WO2007017911A1 - Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation - Google Patents

Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation Download PDF

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Publication number
WO2007017911A1
WO2007017911A1 PCT/IT2005/000490 IT2005000490W WO2007017911A1 WO 2007017911 A1 WO2007017911 A1 WO 2007017911A1 IT 2005000490 W IT2005000490 W IT 2005000490W WO 2007017911 A1 WO2007017911 A1 WO 2007017911A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
blister
package
active substance
coupling
Prior art date
Application number
PCT/IT2005/000490
Other languages
English (en)
Inventor
Vanni Benedetti
Original Assignee
Vanni Benedetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanni Benedetti filed Critical Vanni Benedetti
Priority to PCT/IT2005/000490 priority Critical patent/WO2007017911A1/fr
Publication of WO2007017911A1 publication Critical patent/WO2007017911A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2821—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a blister, a capsule or like sealed container

Definitions

  • the invention relates to a process for packing and a package for substances which are to be mixed at moment of use.
  • the prior art includes a system for inserting a solvent in one container and to close that container with a capsule, generally made in two parts which are assemblable to one another, which are made of a plastic material by injection moulding or the like, in which capsule there is an active substance which at moment of use is introduced into the container following a laceration of a part of the closing capsule.
  • packages single- or multi-dose, which comprise a container (generally a liquid) on which a capsule is mounted, of various types; in known packages, internally of the capsule there is a reservoir, having a breakable bottom, internally of which there is a cutting element that following a pressure exerted thereon causes the laceration of the breakable bottom.
  • An active substance is contained in the reservoir, generally in powder or granule form, which when the bottom of the reservoir is lacerated drops into the container and dissolves in the liquid contained in the container.
  • the substances contained in the reservoir which are soluble in the liquid contained in the container and are in fact dissolved therein at moment of use, are generally sensitive to humidity, both due to their physical characteristics (they can form undesired lumps) and due to their chemical nature (they may undergo changes in their properties); the susceptibility to chemical change is very often the reason why these preparations are dropped into the solution only a few moments before they are to be used.
  • the materials the reservoirs containing the active substance are made of are, by their very nature, permeable to humidity, even if to a modest degree; this permeability leads to certain consequences of small entity in the thickest parts of the reservoir, as the time needed for humidity to migrate to those zones is very long; however the phenomenon of humidity migration is much more relevant in proximity of the circumferential line of the reservoir along which the cut is made as the thickness of the line is very small and the humidity migration time through the line is considerably less.
  • This phenomenon leads to deterioration, in relatively short times, of the chemical-physical characteristics of the active substance contained in the reservoir, or at least a part of it.
  • a further solution has been to indicate a use-by date on the package, which takes into account the humidity absoiption time, which is normally much shorter than the time limit for true active life of the active substance. This solution too is rather expensive.
  • the main aim of the present invention is to obviate the drawbacks in the prior art, by providing a process for packing and a package, which are easy to apply and use and which afford very long humidity permeability times.
  • An advantage of the present invention is to provide a process and a package which can be realised by simple tried and tested manufacturing methods.
  • a further advantage of the invention is that it provides a process and a package which are more economical with respect to known processes and packages.
  • Figure 1 is a vertical elevation, with some parts in section and others represented only partially, of a first embodiment of the package of the invention
  • Figure 2 is a vertical elevation, with some parts in section and others represented only partially, of a second embodiment of the package of the invention
  • Figure 3 is a vertical elevation, with some parts in section and others represented only partially, of a third embodiment of the package of the invention.
  • Figure 4 is an enlarged-scale representation of a section in vertical elevation of a part of the package of the invention.
  • the packaging process of the invention is used to obtain packages which, in two different environments, contain substances that are to be mixed at point of use; this type of package is especially used to obtain single-dose containers for medicinal substances and the like.
  • a further possible use of the packages is to enable an extempore preparation of drinks, syrups and other products of that kind. These would not be single-dose packages but, once the solution had been made up, the package could be reclosed for further use on separate occasions.
  • a container 1 normally a flagon or a bottle made of glass or plastic, which contains a solvent, normally a liquid, in which an active substance 5 is introduced at moment of use.
  • the active substance is inserted internally of a hermetically-closed blister 4, which is the usual English term for a bubble- like container of the type of the invention.
  • the active substance 5 is packaged in a pastille form; however it could also be a powder or even a gas.
  • the blisters have a breakable wall which following a pressure exerted on an opposite wall thereof breaks and lets the contents of the blister exit.
  • the blister 4 is then coupled to the container 1 in such a way that when the blister is broken open following a simple pressure on the upper surface thereof, the active substance falls internally of the container.
  • This coupling is realised in such a way as to guarantee the seal between the inside of the container and the outside environment.
  • the blister 4 is arranged with its breakable wall 4a facing the mouth 2 , i.e. the inside of the container.
  • the coupling between the container and the blister can be realised either directly, by gluing, using known systems, the blister to the mouth of the container, and by interpositioning, between the container and the blister, a capsule 3, which can be of various shapes, which is connected to the neck of the container and which, according to its shape and the system of coupling used between blister and capsule, can have the function of guaranteeing or not the container hermetic seal, proof of its having been opened before, the possibility of re-closure, and so on.
  • the package for realising the described process comprises: as with known- type packages, a container 1 provided with an open mouth 2, which contains the solvent, and which is closed by a closure element internally of which the active substance 5 is inserted.
  • the closure element comprises a blister 4 of known type, hermetically closed and containing the active substance 5.
  • the blister 4 is made with a lacerable wall 4a which is arranged at the mouth 2 of the container, and with a deformable wall 4b which is solidly constrained to the lacerable wall 4a and which is arranged facing the outside of the container.
  • the lacerable wall 4a of the blister 4 is realised according to a known process, with a multi-layer material containing at least a layer of aluminium and a layer of plastic material; this type of material is practically impermeable to humidity.
  • the deformable wall 4b of the blister is made of a heat-formable material, preferably a polypropylene, a PVC or multi-layer polylaminates, impermeable to humidity and deformable by simple pressure. If the material the container is made of allows it, the lacerable walls 4a of the blister 4 can be heat-welded directly on the neck of the container 1 so as to close it hermetically. This solution, which is an easy step to imagine, is therefore not illustrated in the figures of the drawings. This solution however has the difficulty of accessing the inside of the container once the wall 4a has be lacerated; the drawback could be limited by use of a gripping tab, connected to the lacerable wall, which facilitates the removal of the blister from the neck of the bottle.
  • the closure element can comprise a capsule 3 which is provided with an opening 3a and is connected to the neck of the container 1 in such a way that the opening 3a is arranged at the mouth 2 of the container.
  • the coupling between the capsule 3 and the container is preferably realised by means of a threaded coupling.
  • the capsule 3 constitutes a soil of "second neck" of the container 1, and the opening 3a guarantees accessibility to the inside of the container 1.
  • the coupling between the container 1 and the blister 4 is achieved by coupling the blister 4 to the capsule 3 and coupling the capsule 3 to the container 1.
  • the capsule can be of various types.
  • the capsule of figure 1 includes an annular recess 10 in which the blister 4 can be gripped, and also includes a plurality of annular protuberances 11 which, once the capsule containing the blister 4 has been inserted on the container 1 , guarantee the seal on the package.
  • the capsule of figure 2 comprises a flat annular surface 12 on which the lacerable wall 4a of the blister is heat- welded.
  • a ring 13 is included in the capsule which guarantees the container 1 seal. If it is considered important to protect the blister, the capsule can be fitted with a lid 14, as shown in figure 3. All the capsules illustrated and described herein are further provided with a security strip 15 which evidences a first unthreading of the capsule from the container 1.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un procédé qui inclut l’insertion d’une substance active dans un emballage-coque hermétiquement fermé (4), et l’accouplement de l’emballage-coque (4) à un récipient (1) contenant un solvant. L’accouplement est réalisé de telle manière que, à la rupture de l’emballage-coque (4), la substance active tombe à l’intérieur du récipient (1). L’emballage comprend un récipient (1), comportant une gueule ouverte (2) et contenant un solvant, le récipient (1) étant fermé par un élément de fermeture comprenant l’emballage-coque (4), hermétiquement fermé et contenant la substance active et présentant une paroi déchirable (4a) installée face à la gueule du récipient (1) et présentant également une paroi déformable (4b) installée face à une partie externe du récipient (1).
PCT/IT2005/000490 2005-08-11 2005-08-11 Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation WO2007017911A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IT2005/000490 WO2007017911A1 (fr) 2005-08-11 2005-08-11 Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2005/000490 WO2007017911A1 (fr) 2005-08-11 2005-08-11 Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation

Publications (1)

Publication Number Publication Date
WO2007017911A1 true WO2007017911A1 (fr) 2007-02-15

Family

ID=36018013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000490 WO2007017911A1 (fr) 2005-08-11 2005-08-11 Procédé d’emballage et emballage de substances à mélanger immédiatement avant utilisation

Country Status (1)

Country Link
WO (1) WO2007017911A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140617A1 (fr) * 2010-05-13 2011-11-17 Fernandes Rosangela Madalena De Carvalho Emballage-coque formant couvercle pour verres
WO2012045116A1 (fr) * 2010-10-05 2012-04-12 Kambouris, Gillian Anne Emballage coque pour un récipient
WO2012048922A1 (fr) * 2010-10-13 2012-04-19 Rm Beteiligungs Ag Fermeture en matière plastique dotée d'une capsule pour l'émission de substances actives
EP2899137A1 (fr) * 2014-01-22 2015-07-29 Dong a Precision Co., Ltd. Bouchon pour récipient d'aliments/boissons qui contient des additifs fonctionnels
CN106314998A (zh) * 2015-06-19 2017-01-11 乐通（北京）化学有限公司 混合式饮料容器
CN106395123A (zh) * 2016-09-22 2017-02-15 大兴安岭至臻尚品寒带生物技术有限公司 一种固液分离的饮料瓶盖
US9731852B2 (en) 2009-01-17 2017-08-15 Eric William Gruenwald Water bottle with dosage in a blister pack
US10023370B2 (en) 2014-02-25 2018-07-17 Mühlemann Ip Gmbh Dispensing device having a peripheral outer wall

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211168A (en) * 1967-11-17 1970-11-04 Richardson Merrell Spa Improvements in or relating to closure devices for containers
FR2290366A1 (fr) * 1974-11-08 1976-06-04 Contrapac Flacon pour le conditionnement de deux produits a melanger a l'interieur ulterieurement
US5370222A (en) * 1992-06-11 1994-12-06 Wella Aktiengesellschaft Arrangement for mixing two components
WO1999037553A1 (fr) * 1998-01-21 1999-07-29 Uwe Teuchert Systeme de fermeture pour recipient pour liquide
US6230884B1 (en) * 1997-03-12 2001-05-15 Fredrick Michael Coory Discharge cap with releasable tablet basket
WO2005009862A1 (fr) * 2003-07-30 2005-02-03 Rm Beteiligungs Ag Bouteille en plastique pour boisson pourvue d'une capsule

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211168A (en) * 1967-11-17 1970-11-04 Richardson Merrell Spa Improvements in or relating to closure devices for containers
FR2290366A1 (fr) * 1974-11-08 1976-06-04 Contrapac Flacon pour le conditionnement de deux produits a melanger a l'interieur ulterieurement
US5370222A (en) * 1992-06-11 1994-12-06 Wella Aktiengesellschaft Arrangement for mixing two components
US6230884B1 (en) * 1997-03-12 2001-05-15 Fredrick Michael Coory Discharge cap with releasable tablet basket
WO1999037553A1 (fr) * 1998-01-21 1999-07-29 Uwe Teuchert Systeme de fermeture pour recipient pour liquide
WO2005009862A1 (fr) * 2003-07-30 2005-02-03 Rm Beteiligungs Ag Bouteille en plastique pour boisson pourvue d'une capsule

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9731852B2 (en) 2009-01-17 2017-08-15 Eric William Gruenwald Water bottle with dosage in a blister pack
WO2011140617A1 (fr) * 2010-05-13 2011-11-17 Fernandes Rosangela Madalena De Carvalho Emballage-coque formant couvercle pour verres
WO2012045116A1 (fr) * 2010-10-05 2012-04-12 Kambouris, Gillian Anne Emballage coque pour un récipient
EP2625117A4 (fr) * 2010-10-05 2015-07-29 Kambouris Gillian Anne Emballage coque pour un récipient
WO2012048922A1 (fr) * 2010-10-13 2012-04-19 Rm Beteiligungs Ag Fermeture en matière plastique dotée d'une capsule pour l'émission de substances actives
EP2899137A1 (fr) * 2014-01-22 2015-07-29 Dong a Precision Co., Ltd. Bouchon pour récipient d'aliments/boissons qui contient des additifs fonctionnels
US10023370B2 (en) 2014-02-25 2018-07-17 Mühlemann Ip Gmbh Dispensing device having a peripheral outer wall
CN106314998A (zh) * 2015-06-19 2017-01-11 乐通（北京）化学有限公司 混合式饮料容器
CN106395123A (zh) * 2016-09-22 2017-02-15 大兴安岭至臻尚品寒带生物技术有限公司 一种固液分离的饮料瓶盖

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