WO2007004000A1 - Tente solaire avec moyen de liberation de principe actif - Google Patents

Tente solaire avec moyen de liberation de principe actif Download PDF

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Publication number
WO2007004000A1
WO2007004000A1 PCT/IB2006/001717 IB2006001717W WO2007004000A1 WO 2007004000 A1 WO2007004000 A1 WO 2007004000A1 IB 2006001717 W IB2006001717 W IB 2006001717W WO 2007004000 A1 WO2007004000 A1 WO 2007004000A1
Authority
WO
WIPO (PCT)
Prior art keywords
conductive threads
active principle
pair
control circuit
conductive
Prior art date
Application number
PCT/IB2006/001717
Other languages
English (en)
Inventor
Paolo Cappellari
Original Assignee
Paolo Cappellari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITLC20050012 external-priority patent/ITLC20050012A1/it
Priority claimed from ITLC20060004 external-priority patent/ITLC20060004A1/it
Application filed by Paolo Cappellari filed Critical Paolo Cappellari
Publication of WO2007004000A1 publication Critical patent/WO2007004000A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/042—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating with the help of a macromolecular compound as a carrier or diluent
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M1/00—Stationary means for catching or killing insects
    • A01M1/20—Poisoning, narcotising, or burning insects
    • A01M1/2022—Poisoning or narcotising insects by vaporising an insecticide
    • A01M1/2061—Poisoning or narcotising insects by vaporising an insecticide using a heat source
    • A01M1/2077—Poisoning or narcotising insects by vaporising an insecticide using a heat source using an electrical resistance as heat source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12—Apparatus, e.g. holders, therefor
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
    • E04H15/00—Tents or canopies, in general
    • E04H15/32—Parts, components, construction details, accessories, interior equipment, specially adapted for tents, e.g. guy-line equipment, skirts, thresholds
    • E04H15/54—Covers of tents or canopies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Definitions

  • the present invention relates to a sun tent, in particular a sun tent with
  • Controlled release drugs have been available for many years, these being administered orally as simple capsules or pills, but being then released into the body at subsequent precise times. The result is that the action of the active principle can be controlled in a much more refined manner by timing it to patient requirements.
  • the next medicinal products to be administered in this manner will probably be vaccines, but also certain antitumorals or, more simply, local anesthetics for use against postherpetic neuritis or in children prior to injection; however, it will never be possible to administer very large molecules such as insulin in this manner.
  • Chemical absorption intensifiers are known. These are substances which increase skin permeability when added to the patch. Many molecules have been tested for this purpose but are often damaging to the skin,
  • lonophoresis is known. Already in use for physiotherapy or for carrying drugs such as lidocain or phentanyl in back therapy, ionophoresis is a method considered safe. It consists of applying two electrodes to the patient's skin, then by passing current the drug is made to flow from one to the other and forced to enter the body, lonophoresis is fairly widespread for outpatient treatment. But before habitual and domiciliary use, more manageable and portable equipment must be awaited in the not too distant future. Sonophoresis and electrostimulation are also known. In the first case ultrasound is used; in the second case intense but short-duration currents are used which form microperforations on the skin surface such as to enable the drug to pass. Both have been studied so far only at the experimental level: in this respect, sonophoresis requires very large machines and is difficultly implementable in practice; for electrostimulation there are insufficient safety guarantees for use over long periods.
  • An object of the present invention is to provide a sun tent which is more comfortable to remain under or near.
  • Figure 1 shows schematically a sun tent of the present invention
  • FIG. 2 shows schematically a patch in accordance with the present invention.
  • an embodiment of a sun tent of the present invention comprises a fabric 10 having in its interior at least one pair of conductive threads each comprising a first conductive thread 11 and a second conductive thread 12.
  • a first connection system 13 connects all the first conductive threads 11 together.
  • a second connection system 14 connects all the second conductive threads 12 together.
  • the tent comprises an electrical/electronic control circuit connected to the two connection systems 13 and 14. It also comprises a power unit 16 which powers the control circuit 15 and consequently the pairs of conductive threads 11 and 12.
  • the tent comprises one or more patches 17 on which an active principle
  • the active principle 18 is located substantially on the entire surface of the patch 17.
  • the patches are adhesive and are positioned straddling at least one pair of conductive threads 11 and 12.
  • the patches straddle several pairs of conductive threads 11 and 12, in order to involve most of the active principle 18.
  • the patches are for example of circular shape with a size of about 40-50
  • connection systems 13 and 14 are connected to a control circuit
  • the control circuit 15 supplies the voltage of the power unit 16 to the two connection systems 13 and 14 in a controlled manner by manual or
  • it may supply voltage at a predetermined time for a predetermined period, or automatically at sunset and/or for predetermined
  • the voltage supplied can also be varied to vary the intensity of the active principle.
  • It comprises two lateral conductive strips 22 which are positioned over a pair of conductive threads each consisting of a first conductive thread 11 and a second conductive thread 12.
  • band 23 there is a region 24 in which an active principle is deposited, carried for example by liposomes.
  • One strip 22 is connected by a conductive thread 25 to the band 23.
  • the other strip 22 is connected by a conductive thread 26 to the region 24.
  • a conductive thread 27 connects the band 23 to the region 24, preferably by a nearly complete turn about the region 24.
  • the electronic component acts within the system by adapting by varying its component characteristics, to feed an electrical signal to the conductive textile support at the required moment, for the purpose of dissociating the electrical charges on the intermediate, these being momentarily ordered and aligned in mutual equilibrium; they then again seek equilibrium by
  • the two paper supports are connected together by a salt bridge composed of copper wires twisted together.
  • the intermediate used is a hydrophobic gel, with a water-soluble dye (specifically blue) retained in its interior as active principle.
  • the gel (about 5g) applied to one of the two moistened paper surfaces is hydrophobic and remains unchanged with its structure stable with time, With the battery connected the initial equilibrium conditions change, and within a relatively short time (about 10-15 minutes) a light blue halo forms about the gel, indicating the diffusion of the water-soluble dye into the water-wetted paper.
  • These latter can consist of an adhesive or biadhesive outer component, a conductive surface on which one or more intermediates with active principles in their interior are positioned and which is connected by a salt bridge to another conductive surface perimetral to the preceding;
  • conductive surfaces are connected separately to internal or external current generators, necessary for the system.
  • Liposomes pertain precisely to this category, they being in the form of vesicles consisting of a phospholipid membrane.
  • Many anti-cancer drugs are currently presented linked to liposomes, as are many antibacterial, antiviral and anti-inflammatory drugs or vaccines (such as anti-influenza vaccines).
  • a formulation in liposomes is mostly reserved for those substances which are most active, in order to limit the quantity of material which has to be given to achieve the drug therapeutic concentration necessary in vivo to be effective.
  • One of the advantages of liposomes is that they are able to function as
  • a sector of great interest is that concerning the manipulation of liposomes to modify the intensity and rate of release of the drug from the liposome when this reaches the target to which it is aimed and against which it has to perform its action.
  • Various biotechnology companies currently operate exclusively with liposomes in developing various treatments: antibiotic, antitumoral, allergic sensitization, general therapy, etc.
  • liposomes relate to their membrane (consisting of cholesterol and phospholipids), the structure, composition and proportions
  • the phospholipids have a hydrophobic tail and a hydrophilic head: the hydrophobic tails attract each other, while the hydrophilic heads arrange themselves in contact with the outside and with the internal aqueous environment (the arrangement is similar to that of micelles).
  • the characteristics of liposomes can be modified according to the different drugs carried. For example, the liposome degradation rate can be decreased and the release of its contents be decelerated by modifying its composition and dimensions.
  • the affinity of the liposomes for a determined fabric can be increased by modifying their composition, the
  • PEG polyethyleneglycol
  • Liposomes are small vesicles of 50-500 nm diameter surrounded by one or more membranes with a double layer of phospholipids. Material in the liquid phase is contained inside.
  • NiosomesTM a registered acronym for non-ionic liposomes
  • niosomesTM or nanocapsulesTM have dimensions less than 200 nanometres, equivalent to the intercellular space within the corneal layer.
  • non-ionic liposomes are much more stable than the amphoteric phospholipids; moreover their structure, similar to that of epidermic ceramics, cements the corneal lamellas and reduces epidermic dehydration. Finally, being non-ionic, niosomes are less toxic than the vesicles produced with ionic surfactants.
  • Liposomes can be classified on the basis of their different main characteristics: their dimensions, their lamellarity (number of double lipid layers of which the liposome is composed) and the preparation method used. These parameters involve significant characteristics, such as: stability, pharmacokinetics, bioavailability. These characteristics can considerably influence whether the liposomes can be used.
  • the cosmetics industry was the first to widely use liposomes. A considerable number of commercial cosmetics contain liposomes, their applications ranging from skin treating products (creams, lotions, sun cream, foundation cream) to decorative cosmetics.
  • liposomes are generally completely biocompatible, without causing undesired toxic or allergic effects.
  • Liposomes are able to incorporate and carry both hydrophilic and lyophilic substances. The substances carried are protected from the action of enzymes or of denaturing environments (Ph). In this manner very labile substances such as nucleic acids, peptics and proteins can be used; liposomes are able to reduce the toxicity of toxic agents or irritants.
  • the R.STAT company for example produces the most complete range of fibres and conductive threads. It produces for example a copper sulphide thread wrapping a polyamide, or a copper sulphide thread wrapping a high tenacity polyester.
  • the fibres obtained are multi-functional. They act as antistatics and at the same time as antibacterials.
  • the polyamide fibres consist of polyamide 6.6 wrapped by a copper sulphide film of 0.2 ⁇ thickness.
  • the chemical process by which the copper sulphide binds intimately to the polyamide ensures optimal resistance to wear and to chemical treatment. It provides excellent electrical conductivity (105 ohm/cm), permanent conductivity and excellent textile characteristics.
  • the fibres were subjected to numerous tests enhancing the actual utilization conditions. The fibres maintain their original conductivity after many years under normal humidity and temperature conditions. Light does not modify their characteristics.
  • polyester fibres consist of high tenacity polyester wrapped with a copper sulphide film of 0.2 ⁇ thickness.
  • the copper sulphide binds intimately to the polyamide ensures optimal resistance to wear and to chemical treatment.
  • the fibres were developed particularly for gas filtration. They particularly resist long term exposure to high temperature (150°C) and also to acid hydrolysis. Light does not modify their properties. They are also not modified by physical treatment (rubbing, elongation) or chemical treatment (dyeing, dry cleaning).
  • the electronic part acts within the system by adapting by varying its component characteristics, to feed to the conductive support a charge opposite that of the intermediate, for a chemical equilibrium situation, or in contrast by feeding a simple equal on/off charge to disintegrate and consequently release the active principles retained until that moment.
  • a possible application of the aforedescribed could be a new production method for sun tents, or for blinds in general, with the ability to release active principles, preferably insect repellents, in an organized manner for just a few months of the year and only at previously programmed times during the day.
  • active principles preferably insect repellents
  • Other types of active principle such as perfume, etc., can also be released.
  • the tent could also comprise several pairs of conductive threads separately controlled to release different active principles. Techno-commercial requirements must be evaluated in determining the necessary priorities in distributing the final product.
  • the tent must technically reflect normal quality requirements, i.e. the same length of life, dyeing permanence and finishing, with minimum alteration in feel, low production costs, etc. It must immediately be seen to differ from normal commercially available competitive products, and is in no way related to arrangements with active principles deposited by a spray system on the fabric surface.
  • the active principles must not be influenced by the normal opening and closure operations by rolling, and must not suffer losses in active concentration caused by variable climatic conditions such as rain and wind.
  • the system enables the problem to be viewed in another light. Hence even with mosquitoes present, it provides a preferred place to be, rather than in another unprotected place.
  • a tranquillity situation means that the adrenalin which acts as a target for mosquitoes is not produced. Able to remain in a tranquil condition means that a client is most likely to return to the same place.
  • the invention consequently improves the commercial aspect in general.
  • liposomes are to be used, they should be produced from ingredients chosen for greatest resistance to hydrolysis, and specifically from stearylamine to obtain an accentuated positive electrical charge.
  • a known active principle easily analysable by normal spectrophotometry systems, is incorporated in their interior. At this point, a dispersion of positive liposomes is prepared in water in a transparent container and the electrical potential of the mass involved is measured. By connecting a power system of variable potential to an electrode immersed in the dispersion, a stability situation can be verified with the passage of an opposite electrical potential, i.e. with a negative charge; or a turbidity with a positive charge potential. This turbidity of the dispersion indicates the disintegration of the positive liposomes which are "repelled/disintegrated". A subsequent analysis of the active principle residue indicates variations in released concentration as a function of the charge fed and the potential intensity.
  • Finished product production systems use feed systems and intermediates with different specific characteristics useful for various sectors.
  • the ability to combine a diagnostic system with an interactive intervention system for the automatically or remotely programmable release of active principles is of considerable interest for the development of new technologies which in particular sectors represent the core business of research and innovation.
  • An interactive system can be applied to the medical sector, usable for
  • coagulant drugs In the aerospace sector, under gravity-absent operative conditions. In the sports sector, with active principles aimed at a fatigue state, etc.
  • In the textile sector for the production of different conductive supports for: production of conductive sun tents, conductive patches for transdermal use, for medical and cosmetic use, etc.
  • In the industrial sector for example for producing a new generation of active principle diffusers of various types or, again in the industrial sector, the facility to make use of the described characteristics of the system according to the present patent, but used for a contrary purpose.
  • the system enables active principles to be retained and released and can also capture and retain other substances by utilizing its capacity in an opposite direction: consider the case of a filter to be constructed positioned on the inner surface of a tube through which a chemical element dangerous to human health passes, but is so small as not to be retained by currently available normal filters. This case can be represented by the famous MP. 10s; these latter are ionised particles with
  • sensors indicate the passage of the M. P. 10s which activate an opposite electrical potential able to capture them during their passage.
  • the "cartridges" are saturated with MP. 10s they can be

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Architecture (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Insects & Arthropods (AREA)
  • Structural Engineering (AREA)
  • Civil Engineering (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne une tente solaire se caractérisant en ce qu'elle comprend : un tissu contenant à l'intérieur au moins une paire de fils conducteurs ; des moyens destinés à retenir et à libérer un principe actif, lesdits moyens étant appliqués en contact avec ladite paire de fils conducteurs ; un circuit de commande de ladite paire de fils conducteurs ; et une source d'alimentation pour ledit circuit de commande.
PCT/IB2006/001717 2005-07-05 2006-06-23 Tente solaire avec moyen de liberation de principe actif WO2007004000A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITLC20050012 ITLC20050012A1 (it) 2005-07-05 2005-07-05 Oggetto del seguente brevetto e' la descrizione applicativa di un sistema sinergico comprendente tecnologie elettroniche e chimiche.
ITLC2005A000012 2005-07-05
ITLC2006A000004 2006-02-22
ITLC20060004 ITLC20060004A1 (it) 2006-02-22 2006-02-22 Descrizione dell'invenzione e' un sistema applicato ad una struttura tessile conduttiva, capace di trattenere principi attivi di vario tipo complessati in intermedi in grado di rilasciare gli stessi per mezzo di segnali elettrici inviati in tempi org

Publications (1)

Publication Number Publication Date
WO2007004000A1 true WO2007004000A1 (fr) 2007-01-11

Family

ID=36954556

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/001717 WO2007004000A1 (fr) 2005-07-05 2006-06-23 Tente solaire avec moyen de liberation de principe actif

Country Status (1)

Country Link
WO (1) WO2007004000A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11011045B1 (en) 2019-11-01 2021-05-18 Honda Motor Co., Ltd. Object detection and alert for autonomous ride-sharing vehicle
US11358078B2 (en) 2019-11-01 2022-06-14 Honda Motor Co., Ltd. Conductive thread for vehicle maintenance
US11458816B2 (en) 2019-11-01 2022-10-04 Honda Motor Co., Ltd. Self cleaning of ride sharing vehicle

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4037352A (en) * 1975-09-05 1977-07-26 Airwick Industries, Inc. Electrical device which emits insecticidal vapors
US4100920A (en) * 1975-09-02 1978-07-18 Le Goaster Jacqueline Marie Ge Method and apparatus for transferring microorganisms through the skin barrier
FR2678811A1 (fr) * 1991-07-08 1993-01-15 Perrier Noel Parasol solaire multi-fonctions.
EP0605939A1 (fr) * 1991-04-01 1994-07-13 Graniteville Company Toile de tente repoussant les insectes
EP0909568A2 (fr) * 1997-09-29 1999-04-21 Becton, Dickinson and Company Méthodes d'implémentation de profils de courant d'administration utilisés dans un système d'ionophorèse

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100920A (en) * 1975-09-02 1978-07-18 Le Goaster Jacqueline Marie Ge Method and apparatus for transferring microorganisms through the skin barrier
US4037352A (en) * 1975-09-05 1977-07-26 Airwick Industries, Inc. Electrical device which emits insecticidal vapors
EP0605939A1 (fr) * 1991-04-01 1994-07-13 Graniteville Company Toile de tente repoussant les insectes
FR2678811A1 (fr) * 1991-07-08 1993-01-15 Perrier Noel Parasol solaire multi-fonctions.
EP0909568A2 (fr) * 1997-09-29 1999-04-21 Becton, Dickinson and Company Méthodes d'implémentation de profils de courant d'administration utilisés dans un système d'ionophorèse

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11011045B1 (en) 2019-11-01 2021-05-18 Honda Motor Co., Ltd. Object detection and alert for autonomous ride-sharing vehicle
US11358078B2 (en) 2019-11-01 2022-06-14 Honda Motor Co., Ltd. Conductive thread for vehicle maintenance
US11458816B2 (en) 2019-11-01 2022-10-04 Honda Motor Co., Ltd. Self cleaning of ride sharing vehicle

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