WO2007128533A2 - Vorrichtung und verfahren zur untersuchung und bewertung einer biologisch aktiven und/oder aktivierbaren substanz - Google Patents
Vorrichtung und verfahren zur untersuchung und bewertung einer biologisch aktiven und/oder aktivierbaren substanz Download PDFInfo
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- WO2007128533A2 WO2007128533A2 PCT/EP2007/003976 EP2007003976W WO2007128533A2 WO 2007128533 A2 WO2007128533 A2 WO 2007128533A2 EP 2007003976 W EP2007003976 W EP 2007003976W WO 2007128533 A2 WO2007128533 A2 WO 2007128533A2
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- WIPO (PCT)
- Prior art keywords
- substance
- light
- optical
- sensor device
- biologically active
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
Definitions
- the invention relates to a device and a method for the optical examination and evaluation of a biologically active and / or biologically activatable substance, in particular of a human or animal body tissue, by the application of infrared, visible or ultraviolet light, in which the substance under investigation so it is optically excited that it emits light (fluorescence analysis) or changes the wavelength of the incident light (Raman analysis).
- the metabolism differs from person to person as well as from one stage of life to the next, as well as many other factors such as physical stress, illness and stress.
- metabolic analyzes comprehensive information about the current state of health of the human organism can be obtained. So far, only the results of different individual examinations are used in the metabolic analysis. These include, in particular, laboratory analyzes of organ activities, of the immune system, of the hormone system, of lipid metabolism, of mineral metabolism, etc., such investigations being costly and, above all, very time-consuming.
- the collection and analysis of blood samples is still common, and these must be sent to a laboratory for analysis. Apart from the costs, they have further significant disadvantages.
- Cuvette or on a sample carrier must be attached.
- the previous examination procedures take place in the laboratory and are not suitable for immediate, rapid examinations of the subject on site or in the immediate working or leisure environment of the subject.
- the methods used so far are invasive, d. H. connected with an engagement in the body portion.
- the invention is based on the object, an apparatus and a method for optical examination and especially
- Evaluation of a biologically active and / or biologically activatable substance, in particular of a human or animal body tissue, in particular with regard to the substances of the cellular metabolism to provide, with which or a simple, i. can be ensured by the subject itself, immediate, rapid examination of the subject can be guaranteed, on site or in the immediate working or leisure environment of the subject, the device or the method in addition to the mere examination beyond a medically sound, reproducible overall assessment of the organism which belongs to the substance under investigation, guaranteed or at least opened.
- the device according to the invention has a light source which can be operated with electrical energy, an optical light guide, with which the light emitted by the light source can be supplied as radiation of the substance to be examined, an optical or optoelectronic sensor device associated with the substance to be examined, which transmits the biologically active and or the biologically activatable substance emitted or detected by the changed light, and one of the sensor device associated optical or optelektr- lektronische spectrometer on which emitted by the substance under examination or in its wavelength changed light with respect to the intensity of the light at at least one frequency or with respect to the frequency shift, wherein a corresponding measurement signal is output to an evaluation circuit associated with the spectrometer device, and is characterized in that the device is located on its upper side side or on its outer side has a measuring surface section, which is adapted in shape and extent of the biologically active and / or biologically activatable substance to be examined.
- the biologically active and / or biologically activatable substance is a biological tissue, ie a human, animal or plant tissue.
- a biological tissue ie a human, animal or plant tissue.
- an application of the invention to other, not necessarily living matter would be conceivable, for example, to measure biologically relevant factors in a soil substance or humus, or other, under the term biologically activated substances falling, such.
- biologically activated substances falling such.
- nutrient or sugar solutions, and the like are examples of nutrient or sugar solutions, and the like.
- the invention makes possible a noninvasive optical examination of a biologically active and / or biologically activatable substance, in particular tissue material of a test person; no tissue samples have to be taken or inserted or clamped in measuring probes or the like.
- a biologically active and / or biologically activatable substance in particular tissue material of a test person; no tissue samples have to be taken or inserted or clamped in measuring probes or the like.
- the light exit section of the optical Light guide and the sensor device form a structural unit, and this structural unit has on its upper side or outside a measuring surface portion which is adapted in shape and extent to be examined human or animal biological tissue, the optical examination of the substance to be measured simply by suc In this way, the measuring surface section is brought into contact with the skin at or touching the skin surface of the test person so as to contact the skin and is held at this point for the duration of the measuring process, which is usually a few seconds.
- the invention succeeds an easy to be carried out, ie by the subject itself feasible, immediate, rapid examination,
- the device according to the invention an examination and, above all, an evaluation of the biological tissue immediately following the examination is possible within a few seconds, and on the basis of this noninvasive metabolic analysis, the immediate presentation or display of the current overall health or state of health the subject can be guaranteed.
- a representation of the current overall condition of a subject is thus possible, which can already provide the physician with important basic information on medically relevant features of the patient.
- the device according to the invention works by measuring the autofluorescence of the body's own metabolite substances in the interior, which was excited by means of radiation, in particular in the short-wave UV range or in the near UV range.
- the advantages of the device according to the invention, in addition to the bloodless, non-invasive analysis method, are, above all, the measurement and evaluation lasting only a few seconds, so that, for the first time, a cost-effective monitoring of the metabolic regulation can be carried out. lation without compromising the patient is possible.
- the autofluorescence of cells, tissues and substances is based on the stimulation of endogenous fluorofore.
- Interstitium is the fluid-filled space between the cells that is filled with connective tissue, nerves and blood vessels and is in constant contact with the cells, blood vessels and lymphatic system. The interstitium is responsible for the transport of nutrients to the cells and the metabolites of the cells as well as the signaling substances between the cells.
- interstitium Changes in cell metabolism or impaired cell functions affect the composition of the interstitial fluid in a specific manner. For this reason, the interstitium is well suited to measure both transient changes in cellular metabolism through physical or mental stress, as well as metabolic disorders due to organ damage or disease.
- the autofluorescence values measured with the device according to the invention or the method according to the invention are combined with one another in a specific manner and then make it possible to make statements about existing metabolic disorders, the influence of stress or other regulatory disorders, and thus provide information about the current state of health of the subject .
- the determined parameters allow the following statements on the current state of health: metabolism regulation, protection against hyperacidity, immune defense, connective tissue condition, regulation of inflammatory processes, protection against oxidative stress, mental resilience, allergic activation, protection against infectious processes, cellular renewal education processes, cell degradation processes and the current micronutrient requirement.
- the invention makes it possible to produce reproducible, medically sound statements about the general metabolic activity, its regulation and the influence of inflammations, allergies, viral or bacterial
- the invention opens up a wide field of application of light-induced autofluorescence of the body's own substances.
- Acidification takes place where a metabolic process takes place intensively and the acids accumulating during the metabolism are not sufficiently broken down.
- the entire metabolism is based on acid production, all metabolic intermediates are acids that have to be buffered or bound in various ways, for example.
- hyperacidity takes place mainly in the intestine (during the metabolism). If there is an excess of acids and thus a shift in the pH level, especially the enzyme activity is disturbed, which can lead to metabolic disorders to the severest inflammation, unstable immune system and diseases. Values with a tendency to "red
- Inflammation is a life-long process that must be ongoing and expired, as it is part of the normal regulation of metabolism, immune functions and enzyme functions, unless they are chronic events.
- the oxidative protection includes all substances that are able to absorb oxidative stress (free radicals), which are the so-called antioxidants.
- free radicals which are the so-called antioxidants.
- the organism is dependent on oxygen in its existence, because it enables the production of energy from the
- Nutrition to maintain all bodily functions on the other hand, the oxygen also has a destructive effect, since it can lead to the formation of oxygen species, so-called radicals, which are highly aggressive and destructive during the degradation of food.
- radicals which are highly aggressive and destructive during the degradation of food.
- a healthy organism can absorb this burden, but this natural burden may be increased by one unhealthy lifestyles and health-critical living conditions such as physical and psychological pressure to work, stimulants and drug use, environmental toxic influences, changing dietary habits, and the like.
- free radicals that is not adequately protected, and oxidative stress can result.
- 70% of all diseases are caused by oxidative stress. Permanent protection or sufficient supply of antioxidants is therefore a prerequisite for the existence of every organism.
- the device according to the invention operates in such a way that, by placing or applying a human or animal body part on the sensor device, a plurality of substances capable of fluorescence in the tissue fluid are excited by a light pulse emitted by the light source, and these substances themselves now have light components in response thereto transmit this fluorescence light computer-aided and the fluorescence values of these analyzed parameters are calculated in relation to each other.
- a bearing surface section is provided or provided which comprises the measuring surface section or at least partially correlates on which a body part of the subject corresponding to the substance to be examined, in particular a hand, a forearm or a foot or a leg, is placed, wherein the support surface portion formed on or in the top of the housing guide means for aligning the be deposited on the support surface portion Body part of the subject is provided.
- the optical light guide has a light exit portion, which forms a structural unit with the sensor device, said structural unit has on its upper side or outside the measuring surface portion.
- the guide device can be formed by a depression or thickening, which is provided on or in the upper side of the housing and has approximately medium finger widths.
- the optical examination is carried out on an unclothed or easily exposed part of the body of the skin surface of the hand, arm, foot, leg or face or the neck and upper part of the skin. the shoulder of the subject.
- the surface of the measuring surface portion is approximately convexly curved and formed substantially the contours of such a body part, for example, the slightly clenched hand, following.
- the surface of the measuring surface section is strongly convexly curved and formed substantially following the contours of a clenched hand.
- the measuring surface portion may be formed as part of the surface of a handlebar or steering wheel, or a steering wheel, or a joystick, or other steering or control device of a land, water or aircraft or spacecraft.
- an image display device is formed on the measuring surface section or in the immediate vicinity thereof, on which both the measurement results are displayed, and a menu-driven software program for controlling the device according to the invention is displayed.
- the optical spectrometer device may comprise a grating spectrometer, or a Fourier transform spectrometer or a filter spectrometer.
- a grating spectrometer the diffraction of the light radiation on a grating is used for its dispersion.
- the scanning of the spectrum is carried out either by rotating the grating, whereby temporally different wavelengths are detected by a point detector, or by a fixed grid, wherein the spectrum in the desired wavelength range is recorded by an arrow detector.
- a Fourier transform spectrometer is characterized in that an interferometric filter is tuned, and the tuning is recorded in a so-called interferogram.
- the wanted spectrum is then obtained by Fourier transform of the interferogram in the desired wave vector range.
- Filter spectrometers are based on a filter disk, which select the individual wavelengths. Filter spectrometers generally have the two disadvantages that on the one hand a good filter disk can only be produced by very expensive coating techniques, and on the other hand that the light to be analyzed passes through the filter disk, as a result of which a lot of light is lost and a poor signal-to-noise ratio is produced. Because of a structurally simple construction and a very good wavelength resolution, the grating spectrometer is given preference in the embodiment according to the invention.
- the optical or optoelectronic spectrometer device associated with the sensor device has a semiconductor sensor device which has at least one avalanche photodiode with a semiconductor gate, which corresponds to the frequency to be measured.
- the semiconductor sensor device may have a frequency gap which can be varied with respect to the measurement frequency and / or can be tuned.
- the biologically active and / or biologically activatable substance is in particular a biological tissue, ie a human, animal or plant tissue.
- the substances n, m with their measured emission wavelengths ( ⁇ n , ⁇ m ) and their measured intensities (I n , I m ) have in particular the following biochemical substances:
- ⁇ cell division activity
- / or ⁇ metabolic activity
- the method according to the invention can be used for the noninvasive examination of control and regulating processes of human and animal metabolism, and / or for the diagnosis of diseases and preventive examinations, and / or for routine examinations of occupational groups and athletes with high physical and psychological stress, and / or be used for therapy control, and / or the course of dialysis and apheresis treatment as well as for the determination of the antioxidant requirement.
- fluorescence intensities are measured in the wavelength range from about 287 nm to about 800 nm, preferably from 340 nm to 600 nm, in particular for metabolically relevant substances with predetermined emission wavelengths, preferably ATP, GTP, FAD, NADH, NADP, Kynurenine, orotic acid, thromboxane and tryptophan.
- Figure 1 is a schematic view of an inventive
- Figure 2 is an isometric view of the first
- FIG. 1 Embodiment; Figure 4 is an overall view of the first
- Figure 5 is an overall view of the first embodiment with an attached hand
- Figure 6 is an overall view of a second
- Figure 8 is a schematic sectional view of the human
- Figure 9 is an overall view of a third
- Figure 10 is an overall view of the third
- FIG. 11 shows a schematic screen representation of the specific state variables Z n determined by the method according to the invention.
- the figures show a device 1 for the optical examination or analysis of a biologically active and / or biologically activatable substance 2 by the application of infrared, visible or ultraviolet light, in which the examined material 2 is optically excited so that it emits light (fluorescence analysis) or the wavelength of the incident light changes (Raman analysis).
- the device 1 has a light source which can be operated with electrical energy 3, an optical light guide 4, with which the light emitted by the light source 3 as radiation to be examined human or animal biological tissue 2 can be fed, a the human or animal biological tissue to be examined 2 associated optical or optoelectronic sensor device 5, which the detects radiation emitted by the biological tissue, an optical or optoelectronic spectrometer device 6 associated with the sensor device 5 with which the light emitted by the material under investigation or changed in its wavelength and coupled out via an optical waveguide 15 is measured with respect to the intensity of the light at at least one frequency or the frequency shift is, with a corresponding measurement signal via a USB cable 7 to a (not shown) evaluation circuit of an external computer is output.
- a light source which can be operated with electrical energy 3
- an optical light guide 4 with which the light emitted by the light source 3 as radiation to be examined human or animal biological tissue 2 can be fed
- a the human or animal biological tissue to be examined 2 associated optical or optoelectronic sensor device
- the light exit section 8 of the optical light guide 4 and the sensor device 5 form a structural unit 9; this structural unit 9 has on its upper side 10 or outer side a measuring surface section 11, which is adapted in shape and extent to the human or animal biological tissue 2 to be examined.
- the surface of the measuring surface section 11 is approximately convexly curved and essentially follows the contours of a slightly clenched hand.
- the light source 3, the optical light guide 4, the sensor device 5, and the spectro- meter device 6 housed in a housing 12, and on or in the top of the housing 12 is a measuring surface portion 11 comprehensive or at least partially correlating bearing surface portion 13 is formed or provided on which a body part of the test person, in particular a hand, corresponding to the human or animal biological tissue 2 to be examined is placed, wherein the support surface section 13 is one on or in the upper side of the housing 12 formed guide means 14 for aligning the ablated on the support surface portion 13 body part of the subject is provided.
- the guide device 14 is formed in the illustrated embodiment by a provided on or in the top of the housing 12, approximately middle finger wide recess.
- the surface of the measuring surface section 11 is strongly convexly curved and essentially follows the contours of a clenched hand.
- the measuring surface portion 11 may be formed as part of the surface of a car steering wheel 16, or a steering wheel, or a joystick, or other steering or control device of a land, water or aircraft or spacecraft.
- the steering wheel 16 also forms the housing 12 of the device 1 according to the invention.
- the surface of the measuring surface section 11 is formed essentially following the contours of a slightly clenched hand.
- a bearing surface section 13 which encompasses the measuring surface section 11 or at least partially is designed or provided on which the human or animal biological tissue 2 to be examined is placed on the corresponding body part of the test subject, in particular a hand is provided, wherein the support surface portion 13 is provided on or in the top of the housing 12 formed guide means 14 for aligning the bearing on the support surface portion 13 body portion of the subject.
- the edge portions 14a of the housing 12 are rounded, and also serve to guide the hand 2.
- Housing 12 with respect to the illustrated in Figures 1 to 3 first embodiment of the invention structurally essential smaller dimensioned / it can be provided in the third embodiment, that the light source 3 and the spectrometer 6 are housed in a separate component from the housing 12, said accommodated in the separate component optical and optoelectronic components via the optical light guide 4 with the in the housing 12 accommodated sensor device 5 are connected.
- an image reproduction device 17 is formed on the measuring surface section 11 or in the immediate vicinity thereof, for example in the form of a miniature screen 17 integrated in the housing 12.
- function keys 18 are formed, with which the information displayed on the display 17 displayed measuring method can be controlled.
- FIG. 8 schematically shows the anatomy of the skin for explaining the analysis method according to the invention.
- the organ of the human (or animal) skin for example, consists of three interconnected but tissue-different layers, with the outermost
- Layer 20 is referred to as epidermis (epidermis), the middle layer 21 as corium (dermis), and the bottom layer 22 as subcutis (subcutis).
- the epidermis 20 is the vascularized outer layer of the skin, which in turn is divided into sublayers.
- the uppermost layer of the epidermis is the cornea (stratum corneum), on which the light guide is placed. About five to seven percent of the incident light 23 is remitted at this layer 20 a.
- the epidermis 20 is followed by the corium (dermis) 21. It gives the skin its tear resistance and its deformability. This is followed by the subcutis 22, which is loosely connected to the underlying muscle fibers.
- the skin tissue thus consists of different cell types, and is traversed by the smallest muscle-free blood vessels (capillaries) that connect the venules (small veins) and the arterioles (small arteries). In the capillaries of the outward transfer of substances will exchange (such as electrolytes) and the gas exchange (O 2, CO 2) between blood and tissue instead.
- Arteries, veins and capillaries form the transport system in the body, which enables the supply of oxygen and other nutrients to body organs and body tissue as well as the removal of oxygen-poor blood and metabolic products.
- the method according to the invention is based on the measurement of the autofluorescence of endogenous metabolic substances 24 in the interstitium, which are excited by means of the radiation 23, in particular in the short-wave UV range or near UV range, and by intrinsic or intrinsic. Autofluorescence of cells, tissues and substances due to the excitation of endogenous fluorophores reemit specific light beams 25 with different wavelengths, which are detected by the sensor device 5 according to the invention and evaluated.
- ⁇ cell division activity, d. H. a statement as to whether regulated or unregulated cell replication is taking place and, in particular, to what extent the activity of cell regeneration is occurring (normal or disturbed).
- ß metabolic activity, states how the regulation of the metabolic rate, ie the assembly and disassembly, or the utilization of food and nutrients expires. If this is disturbed, fermentation proportions may be activated or the glucose is re-formed mainly by protein degradation. The enrichment of various metabolic products can endanger the organism. It causes damage to the metabolism, which can cause all kinds of diseases.
- ⁇ regulation of immune functions, says how effectively the immune system works against pathogens of all kinds.
- ⁇ inflammatory processes, d. H. It is measured whether inflammatory processes are currently taking place in the body.
- ⁇ energy turnover, it is measured how the energy gained from the food is used, consumed or converted, that is used, eg. For example, for growth, heat production, organ activities, etc., thus expressing how the body is able to produce chemically bound energy from food and then provide it.
- ⁇ energy expenditure for cell division activity, is a part of the energy expenditure needed for the renewal or reproduction of the cells. If this value is in the red, this means an increased destruction of cells, which should actually be regenerated.
- ⁇ regulated and unregulated cell regeneration, indicates in a manner similar to the above value how the relationship between cell assembly and degradation is, and how this may be disturbed.
- ⁇ inflammatory regulated new cell regeneration processes, this is a special statement on cell neoplasm in the context of immune activation in relation to inflammatory processes.
- p risk parameter of damage to health, this is a summary statement that results from all other values.
- ⁇ activated tissue regeneration
- ⁇ complex metabolic characteristics, reflects everything that is involved in the metabolism.
- ⁇ redox equivalent, or redox potential, reflects the measurement of redox regulation or redox changes. Statements are made on the possibility of oxidative stress and, above all, how much reductive capacity is being lost to the organism at the moment. It reproduces the relationship between oxidants and antioxidants and their perturbation, which ultimately suggests disturbed bioregulation.
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002651458A CA2651458A1 (en) | 2006-05-05 | 2007-05-04 | Device and method for examination and evaluation of a biological active and/or biological activatable substance |
JP2009508227A JP2009536053A (ja) | 2006-05-05 | 2007-05-04 | 生物学的に活性および/または活性可能な物質を検査および評価するための装置および方法 |
CN2007800163401A CN101529228B (zh) | 2006-05-05 | 2007-05-04 | 用于生物活性和/或生物可激活物质的检查和评估的设备和方法 |
US12/299,642 US20100030480A1 (en) | 2006-05-05 | 2007-05-04 | Device and method for examination and evaluation of a biological active and/or biological activatable substance |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE202006012071U DE202006012071U1 (de) | 2006-05-05 | 2006-05-05 | Vorrichtung zur optischen Untersuchung eines biologischen Gewebes |
DE202006012071.8 | 2006-05-05 | ||
DE102006021343A DE102006021343A1 (de) | 2006-05-05 | 2006-05-05 | Vorrichtung zur optischen Untersuchung eines biologischen Gewebes |
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WO2007128533A2 true WO2007128533A2 (de) | 2007-11-15 |
WO2007128533A3 WO2007128533A3 (de) | 2008-02-14 |
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WO2013023637A3 (de) * | 2011-08-12 | 2013-05-02 | Opsolution Gmbh | Verfahren und vorrichtung zur erzielung von biofeedback-informationen |
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DE102008056250A1 (de) * | 2008-10-07 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zum Erfassen zumindest eines Vitalparameters einer Person in einem Kraftfahrzeug und Vorrichtung zum Überwachen zumindest eines Vitalparameters einer Person in einem Kraftfahrzeug |
DE102008056251A1 (de) | 2008-10-07 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zum Erfassen eines Vitalparameters |
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DE202006012071U1 (de) | 2007-09-20 |
DE102006021343A1 (de) | 2007-11-08 |
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