WO2006102004A2 - Formulation d'emulsion aqueuse stable comportant de l'uree et de l'acide salicylique et son procede d'utilisation - Google Patents

Formulation d'emulsion aqueuse stable comportant de l'uree et de l'acide salicylique et son procede d'utilisation Download PDF

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Publication number
WO2006102004A2
WO2006102004A2 PCT/US2006/009568 US2006009568W WO2006102004A2 WO 2006102004 A2 WO2006102004 A2 WO 2006102004A2 US 2006009568 W US2006009568 W US 2006009568W WO 2006102004 A2 WO2006102004 A2 WO 2006102004A2
Authority
WO
WIPO (PCT)
Prior art keywords
stable formulation
formulation
agent
stable
salicylic acid
Prior art date
Application number
PCT/US2006/009568
Other languages
English (en)
Other versions
WO2006102004A3 (fr
Inventor
Srinivasa Rao
Suresh Dixit
Folusho Obe
Sandhya Goyal
Avraham Yacobi
Original Assignee
Taro Pharmaceuticals U.S.A., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharmaceuticals U.S.A., Inc. filed Critical Taro Pharmaceuticals U.S.A., Inc.
Priority to EP06738606A priority Critical patent/EP1863434A4/fr
Publication of WO2006102004A2 publication Critical patent/WO2006102004A2/fr
Publication of WO2006102004A3 publication Critical patent/WO2006102004A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • “emollient” refers to an agent, when applied locally onto skin, would increase tissue moisture content, thereby rendering the skin softer and more pliable;
  • % refers to % wt; and % wt refers to % of weight of respective component with respect to the total weight of the composition.
  • the term "about” refers to +/- 10 % of a specified value.
  • the present stable aqueous-based emulsion formulation may include a photoprotectant or antioxidant such as genestein, vitamin C, vitamin E, avobenzone, octinoxate, and the like.
  • Photoprotectant is an agent that prevents UV penetration into skin. The amount of photoprotectant or antioxidant is present at a therapeutic amount to render photoprotection and antioxidation of skins.
  • the stable aqueous-based emulsion formulation composition as disclosed in this example was prepared in the following manner.
  • oil phase components i.e., glyceryl stearate and PEG 100 stearate, cetyl alcohol, stearyl alcohol, mineral oil light and stearic acid were heated to 70 ⁇ 3°C.
  • the water phase components i.e., purified water
  • Urea and glycerin were then added and mixed.
  • Xanthan gum was slowly added with the homogenizer ON at 2,000 RPM and with a gap setting of 2.5-3.0.
  • Benzyl alcohol, propylene glycol, polysorbate 80 and simethicone emulsion were added to the water phase.
  • the water phase components were mixed at 39 RPM and the temperature was maintained at 68 ⁇ 3°C.
  • Example 1 The following table summarizes additional consistent assay results of salicylic acid urea and benzyl alcohol of the cream formulation as prepared in Example 1.
  • the stability was conducted at 35 0 C and 60% relative humidity (RH).
  • the stable aqueous-based emulsion formulation was prepared in a commercial scale-manufacturing kettle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a trait à une formulation d'émulsion aqueuse stable comportant de l'urée et de l'acide salicylique et son procédé de préparation. En particulier, la présente invention a trait à un procédé de traitement d'une condition de la peau comprenant l'étape d'administration topique d'une forme stable d'une formulation comportant de l'urée et de l'acide salicylique.
PCT/US2006/009568 2005-03-16 2006-03-16 Formulation d'emulsion aqueuse stable comportant de l'uree et de l'acide salicylique et son procede d'utilisation WO2006102004A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06738606A EP1863434A4 (fr) 2005-03-16 2006-03-16 Formulation d'emulsion aqueuse stable comportant de l'uree et de l'acide salicylique et son procede d'utilisation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66250805P 2005-03-16 2005-03-16
US60/662,508 2005-03-16
US74808405P 2005-12-07 2005-12-07
US60/748,084 2005-12-07

Publications (2)

Publication Number Publication Date
WO2006102004A2 true WO2006102004A2 (fr) 2006-09-28
WO2006102004A3 WO2006102004A3 (fr) 2007-01-11

Family

ID=37024396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/009568 WO2006102004A2 (fr) 2005-03-16 2006-03-16 Formulation d'emulsion aqueuse stable comportant de l'uree et de l'acide salicylique et son procede d'utilisation

Country Status (2)

Country Link
EP (1) EP1863434A4 (fr)
WO (1) WO2006102004A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867322A1 (fr) * 2006-06-12 2007-12-19 M. Cristina Fernández Rodríguez Composition topique pour le traitement du psoriasis
EP2100586A1 (fr) * 2008-03-11 2009-09-16 L'Oréal Composition cosmétique comprenant un composé d'acide ascorbique ou d'acide salicylique
FR2928541A1 (fr) * 2008-03-11 2009-09-18 Oreal Composition cosmetique comprenant un compose d'acide salicylique
JP2016515525A (ja) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション フルニソリドの局所用組成物および治療方法
US9775851B1 (en) * 2009-08-31 2017-10-03 Dr. Reddy's Laboratories, Ltd. Topical formulations comprising a steroid
US11179465B2 (en) 2014-03-11 2021-11-23 Primus Pharmaceuticals, Inc. Topical compositions comprising a corticosteroid

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110180032A (zh) * 2019-06-12 2019-08-30 东华大学 一种载药控释的同轴静电纺丝纳米纤维支架及其制备方法和应用

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FR2586692B1 (fr) * 1985-08-30 1988-03-11 Oreal Nouveaux polyaminoamides filtrant le rayonnement ultraviolet, leur procede de preparation et leur utilisation pour proteger la peau et les cheveux
US5167950A (en) * 1991-03-28 1992-12-01 S. C. Johnson & Son High alcohol content aerosol antimicrobial mousse
FR2728167A1 (fr) * 1994-12-15 1996-06-21 Cird Galderma Composition cosmetique ou dermatologique sous forme d'une emulsion eau dans huile a teneur elevee en hydroxyacides
US5804203A (en) * 1994-12-21 1998-09-08 Cosmederm Technologies Topical product formulations containing strontium for reducing skin irritation
US5567427A (en) * 1995-03-17 1996-10-22 Helene Curtis, Inc. Emulsified, low ph cosmetic compositions having improved stability
ZA962455B (en) * 1995-03-31 1996-10-02 B Eugene Guthery Fast acting and persistent topical antiseptic
EP0954278B8 (fr) * 1996-11-12 2005-06-15 Pharmacia & Upjohn Company LLC Compositions pharmaceutiques contenant de l'huile de noix de kukui
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DE10133198A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Kreatin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
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US20030064084A1 (en) * 2001-09-24 2003-04-03 Bradley Pharmaceuticals, Inc. Novel benzoyl peroxide compositions for the treatment of dermatological disorders and methods for their use
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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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See references of EP1863434A4 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1867322A1 (fr) * 2006-06-12 2007-12-19 M. Cristina Fernández Rodríguez Composition topique pour le traitement du psoriasis
EP2100586A1 (fr) * 2008-03-11 2009-09-16 L'Oréal Composition cosmétique comprenant un composé d'acide ascorbique ou d'acide salicylique
EP2100585A1 (fr) * 2008-03-11 2009-09-16 L'Oréal Composition cosmétique comprenant un composé d'acide ascorbique ou d'acide salicylique
FR2928541A1 (fr) * 2008-03-11 2009-09-18 Oreal Composition cosmetique comprenant un compose d'acide salicylique
CN101530375B (zh) * 2008-03-11 2012-01-11 莱雅公司 包含抗坏血酸或水杨酸化合物的化妆用组合物
US8980234B2 (en) 2008-03-11 2015-03-17 L'oreal Cosmetic composition comprising an ascorbic acid or salicylic acid compound
US9775851B1 (en) * 2009-08-31 2017-10-03 Dr. Reddy's Laboratories, Ltd. Topical formulations comprising a steroid
US10588914B2 (en) 2009-08-31 2020-03-17 Encore Dermatology, Inc. Topical formulations comprising a steroid
US10905697B2 (en) 2009-08-31 2021-02-02 Encore Dermatology, Inc. Topical formulations comprising a steroid
JP2016515525A (ja) * 2013-03-15 2016-05-30 メディシス ファーマシューティカル コーポレイション フルニソリドの局所用組成物および治療方法
US10953021B2 (en) * 2013-03-15 2021-03-23 Lupin Limited Topical compositions of flunisolide and methods of treatment
US11179465B2 (en) 2014-03-11 2021-11-23 Primus Pharmaceuticals, Inc. Topical compositions comprising a corticosteroid

Also Published As

Publication number Publication date
EP1863434A2 (fr) 2007-12-12
EP1863434A4 (fr) 2012-03-07
WO2006102004A3 (fr) 2007-01-11

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