WO2007074409A2 - Dispositif intra-uterin recuperable - Google Patents
Dispositif intra-uterin recuperable Download PDFInfo
- Publication number
- WO2007074409A2 WO2007074409A2 PCT/IB2006/004136 IB2006004136W WO2007074409A2 WO 2007074409 A2 WO2007074409 A2 WO 2007074409A2 IB 2006004136 W IB2006004136 W IB 2006004136W WO 2007074409 A2 WO2007074409 A2 WO 2007074409A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- perforations
- housing
- wall
- microns
- intrauterine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
Definitions
- the present invention relates to a retroperable intrauterine device, used in particular for implanting gametes or embryos in the uterus.
- the present invention generally relates to the field of in vivo and in utero fertilization in assisted reproduction methods with the implementation of fertilization and / or preimplantation development techniques.
- the intrauterine device comprises a housing adapted to contain the elements intended to be encapsulated in the device and, for example, an embryo, male and / or female gametes, a fertilized oocyte or an unfertilized egg.
- This encapsulation technique makes it possible to fertilize and develop an embryo inside a capsule placed in the uterus. It has the advantage of overcoming a number of problems related to in vitro culture.
- the gametes and / or embryos are placed in a natural environment during preimplantation development, before the final transfer of the embryo to the uterus.
- the complex interactions between the endometrium of the uterus and gametes and / or embryos can thus be allowed.
- the Applicant has noted that the embryos thus obtained were of better quality not only morphologically but also on their ability to develop and be reimplanted into the uterus later.
- the risks of alteration of the embryo by foreign factors are reduced.
- the retrievable intrauterine device described comprises a housing whose wall is made from a porous permeable membrane.
- a porous permeable membrane is fragile and manipulation of this capsule, especially during loading and unloading encapsulated elements, or during implantation and recovery of the capsule inside the uterus, could alter the wall of the capsule and possibly cause the loss of encapsulated elements.
- the exchanges between the interior of the housing and the uterine matrix are limited to small elements, such as oxygen proteins or other hormones, whose size is less than one million Dalton.
- the Applicant has found that exchanges between the elements contained in the capsule, including embryos, and larger elements, including cells, contained in the uterine fluid, could further enhance the development of embryos in the capsule.
- the object of the present invention is to solve the disadvantages of the porous membranes described above and to propose an intrauterine device making it possible to increase exchanges with the uterine matrix in a reliable and reproducible manner.
- the housing wall comprises a series of perforations of sufficient size to allow cellular contact between the uterine matrix and the housing.
- the reproduction within the housing of a medium close to that present in the uterine matrix which includes uterine fluids from both the uterine cavity and the fallopian tubes, could promote the development of embryos.
- cell exchange could possibly facilitate subsequent reimplantation and implantation of the embryo into the uterus.
- the production of perforations in the wall of the housing makes it possible to use non-porous materials or for which the production of a porous structure would be difficult to implement. It is thus possible by controlling the size of the perforations and the nature of the material used to produce a device having a sufficiently permeable wall to allow a cellular interaction with the cells of the uterine matrix while having sufficient rigidity to secure the manipulation of the device by particular view of the loading of embryos or gametes and the introduction and removal of the device in the uterus.
- the device according to the invention can thus be loaded and unloaded without altering the quality of the embryos or other elements loaded in the housing.
- the interaction phenomena with the uterine medium could probably be of a nature to favor the development of the encapsulated elements and, in particular, the development of the embryo or the fertilization of the implanted ovules.
- the perforations have dimensions of between 10 and 150 ⁇ m.
- the perforations have, according to their largest dimension, an opening at most equal to 150 ⁇ m.
- This maximum opening of the perforations allows the housing wall to fully play its role of border, allowing exchanges with the uterine matrix while retaining inside the housing encapsulated elements, such as including oocytes and / or embryos that have a minimum dimension of 150 ⁇ m.
- the perforations are uniformly distributed in the wall of the housing and arranged in a staggered manner. It is thus possible to uniformly promote cell interaction.
- the wall is made of a transparent biocompatible material.
- a transparent material facilitates the handling of the device, especially during loading and unloading of the device, through the viewing of gametes or embryos in the device.
- the wall may be made of polymer, elastomer, silicone or polyurethane, or ceramic, glass, or a metal alloy.
- the invention relates to the use of the intrauterine device for loading and / or unloading elements chosen from the group comprising an embryo, male and / or female gametes, a fertilized oocyte, an unfertilized ovum and a combination of these elements.
- This use of the device allows to load and unload elements of the housing, without altering these elements.
- FIG. 1 is a perspective view of an intrauterine device according to one embodiment of the invention.
- FIG. 2 is a schematic perspective view of the housing of the intrauterine device of Figure 1; and FIG. 3 is an enlarged schematic perspective view of the housing of the intrauterine device of FIG. 1 according to a second embodiment of the invention.
- FIG. 1 the general structure of an intrauterine device according to the invention.
- the intrauterine device 10 as illustrated in FIG. 1 is used in assisted fertilization techniques and makes it possible to transiently implant and maintain male and female gametes (in vivo fertilization) and / or embryos (preimplantation development). in a uterine cavity.
- this intrauterine device makes it possible, in an in vitro assisted fertilization method, to load one or more elements into a permeable housing 11 at the beginning of the embryonic development, to introduce the device into the uterine cavity for a predetermined period of time. (from a few hours to a few days) then recover the intrauterine device to extract the embryo or embryos for implantation in the uterine cavity.
- the housing 11 can be opened at a distal end 11a to allow the loading of the elements (embryos, male gametes and / or females, fertilized oocytes, unfertilized ova) in the housing 11.
- a plug 12 is adapted to close this distal end 11a .
- the housing 11 is also fixed at its proximal end 11b to a silicone element 12 which can itself be connected to a holding member of the capsule, for example stainless steel.
- This device 10 furthermore cooperates with accessories enabling the device to be placed in the uterine cavity.
- the housing 11 has in this embodiment substantially a cylindrical shape.
- the length of the housing may be between 1 and 25 mm, and preferably equal to about 10 mm.
- the outer diameter of this housing is between 0.5 and 2 mm, and preferably equal to substantially 0.9 mm.
- the inside diameter of the housing is between 0.4 and 1.8 mm, and preferably equal to 0.8 mm.
- the membrane of the housing 11 thus has a thickness of the order of 0.1 mm.
- the wall can be made of different materials.
- this wall may be made of a porous polymer, polyethersulfone type (PES), polyacrylate, acrylate copolymer, or polyvinylidiene.
- PES polyethersulfone type
- polyacrylate polyacrylate copolymer
- polyvinylidiene polyvinylidiene
- It can also be made of a plastic material of the silicone or polyurethane type, or of ceramic or glass.
- It can also be made of a metal alloy of the stainless steel or titanium or titanium alloy type.
- the configuration and size of the housing 11 allow its placement into the uterine cavity using a transfer catheter having an inner diameter of 1 cm. Such a catheter is adapted to pass through the cervical canal which generally has a diameter of about 1.5 cm.
- the oocytes, surrounded by complex cells, developing in the housing have a size between 350 and 400 microns such that a housing having an internal diameter of 0.8 mm is sufficient to contain between 5 to 10 embryos.
- the wall of the housing 11 is a porous membrane of the PES type, it already allows the passage of nutrients contained in the uterine fluid inside the housing, to come into contact with the developing embryo.
- the housing 11 is provided with perforations 12.
- FIG. 2 A first embodiment of a perforated wall is illustrated in FIG. 2. These perforations can be made for example by laser cutting in the wall.
- these perforations 12 have a maximum dimension of 150 microns, so as to maintain inside the housing the oocytes and / or embryos whose dimensions are of the order of 150 microns.
- the perforations 12 are of circular shape, and preferably have a diameter of between 40 and 75 ⁇ m. This diameter may be equal in no way limiting to 50 microns.
- the wall comprises at least one, and in this embodiment, several series of perforations 12 aligned in the longitudinal direction of the housing 11. These series of perforations are arranged in parallel to each other and the perforations 12 are arranged in staggered rows.
- the wall of the housing 11 has perforations 12 distributed uniformly throughout the cylindrical wall so that the cellular contact with the intrauterine medium can be made all around the housing 11.
- the distances separating the perforations from one another are between 20 and 200 ⁇ m, so that the wall of the housing 11 is very permeable.
- FIG. 3 illustrates a second embodiment of the invention in which the housing has perforations 12 'of rectangular shape.
- These perforations may have a width of between 10 and 150 ⁇ m and preferably equal to 75 ⁇ m and a length greater than or equal to 150 ⁇ m and possibly equal to the length of the housing 11.
- the housing being of elongated cylindrical shape, the rectangular perforations 12 'are aligned in the longitudinal direction of the housing.
- the wall comprises several series of perforations 12 ', the series being arranged parallel to each other and distributed uniformly in the wall of the housing 11.
- the distance separating the perforations 12 'from each other may also be between 20 and 200 ⁇ m.
- the intrauterine device it is both possible to maintain the oocytes and / or embryos in the cage-shaped housing and at the same time allow an optimized exchange with the cavity environment. uterine.
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Medical Informatics (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006329567A AU2006329567A1 (en) | 2005-12-26 | 2006-12-21 | Recoverable intra-uterine device |
EP06848849A EP1968463A2 (fr) | 2005-12-26 | 2006-12-21 | Dispositif intra-uterin recuperable |
CN200680049239.1A CN101351159B (zh) | 2005-12-26 | 2006-12-21 | 一种可回收的宫内装置 |
CA002635199A CA2635199A1 (fr) | 2005-12-26 | 2006-12-21 | Dispositif intra-uterin recuperable |
JP2008548046A JP5037528B2 (ja) | 2005-12-26 | 2006-12-21 | 回収可能な子宮内器具 |
US12/159,374 US20090012352A1 (en) | 2005-12-26 | 2006-12-26 | Recoverable intra-uterine device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0513317A FR2895229B1 (fr) | 2005-12-26 | 2005-12-26 | Dispositif intra-uterin recuperable |
FR05/13317 | 2005-12-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007074409A2 true WO2007074409A2 (fr) | 2007-07-05 |
WO2007074409A3 WO2007074409A3 (fr) | 2007-12-06 |
Family
ID=36910926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/004136 WO2007074409A2 (fr) | 2005-12-26 | 2006-12-21 | Dispositif intra-uterin recuperable |
Country Status (8)
Country | Link |
---|---|
US (1) | US20090012352A1 (fr) |
EP (1) | EP1968463A2 (fr) |
JP (1) | JP5037528B2 (fr) |
CN (1) | CN101351159B (fr) |
AU (1) | AU2006329567A1 (fr) |
CA (1) | CA2635199A1 (fr) |
FR (1) | FR2895229B1 (fr) |
WO (1) | WO2007074409A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9005108B2 (en) * | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
FR3042966B1 (fr) | 2015-10-30 | 2017-11-24 | Anecova S A | Dispositif intra-uterin recuperable |
JP6932328B2 (ja) | 2017-01-17 | 2021-09-08 | 国立大学法人 東京大学 | 生体胚子宮内移植固定器具 |
EP4137075A1 (fr) * | 2021-08-18 | 2023-02-22 | Anecova S.A. | Dispositif intra-utérin récupérable |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1414812A (en) * | 1970-10-21 | 1975-11-19 | Alza Corp | Device for sustained release of drugs and like active agents |
US5084004A (en) * | 1987-04-30 | 1992-01-28 | Claude Ranoux | Process for intra-uterine fertilization in mammals and device for implementation thereof |
US6050935A (en) * | 1997-05-09 | 2000-04-18 | Biofertec | Container assembly for intravaginal fertilization and culture and embryo transfer and method of intravaginal fertilization and culture employing such a container |
US20030191499A1 (en) * | 2001-01-18 | 2003-10-09 | Vladimir Kalina | Apparatus for inducing an immune response in cancer therapy |
EP1414379A2 (fr) * | 2001-08-01 | 2004-05-06 | Pascal Mock | Dispositif intra-uterin, procede de fabrication d'un tel dispositif et procede de pose d'elements actifs a l'interieur de la cavite uterine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
-
2005
- 2005-12-26 FR FR0513317A patent/FR2895229B1/fr not_active Expired - Fee Related
-
2006
- 2006-12-21 EP EP06848849A patent/EP1968463A2/fr not_active Withdrawn
- 2006-12-21 AU AU2006329567A patent/AU2006329567A1/en not_active Abandoned
- 2006-12-21 JP JP2008548046A patent/JP5037528B2/ja not_active Expired - Fee Related
- 2006-12-21 CA CA002635199A patent/CA2635199A1/fr not_active Abandoned
- 2006-12-21 CN CN200680049239.1A patent/CN101351159B/zh not_active Expired - Fee Related
- 2006-12-21 WO PCT/IB2006/004136 patent/WO2007074409A2/fr active Application Filing
- 2006-12-26 US US12/159,374 patent/US20090012352A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1414812A (en) * | 1970-10-21 | 1975-11-19 | Alza Corp | Device for sustained release of drugs and like active agents |
US5084004A (en) * | 1987-04-30 | 1992-01-28 | Claude Ranoux | Process for intra-uterine fertilization in mammals and device for implementation thereof |
US6050935A (en) * | 1997-05-09 | 2000-04-18 | Biofertec | Container assembly for intravaginal fertilization and culture and embryo transfer and method of intravaginal fertilization and culture employing such a container |
US20030191499A1 (en) * | 2001-01-18 | 2003-10-09 | Vladimir Kalina | Apparatus for inducing an immune response in cancer therapy |
EP1414379A2 (fr) * | 2001-08-01 | 2004-05-06 | Pascal Mock | Dispositif intra-uterin, procede de fabrication d'un tel dispositif et procede de pose d'elements actifs a l'interieur de la cavite uterine |
Non-Patent Citations (1)
Title |
---|
See also references of EP1968463A2 * |
Also Published As
Publication number | Publication date |
---|---|
CN101351159A (zh) | 2009-01-21 |
AU2006329567A1 (en) | 2007-07-05 |
JP5037528B2 (ja) | 2012-09-26 |
FR2895229B1 (fr) | 2008-12-26 |
EP1968463A2 (fr) | 2008-09-17 |
CN101351159B (zh) | 2012-12-12 |
US20090012352A1 (en) | 2009-01-08 |
WO2007074409A3 (fr) | 2007-12-06 |
CA2635199A1 (fr) | 2007-07-05 |
JP2009521296A (ja) | 2009-06-04 |
FR2895229A1 (fr) | 2007-06-29 |
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