WO2007047404A2 - Appareil et procédé d'utilisation d'intelligence relative à un cathéter rfid - Google Patents
Appareil et procédé d'utilisation d'intelligence relative à un cathéter rfid Download PDFInfo
- Publication number
- WO2007047404A2 WO2007047404A2 PCT/US2006/039985 US2006039985W WO2007047404A2 WO 2007047404 A2 WO2007047404 A2 WO 2007047404A2 US 2006039985 W US2006039985 W US 2006039985W WO 2007047404 A2 WO2007047404 A2 WO 2007047404A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- catheter
- rfid chip
- information
- interface device
- rfid
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00059—Operational features of endoscopes provided with identification means for the endoscope
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4438—Means for identifying the diagnostic device, e.g. barcodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4472—Wireless probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0803—Counting the number of times an instrument is used
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
- G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
- G06K19/067—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components
- G06K19/07—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components with integrated circuit chips
- G06K19/077—Constructional details, e.g. mounting of circuits in the carrier
- G06K19/07749—Constructional details, e.g. mounting of circuits in the carrier the record carrier being capable of non-contact communication, e.g. constructional details of the antenna of a non-contact smart card
Definitions
- the present invention relates to a system and method of using backscattered data and known parameters to identify and characterize vascular tissue, or more particularly, to devices and methods of use for identifying the operating frequency and type of catheter being used to acquire the backscattered data and for relaying specific information about the catheter to an attached operation console.
- Ultrasound imaging of the coronary vessels of a patient can provide physicians with valuable information regarding the identify the shape of a blood vessel, its density, its composition that can be useful in the diagnosis and/or treatment of a patient. For example, such information may show the extent of a stenosis in a patient, reveal progression of disease, determine the vulnerability of the atherosclerotic plaque for causing myocardial infarction, help determine whether procedures such as angioplasty, stenting or atherectomy are indicated, or whether more invasive procedures are warranted.
- IVUS intravascular ultrasound
- an ultrasonic transducer is attached to the end of a catheter that is carefully maneuvered through a patient's body to a point of interest such as within a blood vessel.
- the transducer may be a single-element crystal or probe that is mechanically scanned or rotated back and forth to cover a sector over a selected angular range. Acoustic signals are then transmitted and echoes (or backscatter) from these acoustic signals are received. As the probe is swept through the sector, many acoustic lines are processed building up a sector-shaped image of the patient. These signals may then be processed using well known techniques and transformed into a gray scale image of the vasculature on a computer console in the catheter lab, i.e.
- VH databases, or classification trees, used to correlate the patient's IVUS data and identify tissue type are compiled by examining RF backscatter data from known histologic tissue types and correlating the spectral characteristics of the backscatter data with a specific tissue type.
- the VH classification trees must be computed using IVUS catheters operating at a specific frequency since data obtained using catheters operating at other frequencies may result in different spectral characteristics for a given tissue.
- separate VH classification trees must be generated for each catheter operating frequency and the patient data obtained from a catheter operating at a specific frequency must be correlated with the classification tree for that operating frequency in order to achieve an accurate mapping of the patients vasculature and classification of the vascular tissue and plaque type.
- phased array IVUS catheters or rotational IVUS catheters such as those disclosed in such as disclosed in U.S. Patent No. 5,368,037, issued to Eberle and U.S. Patent 5,000,185, issued to Yock, both fully incorporated herein by reference, may be used to gather RF data.
- phased array IVUS catheters or rotational IVUS catheters such as those disclosed in such as disclosed in U.S. Patent No. 5,368,037, issued to Eberle and U.S. Patent 5,000,185, issued to Yock, both fully incorporated herein by reference, may be used to gather RF data.
- different VH classification trees must be generated for data obtained from phased array vs. rotational IVUS catheters.
- Early imaging catheters typically relied on manual recognition of a catheter type. For example, catheters were color coded according to type then the operator had to ⁇
- the present invention provides a method and devices for communication between an imaging catheter and an operation console to select the appropriate VH classification database.
- the appropriate VH database for analyzing data from a specific imaging catheter, it is advantageous to know information regarding the operating frequency of the catheter and whether it is a rotational or phased-array catheter.
- additional information regarding specific catheter performance characteristics such as the unity gain value, the boot mode, the catheter sensitivity may also be stored on the catheter and used to further optimize catheter performance and/or select the appropriate VH tree for analyzing data from the catheter imaging element.
- a Radio Frequency Identification (RFID) chip such as a Maxwell MEl or ME2 RFID chip, mounted on a connector on the proximal end of the catheter, is used to store information about the catheter.
- RFID technology is a wireless technology for data transfer previously used in applications, such as electronic toll collection, railway car identification and tracking, that offers automatic identification functionality as well as the ability to easily and securely store, transfer and update information.
- RFID provides certain advantages over prior catheter identification systems.
- the RFID chip may have a memory capacity of several kilobytes or more, which is substantially greater than the maximum amount of data that may be acquired from the prior methods of catheter identification.
- the information initially stored on the RFID tag may include identifying information about the catheter such as make, model and serial number, operational characteristics of the catheter, ⁇
- the short transmission distance of the RFID chip may avoid interfering with other electronic equipment in the cath lab.
- the RFID technology may also include an antenna capable of reading and writing additional information to the chip.
- the information regarding the catheter may be updated, for example, as the catheter is used and the performance characteristics and/or calibration coefficients for a given operating frequency or catheter model change.
- the catheter interface device includes an RFID scanner mounted in proximity to the connector on the interface device for the catheter.
- the catheter interface device may be a pull back device used to operate an IVUS catheter.
- the RFID scanner is mounted so that when the catheter connecter and the pullback device connector are joined the RFID scanner is located within the given transmitting distance for the RFID chip on the catheter, for example between about 0- 10mm.
- the catheter connector triggers a trip switch located in the interface device connector and activates the RFID scanner.
- the RFID scanner may then read the information on the catheter RFID chip to determine the identity of the catheter.
- the interface device may then relay the catheter identification information to the operation console.
- the interface device may be connected to the operation console via any suitable communication protocol, for example via a USB or serial connection. Once the interface device relays the information to the operation console, the interface device may turn off the RFID scanner.
- the information relayed to the operation console may include one or more of the catheter serial number, catheter name, catheter model number, calibration coefficients, time gain control, post amp gain, date of first use, date of last use, number of times used, number of permissible uses, geographic location of permissible use, boot mode, pulse width, or expiration date of the catheter to the operation console.
- the operation console may then use this information to determine which of the multiple VH classification databases stored on the operation console should be used to analyze the data captured using this catheter and imaging element.
- the operation console may choose the VH classification tree based on the operating frequency of the attached catheter.
- the catheter RFID chip may contain additional information regarding sensitivity of the catheter, in which case, the operation console may choose a VH classification tree based on operating frequency of the catheter and a high, medium or low sensitivity rating.
- the operation console may use additional information relayed from the catheter RFID chip, such as boot mode, time gain control, post amp gain or other calibration coefficients to further optimize the catheter performance and data analysis.
- the operation console may use the information from the catheter RFID chip to determine whether or not to permit catheter operation.
- the catheter RFID chip may further store a security code for the catheter. This security code may be read by the RFID reader on the interface device and if the catheter security code is not authorized for use with the connected catheter interface device, the system will not permit the catheter use.
- the catheter RFID chip may further store an expiration date. This expiration date may be read by the RFID reader on the interface device and if the expiration date had passed, the interface device may prohibit catheter use.
- the RFID chip may be programmed to permit a given number of uses or hours of use.
- the RFID chip may be updated after each use to store the total number of uses or total 'hours of use.
- the interface device may read and compare the values for the permissible hours of use/times used with the total hours of use/times used. Once the total number of uses or total hours of use surpasses the preprogrammed limit, the interface device may prohibit catheter use.
- the RFID scanner located on the interface device may further include RFID read and write capabilities.
- the operation console may instruct the interface device to turn on the RFID scanner at the end of a catheter use to download information regarding the catheter use to the RFID chip.
- the operation console may download patient identification, hospital information and operating physician information to the RFID chip.
- the Virtual Histology images themselves may be downloaded and stored on the catheter RFID chip along with the patient information and used as a medical record of the procedure.
- the RFID chip may also be designed so that it can be removed in order to provide an easily transportable record of the complete procedure that may used with another with another RFID reader to transfer the information to a different storage medium or analysis device.
- the RFID scanner may also be used to update the operational and performance characteristics and use information of the catheter for future catheter use.
- the catheter may have a shield, for example lead, positioned over the RFID chip to protect the RFID chip during a severe sterilization process, such as radiation.
- the RFID chip may be presterilized using gas and sealed hermetically prior to positioning the shield.
- FIG. 1 is a block diagram depicting a system for vascular tissue characterization according to the present invention.
- FIG. 2 illustrates an embodiment of a catheter for use according to the present invention
- Fig. 2A illustrates an embodiment of a catheter connector containing an RFID chip for use according to the present invention.
- Fig. 2B illustrates an embodiment of a catheter connector containing an RFID chip for use according to the present invention.
- Fig. 3 illustrates an embodiment of a pull back device for use according to the present invention.
- FIG. 3 a illustrates an embodiment of a pull back device for use according to the present invention.
- Fig. 4 is a flow chart illustrating exemplary steps for identifying an imaging catheter and selecting the appropriate classification tree for analyzing data from the attached catheter
- Fig.l is a block diagram showing an embodiment of a system for characterizing vascular tissue data.
- the system generally comprises a catheter 102, having an imaging element 104 operably connected at the distal end, connected to an interface device 108 which is then connected to an operation console 110.
- the interface device 108 is triggered and begins reading catheter information stored on a memory device, for example an EPROM, an RFID chip or other suitable memory device, located on the catheter 102.
- the catheter 102 relays information about the imaging element 104 to the interface device 108.
- the catheter may communicate the type of imaging element, for example phased array ultrasonic transducers or rotational ultrasonic transducers, and operating frequency of the imaging element.
- the catheter may also relay additional information regarding specific catheter identification and/or performance characteristics, for example catheter serial number, name, make or model, calibration coefficients, imaging element sensitivity, time gain control, post amp gain, date of first use, date of last use, number of times used, number of permissible uses, geographic location of permissible use, boot mode, pulse width, or expiration date of the catheter to the operation console.
- the interface device 108 then relays the catheter information to the operation console 110.
- the interface device 108 may be connected to the operation console 110 via any suitable communication protocol known in the art, for example USB or Serial.
- the catheter may be directly connected to the operation console,
- the information transfer may be via a wireless communication protocol.
- the operation console 110 contains a plurality Virtual Histology classification trees 112a-c each developed using known method of comparing histology data and IVUS data gathered by different types of catheters operating at different frequencies.
- Virtual Histology classification trees are developed by collecting and correlating RF backscatter signal from an IVUS catheter with known histologic tissue types as disclosed in U.S. Patent application 10/647971, fully incorporated herein by reference.
- the RF data is transformed in to the frequency domain and the various power spectral characteristics of the backscattered signal are correlated with characterization data to determine signature parameters for each tissue type.
- these spectral characteristics of the tissue types vary for catheters operating at different frequencies and thus separate classification trees must be used. Accordingly, specific information about the catheter used for a clinical procedure is needed to select the appropriate classification tree for analyzing that data.
- information regarding specific catheter performance characteristics such as the unity gain value, the boot mode, the catheter sensitivity may also be stored on the catheter and used to further select the appropriate VH tree for analyzing data from the catheter imaging element.
- the operation console 110 could store VH classification trees for low, medium and high sensitivity catheters in each operating frequency. Then, based on information from the catheter regarding the operating frequency and sensitivity of the catheter, the operation console further tailor the selection of the appropriate VH classification tree.
- the VH classification tree for the specific catheter may be stored on the catheter.
- the catheter will relay the specific classification tree to use for analyzing the data it collects to the operation console and the operation console will simply download the classification tree from the catheter.
- the operation console 110 may download the VH image and data to the catheter for storage within the catheter memory device and either the entire catheter, the catheter connector containing the RFID chip or the removable RFID chip may then be used as a portable medical record.
- the operation console may down load specific information regarding the time and duration of use of the clinical procedure to the catheter.
- the catheter 202 may have an RFID chip 203, such as Maxwell MEl or ME2 RFID chip, mounted on the connector 206 on the proximal end of the catheter 202 for storing information and communicating with the interface device 308.
- the catheter may have a second RFID chip (not shown) mounted 180 degrees from the first RFID chip 203 of the connector 206 so catheter can be connected to interface device at more than one circumferential orientation.
- the RPID chip 203 may have a memory of 128 bytes, alternatively IK byte, alternatively 2K bytes alternatively 4K bytes to store catheter specific information, including for example catheter serial number, name, make or model, calibration coefficients, imaging element sensitivity, time gain control, post amp gain, number of permissible uses, geographic location of permissible use, boot mode, pulse width, or expiration date of the catheter.
- catheter specific information including for example catheter serial number, name, make or model, calibration coefficients, imaging element sensitivity, time gain control, post amp gain, number of permissible uses, geographic location of permissible use, boot mode, pulse width, or expiration date of the catheter.
- the catheter connector 206 engages a trip switch 303 which activates the RFID circuit board 305 to start the RFID scanner 309 looking for the catheter RFID chip 203.
- the RFID scanner 309 is located near the connection point of two connectors.
- the RFID scanner will be with in transmission distance, about 0-10 mm, alternatively about 0-3 mm, from the RFID chip 203 located on the catheter connector 206.
- the RFID scanner 309 reads the information stored on the catheter RFID chip 203 and relays this information to the RFID circuit board 305.
- the RFID circuit board 305 may optionally include a microprocessor and instructions for processing and acting on some of the data received from the catheter RFID chip 203 .
- the catheter RFID chip 203 may transmit a security code which must be matched by a corresponding security code on the interface device in order to authorize catheter use.
- the RFID scanner 309 may have read and write capability, in which case the RFID circuit board 305 may further include instructions for writing additional information to the catheter RFID chip 203. This information could be useful for tracking the catheter and for ensuring security and sterility of the catheter.
- the RFID circuit board 305 may receive information from the operation console regarding the patient identification, hospital, operating physician, which could be downloaded and stored on the RFID chip 203.
- the Virtual Histology images themselves, along with the corresponding patient information may be downloaded and stored on the catheter RFID chip which may then be removed from the catheter and used as a medical record of the procedure.
- information regarding the time of use, duration of the procedure and interface device used could be downloaded to the RFID chip to monitor and manage sterility of the catheter. For example, once a catheter is connected to a particular interface device, then the catheter will only operate with that interface device for a limited time period, such as 8 hours, or 12 hours or the typical length of a given procedure.
- the operation console can monitor the duration of use of the catheter and download this information to the catheter RFID chip so that if the catheter is plugged into another interface device, use will not be permitted. If the catheter fails during use, the operation console may also download a failure code as well as complete information regarding the circumstances of the failure to the RFID chip. [0031] Fig.
- step 4 shows exemplary steps of a method for characterizing vascular tissue data using RFID chip mounted on the proximal end of the catheter for communicating catheter information to the operation console to select the appropriate classification tree.
- a system for characterizing vascular tissue data using different methods of storing, transferring and receiving data between the catheter and operation console.
- step 401 data regarding the identification and operating characteristics of the catheter is stored on an RFID chip located on the proximal end of the catheter.
- This may include one or more of the catheter serial number, catheter name, catheter model number, calibration coefficients, time gain control, post amp gain, date of first use, date of last use, number of times used, number of permissible uses, geographic location of permissible use, boot mode, pulse width, or expiration date of the catheter to the operation console.
- the catheter is connected to an interface device.
- the interface device may be a pullback device, such as the VolcanoTM RevolutionTM PIM, or the VolcanoTM RlOO, for operation of a rotational or phased array IVUS catheter.
- the connection between the catheter and the interface device activates the interface device, and at step 403, an RFID scanner on the interface device reads the catheter identification and operating data stored on the catheter RFID chip.
- the interface device may further comprise a microprocessor for initially processing some of the data from the RFID chip, or the interface device may simply relay the information to the operation console for processing.
- the interface device may read a security code or expiration date stored on the RFID chip and if the security code is not authorized or the expiration date has passed, at step 405 the interface device may prohibit operation of the catheter.
- the interface device transfers the information from the catheter RFID chip to the attached operation console using a standard communication protocol, such as USB or serial.
- the operation console uses this data to select one of multiple VH classification trees for analyzing data received from that catheter. For example, the operation console may use data regarding the catheter model number to determine whether the catheter is a phased array or rotational IVUS catheter. The operation console may then use the data regarding the catheter operating frequency to ⁇ ⁇
- the interface device operates the catheter to collect IVUS data from the imaging element located in the patient's vasculature.
- the interface device may use information regarding the catheter performance characteristics that was stored on the RFID chip, for example the catheter boot mode, to operate the catheter.
- the IVUS data is transmitted to the operation console where it is processed and analyzed.
- the operation console may use information received from the catheter RFID chip to process and optimize the IVUS data, e.g. RF backscatter data.
- the time gain control, post amp gain and pulse width data regarding the catheter signal stored on the RFID chip may be used to process IVUS data.
- the spectral parameters of the IVUS data are identified and compared to parameters stored in the VH classification tree for each of the known tissue types, including fibrous tissue, fibro-fatty, necrotic core, dense calcium, thrombus, organized thrombus, blood, highly vascular tissue and not highly vascular tissue.
- non-tissue material such as stent material, can also be identified.
- the image can be blacked out to avoid misinterpretation of the image. The same process can also be used in other applications to identify myocardium or cancer cells.
- the region related with that parameter is correlated to the tissue type stored in the VH classification tree.
- the information regarding the characterization of the tissue is downloaded to the RFID chip via the interface device.
- the operation console may transmit additional information regarding the procedure, including for example patient identification, operating physician, hospital information, time and duration of procedure, etc.
- the RFID chip could be used as a complete medical record of the procedure.
Abstract
L’invention concerne un procédé et un système pour utiliser des données rétrodiffusées et des paramètres connus afin de caractériser un tissu vasculaire. Spécifiquement, l’invention concerne des procédés et dispositifs permettant d’identifier des informations concernant l’élément d'imagerie servant à recueillir des données rétrodiffusées pour permettre à une console de commande possédant une pluralité d’arbres de classification d’histologie virtuelle de sélectionner l’arbre de classification VH approprié pour analyser des données recueillies à l’aide de cet élément d’imagerie. Pour sélectionner la base de données VH appropriée permettant d’analyser les données à partir d’un cathéter d’imagerie spécifique, il est avantageux de connaître des informations concernant la fonction et les performances du cathéter, comme la fréquence de fonctionnement du cathéter et s’il s’agit d’un cathéter rotatif ou à balayage électronique. La présente invention concerne un dispositif et un procédé permettant de stocker ces informations sur le cathéter d’imagerie et de communiquer les informations à la console de commande. En outre, des informations concernant des fonctions supplémentaires du cathéter peuvent également être stockées sur le cathéter et servir à optimiser davantage les performances de cathéter et/ou à sélectionner l’arbre de classification d’histologie virtuelle approprié permettant d'analyser des données provenant de l’élément d'imagerie de cathéter.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06825868.0A EP1933711B1 (fr) | 2005-10-12 | 2006-10-11 | Appareil et procédé d'utilisation d'intelligence relative à un cathéter rfid |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US11/250,159 US7988633B2 (en) | 2005-10-12 | 2005-10-12 | Apparatus and method for use of RFID catheter intelligence |
US11/250,159 | 2005-10-12 | ||
JP2006-092291 | 2006-03-29 | ||
JP2006092291A JP5386057B2 (ja) | 2005-10-12 | 2006-03-29 | RFIDカテーテルインテリジェンス(catheterintelligence)を使用する方法 |
Publications (3)
Publication Number | Publication Date |
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WO2007047404A2 true WO2007047404A2 (fr) | 2007-04-26 |
WO2007047404A8 WO2007047404A8 (fr) | 2007-07-05 |
WO2007047404A3 WO2007047404A3 (fr) | 2007-10-18 |
Family
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PCT/US2006/039985 WO2007047404A2 (fr) | 2005-10-12 | 2006-10-11 | Appareil et procédé d'utilisation d'intelligence relative à un cathéter rfid |
Country Status (4)
Country | Link |
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US (3) | US7988633B2 (fr) |
EP (1) | EP1933711B1 (fr) |
JP (2) | JP5386057B2 (fr) |
WO (1) | WO2007047404A2 (fr) |
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WO2010138463A1 (fr) * | 2009-05-29 | 2010-12-02 | Boston Scientific Scimed, Inc. | Systèmes et procédés de mise en œuvre d'un système de gestion de données pour systèmes d'imagerie à base de cathéter |
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US8884767B2 (en) | 2009-12-02 | 2014-11-11 | Widex A/S | Method and apparatus for alerting a person carrying an EEG assembly |
US11064969B2 (en) | 2014-04-11 | 2021-07-20 | Koninklijke Philips N.V. | Automatic configuration detection for sensor equipped needle |
US10456105B2 (en) | 2015-05-05 | 2019-10-29 | Boston Scientific Scimed, Inc. | Systems and methods with a swellable material disposed over a transducer of an ultrasound imaging system |
CN108618740A (zh) * | 2017-03-18 | 2018-10-09 | 美国瑞德康股份有限公司 | 可强制用后丢弃的内窥镜装置 |
US11064865B2 (en) | 2017-03-18 | 2021-07-20 | Reed Cam, Inc. | Endoscope apparatus with forced disposability |
Also Published As
Publication number | Publication date |
---|---|
WO2007047404A3 (fr) | 2007-10-18 |
US7988633B2 (en) | 2011-08-02 |
JP2007105450A (ja) | 2007-04-26 |
EP1933711A4 (fr) | 2013-02-27 |
US20150342564A1 (en) | 2015-12-03 |
US20070083111A1 (en) | 2007-04-12 |
US9101298B2 (en) | 2015-08-11 |
US10052082B2 (en) | 2018-08-21 |
JP5665682B2 (ja) | 2015-02-04 |
WO2007047404A8 (fr) | 2007-07-05 |
JP2011245326A (ja) | 2011-12-08 |
EP1933711A2 (fr) | 2008-06-25 |
EP1933711B1 (fr) | 2020-12-09 |
JP5386057B2 (ja) | 2014-01-15 |
US20110270091A1 (en) | 2011-11-03 |
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