロースの含有量が乾物質量当たり 10質量 ppm〜 10000質量 ppmであるこ とを特徴とする(3)に記載の飼料。 (4) The feed according to (3), wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry matter.
(5) (3)又は (4)に記載の飼料を泌乳期の哺乳動物に供与することを含む、哺乳動 物の飼育方法。 (5) A method for raising a mammal, comprising supplying the feed according to (3) or (4) to a lactating mammal.
(6)トレハロースを有効成分として含有する哺乳動物に属する家畜のカルシウム吸収 促進剤。 (6) A calcium absorption promoter for livestock belonging to mammals containing trehalose as an active ingredient.
(7)トレハロースを有効成分として含有する哺乳動物に属する家畜の乳中のカルシゥ ム増量剤。 (7) A calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient.
(8)上記家畜が牛、山羊、羊である(6)又は(7)に記載のカルシウム吸収促進剤又 は乳中のカルシウム増量剤。 (8) The calcium absorption enhancer or the calcium extender in milk according to (6) or (7), wherein the domestic animals are cattle, goats and sheep.
(9) (6)〜(8)の何れか一に記載のカルシウム吸収促進剤又は乳中のカルシウム増 量剤を含有する飼料。 (9) A feed containing the calcium absorption promoter according to any one of (6) to (8) or the calcium extender in milk.
(10)トレハロースの含有量が乾物質量当たり 10質量 ppm〜 10000質量 ppmである ことを特徴とする(9)に記載の飼料。 (10) The feed according to (9), wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry substance amount.
(11) (9)又は(10)に記載の飼料を泌乳期の哺乳動物に属する家畜に供与すること を含む、哺乳動物に属する家畜の飼育方法。 (11) A method for raising livestock belonging to mammals, comprising supplying the feed according to (9) or (10) to livestock belonging to lactating mammals.
図面の簡単な説明 Brief Description of Drawings
[図 1]乳牛の乳量の変化を示す図である。 FIG. 1 is a graph showing changes in milk yield of dairy cows.
[図 2]牛乳中に含まれる総カルシウム量を示す図である。
発明を実施するための最良の形態 FIG. 2 is a graph showing the total amount of calcium contained in milk. BEST MODE FOR CARRYING OUT THE INVENTION
[0010] 本発明の乳量増加剤はトレハロースを有効成分として含有することを特徴とする。 [0010] The milk yield increasing agent of the present invention is characterized by containing trehalose as an active ingredient.
本発明の乳量増加剤に含有するトレハロースは、 α , α—トレハロース、 a , j8—ト レハロース、 β , β—トレハロースの何れであってもよいが、好ましくは a , a—トレノヽ ロースである。また、トレハロースの製造方法、由来、形態は制限されない。例えば、 酵母由来のトレハロースなど天然に見出されて 、るトレハロースを用いてもょ 、し、マ ルトースゃデンプン力 製造されたトレハロースを用いてもよい。また、巿販されてい るトレハロースを用いることもできる。 The trehalose contained in the milk yield increasing agent of the present invention may be any of α, α-trehalose, a, j8-trehalose, β, β-trehalose, but preferably a, a-trenorose. is there. Further, the production method, origin and form of trehalose are not limited. For example, trehalose found in nature such as trehalose derived from yeast may be used, and trehalose produced by maltose starch may be used. It is also possible to use trehalose sold on the market.
[0011] 本発明の乳量増加剤におけるトレハロースの含有濃度は、添加する飼料の種類な どによって適宜調節することができる力 トレハロースを 1日 1体重 kg当たり 0. 02g〜 1. Og、好ましくは 0. 02g〜0. 40g与えるのに適した濃度としたり、飼料のトレハロー ス含有量を乾物質量当たり 10質量 ppm〜 10000質量 ppmとするのに適した濃度と することが好ましい。 [0011] The concentration of trehalose in the milk yield increasing agent of the present invention can be adjusted as appropriate depending on the type of feed to be added, etc. Trehalose is 0.02 to 1. Og per kg body weight per day, preferably It is preferable that the concentration is suitable for giving 0.02 to 0.40 g or that the trehalose content of the feed is 10 to 1000 ppm by mass per dry substance.
[0012] 本発明の乳量増加剤の剤形は特に制限されず、例えば粉末、液体、錠剤など任意 の形態とすることができる。本発明の乳量増加剤の製造方法も特に制限されず、例え ば、トレハロース及び必要に応じて任意成分を、混合し、製剤化することにより製造す ることがでさる。 [0012] The dosage form of the milk yield increasing agent of the present invention is not particularly limited, and may be any form such as powder, liquid, tablet, and the like. The method for producing the milk yield-increasing agent of the present invention is not particularly limited, and for example, it can be produced by mixing trehalose and, if necessary, optional ingredients and preparing a formulation.
[0013] 本発明の乳量増加剤には、さらに乳量の増加に有効な成分や保存安定性を高め る成分など任意成分を含有させることができる。 [0013] The milk yield increasing agent of the present invention may further contain optional components such as a component effective for increasing milk yield and a component for improving storage stability.
任意成分としては、例えば、ェンテロコッカス属細菌、バチルス属細菌、ビフィズス 属細菌などの生菌剤、アミラーゼ、リパーゼなどの酵素、 Lーァスコルビン酸、塩ィ匕コ リン、イノシトール、葉酸などのビタミン、塩ィ匕カリウム、クェン酸鉄、酸化マグネシウム 、リン酸塩類などのミネラル、 DL—ァラニン、 DL—メチォニン、塩酸 L—リジンなどの アミノ酸、フマル酸、酪酸、乳酸、酢酸及びそれらの塩類などの有機酸、エトキシキン 、ジブチルヒドロキシトルエンなどの抗酸化剤、プロピオン酸カルシウムなどの防カビ 剤、カルボキシメチルセルロース、カゼインナトリウム、ポリアクリル酸ナトリウムなどの 粘結剤、グリセリン脂肪酸エステル、ソルビタン脂肪酸エステルなどの乳化剤、ァスタ キサンチン、カンタキサンチンなどの色素、エステル類、エーテル類、ケトン類などの
着香料、ブドウ糖、乳糖、ラフイノースなどの単糖、オリゴ糖類が挙げられる。 Optional ingredients include, for example, viable agents such as Enterococcus, Bacillus, and Bifidobacteria, enzymes such as amylase and lipase, vitamins such as L-corsorbic acid, salt 匕 choline, inositol, and folic acid, saltミ ネ ラ ル Minerals such as potassium, iron citrate, magnesium oxide, phosphates, amino acids such as DL-alanine, DL-methionine, L-lysine, organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and their salts, Antioxidants such as ethoxyquin and dibutylhydroxytoluene, fungicides such as calcium propionate, binders such as carboxymethylcellulose, sodium caseinate and sodium polyacrylate, emulsifiers such as glycerin fatty acid ester and sorbitan fatty acid ester, fasta xanthine, Canthaxanthin Which dyes, esters, ethers, such as ketones Examples include flavoring agents, monosaccharides such as glucose, lactose, and raffinose, and oligosaccharides.
[0014] また、本発明のトレハロースを有効成分として含有する乳量増加剤は、哺乳動物の 飼料、ペットフード、ペット用サプリメント(以下、飼料という。 )に用いられる他の飼料 成分と混合して、哺乳動物の乳量増加のための飼料とすることができる。飼料の種類 や成分は、特に制限されない。また、本発明の飼料には、乳量増加剤に添加すること ができる任意成分を加えて調製してもよ!/、。 [0014] Further, the milk yield increasing agent containing trehalose of the present invention as an active ingredient is mixed with other feed ingredients used for mammal feed, pet food, and supplements for pets (hereinafter referred to as feed). It can be used as a feed for increasing the milk yield of mammals. There are no particular restrictions on the type and ingredients of the feed. Further, the feed of the present invention may be prepared by adding an optional ingredient that can be added to the milk yield increasing agent! /.
本発明の飼料におけるトレハロースの含有量は、与える動物の種類、飼料の成分、 年齢、体重、時期等により適宜調節することができ、特に制限されないが、乾物質量 当たり 10質量 ppm〜 10000質量 ppmであることが好ましい。 The trehalose content in the feed of the present invention can be adjusted as appropriate according to the type of animal to be fed, the composition of the feed, age, weight, time, etc., and is not particularly limited, but is 10 mass ppm to 10000 mass ppm per dry matter amount. Preferably there is.
[0015] また、本発明の乳量増加剤は、そのまま飼料成分に添加し、混合してもよ!ヽ。添カロ は、飼料の上力も振りかけるなどの方法で行うことができる。また、粉末状、固形状の 乳量増加剤を添加、混合する場合は、飼料への混合を容易にするために液状又は ゲル状の形態にして使用することもできる。この場合は、水、大豆油、菜種油、コーン 油などの植物油、液体動物油、ポリビュルアルコールやポリビュルピロリドン、ポリアク リル酸などの水溶性高分子化合物を液体担体として用いることができる。また、飼料 中におけるトレハロースの均一性を保っために、アルギン酸、アルギン酸ナトリウム、 キサンタンガム、カゼインナトリウム、アラビアゴム、グァーガム、タマリンド種子多糖類 などの水溶性多糖類を配合することも好ま U、。 [0015] The milk yield increasing agent of the present invention may be added to the feed ingredients as they are and mixed. Carrot supplementation can be performed by sprinkling the top of the feed. In addition, when a powdery or solid milk increasing agent is added and mixed, it can be used in liquid or gel form for easy mixing with feed. In this case, water, vegetable oils such as soybean oil, rapeseed oil and corn oil, liquid animal oils, water-soluble polymer compounds such as polybulal alcohol, polybulurpyrrolidone and polyacrylic acid can be used as the liquid carrier. It is also preferable to add water-soluble polysaccharides such as alginic acid, sodium alginate, xanthan gum, sodium caseinate, gum arabic, guar gum, tamarind seed polysaccharide to maintain the homogeneity of trehalose in the feed.
[0016] 本発明の飼料を供与する動物は、泌乳期の哺乳動物である。泌乳期は動物種によ つても異なるが、通常分娩後から 12ヶ月程度までである。哺乳動物の種類としては、 例えば、家畜や犬、猫などのペットに用いることができる。この中でも家畜、特に牛、 山羊、羊に対して好適に用いることができる。さらにこの中でも乳牛の飼育に特に好 適に用いることができる。供与する飼料の量は、動物の種類、体重、年齢、健康状態 、飼料の成分などにより適宜調節することができる力 トレハロースの投与量が 1日 1 体重 kg当たり 0. 02g〜l. Og、好ましくは 0. 02g〜0. 4gの範囲となるように与えるこ とができる。例えば、乳牛の場合にはトレハロースの投与量を 1日 1頭当たり 10g〜50 Ogとすることが好ましい。また、本発明の飼料を供与する時期は、特に制限されない 1S 乳量が減少し始める分娩後 2ヶ月以降に使用すると特に効果的である。また、飼
料の供与は通常の方法で行えばょ 、。 [0016] The animal that provides the feed of the present invention is a lactating mammal. The lactation period varies depending on the animal species, but is usually about 12 months after delivery. As a kind of mammal, it can use for pets, such as livestock, a dog, and a cat, for example. Among these, it can be suitably used for livestock, particularly cattle, goats and sheep. Furthermore, among these, it can be particularly suitably used for raising dairy cows. The amount of feed to be fed can be adjusted as appropriate according to the type of animal, body weight, age, health condition, ingredients of the feed, etc. Can be given in the range of 0.02g to 0.4g. For example, in the case of dairy cows, the dosage of trehalose is preferably 10 to 50 Og per head per day. Moreover, the time when the feed of the present invention is supplied is not particularly limited, and it is particularly effective when used after 2 months after delivery when the amount of 1S milk starts to decrease. Also keep The fee will be provided in the usual way.
[0017] 本発明の乳量増加剤は、水に添加、溶解させて、泌乳期の哺乳動物に供与するこ とができる。この中でも家畜、特に牛、山羊、羊に対して飲料水として供与することが 好ましい。この場合の乳量増加剤の添カ卩量は、飼料の場合と同様にトレハロースの 投与量が上記範囲となるように調節することができる。また、飲料水を供与する方法も 特に制限されず、例えば、自由摂取であってもよい。 [0017] The milk yield-increasing agent of the present invention can be added to and dissolved in water and provided to lactating mammals. Among these, it is preferable to provide it as drinking water to livestock, particularly cattle, goats and sheep. In this case, the amount of milk added to the milk yield increasing agent can be adjusted so that the dosage of trehalose falls within the above range, as in the case of feed. Moreover, the method for providing drinking water is not particularly limited, and may be, for example, free intake.
[0018] 本発明のカルシウム吸収促進剤は、トレハロースを有効成分として含有することを 特徴とする。本発明のカルシウム吸収促進剤に含有するトレハロースは、上述の乳量 増加剤と同様である。 [0018] The calcium absorption promoter of the present invention is characterized by containing trehalose as an active ingredient. The trehalose contained in the calcium absorption promoter of the present invention is the same as the above-mentioned milk yield increasing agent.
[0019] 本発明のカルシウム吸収促進剤におけるトレハロースの含有濃度、カルシウム吸収 促進剤の剤形、これに含まれる任意成分は、上述した乳量増加剤と同様に適宜選択 することができる。 [0019] The concentration of trehalose in the calcium absorption enhancer of the present invention, the dosage form of the calcium absorption enhancer, and the optional components contained therein can be appropriately selected in the same manner as the milk yield increasing agent described above.
[0020] また、本発明のカルシウム吸収促進剤は、家畜の飼料に用いられる他の飼料成分 と混合して、カルシウム吸収を促進するための飼料とすることができる。飼料の種類 や成分は、特に制限されない。また、本発明の飼料は、本発明の乳量増加剤に添加 することができる上記任意成分を加えて調製してもよい。また、カルシウム補給剤など と組み合わせる形態も好ま 、。 [0020] In addition, the calcium absorption promoter of the present invention can be mixed with other feed ingredients used in livestock feed to make a feed for promoting calcium absorption. There are no particular restrictions on the type and ingredients of the feed. Further, the feed of the present invention may be prepared by adding the above-mentioned optional components that can be added to the milk yield increasing agent of the present invention. Also preferred is a combination with calcium supplements.
本発明のカルシウム吸収を促進するための飼料におけるトレハロースの含有量も乳 量増加剤と同様に適宜調節することができる。 The trehalose content in the feed for promoting calcium absorption according to the present invention can be adjusted as appropriate as in the case of the milk yield increasing agent.
[0021] また、本発明のカルシウム吸収促進剤を含有する飼料を供与する動物は、哺乳動 物に属する家畜である。この中でも牛、山羊、羊に対して好適に用いることができる。 本発明の飼料を供与する方法も特に制限されず、乳量増加剤を含有する飼料の供 与と同様に行うことができる。 [0021] Further, the animal that supplies the feed containing the calcium absorption enhancer of the present invention is a livestock belonging to a mammal. Among these, it can use suitably with respect to a cow, a goat, and a sheep. The method for supplying the feed of the present invention is not particularly limited, and can be performed in the same manner as the feed containing the milk yield increasing agent.
[0022] 本発明の乳中のカルシウム増量剤は、トレハロースを有効成分として含有することを 特徴とする。本発明のカルシウム増量剤は、哺乳動物に属する家畜の乳量を増加さ せ、かつ乳中のカルシウム濃度を維持する作用を有する。その結果、乳の生産に利 用される総カルシウム量を増加させる。本発明のカルシウム増量剤におけるトレハロ ースの含有濃度、カルシウム吸収促進剤の剤形、これに含まれる任意成分は、上述
した乳量増加剤やカルシウム吸収促進剤と同様に適宜選択することができる。 [0022] The calcium extender in milk of the present invention is characterized by containing trehalose as an active ingredient. The calcium extender of the present invention has the action of increasing the milk yield of livestock belonging to mammals and maintaining the calcium concentration in the milk. As a result, the total amount of calcium used for milk production is increased. The concentration of trehalose in the calcium extender of the present invention, the dosage form of the calcium absorption promoter, and the optional ingredients contained therein are as described above. It can be appropriately selected in the same manner as the milk yield increasing agent and calcium absorption promoter.
また、本発明の乳中のカルシウム増量剤を家畜の飼料に用いられる他の飼料成分 と混合して、乳量を増カロさせ、かつ乳中のカルシウム濃度を維持するための飼料とす ることができる。トレハロースの含有量、飼料の種類や成分は、特に制限されず、本発 明の乳量増加剤やカルシウム吸収促進剤を含む飼料と同様に調製することができる 。また、カルシウム補給剤などと組み合わせる形態も好ましい。 In addition, the calcium extender in milk of the present invention is mixed with other feed ingredients used in livestock feed to increase the milk yield and serve as a feed for maintaining the calcium concentration in the milk. Can do. The trehalose content, the type and ingredients of the feed are not particularly limited, and can be prepared in the same manner as the feed containing the milk yield-increasing agent and calcium absorption promoter of the present invention. Moreover, the form combined with a calcium supplement etc. is also preferable.
また、飼料の供与方法についても特に制限されず、乳量増加剤やカルシウム吸収 促進剤を含有する飼料の供与と同様に行うことができる。 Also, the feed supply method is not particularly limited, and can be performed in the same manner as the feed supply containing a milk yield increasing agent or a calcium absorption promoter.
実施例 Example
[0023] トレハロースを含有する飼料を用いた乳牛 (ホルスタイン種、分娩後 2— 3ヶ月)の飼 育試験を以下の方法で行った。 [0023] Breeding tests of dairy cows (Holstein, 2-3 months after parturition) using a feed containing trehalose were conducted as follows.
試験開始前の所見において異常の認められない健康な乳牛 15頭を使用し、乳量 にばらつきが生じないようにして、乳牛 15頭を 3頭ずつ 5群に分けて 28日間の飼育 試験を行った。このうち 3群に対しては、乳牛用飼料 (ハイデーリイバルキー 72、日本 農産工業 (株)製)にトレハロース (和光純薬工業製)を 1日 1回それぞれ 10g、 50g、 2 OOg添カ卩して供与し、 1群に対してはトレハロースの代わりにマルトース(和光純薬ェ 業製) 50gを添加して飼料を供与し、別の 1群に対してはトレハロースを添加せずに 飼料を供与した。トレハロース及びマルトースは飼料供与時に上カゝら振りかけた。 飼育期間中の乳量を測定し、各群の乳量の平均を求めた。乳量の変化を図 1に示 す。 Use 15 healthy dairy cows with no abnormalities in the findings before the start of the study, and make sure that the milk yield does not vary. It was. For the three groups, trehalose (made by Wako Pure Chemical Industries, Ltd.) and 10g, 50g, and 2OOg supplements each day were fed to dairy cattle feed (Haiday Valky 72, Nippon Agricultural Industry Co., Ltd.) Feed 50g maltose (manufactured by Wako Pure Chemical Industries, Ltd.) instead of trehalose for one group, and feed for another group without adding trehalose. Was provided. Trehalose and maltose were sprinkled on the top of the feed. The milk yield during the breeding period was measured, and the average milk yield of each group was determined. Figure 1 shows changes in milk yield.
[0024] 図 1から分力るように、トレハロース無添加飼料により飼育した群では乳量が次第に 低下していく傾向にあるが、トレハロース添加飼料により飼育した群では、全体的に 乳量が高ぐさらに乳量の低下も少ないことが分力つた。特に、トレハロースを 1日当 たり 50g、 200g投与した群では、乳量の増加が顕著であった。一方、マルトースを添 加した群では、乳量の増加は確認できな力つた。 [0024] As can be seen from Fig. 1, milk yield tends to decrease gradually in the group bred with no trehalose-added feed, but overall milk yield is higher in the group bred with trehalose-added feed. In addition, the decrease in milk yield was also low. In particular, the increase in milk yield was significant in the group administered trehalose at a daily dose of 50 g or 200 g. On the other hand, in the group to which maltose was added, an increase in milk yield was not confirmed.
[0025] また、試験期間中一週間ごとに牛乳をサンプリングし、牛乳中のカルシウム濃度を 原子吸光光度法により測定した。測定結果 (平均値)を表 1及び図 2に示す。 [0025] Milk was sampled every week during the test period, and the calcium concentration in the milk was measured by atomic absorption spectrophotometry. The measurement results (average values) are shown in Table 1 and Fig. 2.
[0026] [表 1]
日本国特許庁 05.3.2007 [0026] [Table 1] Japan Patent Office 05.3.2007
トレハロース無添加飼料及びマルトース添加飼料により飼育した群では乳量の顕著 な減少に伴レ、経時的に乳中のカルシウム濃度が増加する傾向が確認されたが、総力 ルシゥム質量 (乳質量 Xカルシウム濃度 (乳の比重を 1として質量を算出) )は、わず In groups fed with trehalose-free diet and maltose-added diet, it was confirmed that the calcium concentration in milk increased over time with a significant decrease in milk yield. (Calculate the mass with the specific gravity of milk as 1))
かに減少した。一方、トレハロース 10g添加飼料により飼育した群では、乳量のわず 差替 え 周 銑(mU26)
かな減少に伴って、乳中のカルシウム濃度が増加する傾向が確認され、総カルシゥ ム量もわずかに増加した。トレハロース 50g、 200g添加飼料により飼育した群では、 乳量が顕著に増加し、カルシウム濃度も維持された。すなわち、総カルシウム量は顕 著に増加したことが分かる。 It decreased. On the other hand, in the group fed with 10g trehalose supplemented feed, the amount of milk was not changed. With a slight decrease, a trend of increasing calcium concentration in milk was confirmed, and the total calcium content also increased slightly. In the group fed with trehalose 50g and 200g supplemented feed, milk yield increased significantly and calcium concentration was maintained. That is, it can be seen that the total calcium content has increased significantly.
以上より、トレハロースを添加した飼料を与えることにより、乳量が増加すると同時に 、カルシウム吸収も促進され、結果として、乳中のカルシウム濃度が維持されることが 分力つた。また、乳の生産に利用される総カルシウム量が増加することも分力つた。 産業上の利用の可能性 From the above, it was found that feeding with trehalose added increased the milk yield and also promoted calcium absorption, resulting in maintaining the calcium concentration in the milk. It also contributed to the increase in total calcium used for milk production. Industrial applicability
トレハロースを含有する飼料を哺乳動物に投与することにより、哺乳動物の乳量を 増加させ、安定化する。また、哺乳動物のカルシウム吸収を促進し、乳量を増加させ た場合でも、乳中のカルシウム濃度が低下することなぐ一定の品質を維持すること ができる。その結果、哺乳動物の乳の生産に利用される総カルシウム量が増加する。 本発明の乳量増加剤を含有する飼料及びカルシウム吸収促進剤を含有する飼料は 、特に、牛、山羊、羊に供与するのに好適である。
By administering a feed containing trehalose to a mammal, the milk yield of the mammal is increased and stabilized. In addition, even if the absorption of calcium by mammals is promoted and the milk yield is increased, a certain quality can be maintained without lowering the calcium concentration in milk. As a result, the total amount of calcium utilized for the production of mammalian milk is increased. The feed containing the milk yield increasing agent and the feed containing the calcium absorption enhancer of the present invention are particularly suitable for feeding to cattle, goats and sheep.
Claims
請求の範囲 The scope of the claims
[I] トレハロースを有効成分として含有する哺乳動物の乳量増加剤。 [I] A milk yield increasing agent for mammals containing trehalose as an active ingredient.
[2] 上記哺乳動物が牛、山羊、羊である請求項 1に記載の乳量増加剤。 [2] The milk yield increasing agent according to claim 1, wherein the mammal is cow, goat or sheep.
[3] 請求項 1又は 2に記載の乳量増加剤を含有する飼料。 [3] A feed comprising the milk yield increasing agent according to claim 1 or 2.
[4] トレハロースの含有量が乾物質量当たり 10質量 ppm〜 10000質量 ppmであること を特徴とする請求項 3に記載の飼料。 [4] The feed according to claim 3, wherein the trehalose content is 10 mass ppm to 10000 mass ppm per dry matter amount.
[5] 請求項 3又は 4に記載の飼料を泌乳期の哺乳動物に供与することを含む、哺乳動 物の飼育方法。 [5] A method for raising a mammal, comprising supplying the feed according to claim 3 or 4 to a lactating mammal.
[6] トレハロースを有効成分として含有する哺乳動物に属する家畜のカルシウム吸収促 進剤。 [6] A calcium absorption promoter for domestic animals belonging to mammals containing trehalose as an active ingredient.
[7] トレハロースを有効成分として含有する哺乳動物に属する家畜の乳中のカルシウム 増量剤。 [7] A calcium extender in the milk of livestock belonging to mammals containing trehalose as an active ingredient.
[8] 上記家畜が牛、山羊、羊である請求項 6又は 7に記載のカルシウム吸収促進剤又 は乳中のカルシウム増量剤。 [8] The calcium absorption enhancer or the calcium extender in milk according to claim 6 or 7, wherein the livestock is cow, goat or sheep.
[9] 請求項 6〜8の何れか一項に記載のカルシウム吸収促進剤又は乳中のカルシウム 増量剤を含有する飼料。 [9] A feed comprising the calcium absorption enhancer according to any one of claims 6 to 8 or a calcium extender in milk.
[10] トレハロースの含有量が乾物質量当たり 10質量 ppm〜 10000質量 ppmであること を特徴とする請求項 9に記載の飼料。 [10] The feed according to claim 9, wherein the trehalose content is 10 ppm by mass to 10,000 ppm by mass per dry substance.
[II] 請求項 9又は 10に記載の飼料を泌乳期の哺乳動物に属する家畜に供与すること を含む、哺乳動物に属する家畜の飼育方法。
[II] A method for raising livestock belonging to mammals, comprising supplying the feed according to claim 9 or 10 to livestock belonging to lactating mammals.
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JP2006-127400 | 2006-05-01 | ||
JP2006127400 | 2006-05-01 | ||
JP2006-193924 | 2006-07-14 | ||
JP2006193924A JP5346433B2 (en) | 2006-05-01 | 2006-07-14 | Livestock feed |
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WO2007129487A1 true WO2007129487A1 (en) | 2007-11-15 |
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PCT/JP2007/052245 WO2007129487A1 (en) | 2006-05-01 | 2007-02-08 | Livestock feed |
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JP (1) | JP5346433B2 (en) |
TW (1) | TW200742552A (en) |
WO (1) | WO2007129487A1 (en) |
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JP2009291151A (en) * | 2008-06-06 | 2009-12-17 | Dainichiseika Color & Chem Mfg Co Ltd | Feed composition and drinking water for livestock or companion creature |
JP2013223481A (en) * | 2012-07-24 | 2013-10-31 | Meiji Shiryo Kk | Milk quality improver for livestock |
JP5899098B2 (en) * | 2012-10-04 | 2016-04-06 | 明治飼糧株式会社 | Blue odor control agent for livestock milk |
JP5894615B2 (en) * | 2014-01-30 | 2016-03-30 | 明治飼糧株式会社 | Heat stress reducing agent for livestock |
EP4252541A1 (en) * | 2020-12-25 | 2023-10-04 | Hayashibara Co., Ltd. | Method for improving productivity in livestock and/or poultry and method for improving intestinal flora in livestock and/or poultry |
Citations (4)
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JP2000316513A (en) * | 1999-05-13 | 2000-11-21 | Tajimaya Shokuhin Kk | Soybean processed food containing natto oil |
JP2001095499A (en) * | 1999-09-29 | 2001-04-10 | Showa Sangyo Co Ltd | Egg shell-strengthening agent and feed for chicken containing the same |
WO2002038146A1 (en) * | 2000-11-07 | 2002-05-16 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Mucosal immunomodulator and use thereof |
JP2004129622A (en) * | 2002-10-15 | 2004-04-30 | Nippon Formula Feed Mfg Co Ltd | Feed for fish culture |
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NZ515869A (en) * | 2001-11-30 | 2003-09-26 | Med Chem Ingredients Ltd | Compositions and methods for animal treatment comprising gluco- and isomalto- oligosaccharides |
-
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2007
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2000316513A (en) * | 1999-05-13 | 2000-11-21 | Tajimaya Shokuhin Kk | Soybean processed food containing natto oil |
JP2001095499A (en) * | 1999-09-29 | 2001-04-10 | Showa Sangyo Co Ltd | Egg shell-strengthening agent and feed for chicken containing the same |
WO2002038146A1 (en) * | 2000-11-07 | 2002-05-16 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Mucosal immunomodulator and use thereof |
JP2004129622A (en) * | 2002-10-15 | 2004-04-30 | Nippon Formula Feed Mfg Co Ltd | Feed for fish culture |
Non-Patent Citations (2)
Title |
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KATAYAMA Y.: "Mg Kyushu ni Oyobosu Trehalose no Eikyo", JOURNAL OF APPLIED GLYCOSCIENCE, vol. 51, no. SUPPL., 2004, pages 44, XP003016983 * |
NISHIOKA S.: "Trehalose Sesshu ni yoru Kotsumitsudo to Kotsutaisha Marker no Henka", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE SOKAI KOEN YOSHISHU, vol. 55TH, 2001, pages 114, XP003016984 * |
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TW200742552A (en) | 2007-11-16 |
JP5346433B2 (en) | 2013-11-20 |
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