WO2007063648A1

WO2007063648A1 - Agent for improving obesity conditions

Info

Publication number: WO2007063648A1
Application number: PCT/JP2006/320476
Authority: WO
Inventors: Ken Harada; Chiho Motonaga; Kiyohito Sawano; Kazutoshi Sakurai; Hidetsuna Watanabe; Seiji Kawano
Original assignee: Kose Corporation; Takasago International Corporation; Fukushima University
Priority date: 2005-11-30
Filing date: 2006-10-13
Publication date: 2007-06-07
Also published as: JP5814495B2; TW200730185A; JPWO2007063648A1

Abstract

[PROBLEMS] To provide an excellent agent for improving obesity conditions. To provide an excellent agent for improving obesity conditions which further has an antidepressant effect and/or a stress-relieving effect and can be easily prepared. [MEANS FOR SOLVING PROBLEMS] Cypress essential oil or δ-3-carene is used as the active ingredient for improving obesity conditions. It is advantageous to use the thus obtained agent for improving obesity conditions in an external skin preparation or a fragrance. It is also possible to volatilize a perfume, which contains cypress essential oil or δ-3-carene, in a human living space.

Description

Obesity improving agent

Technical field

[0001] The present invention relates to an obesity improving agent comprising a specific essential oil or synthetic fragrance, and a skin external preparation and fragrance containing the same.

Background art

[0002] The number of people called “force obesity” is increasing due to recent changes in social conditions such as intake of high-calorie diet and lack of exercise. Obesity is a hotbed for various lifestyle-related diseases such as diabetes, hypertension, and arteriosclerosis, and improvement of obesity is important for maintaining health. For example, methods for using various exercise equipment to improve obesity, adoption of diet foods, and appetite suppressant therapy are known, but there are not many reports that they have improved obesity. . There may be various reasons for this, but it is not easy to purchase and store various instruments used to improve obesity, and it is not easy to prepare to use the instruments. The degree to which the improvement effect is less felt against the time and effort made to improve obesity, and the action to improve obesity gives a feeling of mental pressure Once you become obese, there is a problem that it is not so easy to get out of your obesity. Eventually, the desire to improve obesity will be reduced and actions to improve obesity will continue for a long time It may be impossible to do this, or stimulation at the feeding center and so-called abdominal clock, and other structural points of the body.

In the present invention, the obesity state is represented by the BMI value (= Body

Mass Index Weight (kg) Z Height ² (m)) is 25 or more.

[0003] In this regard, a skin external preparation containing a so-called slimming agent is directly applied to human skin, a food containing a slimming agent is taken, and a body soap containing a slimming agent is used to treat the body. It can be said that the method of cleaning is an effective method that eliminates problems such as giving a feeling of mental pressure. Specific techniques include, for example, a method of adding cognac oil or mate oil to an external preparation for skin or food (Patent Document 1), from grapefruit oil to limonate. For example, there is a method of adding modified grapefruit oil from which LOO mass% is removed to a cosmetic or food (Patent Document 2). However, even with these techniques, the effect of improving obesity is not sufficient, leaving room for improvement.

Patent Document 3 describes that one or more selected from limonene, vinylene, myrcene and benzylbenzoate, which are known as synthetic fragrances, are used as a fragrance for slimming. However, that document only exemplifies those fragrances, and the above fragrance alone or a mixture of the above fragrances itself is not used as a fragrance for slimming in the examples. The fragrance is merely exemplified as a slimming fragrance, and is only to the extent that it is unclear how effective it is as a slimming fragrance.

[0004] On the other hand, Patent Document 4 describes a cypress essential oil as an example of an activity-enhancing essential oil. Further, Patent Document 5 discloses a jelly-like food having a relaxed effect containing a herb extract as a plant extract, and Cypress essential oil is disclosed as a herb extract. There is no description that Cypress essential oil has an effect of improving obesity. Patent Document 6 describes a mixture comprising lavender essential oil, rosemary essential oil or bergamot essential oil, lemon essential oil or lime essential oil, cypress essential oil or juicer essential oil, and carrier oil. The mixture is described as having an effect of improving facial contours by quickly and thoroughly removing excess fat on the facial surface. However, in the mixture, lemon essential oil, rosemary essential oil, and lavender essential oil have been described to suggest fat removal, but cypress essential oil has no description to suggest such a point.

Patent Document 1: Japanese Patent Application Laid-Open No. 2005-68176

Patent Document 2: JP-A-2005-194252

Patent Document 3: Japanese Patent Laid-Open No. 2002-265977

Patent Document 4: Japanese Patent Publication No. 7-57734

Patent Document 5: Japanese Patent Laid-Open No. 2003-245048

Patent Document 6: Chinese Patent Publication No. 1247735

Disclosure of the invention

Problems to be solved by the invention [0006] Accordingly, an object of the present invention is to provide an excellent agent for improving obesity state. Another object of the present invention is to provide an agent for improving obesity status, which is an excellent agent for improving obesity status, which has both an antidepressant action and Z or stress reduction action, and is easy to prepare.

Means for solving the problem

[0007] As a result of diligent research to solve the above problems, the present inventor has paid attention to a specific essential oil and added the essential oil to a body soap. The knowledge that it brings about an effect was acquired. In addition, when an obese person smells cypress essential oil, the anti-depressive action and Z or stress-reducing action improve lifestyle habits such as eating and sleeping behaviors and mood disorders, thereby improving obesity. The knowledge that it is effective was obtained. Through further research, we have found that δ-3-carene has the same effect. Based on these findings, further research was conducted and the present invention was finally completed.

[0008] That is, the invention of claim 1 is an obesity improving agent characterized by comprising a cypress essential oil. The invention of claim 1 is also an obesity improving agent characterized in that it contains cypress essential oil. Further, the invention of claim 1 is an obesity improving agent characterized by containing cypress essential oil as an active ingredient.

The invention of claim 2 is an obesity-condition improving agent characterized by having a δ 3 -force force. The invention of claim 2 is also an obesity condition improving agent characterized by containing δ 3 -strength. Furthermore, the invention of claim 2 is an obesity condition improving agent characterized by containing δ 3 -strength as an active ingredient.

The invention of claim 3 is characterized in that in the invention of claim 1 or 2, it further has an antidepressant action and a wrinkle or stress reducing action. That is, the obesity condition-improving agent is further characterized by having an antidepressant action, the obesity condition-improving agent is further having a stress-reducing action, and the obesity condition-improving agent is characterized by an antidepressant action and It further has a stress reducing effect. The invention of claim 3 is also an invention characterized in that, in the invention of claim 1 or 2, the obesity state is improved by an antidepressant action and an epilepsy or stress reducing action.

The invention of claim 4 is an external preparation for skin containing the obesity condition-improving agent of any one of claims 1 to 3, and the invention of claim 5 is any of claims 1 to 3. The A fragrance comprising an obesity-condition improving agent.

The invention of claim 6 is an invention of a method of using a fragrance containing cypress essential oil or δ3-strength for improving obesity.

As one of the functions of the obesity condition-improving agent of the present invention, the obesity condition disappears from the obesity condition, that is, the phenomenon is slimming. Therefore, the obesity condition-improving agent of the present invention is expressed as a slimming agent. You can also.

Hereinafter, the present invention will be described in detail.

The cypress essential oil in the present invention is a known essential oil, and an Italian cypress essential oil is particularly preferable. The Italian cypress essential oil can be prepared from a cypress plant of the genus Cypressaceae by a conventional method, but a commercially available product may be purchased.

The δ3-force len in the present invention is a known synthetic fragrance compound, and can be obtained by extraction from a natural product, or obtained by a biochemical synthesis method or a known chemical synthesis method. You can also purchase a commercial product.

[0010] A feature of the present invention is that the above-mentioned Cypress essential oil or δ3-strength is used as an obesity improving agent. The improvement of obesity state here means reducing the degree of obesity, and also includes maintaining the degree of obesity. Therefore, the agent for improving obesity condition is an agent having the property 'function of reducing the degree of obesity and also includes an agent for maintaining the degree of obesity.

[ooii] The obesity condition-improving agent of the present invention further has an antidepressant action and an epilepsy or stress-reducing action. The antidepressant action is well known in the pre-application, and there are various causes and reasons for depression, and one person is able to change the condition as much as possible.

The stress reduction effect is also well known before the filing of this application. For example, it refers to the human power that has received stress due to the influence of the complex social environment in recent years. The agent for improving obesity condition in the present invention may be added with other binders as long as the intended purpose can be achieved. These compounding agents will be described later.

[0012] The obesity condition-improving agent of the present invention may be contained in an external preparation for skin. Such external preparations for skin include emulsions, creams, lotions, cosmetics, packs, facial cleansers, body soaps, makeup agents, bath preparations, fragrances, shampoos, hair treatments, hair styling agents, hair nourishing agents, hair restorers, etc. (Including medicated cosmetics), ointments, patches, patches Any of external medicines such as pills and liniments may be used. The amount of the external preparation for skin to contain the agent for improving obesity condition of the present invention cannot be defined unconditionally because the optimal range differs depending on the external preparation for skin, but for example, 0.1% for external preparation for skin. It is preferable to contain ˜20% by weight. 0.1˜: It is more preferred to contain L0% by weight.

Furthermore, the obesity condition-improving agent of the present invention can also be incorporated into oral care products such as toothpaste and mouthwash, foods and the like. The compounding amount of the obesity condition improving agent is not particularly limited. For example, it is preferable to contain 0.1 to 20% by weight with respect to the product, food, etc. 0.1 to 10% by weight is more preferable. preferable.

[0013] The obesity condition-improving agent of the present invention can be contained in a fragrance such as a room fragrance, a car fragrance, an aroma candle, an aroma oil, etc. as it is or by mixing and mixing with other ingredients. . The amount of the fragrance containing the agent for improving obesity condition of the present invention cannot be generally specified because the optimum range varies depending on the fragrance, but for example, 0.5 to: It is preferable to contain L00% by weight.

[0014] The present invention provides a composition for improving obesity which consists essentially of cypress essential oil and base power. Also provided is a composition for improving obesity which is essentially composed of δ 3 -strength and a base. Here, the base means a substance that can carry Cypress essential oil or δ 3 -strength, and any substance that can carry Cypress essential oil or δ 3 -strength is used. Is possible. Representative examples include, but are not limited to, various solvents such as alcohols and various oils such as petrolatum.

[0015] The present invention also provides a method of using a fragrance containing cypress essential oil or δ3-strength to improve obesity. Examples of such a method include a method of evaporating a fragrance containing cypress essential oil or δ 3 -strength in a space where a person lives to improve obesity. Examples of spaces in which people live include, but are not limited to, spaces in offices, health maintenance, and, in some cases, fitness spaces for beauty and living spaces such as in living rooms and bathrooms. Not. The method can also be said to be the use of cypress essential oils or fragrances containing δ-3-carene as an environmental flared lance to improve obesity. The method of volatilization is not particularly limited, and a fragrance containing Cypress essential oil or δ3-power lenght is volatilized at a predetermined site in the aeration apparatus. And a method of volatilizing in the space together with air, a method of arranging an arbitrary fragrance volatilization device in the space, and volatilizing perfume containing Cypress essential oil or δ 3 -power len in the space, and the like.

It was found that peppermint essential oil also has an improvement in obesity status, although it is not as effective as an obesity improvement agent as Cypress essential oil or δ 3 -strength.

[0016] A conventional compounding agent may be added to the external preparation for skin or fragrance according to the present invention.

These added ingredients include water (purified water, hot spring water, deep water, ion-exchanged water, etc.) and solvents (alcohols, polyhydric alcohols, etc.) that are commonly used in preparations for external preparations for skin and external medicine Etc.) Surfactant, oil agent, gelling agent, colorant, water-soluble polymer, film forming agent, grease, UV protection agent, antioxidant, preservative, fragrance, deodorant, salt, wrinkle adjustment Agent, freshener, animal, microbial extract, plant extract, blood circulation promoter, astringent agent, anti-seborrheic agent, whitening agent, anti-inflammatory agent, active oxygen scavenger, cell activator, moisturizer, chelating agent, Examples include keratolytic agents, enzymes, hormones, and vitamins.

[0017] Examples of the surfactant include polyoxyethylene glyceryl fatty acid esters such as polyoxyethylene monostearate glyceryl and polyoxyethylene monooleate glyceryl; monomyristate hexaglyceryl, monolaurate decaglyceryl, monostearate Polyglycerin fatty acid esters such as decaglyceryl acid; Polyoxyethylene monomyristate Polyoxyethylene sorbitan fatty acid esters such as sorbitan polyoxyethylene monostearate, sorbitan polyoxyethylene tristearate; Polyoxyethylene hydrogenated castor oil, polyoxyethylene Polyoxyethylene hardened castor oil such as hardened castor oil; polyoxyethylene cholesteryl ether, polyoxyethylene cholesteryl ether, etc. Polyoxyethylene cholesteryl ethers; polyoxyethylene phytosteryl ethers, polyoxyethylene phytosteryl ethers such as polyoxyethylene phytosteryl ethers; polyethylene glycol fatty acid esters such as polyoxyethylene glycol monolaurate and polyoxyethylene glycol monostearate; Polyoxyethylene alkyl ethers such as polyoxyethylene lauryl ether, polyoxyethylene benoyl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether; polyoxyethylene polyoxypropylene cetyl ether, polyethylene Examples include polyoxyethylene polyoxypropylene alkyl ethers such as reoxyethylene polyoxypropylene tetradecyl ether; polyoxyethylene alkyl ethers such as polyoxyethylene nonyl phenyl ether and polyoxyethylene octyl phenyl ether; .

Also, fatty acid salts such as sodium laurate, sodium myristate, and sodium palmitate; polyoxyethylene such as sodium polyoxyethylene lauryl ether, sodium polyoxyethylene cetyl ether, sodium dipolyoxyethylene cetyl ether phosphate Ethyl alkyl ether phosphates; Acyl taurine salts such as sodium cocoyl methyl taurate and sodium stearoyl methyl taurate; Alkyl sulfates such as sodium lauryl sulfate and sodium cetyl sulfate; Sodium polyoxyethylene lauryl ether sulfate, Polyoxyethylene urea ether Examples thereof include polyoxyethylene alkyl ether sulfates such as sodium sulfate. You can use one or more of these!

Here, a polyoxyethylene unit is about 3-60.

[0018] Examples of the high molecular weight compound include gum arabic, xanthan gum, tara gum, gati gum, carrageenan, cara gum, guar gum, tamarind seed gum, methyl cellulose, hydroxy methenoresenolellose, hydroxy ethyl cellulose, polyvinyl alcohol, hydroxy pour cellulose , Carboxymethyl cellulose, etc .; (meth) acrylic acid '(meth) acrylic acid alkyl copolymer, (meth) acrylic acid alkyl. Styrene copolymer, poly (acetate butyl), butylpyrrolidone. Styrene copolymer, acrylic-silicone copolymer Polymers of polymers, trimethylsiloxanes; curdlan, xanthan gum, dielan gum, hyaluronic acid, alkaline genus-producing polysaccharides such as polysaccharides, and one or more of these It is possible.

[0019] As a colorant, titanium oxide, black titanium oxide, konjiio, ultramarine blue, bengara, yellow iron oxide, black iron oxide, zinc oxide, acid-aluminum, magnesium oxide, acid-zirconium, magnesium carbonate, calcium carbonate, Examples thereof include barium sulfate, chromium oxide, chromium hydroxide, carbon black, and tar dyes.

[0020] Oils include liquid paraffin, squalane, petrolatum, polyisobutylene, polybutene, Hydrocarbons such as paraffin wax, ceresin wax, microcrystalline wax, and Phytschatrops wax; fats and oils such as moscow, olive oil, castor oil, mink oil, and mash demian nut oil; montan wax, beeswax, carnau Waxes such as waxes, candelilla wax, gay wax; jojoba oil, cetyl isooctanoate, isopropyl myristate, isopropyl normitate, octyldodecyl myristate, glyceryl trioctanoate, diglyceryl disostearate, triisostearin Diglyceryl acid, glyceryl tribehenate, pentaerythritol ester of rosin acid, neopentyl glycol dioctanoate, cholesterol fatty acid ester, N-lauroyl-L-di-glutamic acid (cholesteryl Esters such as steatilic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, 12-hydroxystearic acid; stearino-leanolenoleole, cetyl alcohol, lauryl alcohol, Higher alcohols such as rail alcohol, nostearyl alcohol, and beryl alcohol; Sphingosines; Ceramides; Pseudoceramides; Low polymerization dimethylpolysiloxane, High polymerization dimethylpolysiloxane, Methylphenylpolysiloxane, Silicones such as decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, and fluorine-modified silicones; fluorinated oils such as perfluoropolyether, perfluorodecane, and perfluorooctane; lanolin, lanolin acetate, Phosphorus fatty isopropyl, lanolin derivatives such as lanolin alcohols; and the like, and these can be used singly or in combination.

The invention's effect

[0021] According to the present invention, an agent for improving obesity is provided that is excellent in the effect of improving obesity. This obesity-improving agent can be prepared by simple operations, and can be easily added to and blended with familiar products. In addition, since there is almost no sensitization to the skin, an extremely excellent effect is exhibited especially when blended with an external preparation for skin or a fragrance. The present invention is extremely practical.

BEST MODE FOR CARRYING OUT THE INVENTION

[0022] Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited to these examples. The following numerical values are parts by weight or% by weight unless otherwise specified. Example 1 Preparation of Body Soap Containing Obesity Condition Improvement Agent

A body soap was prepared by the following preparation procedure. Table 1 shows the body soap prescriptions.

(Body soap preparation procedure)

First, ingredients 4 to 6 in Table 1 were uniformly mixed at 75 ° C. to obtain a mixture A. Next, components 7 to 9 are uniformly mixed and dissolved at 75 ° C., and added to and mixed with the mixture A to neutralize. After cooling the neutralized mixture, ingredients 1-3 and ingredients 10, 11 were collected to obtain a body soap.

[0024]

1, ethylene glycol distearate

2. Palm oil fatty acid ditanolamide

3. Lauryldimethylaminoacetic acid petite ^

4. Potassium hydroxide

5. Disodium detoate

6 Purified water

7. Lauric acid

S. Tinic acid

9. Tinic acid

0. Preservatives

1. Plant essential oil

In the table, the plant essential oil is an Italian cypress essential oil. The essential oil was purchased from Biolandes (hereinafter the same).

Example 2 Preparation of a body soap containing an obesity-condition improving agent

A body soap was prepared by the following preparation procedure. Table 2 shows the body soap prescriptions.

(Body soap preparation procedure)

First, ingredients 4 to 6 in Table 2 were uniformly mixed at 75 ° C. to obtain a mixture A. Thereafter, the same operation as in Example 1 was performed, and a body soap was obtained. [0026] Table 2

Bodiso

(Ingredient)

1. Ethylene glycol distearate 0.8

2. Palm oil fatty acid jetanolamide 3. 8

3. Lauryldimethylaminoacetate betaine 1.2

4. Potassium hydroxide 4.8

5. Disodium edetate 0.1

6. Purified water remaining

7. Lauric acid 5.4

8. Myristic acid 9.0

9. Palmitic acid 3.6

0. Preservative appropriate amount

1. δ— 3—Power Len 0.8

Δ-3-Carene was purchased from 11 (11 ^ 11 Chemical Company Inc. (hereinafter the same)

[0027] Comparative Example 1 Preparation of body soap

The same operation as in Example 1 was performed to obtain a body soap. However, the plant essential oil is one of laurel essential oil, neroli essential oil, ginger essential oil, and coffee essential oil. Laurel essential oil and neroli essential oil were purchased from Biolandes, Ginger essential oil was purchased from Ungerer, and coffee essential oil was purchased from Danisco (hereinafter the same).

Example 3 Preparation of Body Giel Containing Obesity Condition Improvement Agent

Body jewel was prepared by the following procedure. Table 3 shows the prescriptions for Body Gier. (Body Jewel preparation procedure)

First, components 1 to 6 in Table 3 were uniformly mixed at 70 ° C. to obtain a mixture A. Ingredients 7-8 are uniformly mixed and dissolved at 70 ° C, and added to mixture A to emulsify. While cooling this emulsion, ingredients 9 and 10-12 were added and mixed uniformly to obtain a body jewel. [0029] Table 3

Body jewel

(Ingredient) (%)

1. Stearic acid 0.5

2. Polyoxyethylene sorbitan monooleate 0.5

3. cetostearyl alcohol, 0.5 4. liquid paraffin 2.

5. Methylenopolysiloxane 3.0

6, dipropylene glycol 10.0

7. Triethanolamine 0.4 4 8. Purified water Remaining 9. Atalyl methacrylic acid copolymer 1% aqueous solution (Note 1) 20. 0

10. Etano 1 7.0

1 1. Preservative appropriate amount 1 2. Plant essential oil 0. 3

(Note 1) Carbopole 1342 (Goodrich)

In the table, the plant essential oil is a cypress essential oil.

Example 4 Preparation of body jewel containing an obesity condition-improving agent

Body jewel was prepared by the following procedure. Table 4 shows the prescriptions for Body Gier. (Body Jewel preparation procedure)

First, ingredients 1 to 6 in Table 2 were uniformly mixed at 70 ° C. to obtain a mixture A. Thereafter, the same operation as in Example 3 was performed to obtain a body gel.

[0031] Table 4

Body jewel

(Ingredient) (%)

1. Stearic acid 0.5

2. Polyoxyethylene sorbitan monooleate. 0.5

3. Setostearylanolo Cornole 0.5

4. Liquid paraffin 2. 0

5. Methylpolysiloxane 3.0

6. Dibropyrender Recall 10.0

7. Triethanolamine 0.4

8. Remaining amount of purified water

9. 1% aqueous solution of acrylic acid / methacrylic acid copolymer (Note 1) 20. 0

1 0. Ethanol 7.0

1 1. Preservative appropriate amount

1 2.δ_3—Karen 0.3

(Note 1) Carbopole 1342 (Goodrich)

[0032] Comparative Example 2 Preparation of body gel

The same operation as in Example 3 was performed to obtain a body jewel. However, the plant essential oil is one of laurel essential oil, neroli essential oil, ginger essential oil, and coffee essential oil.

Example 5 Preparation of bath essence containing an obesity condition-improving agent

A bath essence was prepared by the following procedure. Table 5 shows the nose essence prescriptions.

(Bath essence preparation procedure)

Ingredients 1 to 5 were mixed uniformly to obtain a bath essence.

[0034] Table 5

Bath essence

(Ingredient) (%)

1. Liquid paraffin 68.5

2. Glyceryl tri-2-ethylhexylate 15. 0

3. Tetraoleic acid polyoxye y 卜 7.0

4. Polyoxyethylene oil ether 4.5

5. Plant essential oil 5.0

In the table, the plant essential oil is a cypress essential oil.

Example 6 Preparation of a bath essence containing an obesity-improving agent

Nose essence was prepared by the following procedure. Table 6 shows the prescriptions for luminescence. (Bath essence preparation procedure)

Ingredients 1 to 5 were mixed uniformly to obtain a bath essence.

[0036]

Table 6

(Ingredients) (%) Liquid paraffin 68.5 Dariceryl triethyl hexylate 1 5. 0 Polyoxyethylene sorbitol tetraoleate 卜 7.0 Polyenoethylene-based Reynoleetenoret 4.5 5 δ-3—Strength 6 . 0

[0037] Comparative Example 3 Preparation of bath essence

The same operation as in Example 5 was performed to obtain a no essence. However, the plant essential oil is one of laurel essential oil, neroli essential oil, ginger essential oil, and coffee essential oil.

[0038] Test Example 1

Test is ΒΜΙ (= Body Mass

Index weight (kg) Z height ² (m)) was conducted on obese students (20 students) who showed 25 or more . First, as a control period, you can spend 2 weeks without using the cosmetics shown in the examples and comparative examples!ヽ (obesity condition-improving agent non-intervention phase), obesity-conditioning agent non-intervention period, physical examination (body weight, body fat percentage), salivary cortisol measurement (stress scale), GHQ, SDS (depression scale) were conducted.

Next, 20 subjects were divided into 5 groups (1 group: 4 people), and body soap, body jewel, and nose essence were added to each group with one of the 5 essential oils shown in the examples and comparative examples. For 2 weeks (obesity condition improving agent intervention phase), obesity condition improving agent physical measurement (body weight, body fat percentage), salivary cortisol measurement (stress scale), G HQ, SDS (depression scale) after the intervention period Was done.

The results are shown in Table 7.

Table 7 Examples Comparative Examples 1-4

Cypress δ-3-Kuchiichi Renello Resin Coffee

Essential oil essential oil essential oil essential oil

Oil

Weight loss effect ○ ○ Δ

Body fat percentage reduction effect ○ ○ Δ

Salivary cortisol reduction effect ○ ○ ―

G H Q Interview comprehensive results 〇〇 △ 〇

G H Q Interview Results (Anxiety and mood improvement) ○ ○ Δ ○

GH Q Questionnaire Result (Sleep Disorder) ○ ○ ○ Δ

SDS interview results ○ ○ ― ―

[0040] In the table, body weight loss effect 〇 Average body weight lkg or more decreased

Δ Average weight 0 ~: Less than Lkg

X Average weight gain

Decrease in body fat percentage 〇 Decrease in average body fat percentage by 2% or more

Δ Average body fat percentage decreased by less than 0-2%

X Increased average body fat percentage

Salivary cortisol reduction effect 〇 Average cortisol concentration decreased by 20 or more

Δ Average cortisol concentration 0 ~ 20 decrease

X Increased mean cortisol concentration

G H Q interview comprehensive result 〇 Decreased by 7 or more GHQ points

△ Decreased by more than GHQ points

X GHQ point increase

G H Q interview results (anxiety and mood improvement) 〇 Decreased by 4 or more GHQ points

Δ GHQ point 0 ~ 3 or more decrease

X GHQ point increase

G H Q interview results (sleep disorders) 〇 Decreased by 4 or more GHQ points

Δ GHQ Boyt 0 ~ 3 or more decrease

X GHQ point increase

S D S Interview Result 〇 Decrease SDS point by 5 or more

Δ SDS Boyd 0 ~ 4 or more decrease

X SDS points increase In the table, body fat percentage reduction effect was measured using TANITA BODY FAT ANALYZER TBF-110.

[0041] The salivary cortisol reduction effect was explained to the subjects using the gamma-one-coated cortisol measurement kit by explaining the precautions (meal time, designated food and drink prohibited, saliva collection time, etc.) to each individual. The saliva was collected. Put the absorbent cotton of the measurement kit in the mouth, and after 2-3 minutes (appropriately, the absorbent cotton is covered with saliva and lightly bites and oozes out). The absorbent cotton is returned to the kit container, and after freezing, concentration analysis is performed. The analysis method is the Radioimmune Assay (RIA), and the measuring instrument is the Autouel Gamma System AceuFLEX a 7010. [0042] The results of GHQ interviews were conducted according to the following references.

Reference Yasutoshi Nakagawa, Ikuo Daibo (Japanese version) 1985 Japanese version GHQ Mental Health Questionnaire Guidance

The results of SDS inquiry were conducted according to the following references.

References Kazuhiko Fukuda, Shigeo Kobayashi (Japanese version) 1983 Japanese version SDS mental health questionnaire usage guide Japan Cultural Science

[0043] As shown in Table 7, it was recognized that the weight reduction effect of cypress essential oil and δ3-force len was particularly high. Note that weight loss here means both weight loss and body fat percentage reduction. In addition, laurel essential oil did not show a significant weight loss effect, and neroli essential oil, ginger essential oil, and coffee essential oil tended to increase in both body weight and body fat percentage. Cypress essential oil and δ-3-carene also contributed to weight loss.

Example 7 Preparation of Fresh Colon Containing Obesity Condition Improvement Agent

Based on the following formulation, a fresh colon was prepared by a conventional method.

Formulation Example 1: Fresh Colon

(Ingredient) (%)

1 Ethanol 9 0. 0

2 Purified water 7.0

3. Cypress Essential Oil 3.0

Example 8 Preparation of Eau De Toilette Containing Obesity Condition Improvement Agent

Based on the following formulation examples, eau de toilette was prepared by a conventional method.

Formulation Example 2: Eau De Toilette

(Ingredient) (%)

1 Etano 1 9 0. 0

2 Purified water 7.0

3. Δ— 3 _ Karen 3.0

Example 9 Preparation of Body Lotion Containing Obesity Condition Improvement Agent Based on the following formulation examples, a body lotion was prepared by a conventional method.

Formulation Example 3: Body Lotion

(Ingredient) (%)

1. Purified water 75.5

2. Etano 1 1 0. 0

3. Glycerin 5.0

4.1, 3-Petit Render Recall 9.0

5. Cypress essential oil 0.5

Example 10 Preparation of body milk containing an obesity-improving agent

Body milk was prepared by the following procedure. The formula for body milk is shown in Formulation Example 4.

(Body milk preparation procedure)

First, components 1 to 8 were uniformly mixed at 70 ° C. to obtain a mixture A. Ingredient 9 ~: LO is uniformly mixed and dissolved at 70 ° C, and added to mixture A to emulsify. While this emulsion was cooled, ingredients 11-12 and 13 previously swollen were added and mixed uniformly to obtain body milk.Prescription Example 4: Body milk

(Ingredients) '(%)

1. Stearic acid 0.2

2. Dipropylene Darikonore 4.0

3. Glycerin 4.0

4. 1, 3 1-Putylene Glycol 2.0

5. Boroxyethylene sorbitan monooleate 〇 .5

6. Behenino Reno Conorre 0.5

7. 2-Ethylhexanoic acid triglyceride 2.0

8. Boroxyethylene sorbitan monooleate 0.5

9. Sodium hydroxide ○ 13

10. Purified water 12, 87

1 1-Forced Roxyl vinyl polymer 0.22

1 2. Purified water remaining

1 3. δ—3—Power Len 0.5 Example 11 Preparation of Aloma Oil Containing Obesity Improvement Agent

Based on the following prescription examples, an aroma oil was prepared by a conventional method. Example 12 Preparation of Aloma Oil Containing Obesity Condition Improvement Agent

Based on the following prescription examples, an aroma oil was prepared by a conventional method.

Formulation Example 6: Aroma Oil

(Ingredient) (%)

1. 2-Ethylhexanoic acid tridallylide 89.0

2. Dipropylene Dalicol 10.0

2. δ_3-Karen 1.0 Example 13 Preparation of Room Frederance Containing Obesity Condition Reducing Agent

Based on the following formulation examples, room fredalance was prepared by a conventional method.

Formulation Example 7: Room Fragrance (Aerosol)

(Ingredient) (%)

1. Etano Nore 19.5

2. Cypress essential oil 0.5

3. LPG 80. 0

Example 14 Preparation of Room Frederance Containing Obesity Condition Improvement Agent

Formulation Example 8: Room Fragrance (Aerosol)

1. Etano Nore 89.5

2. Dipropylene glycol 10.0

3. δ— 3—Power Len 0, 5

[0052] Fresh colon containing an obesity condition improving agent prepared above, body mouth containing obesity condition improving agent, aroma oil containing obesity condition improving agent, and room fat containing obesity condition improving agent Each of the fragrances was confirmed to have an excellent effect of improving obesity, such as an improvement in anxious mood and an improvement in sleep disorder, which was effective in relieving stress and was excellent in weight loss.

The present invention also includes the invention described below.

(1) Cypress essential oil and base power A composition essentially composed of a novel composition characterized by being able to improve obesity.

(2) A novel composition characterized in that it is a composition essentially composed of δ 3 -strength and a base and can improve obesity.

(3) Cypress essential oil and base power It is a composition that is essentially composed, it can improve obesity, and the strength also has an antidepressant action and acupuncture or stress reduction action. New composition.

(4) A composition consisting essentially of δ 3 -strength and a base, which is capable of improving obesity and also has an antidepressant action and an acupuncture or stress reducing action. New composition.

(5) Cypress essential oil and base power A composition essentially composed of a novel composition characterized in that it can improve obesity and is useful as a skin external preparation or fragrance.

(6) A novel composition characterized by comprising δ 3 -strength and a base, which can improve obesity and is useful as an external skin preparation or fragrance. object.

(7) The above-mentioned new composition is applied to the skin, and the cypress essential oil or δ-3-carene or the volatile component containing Cypress essential oil or δ-3-calen from the above-mentioned new composition is incorporated into the body. To improve obesity.

(8) The new composition is stored so that it can freely come into contact with air, and through the air in the space where the new composition is stored, Cypress essential oil or δ-3-calen from the new composition, Alternatively, a method for improving an obesity state, comprising incorporating a volatile component containing cypress essential oil or δ 3 -strength into the body.

(9) A fragrance composition containing cypress essential oil or δ 3-strength for improving obesity Use of

Claims

The scope of the claims

[1] An obesity improving agent comprising cypress essential oil.

[2] An agent for improving obesity, characterized by:

[3] The method according to claim 1 or 2, further comprising an antidepressant action and an acupuncture or stress reducing action.

2. The obesity condition-improving agent according to 2.

[4] A skin external preparation comprising the obesity-condition improving agent according to any one of claims 1 to 3.

[5] A fragrance comprising the obesity condition-improving agent according to any one of claims 1 to 3, and a method of using a fragrance comprising cypress essential oil or δ3-strength for obesity condition improvement