WO2006108713A3 - Derives de tetrahydronaphthaline, procede pour les preparer, et leur utilisation en tant qu'inhibiteurs d'inflammation - Google Patents

Derives de tetrahydronaphthaline, procede pour les preparer, et leur utilisation en tant qu'inhibiteurs d'inflammation Download PDF

Info

Publication number
WO2006108713A3
WO2006108713A3 PCT/EP2006/003782 EP2006003782W WO2006108713A3 WO 2006108713 A3 WO2006108713 A3 WO 2006108713A3 EP 2006003782 W EP2006003782 W EP 2006003782W WO 2006108713 A3 WO2006108713 A3 WO 2006108713A3
Authority
WO
WIPO (PCT)
Prior art keywords
naphthaline
derivates
tetrahydro
amino
inflammatory agents
Prior art date
Application number
PCT/EP2006/003782
Other languages
German (de)
English (en)
Other versions
WO2006108713A2 (fr
Inventor
Anne Mengel
Konrad Krolikiewicz
Stefan Baeurle
Heike Schaecke
Original Assignee
Schering Ag
Anne Mengel
Konrad Krolikiewicz
Stefan Baeurle
Heike Schaecke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Anne Mengel, Konrad Krolikiewicz, Stefan Baeurle, Heike Schaecke filed Critical Schering Ag
Publication of WO2006108713A2 publication Critical patent/WO2006108713A2/fr
Publication of WO2006108713A3 publication Critical patent/WO2006108713A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des dérivés de tétrahydronaphthaline à substitutions multiples, de formule (I), un procédé pour les préparer, et leur utilisation en tant qu'inhibiteurs d'inflammation.
PCT/EP2006/003782 2005-04-14 2006-04-13 Derives de tetrahydronaphthaline, procede pour les preparer, et leur utilisation en tant qu'inhibiteurs d'inflammation WO2006108713A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005017316A DE102005017316A1 (de) 2005-04-14 2005-04-14 Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005017316.0 2005-04-14

Publications (2)

Publication Number Publication Date
WO2006108713A2 WO2006108713A2 (fr) 2006-10-19
WO2006108713A3 true WO2006108713A3 (fr) 2006-12-14

Family

ID=36889239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003782 WO2006108713A2 (fr) 2005-04-14 2006-04-13 Derives de tetrahydronaphthaline, procede pour les preparer, et leur utilisation en tant qu'inhibiteurs d'inflammation

Country Status (8)

Country Link
AR (1) AR053582A1 (fr)
DE (1) DE102005017316A1 (fr)
DO (1) DOP2006000089A (fr)
GT (1) GT200600152A (fr)
PE (1) PE20061360A1 (fr)
TW (1) TW200716565A (fr)
UY (1) UY29482A1 (fr)
WO (1) WO2006108713A2 (fr)

Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63220242A (ja) * 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd フオトレジスト組成物
WO1988008836A2 (fr) * 1987-05-15 1988-11-17 Schering Corporation Derives de benzocycloheptene, benzazepine, benzoxepine et de naphtalene a substitution aryle
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0579223A1 (fr) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Dérivés des acides carboxyliques comme inhibiteurs de 5-alpha-réductase
WO1999004778A1 (fr) * 1997-07-22 1999-02-04 Eli Lilly And Company Composes pharmaceutiques
WO1999006388A2 (fr) * 1997-07-31 1999-02-11 Proteome Sciences Plc. COMPOSES PHARMACEUTIQUES ISOLES A PARTIR DE L'$i(ARISTOLOCHIA TALISCANA)
WO1999037607A1 (fr) * 1998-01-27 1999-07-29 Icagen, Inc. Inhibiteurs des canaux de potassium
WO1999050205A2 (fr) * 1998-03-30 1999-10-07 Sepracor Inc. Synthese asymetrique par reactif de grignard a l'aide de 1,2-aminoalcools cycliques
WO2000010977A1 (fr) * 1998-08-21 2000-03-02 The Scripps Research Institute Aminohydroxylation catalytique asymetrique avec des heterocycles a substitution amino
JP2000256255A (ja) * 1999-03-10 2000-09-19 Kuraray Co Ltd （±）−トランス−ペルメトリン酸の光学分割法
WO2001030734A1 (fr) * 1999-10-29 2001-05-03 Astrazeneca Ab Nouveaux composes hydronaphthalene prepares par reaction d'ouverture du cycle catalyse par le rhodium en presence d'un ligand de phosphine
WO2003000694A1 (fr) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. Derives de 6-phenyldihydropyrrolopyrimidinedione
WO2003027061A2 (fr) * 2001-09-21 2003-04-03 Eli Lilly And Company Agonistes muscariniques
WO2003040107A1 (fr) * 2001-09-24 2003-05-15 Bayer Pharmaceuticals Corporation Preparation et utilisation de derives d'imidazole dans le traitement de l'obesite
WO2003045924A1 (fr) * 2001-11-21 2003-06-05 Pharmacia & Upjohn Company Derives d'aryle-1,4-pyrazine substitues
US20030199690A1 (en) * 2002-02-21 2003-10-23 Schering Corporation Process for synthesis of D1 receptor antagonists
WO2004020375A1 (fr) * 2002-08-26 2004-03-11 Merck Patent Gmbh Dérivés de cyclopenta[b]naphtaline
CN1524835A (zh) * 2003-09-12 2004-09-01 中国科学院上海有机化学研究所 利用固载化的双辛可尼类生物碱配体进行不对称羟胺化和双羟化反应的方法
WO2005021682A1 (fr) * 2003-08-22 2005-03-10 Merck Patent Gmbh Derives de cyclopenta[a]naphthaline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890701585A (ko) * 1987-07-16 1989-12-21 헤르베르크 슈키·울리히 볼프 새로운 디아졸
US5489584A (en) * 1994-12-29 1996-02-06 Allergan, Inc. Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63220242A (ja) * 1987-03-10 1988-09-13 Fuji Photo Film Co Ltd フオトレジスト組成物
WO1988008836A2 (fr) * 1987-05-15 1988-11-17 Schering Corporation Derives de benzocycloheptene, benzazepine, benzoxepine et de naphtalene a substitution aryle
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
EP0579223A1 (fr) * 1992-07-17 1994-01-19 Mitsubishi Chemical Corporation Dérivés des acides carboxyliques comme inhibiteurs de 5-alpha-réductase
WO1999004778A1 (fr) * 1997-07-22 1999-02-04 Eli Lilly And Company Composes pharmaceutiques
WO1999006388A2 (fr) * 1997-07-31 1999-02-11 Proteome Sciences Plc. COMPOSES PHARMACEUTIQUES ISOLES A PARTIR DE L'$i(ARISTOLOCHIA TALISCANA)
WO1999037607A1 (fr) * 1998-01-27 1999-07-29 Icagen, Inc. Inhibiteurs des canaux de potassium
WO1999050205A2 (fr) * 1998-03-30 1999-10-07 Sepracor Inc. Synthese asymetrique par reactif de grignard a l'aide de 1,2-aminoalcools cycliques
WO2000010977A1 (fr) * 1998-08-21 2000-03-02 The Scripps Research Institute Aminohydroxylation catalytique asymetrique avec des heterocycles a substitution amino
JP2000256255A (ja) * 1999-03-10 2000-09-19 Kuraray Co Ltd （±）−トランス−ペルメトリン酸の光学分割法
WO2001030734A1 (fr) * 1999-10-29 2001-05-03 Astrazeneca Ab Nouveaux composes hydronaphthalene prepares par reaction d'ouverture du cycle catalyse par le rhodium en presence d'un ligand de phosphine
WO2003000694A1 (fr) * 2001-06-22 2003-01-03 Almirall Prodesfarma S.A. Derives de 6-phenyldihydropyrrolopyrimidinedione
WO2003027061A2 (fr) * 2001-09-21 2003-04-03 Eli Lilly And Company Agonistes muscariniques
WO2003040107A1 (fr) * 2001-09-24 2003-05-15 Bayer Pharmaceuticals Corporation Preparation et utilisation de derives d'imidazole dans le traitement de l'obesite
WO2003045924A1 (fr) * 2001-11-21 2003-06-05 Pharmacia & Upjohn Company Derives d'aryle-1,4-pyrazine substitues
US20030199690A1 (en) * 2002-02-21 2003-10-23 Schering Corporation Process for synthesis of D1 receptor antagonists
WO2004020375A1 (fr) * 2002-08-26 2004-03-11 Merck Patent Gmbh Dérivés de cyclopenta[b]naphtaline
WO2005021682A1 (fr) * 2003-08-22 2005-03-10 Merck Patent Gmbh Derives de cyclopenta[a]naphthaline
CN1524835A (zh) * 2003-09-12 2004-09-01 中国科学院上海有机化学研究所 利用固载化的双辛可尼类生物碱配体进行不对称羟胺化和双羟化反应的方法

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1983, THIEM, JOACHIM ET AL: "2,6-Dideoxy saccharide glycosides of .alpha.-hydroxy ketones: synthesis and configurational assignment of glycosides with the tetralone substructure of olivomycin", XP002397135, retrieved from STN Database accession no. 1983:215911 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, SRIVASTAVA, J. N. ET AL: "Synthesis of 7-methoxy- and 6-methoxytetralino[3,4-c]isocoumarins and 7-methoxy- and 6-methoxytetralino[3,4-c]isoquinolones", XP002397133, retrieved from STN Database accession no. 1994:409135 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2001, FERRAZ, HELENA M. C. ET AL: "The reaction of 1-tetralones with thallium trinitrate supported on clay: ring contraction vs .alpha.-oxidation", XP002397132, retrieved from STN Database accession no. 2001:730084 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2004, PATONAY, TAMAS ET AL: "Synthesis of Racemic and Enantiomerically Enriched .alpha.-Oxyfunctionalized Benzocyclanones and Chromanones by Dimethyldioxirane and Dimethyldioxirane/Mn(III) salen System", XP002397131, retrieved from STN Database accession no. 2004:392983 *
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY , 3(3), 171-6 CODEN: IJCHEI; ISSN: 0971-1627, 1994 *
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY , 12(5), 680-684 CODEN: JOCSET; ISSN: 0103-5053, 2001 *
LIEBIGS ANNALEN DER CHEMIE , (3), 448-61 CODEN: LACHDL; ISSN: 0170-2041, 1983 *
MONATSHEFTE FUER CHEMIE , 135(6), 743-756 CODEN: MOCMB7; ISSN: 0026-9247, 2004 *

Also Published As

Publication number Publication date
UY29482A1 (es) 2006-10-31
DE102005017316A1 (de) 2006-10-19
DOP2006000089A (es) 2006-11-15
TW200716565A (en) 2007-05-01
WO2006108713A2 (fr) 2006-10-19
PE20061360A1 (es) 2007-01-26
GT200600152A (es) 2007-03-19
AR053582A1 (es) 2007-05-09

Similar Documents

Publication Publication Date Title
ZA200804489B (en) 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors
EP1889842A4 (fr) Composé hétérocyclique
IL172899A0 (en) Heterocyclically substituted pentanol derivatives, method for the production thereof, and use thereof as anti-inflammatory agents
WO2006059149A8 (fr) Derives de l'arylsulfonylnaphtalene utilises en tant qu'antagonistes de 5ht2a
IL179758A0 (en) Substituted tetrahydro - 2h - isoquinolin - 1 - one derivatives, method for the production thereof, and use of the same as medicaments
AU2003282094A1 (en) Novel dihydroxy-methylphenyl derivatives, method for the production and use thereof as medicaments
WO2008032157A3 (fr) Synthèse de 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
WO2006018279A3 (fr) Amines polycycliques substitues par aryle, procede de production associe et leur utilisation en tant que medicaments
IL174469A0 (en) Rearranged pentanols, a method for the production thereof, and their use as antiphlogistics
WO2006066950A3 (fr) Aminoalcools tricycliques, procedes de realisation associes et utilisation comme anti-inflammatoires
WO2008058936A3 (fr) Engrais contenant du formiate de calcium
WO2007065684A3 (fr) Composes organiques
IL164516A0 (en) 2,6-Quimolinyl and 2,6-naphthyl derivatives, processes for preparation them and their uses as vla-4 inhibitors
WO2007012626A3 (fr) Nouveau procede de production de sels de tiotropium
UA94603C2 (ru) Производные тетрагидронафталина, способ их получения и их применения в качестве ингибиторов воспаления
WO2006108714A3 (fr) Derives de tetrahydronaphthaline, procede pour les preparer, et leur utilisation en tant qu'inhibiteurs d'inflammation
PT1838683E (pt) Um processo para a preparação de derivados de [1,4,5]-oxadiazepina
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
IL186862A0 (en) Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives
PL374461A1 (pl) Sposób otrzymywania pochodnych 13,14-dihydro-PGF
WO2008019356A3 (fr) Méthode de préparation de dérivés tétrahydroisoquinoléine substitués en 1,2,3,4
WO2006122777A3 (fr) Utilisation de derives de thiazol-4-one 2,5-disubstitues dans des medicaments
EP1939184A4 (fr) Compose 1,3-diiodohydantoine et son procede de fabrication
WO2007057316A3 (fr) Nouveau procede de preparation de thoc
WO2006063578A3 (fr) Procede de production de candesartan

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06724545

Country of ref document: EP

Kind code of ref document: A2