WO2007037307A1 - Procédé de calibrage de dispositif de tomographie et procédé de superposition d’image de tomographie - Google Patents

Procédé de calibrage de dispositif de tomographie et procédé de superposition d’image de tomographie Download PDF

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Publication number
WO2007037307A1
WO2007037307A1 PCT/JP2006/319264 JP2006319264W WO2007037307A1 WO 2007037307 A1 WO2007037307 A1 WO 2007037307A1 JP 2006319264 W JP2006319264 W JP 2006319264W WO 2007037307 A1 WO2007037307 A1 WO 2007037307A1
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gantry
position data
tomographic
data
coordinate system
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PCT/JP2006/319264
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English (en)
Japanese (ja)
Inventor
Hidehiro Iida
Hiroshi Watabe
Toshihiro Ota
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Japan Health Sciences Foundation
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Priority to JP2007537664A priority Critical patent/JP5140810B2/ja
Publication of WO2007037307A1 publication Critical patent/WO2007037307A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/12—Arrangements for detecting or locating foreign bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5235—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/54—Control of apparatus or devices for radiation diagnosis
    • A61B6/547—Control of apparatus or devices for radiation diagnosis involving tracking of position of the device or parts of the device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00681—Aspects not otherwise provided for
    • A61B2017/00725—Calibration or performance testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046—Tracking techniques
    • A61B2034/2055—Optical tracking systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/364—Correlation of different images or relation of image positions in respect to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
    • A61B2090/3762—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy using computed tomography systems [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3983—Reference marker arrangements for use with image guided surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50—Supports for surgical instruments, e.g. articulated arms
    • A61B2090/502—Headgear, e.g. helmet, spectacles

Definitions

  • the present invention is standardized by a calibration method of a tomography apparatus for standardizing an imaging apparatus so that images obtained from different tomography apparatuses can be displayed on top of each other, and this calibration method.
  • X-ray CT X-ray computed tomography device
  • SPECT single photon transmission CT device
  • PE T positron
  • MRI magnetic resonance equipment
  • PET a radiopharmaceutical is administered to a subject, and radiation emitted from the drug is detected by a number of radiation detectors to create a tomographic image of the radioactivity distribution in the body. Is. This makes it possible to know the distribution of drugs in the body non-invasively with very high sensitivity. Therefore, an image having physiological information can be obtained by using PET. Because of this property, PET is widely used in various fields such as neurology, cardiology, and oncology. In particular, attention has been paid to the fact that in recent years, subjects who have been administered 18 F-FDG (fluordeoxyglucose) can easily detect cancer early and check for cancer metastasis by imaging the whole body with PET. Has been.
  • F-FDG fluordeoxyglucose
  • 18 F-FDG is a kind of sugar and has a characteristic that it is particularly easy to accumulate in tumors. For this reason, in the PET image, the tumor site has a higher count than the normal site. Therefore, the presence or absence of a tumor can be easily determined by just looking at the PET image.
  • PET images provide such physiological information but lack anatomical information. For this reason, it is not sufficient to identify the detailed anatomical location of the tumor. The tumor force displayed on the PET image Deciding which part of the tissue is present is extremely important for the subsequent treatment planning. Therefore, it is hoped that the detailed anatomical position of the tumor can be identified by using PET images together with MRI images and X-ray CT images.
  • the present inventors previously prepared an optical tracking device, attached a marker that can be detected by the tracking device to the gantry of the PET device as a reference marker, and attached the same marker to the patient's head. Scanning, the patient's relative movement with respect to the gantry at the time of imaging is detected to monitor the patient's body movement, and the body movement is corrected by correcting the image data captured based on the body movement. It was proposed to obtain corrected images (see Non-Patent Documents 1 and 2). However, here, the optical tracking device is only used to correct body movement.
  • Patent Document 1 Japanese Patent Publication No. 6-16099
  • Patent Document 2 JP-A-9 113636
  • Non-Patent Document 1 WOO et al., "SINOGRAM-BASED MOTION CORRECTION OF PET I MAGES", IEEE TRANSACTIONS ON NUCLEAR SCIENCE, VOL. 51, N0.3, p.782 -788, JUNE 2004
  • Non-Patent Document 2 H. Watabe et al, International Congress Series 1265 (2004) p.31-38. Disclosure of the Invention Problems to be solved by the invention
  • the present invention acquires tomographic data at the time of scanning with a tomographic apparatus, simultaneously acquires position data corresponding thereto, and further converts the position data into position data in a coordinate system common to different tomographic apparatuses. Accordingly, an object of the present invention is to accurately align tomographic data captured by different tomographic apparatuses based on the converted position data and to superimpose both images.
  • the present inventors use the conversion matrix obtained by calibrating the tomographic apparatus, using the position data of the subject acquired using the optical tracking apparatus during scanning of the tomographic apparatus. By converting to position data in the scanner coordinate system, it has been found that tomographic images captured by different imaging devices can be easily and accurately superimposed, and the present invention has been completed.
  • a gantry having a detector attached thereto and a holding device that holds a subject in the gantry are provided, and the gantry or the holding device is moved.
  • a calibration jig having a marker and a radiation source that can be detected by the detector is held by the holding device, and the position data of both markers when the gantry or the holding device is moved and scanned. Is obtained by the optical tracking device, and the gantry coordinate system C
  • a method for calibrating a tomographic apparatus characterized in that ⁇ is obtained, is provided.
  • the conversion matrix T is the optical tracking.
  • the device is connected to a computer, the position data of both markers acquired by the tracking device is stored in the storage device of the computer, and the relationship between the stored position data can be calculated. Usually, it can be easily performed using a computer.
  • a gantry having a detector attached thereto, and the gantry A computer program for calibrating a tomographic apparatus that scans the subject and acquires tomographic data by moving the gantry or the holding device by holding the subject in a bird Because
  • An optical tracking device is prepared, a marker that can be detected by the tracking device is attached to the gantry, and a calibration jig having the same marker and a radiation source that can be detected by the detector is held by the holding device.
  • the position data of the gantry coordinate system C is
  • the tomographic data can be accurately displayed on the screen.
  • a gantry including a detector and a holding device that holds a subject in the gantry are provided, and the gantry or the holding device is moved.
  • the tomographic apparatus that scans the subject to obtain tomographic data is used to obtain tomographic data, and at the same time, an optical tracking device is prepared, and markers that can be detected by the tracking device are used as the gantry and the subject.
  • the position data corresponding to the tomographic data of the subject is acquired using the tracking device during the scan, and the obtained position data is the position of the coordinate system C of the marker attached to the gantry. Data, and the converted position data is converted into the key.
  • a method for obtaining tomographic data is provided.
  • a method for acquiring the tomographic data is provided.
  • a plurality of pieces of tomographic data acquired are based on the position data of the coordinate system C.
  • These coordinate system conversion procedures and image display can usually be performed using a computer.
  • the optical tracking device is connected to a computer and acquired by the tracking device.
  • the position data is stored in a storage device of a computer, the stored position data is converted by a conversion matrix T, and the data connected to the computer is converted.
  • a gantry having a detector attached thereto and a holding device that holds a subject in the gantry are provided, and the gantry or the holding device is moved.
  • Preparing tomographic data acquired by using a tomographic apparatus that scans the subject to acquire tomographic data and an optical tracking device, and markers that can be detected by the tracking device are detected in the gantry and the subject.
  • the obtained position data is changed to the position data of the coordinate system C of the marker attached to the gantry.
  • the converted position data is converted into the converted matrix ⁇ obtained by the above method.
  • a computer program for processing tomographic data for executing the above is provided.
  • a plurality of tomographic data processed by the computer program are superimposed on the basis of the position data of the coordinate system C and displayed as a tomographic image.
  • a computer program for overlaying and displaying tomographic images characterized by including a procedure is provided.
  • Any of the above computer programs can be provided by being stored in an appropriate storage medium such as a flexible disk, CD-ROM, hard disk, RAM, ROM, etc., or can be downloaded online and installed on a computer It may be.
  • a rack and a rack detachably attached to the rack are provided.
  • a calibration jig for a tomography apparatus comprising one get, the target accommodating a marker that can be detected by an optical tracking device and a radiation source that can be detected by a detector of the tomography apparatus
  • a calibration jig for a tomography apparatus is provided.
  • the position data of the image data is converted into the scanner coordinate system C using the transformation matrix T.
  • the position data of the subject obtained from various tomography apparatuses is converted into a conversion unique to each imaging apparatus.
  • the matrix T is the position data in the scanner coordinate system.
  • the three-dimensional position of the subject is accurately determined using the optical tracking device.
  • results that do not depend on image quality are obtained, and PET and MRI images can be overlaid, making it versatile regardless of modality.
  • a system is provided.
  • the present invention can be easily applied to an existing tomography apparatus that only requires an optical tracking device and a marker that can be detected, and thus enables high-precision image superposition at low cost. As a result, an economical and advanced diagnosis becomes possible.
  • tomography apparatuses such as X-ray CT, SPECT, PET, and MRI, as shown in FIG. 1, hold a so-called bed that holds a gantry 1 and a subject such as a patient therein.
  • a detector is attached to the inner periphery of the gantry 1.
  • the detector is a scintillator for PET, SPECT and X-ray CT, and an RF coil for MRI.
  • the subject is held by the holding device 2 and the gantry 1 or the holding device 2 is linearly moved to scan the subject and acquire one or more tomographic data.
  • an optical tracking device 3 is further prepared and installed outside the tomography apparatus.
  • a force that can use a position sensor using a CCD camera is usually used.
  • two CCD cameras 33 and 33 are provided, and the three-dimensional (3D) of a marker attached to a rigid body )
  • An optical tracking device that can measure the 6-dimensional (6D) motion (ie, position and direction) of the rigid body in real time by measuring the position is preferably used.
  • An example of a device equipped with two powerful CCD cameras is the POLARIS (registered trademark) system (manufactured by Northern Digital Inc.).
  • the optical tracking device 3 is connected to a computer with an RS-232C cable or the like, and the obtained position data can be transmitted to the computer, stored in a storage device, and displayed.
  • a marker 4 that can be detected by the tracking device 3 is attached to the gantry 1.
  • the marker 4 is configured as a unit having four plastic spheres 42, 42... On the surface of a substantially rectangular substrate 41, and this substrate 41 is attached to the front surface of the gantry 1. It is fixed by.
  • the spheres 42, 42,... Have a property of reflecting light rays such as infrared rays emitted from the tracking device 3, and the tracking device 3 acquires position data of the marker 4 by capturing the reflected light.
  • the unit of the marker 4 has three spheres 42, 42...
  • the calibration jig 6 is placed on the holding device 2 and fixed.
  • the calibration jig 6 includes a marker 61 having the same configuration as the marker 4 and a radiation source 62 that can be detected by a detector attached to the gantry 1.
  • the position data of both markers 4 and 61 when the tomography apparatus is scanned are tracked and acquired by the optical tracking device 3 and the tomography apparatus is calibrated.
  • the scanning of the slice imaging apparatus is performed in the same manner as when imaging the subject.
  • the holding apparatus 2 is moved, and the tomography with the holding apparatus 2 fixed
  • the gantry 1 is moved.
  • the marker 61 attached to the holding device 2 serves as a reference for the fixed position.
  • the rack 6A also has a pair of beam portions 63a, 63b extending in parallel with each other at the upper and lower portions thereof and a plurality of beam portions 64, 64,.
  • the target portion 6B is provided with bay portions 67, 67 opened downward at both ends so that the beam portions 63a, 63b of the rack 6A can be detachably fitted to each other, and the accommodating portion 62 for accommodating the radiation source is provided at the center.
  • a marker 61 attached to the upper center of the substrate.
  • the marker 61 is composed of a substantially rectangular frame 65 and a total of four spheres 66 attached adjacent to each of its four corners. Sphere 66 is similar to sphere 42 of marker 4.
  • the source storage unit 62 stores positron-emitting nuclides such as 18 F when used for PET, Gd contrast media and the like when used for MRI, and ⁇ -ray emitting nuclides when used for SPECT. When used for X-ray CT, it contains metal and functions as a point source.
  • the calibration jig 6 usually has only one target part 6 mm fitted and fixed to the appropriate part of the beam part 63 of the rack 6 mm, but it holds multiple target parts 6 mm on the rack 6 mm. You may use it.
  • the beam portions 63a and 63b are provided with a large number of guide grooves 69, 69,.
  • the target portion 6B can be extended and fixed in a direction perpendicular to the longitudinal direction of the rack 6A.
  • Use of the calibration jig 6 shown in FIG. 2 is advantageous because the target portion 6B can be easily fixed at a position that can be tracked by the optical tracking device 3. It is preferable that all of the calibration jigs of the present invention are made of plastic or carbon so as not to affect the image of the tomography apparatus.
  • the rack 6A is preferably heavy so that it does not move easily when placed on the holding device 2.
  • the markers 4 and 61 are observed by the optical tracking device 3 for the position data of the gantry 1 and the holding device 2 corresponding to the acquired tomographic data. Measure by. As shown in Fig. 3, from this measured position data, the coordinate system C of the gantry represented by the marker 4 attached to the gantry 1
  • the transformation matrix T between the coordinate system C and the scanner coordinate system C can be obtained.
  • one of the coordinate axes (usually referred to as the Z-axis) is a scan of the tomography apparatus.
  • the obtained data is obtained by statistical processing. This statistical process can be easily performed using a computer. Specifically, the gantry coordinate system C and the scan
  • the relationship with the cannadian coordinate system C is obtained as follows. [0037] First, the calibration jig 6 is firmly fixed to the holding device 2, and the tomography apparatus is scanned. During this time, the PET image, MRI image, etc. of the marker 61 of the calibration jig 6 are scanned. At the same time as measuring the position (X, y, z) on the image, the optical tracking device
  • the optical tracking device starts from the coordinate system T of the gantry 1
  • the transformation matrix ⁇ is obtained. Note that the transformation matrix T obtained here is
  • the acquisition of G ⁇ P is a standard for superimposing the tomographic images described below.
  • the tomographic data on the scanner coordinates C is converted using the transformation matrix T.
  • the patient as the subject in this case wears a marker for the optical tracking device.
  • FIG. 4 (A) is obtained by attaching the marker 61 of the calibration jig 6 in FIG. 2 to the frame portion 71.
  • the frame portion 71 can be mounted in the same manner as the glasses frame.
  • Marker 7B in FIG. 4B is one in which three spheres 72 are attached to the front surface of the eyeglass frame, and sphere 72 is the same as sphere 42 of marker 4 shown in FIG.
  • a marker 7C in FIG. 4 (C) is obtained by attaching the marker 61 of the calibration jig 6 in FIG. 2 on a pedestal 73 for placing on the chest.
  • the patient is examined by the PET apparatus having the configuration shown in FIG. Then, the tomographic data is acquired and the corresponding position data (X,
  • ⁇ , ⁇ is obtained using the optical tracking device 3 and the transformation matrix ⁇ .
  • the patient is examined by an MRI apparatus having the configuration shown in FIG. Then, the slice data is acquired and the corresponding position data ( ⁇ ', ⁇
  • the image data obtained by PET inspection is the corresponding position data of the scanner coordinate system C.
  • Fig. 3 the five coordinate systems shown in Fig. 3, namely the coordinate system C of the optical tracking device 3, the coordinate system C of the marker 61 attached to the patient, and the marker attached to the PET gantry 1 are shown.
  • the optical tracking device 3 uses a transformation matrix T between C bindings.
  • the C force obtained during imaging can also be written as the following equation (6) from the conversion matrix T 'to C.
  • the transformation matrix M between can be expressed as the following equation (8).
  • images obtained from different tomographic apparatuses can be accurately superimposed on each other. Similar to the normal image processing method, this superposition can be visualized by calculating using a computer programmed according to the flowchart shown in FIG. 5 and displaying it as an image on a display device. You can also print and display images.
  • the tomographic images to be superimposed may be images obtained with different modalities. Specifically, images obtained with PET, images obtained with SPECT, images obtained with MRI, and Images obtained by X-ray CT may be at least two types of images selected from the group consisting of, for example, tomographic images obtained by PET and tomographic images obtained by MRI or X-ray CT And so on. The same patient with the same modality but also different device capabilities These images can be superimposed on each other for the purpose of comparison.
  • the tomographic images to be superimposed have been subjected to body motion correction by the method described in Non-Patent Documents 1 and 2 above. In this case, the images are superimposed more accurately. Can be.
  • the scan may be performed before the subject is scanned using the tomography apparatus, or may be performed simultaneously with or after the scan of the subject.
  • the tomographic data of the subject and the corresponding position data measured by the optical tracking device 3 using the apparatus having the configuration shown in FIG. 1 are obtained and stored as tomographic data in an appropriate storage device such as a hard disk.
  • the calibration method of the present invention is performed to obtain the transformation matrix T, and the accumulated tomographic data position data is converted into the position data of the scanner coordinate system C.
  • Example 1 (superposition of MRI image and PET image by phantom experiment)
  • SIGNA3T (trade name) manufactured by GE was used as the MRI apparatus
  • E CAT47HR (trade name) manufactured by Siemens was used as the PET apparatus.
  • Both devices are pre-calibrated in the manner described above and their respective transformation matrices T and
  • the G, ⁇ P transformation matrix T was found.
  • the jig shown in Fig. 2 is used as the calibration jig, the same marker as the calibration jig as the marker attached to the gantry, and the POLALIS (registered trademark) system (Northe as the optical tracking device). rn Digital Inc.), and the optical tracking device was connected to a Windows® computer with an RS-232C cable.
  • a tea solution was embedded as an MRI marker in the esophagus of a domestic pig, and the whole body was scanned with an MRI apparatus to obtain tomographic data, and at the same time, position data was obtained with the optical tracking apparatus.
  • 18F-FDG was administered to the same pig in the same pig, and the whole body was scanned with a PET device. At the same time as acquiring tomographic data, position data was acquired with the optical tracking device.
  • Example 2 (Superposition of MRI image and PET image of patient with unstable plaque) MRI image and PET image of patient with unstable plaque in the neck in the same manner as in Example 1 Coronal tomograms were also taken.
  • FIG. 7 The left side of Fig. 7 is an MRI image of the cervix, and the right side of Fig. 7 is an overlay of PET images. As can be seen from the latter image, the unstable plaque region reflecting the accumulation of FDG in the PET image was clearly superimposed on the blood vessel region in the MRI image.
  • the present invention is useful for standardizing a tomographic diagnosis apparatus in order to superimpose images obtained by a tomography apparatus, and thus the standardized apparatus power obtained images are accurately superimposed.
  • it can be used in the fields of medical equipment and diagnostic imaging.
  • FIG. 1 is a schematic diagram showing the configuration of an apparatus used in the method of the present invention.
  • FIG. 2 is a perspective view showing a specific example of a calibration jig of the present invention.
  • FIG. 3 is a top view showing the configuration of the apparatus used in the method of the present invention together with various coordinate axes.
  • FIG. 4 is a schematic view of markers used by a patient in the method of the present invention.
  • FIG. 5 is a flowchart showing an image superposition process according to the present invention.
  • FIG. 6 Pig images obtained in Example 1, upper row is MRI image, middle row is PET image, lower row is an overlay of both, and in each row, left is coronary tomogram, right Is a sagittal cross-sectional view, and the arrows indicate each marker portion.
  • FIG. 7 is an image of a human cervix (coronary tomogram) obtained in Example 2, the left is an MRI image, and the right is an image in which a PET image is superimposed on an MRI image.

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Abstract

L'invention permet de convertir des données de position correspondant à des données de tomogramme acquises à partir d’un dispositif de tomographie en données de position d’un système de coordonnées commun entre différents dispositifs de tomographie et de superposer les données. Un dispositif de poursuite optique (3) est préparé et un marqueur (4) que peut détecter le dispositif de poursuite, est monté sur un portique (1). Un gabarit de calibrage doté d’un marqueur similaire (61) et une source de rayons (62) que peut détecter un détecteur de portique est maintenue par un dispositif de maintien (2). Les données de position sur les deux marqueurs (4, 61) pendant le balayage sont acquises par le dispositif de poursuite pour obtenir une matrice de transformation TG→P permettant de convertir les données de position du système de coordonnées de portique CG en données de position du système de coordonnées de scanner CP du dispositif de tomographie. Les images ayant des données de position du système de coordonnées de scanner CP sont superposées les unes sur les autres.
PCT/JP2006/319264 2005-09-28 2006-09-28 Procédé de calibrage de dispositif de tomographie et procédé de superposition d’image de tomographie WO2007037307A1 (fr)

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