JP5899098B2 - Blue odor control agent for livestock milk - Google Patents

Description

  The present invention relates to a blue odor control agent for livestock milk. In detail, it is related with the agent, method, etc. which reduce the hexanal density | concentration in the milk of livestock and suppress the blue smell.

  In livestock belonging to mammals, for example, livestock in which human milk is used for food, an increase in blood lipid peroxide concentration in the early lactation due to a large oxidative stress at the time of parturition is a serious problem. It has been reported that this oxidative stress is also related to the generation of oxidized odor in milk (Non-Patent Document 1).

  Oxidized odor generation in milk is not preferable because it directly leads to abnormal flavor of milk. In addition, increased concentrations of hexanal in milk (known as a causative agent of blue odors such as soybeans and grasses and caused by various factors including oxidation of fatty acids) are caused by “paper odor” and “cardboard odor” It is a problem because it causes a blue odor of milk, which is also called “Odor”.

  As countermeasures against the generation of such an oxidative odor of milk, the administration or feeding of antioxidants to livestock has been attempted. However, for example, the addition of vitamin E to dairy cow feed does not have a high effect of increasing antioxidant capacity in milk (Non-patent Document 2), and there are many cases where no effect is seen at all depending on the type of antioxidant component to be given. At present, there is a technical background that oral administration or feeding of antioxidants to livestock does not always work directly or closely related to the suppression of the generation of oxidized odor in milk.

Trehalose, on the other hand, is a naturally occurring disaccharide that is also contained in microorganisms and insects, and is a combination of two α-glucose molecules with a 1-1 glycoside bond, and there is also a technology for producing high-purity trehalose in large quantities and at low cost. It has been developed (Patent Document 1).
Trehalose is a very stable substance and is known to have various functions such as resistance to freezing, suppression of discoloration, suppression of starch and protein denaturation, and is used in a wide range of fields such as food and cosmetics.

  Regarding the effects of trehalose on livestock such as cattle, it is known that trehalose is fed to beef cattle (fattening cattle) to improve the meat color and reduce the drip amount and improve the meat quality of the cow ( Patent Document 2). In addition, the effects of promoting the growth of livestock and pets by feeding trehalose, improving fecal properties, and improving meat quality (color, gloss) of livestock and poultry are also known (Patent Document 3). Furthermore, it is known that milk is increased by feeding trehalose to mammals such as cattle, goats and sheep, and the calcium concentration in the milk is further stabilized (Patent Document 4).

  However, it has not been known so far to reduce the hexanal concentration in livestock milk by oral administration or feeding of trehalose or to suppress the blue odor of milk. There is a situation in the industry that there is a continuing demand for the development of oral administration and feeding components that can easily and efficiently suppress the blue odor of livestock milk.

JP-A-9-009986 JP 2007-097409 A JP 2008-019236 A JP 2007-319156 A

British Journal of Nutrition 2000 Nov; 84, S103-S110 J. et al. Dairy Sci. 87: 406-412,2004

  In view of the importance of livestock milk as food, the present invention contributes to improving the quality and stability of the nation by contributing to the improvement of the national QOL. Therefore, the concentration of hexanal in livestock milk is reduced, The purpose of the present invention is to provide an agent and a method that can suppress the occurrence of blue odor, which is one of the quality degradations, and exhibit a sufficient effect by oral administration or feeding.

  In order to achieve the above object, as a result of intensive studies, the present inventors have studied the effect of oral administration or feeding of trehalose on the concentration of hexanal in livestock milk, and the concentration can be reduced or suppressed by oral administration or feeding of trehalose. I found. As a result of further research based on these useful new findings, the present invention, which is trehalose as an active ingredient, is a blue odor inhibitor for livestock milk, a hexanal concentration reducing agent for livestock milk, etc. is completed. It came to.

That is, the embodiment of the present invention is as follows.
(1) Trehalose is contained as an active ingredient, and a blue odor suppressor for livestock milk (a paper odor suppressor for livestock milk, a corrugated cardboard odor suppressor for livestock milk).
(2) A hexanal concentration-reducing agent in livestock milk (inhibitor for hexanal generation in livestock milk), characterized by containing trehalose as an active ingredient.
(3) The agent according to (1) or (2), wherein the livestock is at least one selected from cattle, sheep and goats.
(4) A method for suppressing the blue odor of livestock milk characterized by orally administering or feeding trehalose to livestock (a method for suppressing the generation of paper odor in livestock milk and a method for suppressing the generation of cardboard odor in livestock milk).
(5) A method for reducing the concentration of hexanal in the milk of livestock (a method for suppressing the generation of hexanal in the milk of livestock), characterized in that trehalose is orally administered or fed to livestock.
(6) The method according to (4) or (5), wherein the livestock is at least one selected from cattle, sheep and goats.
(7) Hexanal concentration in milk obtained from livestock to which the method according to any one of (4) to (6) is applied (for example, livestock fed with feed mainly composed of tofu cake) Is reduced to less than 40%, 30% or even 25% when not applied (when trehalose is not administered or not).

  According to the present invention, it is possible to efficiently reduce the concentration of hexanal in livestock milk only by oral administration or feeding of trehalose to livestock (for example, the concentration of hexanal in milk is 40% of that when trehalose is not administered or not fed). Less than, or less than 30%, and even less than 25%), and the milk quality can be maintained well. Furthermore, it is possible to efficiently breed livestock producing milk of good quality in which the concentration of hexanal is suppressed even before and after childbirth that is susceptible to oxidative stress. Thereby, the quality improvement of livestock milk, stabilization, and flavor improvement can be achieved simply.

  Hereinafter, the present invention will be described in detail.

  In the present invention, trehalose (at least one selected from α, α-trehalose, α, β-trehalose, β, β-trehalose) is used as an active ingredient. Trehalose can be used as a pure product or a crude product (pasteized product, diluted product, emulsion, suspension, etc.). In addition, it is possible to use a granulated product by adding an excipient such as starch or dextrin, or a tableted product. Furthermore, what was coated with fats and oils etc. (by-passing) so that it may not be decomposed | disassembled by a lumen can be used. Trehalose is relatively difficult to be broken down by rumen, so there is basically no problem even if it is administered without such processing.

  The target animal of the present invention is a domestic animal belonging to mammals. In particular, livestock whose milk or dairy products are edible are shown as preferred examples, such as cattle (particularly dairy cattle such as Holstein and Jersey), sheep, goats, etc., but are not limited thereto. Absent. In addition, horses, buffaloes, camels, yaks, etc. are also exemplified, and livestock that do not use the milk (pigs, etc.) may be targeted. In particular, it is very preferable to target livestock that is fed a feed mainly composed of tofu koji, which is one of the causes of the occurrence of hexanal in milk (including 30% or more).

  Trehalose can be used as an active ingredient as it is as a feed additive, feed, feed composition, animal medicine, promoter (enhancement agent), and other agents. Moreover, it is also possible to provide feed additives, feeds, feed compositions by adding and mixing commonly used feed ingredients, and also to provide animal pharmaceutical preparations containing trehalose as an active ingredient. it can. In this case, it may be formulated according to a conventional method of animal pharmaceutical preparation, and other active ingredients having other physiological functions can be used in combination.

  The active ingredient is orally administered in various forms, and examples of the dosage form include oral administration using tablets, capsules, granules, powders, sylobic agents, and the like. These various preparations are usually used in the field of veterinary pharmaceutical formulation techniques such as excipients, binders, disintegrants, lubricants, flavoring agents, solubilizers, suspension agents, coating agents, etc. It can be formulated with known adjuvants. It is also possible to use a pure trehalose product (powder, crystal, etc.) as it is as a preparation.

  In addition, what was formulated in this way can be used as a feed composition, and can be fed directly to livestock as a feed, or used as a feed additive in other feed ingredients. It is also possible to add and mix them.

  The oral administration or the amount of trehalose is 0.01 to 1.0 g / day per kg of animal body weight (preferably 0.05 to 0.4 g / day per kg body weight of animal), and 7 to 50 days or more. More preferably, it is administered orally or continuously (preferably for 10 to 20 days) continuously (daily). In particular, oral administration or feeding to livestock before and after delivery is very effective in maintaining milk quality during lactation. When trehalose is administered orally or in excess of the above range, there is no particular problem in terms of its effect. However, if it is less than the above range, the effect of the present invention may not be sufficiently exhibited, which is not preferable. . For example, taking a dairy cow (body weight of about 500 to 1000 kg) as an example, 10 to 500 g / head, preferably 50 to 200 g / head per day is shown as a suitable oral administration or feed amount. In other livestock, it may be set in consideration of the body weight and the like, but it does not completely exclude oral administration or the amount of feeding and the period other than the above including dairy cows.

  Furthermore, in this invention, in addition to the above trehalose, it does not prevent using antioxidants, such as vitamin E, together. However, in the present invention, it is more preferable to use trehalose alone as an active ingredient for suppressing the blue odor of livestock milk and reducing the concentration of hexanal in livestock milk.

  The present invention has a great feature in that the effectiveness (functionality) of trehalose is directly confirmed using livestock. Specifically, trehalose is actually orally administered to Holstein dairy cows for 3 weeks, the concentration of hexanal in the milk is analyzed, and it can be said that it is extremely characteristic in that its physiological action was directly confirmed in Holstein dairy cows.

  And the present invention is a new that trehalose reduces the hexanal concentration in milk by oral administration or feeding to livestock, suppresses its blue odor, and maintains its quality well without affecting the milk quality. It has been found for the first time that there is a use, that is, the present invention can be said to be a novel use invention of trehalose as a blue odor inhibitor of livestock milk and a hexanal concentration reducing agent in livestock milk. .

  Examples of the present invention will be described below, but the present invention is not limited to these examples, and various modifications can be made within the technical idea of the present invention.

  In order to investigate the effects of oral administration of trehalose or feeding on the concentration of hexanal in the milk of dairy cows fed tofu cake, the following tests were conducted.

  Of the Holstein dairy cows raised mainly with tofu cake, 32 dairy cows with relatively high hexanal concentrations in milk were divided into two groups, and 16 were given trehalose at 100 g per day for 3 weeks. Was used as the test group, and the remaining 16 animals were used as the control group.

  The average milk yield of the 32 heads is 34.5 kg / day, milk fat is 3.55%, milk protein is 3.27%, lactose is 4.46%, and nonfat milk solids (SNF) is 8. 73%, urea nitrogen (MUN) in milk was 11.1 ml / dl, and the number of somatic cells in milk was 10.0 million cells / ml.

  Sampling of milk from individuals in each section is performed before the start of trehalose administration and 3 weeks after administration, and the hexanal concentration in the sample is measured (the aroma component in milk is extracted by solid-phase microextraction and analyzed by GC-MS). And compared.

  Table 1 shows the feed and feed menu and order of feeding, and Table 2 shows the hexanal concentration measurement results (average values for each section). In addition, in the feed, Oat Hay was cut and dried from oats, Hay Cube was cut from alfalfa hay and dried in the sun and compression-molded into cubes. Mirai 16 represents Kyodo Feed Co., Ltd., Urcal represents Coral International Co., Ltd., Maymix P represents Meiji Feeding Co., Ltd., Buffer Aid M represents Meiji Feeding Co., Ltd., and Vitacogen represents Seiwa Co., Ltd.

  The test results showed that the hexanal concentration in milk before feeding was high at 47 μg / L in the test group and 49 μg / L in the control group, but the test group in the test group was 11 μg / L in 3 weeks (administration). It decreased significantly to the previous 23.4%). In contrast, the control group maintained a relatively high hexanal concentration of 30 μg / L even after 3 weeks. From the above, it was shown that administration of trehalose to dairy cows reduced the hexanal concentration in milk to less than 15 μg / L, and exerted the effect of suppressing the blue odor of milk.

  The present invention is summarized as follows.

  That is, the present invention can reduce the concentration of hexanal in the milk of livestock (dairy cows, sheep, goats, etc.) and suppress the blue odor, which is said to be an abnormal flavor, which is one of the quality deterioration of livestock milk. Another object is to provide agents and methods that exhibit sufficient effects by oral administration or feeding.

  Then, trehalose is orally administered or fed to livestock as an active ingredient to reduce the concentration of hexanal in the milk of the livestock (for example, the concentration of hexanal in milk is less than 40% when trehalose is not administered or not fed). ), Suppressing the blue odor of the milk of the livestock and improving the quality and stabilization of the livestock milk.

Claims (3)

A method for suppressing the blue odor of milk from cows fed with tofu, characterized in that trehalose is orally administered or fed to cows fed with tofu for 50 to 200 g / head for 10 to 20 days or more . A method for reducing the concentration of hexanal in milk of cows fed with tofu, characterized in that trehalose is orally administered or fed to cows fed with tofu for 50 to 200 g / day for 10 to 20 days or more . The method according to claim 1 or 2, wherein the bean curd feeding cow is a cow fed with a feed containing 30% or more of tofu curd.