WO2006123784A1 - Composition antibactérienne et matière antibactérienne - Google Patents

Composition antibactérienne et matière antibactérienne Download PDF

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Publication number
WO2006123784A1
WO2006123784A1 PCT/JP2006/310048 JP2006310048W WO2006123784A1 WO 2006123784 A1 WO2006123784 A1 WO 2006123784A1 JP 2006310048 W JP2006310048 W JP 2006310048W WO 2006123784 A1 WO2006123784 A1 WO 2006123784A1
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WIPO (PCT)
Prior art keywords
iodine
sheet
substrate
compound
antibacterial
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Application number
PCT/JP2006/310048
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English (en)
Japanese (ja)
Inventor
Hirokazu Shiga
Nobuhiro Taguchi
Akio Maeda
Original Assignee
Nippoh Chemicals Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippoh Chemicals Co., Ltd. filed Critical Nippoh Chemicals Co., Ltd.
Priority to CN2006800171526A priority Critical patent/CN101175405B/zh
Priority to JP2007516353A priority patent/JPWO2006123784A1/ja
Publication of WO2006123784A1 publication Critical patent/WO2006123784A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/12—Iodine, e.g. iodophors; Compounds thereof

Definitions

  • the present invention relates to an antibacterial composition and an antibacterial material. Specifically, the present invention relates to an antibacterial composition and an antibacterial material containing iodine.
  • Microbes such as various bacteria and molds exist in our living space. These organisms can cause us to feel uncomfortable, causing food rot and odors. In addition, the human body causes various diseases such as food poisoning. In order to live a hygienic life, it is important to suppress the growth of these microorganisms or to remove these microorganisms.
  • iodine tends to sublime even at room temperature. For this reason, if iodine is used alone for applications such as antibacterial and deodorizing, there is a problem that sufficient effects cannot be obtained by sublimation of iodine.
  • PVP polyvinylpyrrolidone
  • ovidone iodine
  • JP-A-5-88625 discloses an iodine-cyclodextrin inclusion complex (hereinafter also referred to as “CDI”) in which an iodine atom is included in a cyclodextrin !
  • CDI iodine-cyclodextrin inclusion complex
  • 2001-89974 discloses a fiber base material in which povidone is held on a fiber surface together with a predetermined polymer.
  • Japanese Patent Application Laid-Open No. 51-100892 discloses a sterilized and antiseptic packaging paper provided with a ⁇ -cyclodextrin inclusion product of iodine.
  • JP-A-63-225308 and JP-A-2-110 disclose a powder having a property of foaming by reacting with an iodine carrier, an iodide, an oxidizing agent, a powdered acid and, if necessary, a powdered acid.
  • a solid odor hall composition (formulation) containing a base is disclosed. According to these techniques, a solid squeeze hole composition (formulation) that is easy to manufacture and stable can be provided.
  • an antibacterial material for example, a sheet-like antibacterial material
  • a certain amount of iodine is sublimated from the base material surface and held on the base material. Reduced iodine concentration.
  • the antibacterial action also decreased over time, and as a result, the antibacterial action sometimes disappeared.
  • the substrate surface force can also sublimate iodine because the sterilization and antiseptic mechanism of the wrapping paper described in Reference 6 is based on sublimated iodine (I) released into the package space.
  • iodine is triiodide ion (I-) or pentaiodine.
  • the strong iodide ion ( ⁇ ) is once again transferred to the Eodohole carrier (for example, poly
  • the Eodohole carrier for example, poly
  • the antibacterial activity disappears after almost a certain time.
  • the antibacterial material exhibits an iodine color, and there is a problem in appearance when applied to a product labeled “antibacterial”.
  • there is a repulsive force S in which iodine color adheres to the object to be processed or corrosion of the object to be processed occurs.
  • an object of the present invention is to provide a means that enables effective use of iodine in an antibacterial material using iodine.
  • the present inventors have conducted intensive research to solve the above problems. In the process, if an excessive amount of an iodine-based oxidant such as iodate is present in an iodine-based compound such as an iodide salt, iodine is produced after exhibiting antibacterial properties.
  • an oxidizing agent other than an iodine-based oxidizing agent is used in the antibacterial composition or antibacterial material of the present invention, a small amount of coexisting iodine-based compounds are instantly oxidized and the reaction is terminated. After I— and I— are consumed over time, Since the regeneration is not performed, the antibacterial composition and the antibacterial material are exhausted, and the effects of the present invention cannot be obtained. Further, in all of the examples described in the above documents, the content of iodine-based oxidant is less than the content of S-iodine compound (iodide). Can hardly be expected.
  • an iodine compound (A), an iodine oxidant (B), and an acid compound (C), the iodine compound (A ) And the iodine-based oxidizing agent (B) in a mass ratio of (B) / (A) 1 to: LOOO.
  • the solid substrate is preferably a sheet-like substrate or a granular substrate.
  • the above antibacterial composition and antibacterial material can be used as an antibacterial agent for rugs, dipping, filters, wiping, spraying, or filling.
  • FIG. 1 is a cross-sectional view showing a preferred embodiment of an antibacterial material of a second embodiment.
  • FIG. 2 is a cross-sectional view showing a preferred position embodiment of the antibacterial material of the second embodiment, which is a laminated sheet-like antibacterial material.
  • FIG. 3 is a view showing a state of manufacturing a laminated sheet-like antibacterial material of a second embodiment.
  • the iodine compound (A), the iodine oxidant (B), and the oxide compound (C) are contained, and the iodine compound (A) and the iodine oxidant are included.
  • antibacterial is a concept that means that the growth of microorganisms is suppressed by iodine. This concept includes a bactericidal action in which microorganisms are killed by iodine and a slight effect by iodine.
  • Microorganisms whose growth is suppressed by the antibacterial composition of this embodiment and the antibacterial material described below are not particularly limited, and include viruses and fungi in addition to bacteria.
  • the antibacterial composition of the present embodiment first contains an iodine compound (A).
  • the “iodine-based compound” means a compound that can generate iodide ions ( ⁇ ) upon contact with moisture, an organic solvent, or in some cases, air. In this way, it is oxidized to I- and I- by the action of iodine-based oxidant 14 described in detail later, and exhibits antibacterial action.
  • iodine-based compound means a compound that can generate iodide ions ( ⁇ ) upon contact with moisture, an organic solvent, or in some cases, air. In this way, it is oxidized to I- and I- by the action of iodine-based oxidant 14 described in detail later, and exhibits antibacterial action.
  • the compound contained in the boron-based oxidant (B) is not included in the concept of the iodine-based compound (A).
  • the specific type of the iodine-based compound (A) is not particularly limited as long as it is a compound exhibiting the above-described action.
  • examples include iodide salts such as potassium iodide (KI) and sodium iodide (Nal).
  • KI potassium iodide
  • Na sodium iodide
  • I iodine molecules alone
  • disulfide compound (A) it may be used as a disulfide compound (A).
  • iodine compounds (A) may be used alone or two or more of them may be used in combination.
  • the antibacterial composition of this embodiment contains an iodine-based oxidizing agent (B).
  • the “iodine-based oxidant” means an activity capable of oxidizing ⁇ generated from the above iodine-based compound (A) to I— or I—.
  • ⁇ _ hypoiodite ion
  • IO- iodate ion
  • IO- periodate ion
  • the amount of I— and I— is kept at a low concentration throughout.
  • the iodine-based oxidizing agent (B) not only functions as a source of the active species but also contains iodine through the reactions of the above reaction formulas (1) to (3). It also functions as a supply source. Therefore, according to the present invention, by employing a compound containing iodine as an oxidant for oxidizing iodide ions to form a silicon molecule, the effect of the present invention for effective use of iodine is further improved. It can be further demonstrated. As described above, these effects cannot be obtained when an oxidizing agent other than iodine-based oxidizing agents is used.
  • the specific type of the iodine-based oxidizing agent (B) is not particularly limited as long as it is a compound that can generate the active species by contact with moisture.
  • examples include iodic acids such as hypoiodous acid (HIO), iodic acid (HIO), paraperiodic acid (HIO), periodic acid (HIO),
  • Iodine salts such as 3 and iodic acid (I 0), iodine trioxide (I O), iodine pentoxide (I o),
  • Iodic acid compounds such as silicon (I ⁇ ) and iodine tetroxide (IO). These iodine
  • elemental oxidant (B) only one kind may be used alone, or two or more kinds may be used in combination.
  • the antibacterial composition of the present embodiment thirdly contains an acid compound (C).
  • acid compound means contact with moisture. It means a compound that can make the water more acidic.
  • salts of strong acids and weak bases can be mentioned.
  • the acid compound includes citrate monohydrate, succinic acid, malic acid, oxalic acid, tartaric acid and the like. Derivatives such as these hydrates may be used.
  • the oxides include salts of strong and weak bases such as ammonium chloride, ammonium sulfate, and ammonium iodide, as well as acid salts such as sodium hydrogen sulfate and phosphorus.
  • Potassium dihydrogen acid, basic salts such as salt, sodium hydroxide, and magnesium can be used.
  • acid compounds (C) only 1 type may be used independently and 2 or more types may be used together.
  • each component contained in the antibacterial composition of the present embodiment has been described above, but the content of each component in the antibacterial composition is not particularly limited, and the above chemical reaction formula ( It can be adjusted as appropriate by considering the stoichiometric ratio, production method, presence or absence of additives in (1) to (3).
  • the content of each component contained in the antibacterial composition is not particularly limited as long as the above-mentioned regulations are satisfied.
  • the content of the iodine compound (A) is preferably 0 with respect to the total amount of the composition as long as the iodine produced by oxidation is sufficient to exhibit an antibacterial action.
  • the content of the iodine-based acid additive (B) is controlled so that the mass ratio with the iodine-based compound (A) is a value within the above range.
  • the content of the iodine-based oxidant (B) is preferably 1 to 95% by mass, more preferably 5 to 90% by mass, and further preferably 10 to 80% with respect to the total amount of the composition. % By mass.
  • the content of the acid compound (C) is preferably 1 to 95% by mass, more preferably 5 to 90% by mass, and further preferably 10 to 80% by mass with respect to the total amount of the composition. It is.
  • the initial amount and regeneration amount of iodine i.e., the amount of iodine concentration maintained
  • the amount of the iodine concentration maintained becomes too large, improving the corrosivity and color tone, and reducing the concentration at low concentrations.
  • the effects of the present invention, such as stabilization of iodine may not be sufficiently exhibited.
  • the content of the iodine-based oxidant (B) is too large, the amount of the acid compound (C) necessary to consume all the iodine-based oxidant (B) will increase, and antibacterial activity will occur. There is a possibility that the acidity of the sexual composition may increase excessively. If various additives described later are added, the contents of (A) to (C), which are essential components in the antibacterial composition, may be out of the above-mentioned range. However, it can be included in the technical scope of the present invention.
  • JP-A-2000-507217, JP-A-59-202248, JP-A-56-99419, JP-A-53-148540, etc. also disclose iodine-based compounds and iodine-based compounds. Disinfectant compositions comprising an oxidizing agent and an acid compound are disclosed. However, in the techniques described in these documents, iodine-based oxidizers are added for the purpose of stabilizing separately added iodine and iodine holes. In combination with a silicon-based oxidant, I
  • the antibacterial composition of the present embodiment may further contain other additives as required! There are no particular restrictions on specific forms of other additives, and conventionally known findings can be referred to as appropriate.
  • Preferable additives include, for example, compounds that can form a complex with iodine.
  • the compound that can form a complex with iodine include cyclodextrin (CD), polyvinylpyrrolidone (PVP), glycine, and the like. Add these compounds As a result, the sublimation and corrosion properties of iodine are alleviated. Of these, cyclodextrin is preferably included.
  • the cyclodextrin additive provides a deodorizing effect by including various compounds in the pollutant in its own cyclic structure.
  • “Cyclodextrin” is a compound in which D-glucose is bound cyclically by ⁇ -1,4 bonds. Cyclodextrins are broadly classified into 6 cyclodextrin (6), ⁇ -cyclodextrin (7), and ⁇ -cyclodextrin (8) according to the number of D-glucose that constitutes it. Any of these may be used in the antibacterial composition of this embodiment.
  • cyclodextrin is not particularly limited, and a conventionally known form can be appropriately employed. Of course, not only the above three cyclodextrins but also derivatives thereof may be used. Examples of cyclodextrin derivatives include alkylated (methylated, ethylated, propylated, isopropylated, butylated, etc.), monoacetylated, triacetylated, monochlorotriazinylated. Specific examples of cyclodextrin include those commercially available as CAVAMAX (registered trademark) series and CAVASOL (registered trademark) series (both manufactured by Sakka).
  • cyclodextrins such as a maltosyl group-substituted cyclodextrin commercially available as Dextrin Pearl or Isoelite (manufactured by Yokohama International Bio-Laboratory Co., Ltd.) may be used. Of these cyclodextrins, only one kind may be used alone, or two or more kinds may be used in combination.
  • the cyclodextrin contained in the antibacterial composition can exert a deodorizing action by including various compounds in the contaminants in its cyclic structure.
  • cyclodextrin is produced by the above mechanism I- or I-
  • iodine-cyclodextrin inclusion compound which is a kind of iodine hole. Therefore, when I— or I— decomposes, it becomes I and sublimates.
  • the antibacterial durability will be improved when the antibacterial composition is used.
  • the cyclodextrin mono-iodine inclusion complex in which part or all of the cyclodextrin is initially included in the inclusion of iodine is also included. Also good.
  • the antimicrobial composition of this form can form a complex with iodine.
  • the content of the compound that can form a complex with the iodine is not particularly limited, but is preferably 0 to 90% by mass, more preferably 0 to 80%, based on the total amount of the composition. % By mass, more preferably 0 to 70% by mass.
  • the antibacterial composition of the present embodiment may contain a known antibiotic or synthetic antibacterial if necessary.
  • known antibiotics include, for example, penicillins, cefems, strong rubapenems, monobatams, etc. —lactam antibiotics; aminoglycoside antibiotics; macrolide antibiotics; tetracycline antibiotics Chloramphenicol; lincomycin; fosfomycin; peptide antibiotics; and antifungal antibiotics.
  • Examples of synthetic antibacterial agents include naliditasic acid, new quinolone antibacterial agents, and azole antifungal agents.
  • the various compounds used as an external preparation and a disinfectant can be added as an additive. In some cases, an antiviral agent may be added.
  • only one kind may be used alone, or two or more kinds may be used in combination.
  • the antibacterial composition of the present embodiment may be a powdery composition obtained by mixing the above-described essential components (i) to (C) and an additive as necessary.
  • An aqueous solution-like composition further containing According to the form of the aqueous solution, there are advantages that handling and storage are easy and that the applicable range is widened because it can be used by spraying or spraying.
  • the amount of water added is not particularly limited, but is preferably 1 to 2000 times by mass, more preferably 2 to 1000 times the total amount of components other than water. It is mass times, More preferably, it is 20-500 mass times. However, it is needless to say that a form outside these ranges may be adopted.
  • the production method of the antibacterial composition of the present embodiment is not particularly limited, and conventionally known knowledge relating to the production of a powdery composition or an aqueous solution composition can be appropriately referred to.
  • a powdery composition prepares the components of the composition, and then granulate or pulverize each prepared component to the desired particle size and mix homogeneously with a mixer! ⁇ method.
  • granulation and pulverization may be performed simultaneously with mixing.
  • an aqueous composition is produced !, in the case where a predetermined amount of components of the composition is weighed, added to water, and dissolved by stirring.
  • other methods may be used.
  • a granular antibacterial material in which a granular substrate as described below is used as a solid substrate is also included in the technical scope of the present invention.
  • FIG. 1 is a cross-sectional view showing one preferred embodiment of the antibacterial material of the present embodiment.
  • the antibacterial material in the form shown in FIG. That is, the sheet-like substrate 12 is used as the solid substrate.
  • an iodine-based compound (A) 14, an iodine-based oxidant (B) 16, and an oxidized compound (C) 18 are held inside a sheet-like base material 12. It has the composition which becomes.
  • each component is held only inside the sheet-like base material 12, but is not limited to such a form.
  • each of the above components is held only on the surface of the sheet-like base material 12 or a form in which both of the components are held on the inside and the surface of the sheet-like base material 12 can also be adopted. Further, when each component is held on the surface of the sheet-like substrate 12, it may be held only on one side of the sheet-like substrate 12, or may be held on both sides of the sheet-like substrate 12. ,.
  • the sheet-like antibacterial material 10 having the form shown in FIG. 1 includes a sheet-like substrate 12 as a solid substrate.
  • the specific form of the sheet-like substrate 12 is not particularly limited.
  • Examples of the constituent material of the sheet-like substrate 12 used for the sheet-like antibacterial material 10 of this embodiment include paper, woven fabric, and non-woven fabric.
  • paper Japanese paper, filter paper, drawing paper, high-quality paper, cardboard paper, cardboard Recycled paper, synthetic paper, white paperboard, yellow paperboard, chipball, colored paperboard, building material base paper, backing paper, thin paper, thermal paper, synthetic fiber paper, etc. are included.
  • Either organic fiber or inorganic fiber may be used as a raw material for the woven fabric and the nonwoven fabric.
  • the organic fibers include plant fibers, animal fibers, regenerated fibers, semi-synthetic fibers, synthetic fibers, and the like.
  • inorganic fibers include glass fibers, carbon fibers, ceramic fibers, and the like.
  • Sarayoko and plant fibers include wood pulp, straw pulp, bamboo pulp, kenaf pulp, and other woods, herbs, cotton, hemp, etc.
  • Animal fibers include silk, wool, etc. Fiber.
  • Examples of recycled fibers include rayon and cuvula.
  • Examples of semi-synthetic fibers include acetate, triacetate, and promix.
  • synthetic fibers include nylon, acrylic, vinylon, vinylidene, polyvinyl chloride, polyester, polyethylene, and polypropylene. , Benzoate, polyclar
  • the sheet-like base material 12 a commercially available one may be used, or a self-synthesized one may be used.
  • the size and shape of the sheet-like substrate 12 can also be appropriately determined according to the use of the sheet-like antibacterial material, which is not particularly limited.
  • the content of each component is controlled so that the content of the iodine-based oxidizing agent (B) is equal to or higher than the content of the iodine-based compound (A)
  • This mechanism proceeds well and iodine contained in the antibacterial material can be effectively used.
  • the content of each component contained therein is not particularly limited as long as the above-mentioned regulations are satisfied.
  • the content of iodine compound (A) is sufficient depending on the type of solid substrate (for example, non-woven fabric or paper) as long as the concentration of iodine generated by oxidation is sufficient to exhibit antibacterial action.
  • the specific gravity can vary accordingly, so it is difficult to define it unambiguously.
  • the content of the iodine-based compound (A) is preferably from 0.0001 to 20% by mass relative to the total amount of the antibacterial material. Preferably it is 0.0001-5 mass%, More preferably, it is 0.0001-1 mass%.
  • the content of the silicon-based oxidant (B) is controlled so that the mass ratio with the iodine-based compound (A) is a value within the above range, and further, For product (C), use an amount sufficient to react all the iodine-based acid oxidants (B).
  • the antibacterial material can be visually identified as before or after use.
  • iodine can be reused by the mechanism described above. Therefore, even when it is iodine color and is identified as “after use”, it can sufficiently exhibit antibacterial action.
  • additives may be further retained on the solid substrate as necessary.
  • examples of the additive that can be further retained on the solid substrate include the additives described in the column of the antibacterial composition of the first embodiment.
  • iodine exhibits an antibacterial effect
  • iodine color is similar in color to common contaminants.
  • the sheet-like base material 12 holds starch or a derivative thereof in the sheet-like antibacterial material 10 of the present embodiment. According to the form of force, when I— or I— is generated by the above mechanism,
  • I- and I- are starches and their derivatives.
  • the solid substrate is paper
  • Various fillers such as diatomaceous earth and acid titanium, dyes such as garlic, pigments such as chrome yellow, various sizing agents such as rosin, starch, rice bran, carboxymethylcellulose, polyvinyl alcohol, glycerin Brighteners, surfactants, fragrances, etc. Dyes, pigments, etc.
  • the solid substrate is a nonwoven fabric made of fiber
  • an antistatic agent, a stabilizer, an anti-yellowing agent, a lubricant and the like can be retained.
  • the sheet-like antibacterial material 10 of the present embodiment may be dried or wet.
  • the viewpoint power of reducing the corrosiveness to metals and improving the stability of iodine is preferably dry.
  • the impregnating liquid impregnated in the sheet-like antibacterial material 10 include water, water-containing alcohol, and surfactant.
  • the sheet-like antibacterial material 10 of the present embodiment may be a laminated type! / ⁇ .
  • Examples of the form of the laminated sheet-like antibacterial material 10 include the form shown in FIG. FIG. 2 is a cross-sectional view showing a laminated sheet-like antibacterial material.
  • the sheet-like antibacterial material 10 includes a first sheet-like material 10A and a second sheet-like material 10B.
  • the first sheet-like material 10A has a configuration in which only the iodine compound (A) 14 is held on the first sheet-like substrate 12A.
  • the second sheet-like material 10B has a configuration in which the iodine-based oxidizing agent (B) 16 and the acid compound (C) 18 are held on the second sheet-like base material 12B.
  • the laminated sheet-like antibacterial material 10 in which the iodine compound (A) 14 and the iodine oxidant (B) 16 are held on separate solid substrates is used. It is preferable because it hardly exhibits iodine color before.
  • I the laminated sheet-like antibacterial material 10 in which the iodine compound (A) 14 and the iodine oxidant (B) 16 are held on separate solid substrates. It is preferable because it hardly exhibits iodine color before.
  • the technical scope of the present invention is not limited only to the form in which the iodine color exhibited by the sheet-like antibacterial material 10 is thinned.
  • the reason why the iodine color exhibited by the sheet-like antibacterial material 10 having the form shown in FIG. 2 is reduced will be described in detail in the column of the production method below.
  • the acid compound (C) 18 is held on a solid substrate different from the iodine compound (A) 14, in other words, the iodine oxidant (B) is held.
  • the iodine compound (A) power iodine (I— or I ") due to the influence of the acid compound (C)
  • each sheet-like material (10A, 10B) constituting the sheet-like antibacterial material 10 having the form shown in FIG. 2 and each sheet-like substrate (12A, 12B) which is the main body of each sheet-like material are provided. Crowned
  • first and second mean that iodine-based compound 14, iodine-based oxidizing agent 16 and acid compound 18 are held on separate sheet-like substrates, respectively. It is only used for convenience to show that each sheet is composed of a separate sheet of material. Therefore, the “first” and “second” orders themselves have no special meaning.
  • the raw material of the first sheet-like base material 12A and the raw material of the second sheet-like base material 12B may be the same or different.
  • the form in which each component is held on the sheet-like base material is not limited to the form shown in FIG. Can be adopted.
  • the iodine compound (A) and the iodine acid oxidizing agent (B) are held on the first sheet-like substrate, and the acid compound (C) is the second compound.
  • Iodine-based compound (A) and acid compound (C) are held on the first sheet-like substrate, and iodine-based oxidant (B) is the second sheet.
  • Iodine compound (A) is held on the first sheet-like substrate and iodine-based oxidant (B) is held on the second sheet-like substrate.
  • any form such as a form in which the acid compound (C) is held on the third sheet-like substrate (however, the order of stacking the first to third sheet-like substrates is not limited) It can be adopted.
  • the sheet-like antibacterial material 10 of this embodiment is further provided with a sheet other than the sheet-like antibacterial material of this embodiment on one or both sides of the sheet-like antibacterial material 10 of the form shown in FIGS. It may be a laminated sheet formed. As described above, the sheet-like antibacterial material of this embodiment may exhibit an iodine color when used. In such a case, by forming a laminated sheet laminated with another sheet, the sheet-like antibacterial material of the present embodiment exhibiting iodine color can be coated and the appearance can be improved.
  • the contaminants including microorganisms attached to the surface of the stacked sheet can diffuse to the layer of the sheet-like antibacterial material of this embodiment, so that the antibacterial action can be sufficiently exerted.
  • the sheet-like antibacterial material 10 of the form shown in FIG. 2 the sheet-like antibacterial material and the material in this embodiment are configured between the first sheet-like material 10A and the second sheet-like material 10B. Sheets other than the sheet to be performed may be further arranged. Antibacterial action can be fully exerted even in powerful laminated sheets.
  • the sheet-like antibacterial material of this embodiment is a laminated sheet
  • the sheet that can be disposed in addition to the sheet-like antibacterial material of this embodiment is particularly limited.
  • a sheet that also serves as a base material that can be used in the present embodiment can be adopted.
  • the method for producing the sheet-like antibacterial material 10 of the present embodiment is not particularly limited.
  • the sheet-like antibacterial material 10 having the form shown in FIG. 1 is prepared by, for example, preparing an immersion solution containing components to be retained, immersing the sheet-like base material 12 in the solution, taking out and drying it. It can be manufactured by a method. Hereinafter, it demonstrates in order of a process.
  • an appropriate solvent is prepared, and the above-mentioned iodine-based compound (A) 14, iodine-based oxidizing agent (B) 16, and acid compound (C) 18 are added to the prepared solvent.
  • the components to be held may be added simultaneously to the dipping solution.
  • other additives such as stabilizers may be added for the purpose of changing the properties of the solution based on known knowledge.
  • the solvent to be prepared is not particularly limited, and water, ethanol, methanol, toluene, ethyl acetate, acetone, tetrahydrofuran, dimethyl sulfoxide, and a mixed solvent thereof can be used. However, from the viewpoint of being able to sufficiently dissolve each of the above components, water or a solvent containing water as a main component can be preferably used.
  • the separately prepared sheet-like substrate 12 is immersed in the immersion solution prepared above.
  • each component contained in the dipping solution is held inside and on the surface of the sheet-like substrate 12.
  • the sheet-like base material 12 is taken out and dried with a dipping solution force.
  • a dipping solution force There are no particular restrictions on the specific drying method, natural drying may be used, or forced drying by heating or blowing may be used. There are no particular restrictions on the temperature conditions and the drying time during heating, and it may be set as appropriate with reference to known knowledge.
  • any method may be employed when the solution prepared above is applied to the surface of the sheet-like substrate 12 by a method such as spray coating or roll attachment. Then, after applying the same drying process Yes.
  • the sheet-like antibacterial material 10 in a form in which each component in the solution is held on the surface of the sheet-like substrate 12 can be produced.
  • a method may be adopted in which the raw material of the sheet-like substrate 12 is further added to the above immersion solution and paper is made.
  • the sheet-like antibacterial material having the configuration shown in FIG. 2 can be manufactured. That is, in this embodiment, the first sheet-like substrate is immersed in a solution in which the iodine-based compound (A) is dissolved in a solvent, and the iodine-based compound (A) is added to the first sheet-like substrate.
  • the step of holding, the second sheet-like substrate is immersed in a solution in which the iodine-based oxidizing agent (B) and the acid compound (C) are dissolved in a solvent, and the second sheet-like substrate is A step of retaining the iodine-based oxidizing agent (B) and the acid compound (C), a step of drying the first sheet-like substrate and the second sheet-like substrate, and the first sheet. And a step of laminating the second sheet-shaped substrate and the second sheet-shaped substrate.
  • Figure 3 shows how a laminated sheet-like antibacterial material is manufactured by the manufacturing method of this embodiment.
  • the production method of the present embodiment separately includes an immersion solution containing an iodine-based compound (A) and an immersion solution containing an iodine-based oxidizing agent (B) and an acid compound (C). Except for preparing the sheet-like antibacterial material 10 by laminating each sheet-like base material 12 by laminating each sheet-like base material 12 by immersing a separate sheet-like base material 12 in each of them, It is the same as that of said manufacturing method about the sheet-like antibacterial material of the form shown to.
  • the sheet-like antibacterial material 10 of the form shown in FIG. 2 produced by the production method of the present embodiment exhibits almost no iodine color before use. This is explained as follows.
  • the sheet-like antibacterial material 10 exhibits a certain iodine color.
  • each component to be retained does not coexist in the immersion solution at a time. Therefore, I-, I-, and I showing iodine color are not generated. For this reason, the manufacturing method of this embodiment
  • the sheet-like antibacterial material produced in this way rarely shows an iodine color before use. Therefore, according to the manufacturing method of the present embodiment, an aesthetically preferable sheet-like antibacterial material 10 can be manufactured. Furthermore, since there is no I- or I- in the manufacturing process,
  • each of the first sheet-like base material 12A and the second sheet-like base material 12B is made to hold desired components and then laminated to form a laminated sheet.
  • Antimicrobial material 10 At this time, after each sheet-like substrate 12 is also taken out of each immersion solution force, it may be laminated before drying, and dried after lamination, or each sheet-like substrate 12 may be taken out from each immersion solution, and then each The sheet-like substrate 12 may be dried and laminated after drying. From the point of view that I-, I-, and I are not generated by the mechanism described above,
  • a laminated form can be preferably adopted.
  • the method of laminating when the sheet-like base materials 12 are laminated to form a laminated sheet is not particularly limited, and conventionally known methods can be appropriately employed in the field of producing laminated sheets.
  • the lamination method it is preferable to consider that the component held on the first sheet-like substrate 12A and the component held on the second sheet-like substrate 12B hardly react at the time of lamination.
  • the laminating method for example, there is a method in which the first sheet-like substrate 12A and the second sheet-like substrate are laminated to form a laminated body, and only the peripheral part of the laminated body is thermally bonded. It is done. Of course, other methods may be adopted.
  • the sheet-like antibacterial material 10 of the present embodiment can be applied to various uses by appropriately adjusting the amount of each component retained and the form of a solid substrate.
  • the contaminant adheres to the sheet-shaped antibacterial material 10 of this embodiment, and moisture in the adhered contaminants.
  • Iodine ions ( ⁇ ) generated by contact with iodine, iodine-based oxidants (IO_, IO-I, IO-), and
  • Ton (H +) produces I- and I- by the mechanism shown in the chemical reaction formulas (1) to (3) above.
  • the microorganisms contained therein can be effectively sterilized. That is, an antibacterial action is exhibited.
  • a specific application of the sheet-like antibacterial material 10 of the present embodiment is, for example, a toilet Laid on the floor of the toilet as a laboratory mat; laid on a laboratory table or floor as a laboratory table, and placed on a laboratory table or floor; laid on a work table or floor in a medical institution as a medical sheet;
  • a kitchen paper for rugs such as laying on a kitchen workbench or floor, as a soaking sterilization sheet, for soaking in a solution contaminated by microorganisms, as a filter
  • filters for air conditioners, air cleaners, and vacuum cleaners but are not limited to these. Of course, it may be used for wiping off contaminants in various places as described above.
  • the configuration of the antibacterial material of the present invention and the manufacturing method thereof have been described in detail by taking as an example a sheet-like antibacterial material using a sheet-like base material as a solid substrate. It should be determined based on the description of the scope of claims, and is not limited to the sheet form.
  • Examples of forms other than the sheet form of the antibacterial material of the present embodiment include a granular form in which a granular base material is used as a solid base material. That is, the present application also provides an antibacterial material whose solid substrate is a granular substrate.
  • the antibacterial material of the present embodiment is the same as the above-described sheet-like antibacterial material except that the solid substrate has a granular shape. Therefore, detailed description is omitted here.
  • the particle size of the granular substrate is not particularly limited, and can be appropriately determined according to the use of the granular antibacterial material.
  • each component described in the column of the first embodiment is included in the granular base material.
  • the iodine compound (A), the iodine oxidant (B), and the acid compound (C) may all be held on the same granular base material.
  • This form conceptually corresponds to the sheet-like antibacterial material shown in FIG.
  • the particulate antibacterial material of the present embodiment includes a first particulate material in which the iodine compound (A) is held on the first particulate substrate, and an iodine oxidant on the second particulate substrate.
  • iodine compound (A) and iodine oxidant (B) are held on the first granular base material, and acid compound (C) is the second.
  • the iodine compound (A) and the acid compound (C) are held on the first granular substrate, and the iodine oxidant (B) is the second granular substrate.
  • Iodine compound (A) is held on the first granular substrate, iodine oxidant (B) is held on the second granular substrate, and acid compound (C ) Is held on the third granular base material, and any form can be adopted such as a form in which these granular base materials are mixed homogeneously.
  • the shape and size of the granular substrate are not particularly limited.
  • the shape of the granular base material may be spherical, or a rectangular parallelepiped shape or an indefinite shape.
  • the size is small enough to be referred to as granular, and in addition to lumps and solids, large sizes that can give an impression can also be used as granular substrates.
  • the method for producing the antibacterial material of this embodiment is not particularly limited.
  • the granular antibacterial material of this embodiment can be manufactured by replacing the solid substrate to be used from a sheet-like substrate with a granular substrate. Further, the iodine compound (A) is held on the first granular substrate and the iodine-based oxidant (on the second granular substrate) according to the same idea as the method of manufacturing the antibacterial material of the second embodiment described above.
  • a mixed granular antibacterial material can be produced by retaining the B) and the acid compound (C) and mixing the first granular substrate and the second granular substrate in which the respective components are retained. .
  • the antibacterial material of this form which is granular can be applied to various uses by the same mechanism as the sheet-like antibacterial material by appropriately adjusting the content of each component and the form of the solid substrate. And can exhibit antibacterial properties. In this case, iodine can be used effectively.
  • antibacterial material of the present embodiment which is granular include, for example, for rugs such as pet toilet sand laid on the bottom of pet toilets; When filling the inside of the container, there are forms for filling, etc., but it is not limited to these.
  • Water iodine compound potassium iodide is (A) (KI) (0. 109 mass%), potassium iodate is iodine Sani ⁇ agent (B) (KIO) (1. 0 mass 0/0) , Acid compound (C)
  • iodide ion ( ⁇ ) present in the aqueous solution is constantly regenerated into iodine (I— and I—).
  • the laminated sheet-like antibacterial material shown in FIG. 2 was produced by the following method according to the production method shown in FIG.
  • water was prepared as a solvent for the first immersion solution.
  • This water iodine compounds potassium iodide is (A) (KI) (0. 109 mass 0/0), as well as, a-CD (3. 0 mass 0/0) cyclodextrin (CD) and and ⁇ Ka ⁇ the methyl-beta-CD (2. 0 mass 0/0), and uniformly mixed by stirring to prepare a first dip solution.
  • a second immersion solution was prepared by adding citric acid monohydrate (2.0% by mass) and methyl- ⁇ CD (5.0% by mass) as described above, and mixing uniformly by stirring. .
  • a commercially available pulp woven fabric manufactured by Sun 'Japan Co., Ltd .; "Paper Chemical Thick Skin Thick" was cut into a total size of 5 cm x 5 cm, and the first and first 2 sheet-like base materials were prepared.
  • the first and second sheet-like base materials prepared above are immersed in the first and second immersion solutions prepared above, respectively, and left at 25 ° C for 1 minute. Each component therein was held on a sheet-like substrate.
  • each sheet-like substrate was taken out from each dipping solution, and these were applied to hot air at 80 ° C for 30 minutes by a dryer to dry each sheet-like substrate.
  • the antibacterial material of the present invention can exert an antibacterial action even when it comes into contact with contaminants.

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  • Life Sciences & Earth Sciences (AREA)
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  • Agronomy & Crop Science (AREA)
  • Inorganic Chemistry (AREA)
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Abstract

Il est exposé des moyens servant à utiliser efficacement l'iode dans une matière antibactérienne. L'invention concerne une composition antibactérienne comprenant (A) un composé contenant de l'iode, (B) un agent oxydant contenant de l'iode et (C) un composé acide, le composé contenant de l'iode (A) et l'agent oxydant contenant de l'iode (B) étant contenus avec un rapport des poids : (B)/(A) = 1 à 1000 ; et une matière antibactérienne comprenant un substrat solide et (A) un composé contenant de l'iode, (B) un agent oxydant contenant de l'iode et (C) un composé acide retenus à l'intérieur du substrat solide ou sur la surface de celui-ci, le composé contenant de l'iode (A) et l'agent oxydant contenant de l'iode (B) étant contenus avec un rapport des poids : (B)/(A) = 1 à 1000.
PCT/JP2006/310048 2005-05-19 2006-05-19 Composition antibactérienne et matière antibactérienne WO2006123784A1 (fr)

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EP2366554A2 (fr) 2010-03-16 2011-09-21 Ricoh Company, Ltd. Support d'enregistrement thermosensible
JP6904626B1 (ja) * 2020-08-27 2021-07-21 株式会社都ローラー工業 不活性化方法、不活性化装置
CN114917267A (zh) * 2022-04-25 2022-08-19 杭州西子卫生消毒药械有限公司 一种皮肤用含碘消毒剂及其制备方法

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CN102617225A (zh) * 2012-03-12 2012-08-01 河北科技大学 一种农用无机灭菌组合物及其制备方法
US20210387121A1 (en) * 2018-11-22 2021-12-16 Nikki-Universal Co., Ltd. Filtering material for air filters and method for manufacturing filtering material for air filters
CN111632192B (zh) * 2020-06-19 2021-09-24 浙江大学 兼具抗菌、促成骨分化及矿化的载碘钛合金植入物及其制备方法

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JP2005065965A (ja) * 2003-08-22 2005-03-17 Kao Corp 消臭剤組成物

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JPH02110A (ja) * 1987-10-02 1990-01-05 Sanyo Chem Ind Ltd 固形ヨードホール製剤
JPH01290608A (ja) * 1988-05-18 1989-11-22 Sunstar Inc 殺菌剤組成物
JP2005065965A (ja) * 2003-08-22 2005-03-17 Kao Corp 消臭剤組成物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366554A2 (fr) 2010-03-16 2011-09-21 Ricoh Company, Ltd. Support d'enregistrement thermosensible
US8709974B2 (en) 2010-03-16 2014-04-29 Ricoh Company, Ltd. Thermosensitive recording medium
JP6904626B1 (ja) * 2020-08-27 2021-07-21 株式会社都ローラー工業 不活性化方法、不活性化装置
JP2022039920A (ja) * 2020-08-27 2022-03-10 株式会社都ローラー工業 不活性化方法、不活性化装置
CN114917267A (zh) * 2022-04-25 2022-08-19 杭州西子卫生消毒药械有限公司 一种皮肤用含碘消毒剂及其制备方法
CN114917267B (zh) * 2022-04-25 2023-04-11 杭州西子卫生消毒药械有限公司 一种皮肤用含碘消毒剂及其制备方法

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TW200640369A (en) 2006-12-01
CN101175405B (zh) 2012-08-15
TWI365042B (fr) 2012-06-01
JPWO2006123784A1 (ja) 2008-12-25

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