WO2006094945A3 - Verfahren zur herstellung optisch aktiver alkohole durch enzymatische reduktion - Google Patents

Verfahren zur herstellung optisch aktiver alkohole durch enzymatische reduktion Download PDF

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Publication number
WO2006094945A3
WO2006094945A3 PCT/EP2006/060452 EP2006060452W WO2006094945A3 WO 2006094945 A3 WO2006094945 A3 WO 2006094945A3 EP 2006060452 W EP2006060452 W EP 2006060452W WO 2006094945 A3 WO2006094945 A3 WO 2006094945A3
Authority
WO
WIPO (PCT)
Prior art keywords
optically active
producing optically
enzymatic reduction
active alcohols
thienyl
Prior art date
Application number
PCT/EP2006/060452
Other languages
English (en)
French (fr)
Other versions
WO2006094945A2 (de
Inventor
Rainer Stuermer
Juergen Daeuwel
Maria Kesseler
Brigitte Achatz
Michael Breuer
Original Assignee
Basf Ag
Rainer Stuermer
Juergen Daeuwel
Maria Kesseler
Brigitte Achatz
Michael Breuer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Rainer Stuermer, Juergen Daeuwel, Maria Kesseler, Brigitte Achatz, Michael Breuer filed Critical Basf Ag
Priority to EP06724927A priority Critical patent/EP1863918A2/de
Priority to JP2008500175A priority patent/JP2008538076A/ja
Publication of WO2006094945A2 publication Critical patent/WO2006094945A2/de
Publication of WO2006094945A3 publication Critical patent/WO2006094945A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Verfahren zur Herstellung von optisch aktiven-Alkanolen der Formel (I), durch enzymatische Reduktion der entsprechenden Ketone, insbesondere die Herstellung von (1S)-3-Methylamino-1-(2-thienyl)-propan-1-ol und (1S)-3-Chlor-1-(2-thienyl)-propan-1-ol.
PCT/EP2006/060452 2005-03-07 2006-03-03 Verfahren zur herstellung optisch aktiver alkohole durch enzymatische reduktion WO2006094945A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06724927A EP1863918A2 (de) 2005-03-07 2006-03-03 Verfahren zur herstellung optisch aktiver alkohole durch enzymatische reduktion
JP2008500175A JP2008538076A (ja) 2005-03-07 2006-03-03 光学活性アルコールの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005010804.0 2005-03-07
DE200510010804 DE102005010804A1 (de) 2005-03-07 2005-03-07 Verfahren zur Herstellung optisch aktiver Alkohole

Publications (2)

Publication Number Publication Date
WO2006094945A2 WO2006094945A2 (de) 2006-09-14
WO2006094945A3 true WO2006094945A3 (de) 2007-03-15

Family

ID=36603441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/060452 WO2006094945A2 (de) 2005-03-07 2006-03-03 Verfahren zur herstellung optisch aktiver alkohole durch enzymatische reduktion

Country Status (5)

Country Link
EP (1) EP1863918A2 (de)
JP (1) JP2008538076A (de)
CN (1) CN101171339A (de)
DE (1) DE102005010804A1 (de)
WO (1) WO2006094945A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796192B (zh) * 2007-06-20 2014-01-15 巴斯夫欧洲公司 使用固氮弧菌属物种(Azoarcus Sp)EBN1脱氢酶产生光学活性醇的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102159719B (zh) 2008-09-17 2015-03-11 巴斯夫欧洲公司 使用aromatoleum aromaticum ebn1(固氮弧菌属物种ebn1)的醇脱氢酶生产l-去氧肾上腺素的方法
JP2012511922A (ja) 2008-12-17 2012-05-31 ビーエーエスエフ ソシエタス・ヨーロピア デュロキセチンアルコールを製造するための改良型生体触媒
CN102803233B (zh) 2009-06-22 2017-03-01 爱思开生物制药株式会社 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
EP4112727A3 (de) 2010-11-17 2023-03-15 Basf Se Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
WO2014086702A2 (de) 2012-12-03 2014-06-12 Basf Se Enzymatische reduktion von hydroxymethylfurfuralen
MY196447A (en) 2016-02-19 2023-04-12 Basf Se Enzymatic Cyclization Of Homofarnesylic Acid
BR112020017362A2 (pt) 2018-03-29 2020-12-29 Firmenich S.A. Método para produzir vanilina

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763236A (en) * 1993-09-24 1998-06-09 Daicel Chemical Industries Ltd. Method for producing ketone or aldehyde using an alcohol dehydrogenase of Candida Parapsilosis
WO2003078615A1 (en) * 2002-03-18 2003-09-25 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with high solvent and temperature stability
WO2004090094A2 (de) * 2003-04-07 2004-10-21 Basf Aktiengesellschaft L-carnitin dehydrogenasen, deren derivate und ein verfahren zur herstellung von substituierten (s)-alkanolen
WO2004111083A2 (de) * 2003-06-18 2004-12-23 Iep Gmbh Oxidoreduktase aus pichia capsulata
WO2005033094A2 (de) * 2003-10-01 2005-04-14 Basf Aktiengesellschaft Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol
WO2005108590A2 (de) * 2004-05-05 2005-11-17 Basf Aktiengesellschaft Verfahren zur herstellung optisch aktiver alkohole aus alkanonen unter verwendung einer dehydrogenase aus azoarcus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763236A (en) * 1993-09-24 1998-06-09 Daicel Chemical Industries Ltd. Method for producing ketone or aldehyde using an alcohol dehydrogenase of Candida Parapsilosis
WO2003078615A1 (en) * 2002-03-18 2003-09-25 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with high solvent and temperature stability
WO2004090094A2 (de) * 2003-04-07 2004-10-21 Basf Aktiengesellschaft L-carnitin dehydrogenasen, deren derivate und ein verfahren zur herstellung von substituierten (s)-alkanolen
WO2004111083A2 (de) * 2003-06-18 2004-12-23 Iep Gmbh Oxidoreduktase aus pichia capsulata
WO2005033094A2 (de) * 2003-10-01 2005-04-14 Basf Aktiengesellschaft Verfahren zur herstellung von 3-methylamino-1-(thien-2-yl)-propan-1-ol
WO2005108590A2 (de) * 2004-05-05 2005-11-17 Basf Aktiengesellschaft Verfahren zur herstellung optisch aktiver alkohole aus alkanonen unter verwendung einer dehydrogenase aus azoarcus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUMMEL W: "NEW ALCOHOL DEHYDROGENASES FOR THE SYNTHESIS OF CHIRAL COMPOUNDS", ADVANCES IN BIOCHEMICAL ENGINEERING, BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 58, 1997, pages 145 - 184, XP000677754, ISSN: 0724-6145 *
KNIEMEYER O ET AL: "(S)-1-Phenylethanol dehydrogenase of Azoarcus sp. strain EbN1, an enzyme of anaerobic ethylbenzene catabolism", ARCHIVES OF MICROBIOLOGY, BERLIN, DE, vol. 176, no. 1-2, July 2001 (2001-07-01), pages 129 - 135, XP002358595, ISSN: 0302-8933 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796192B (zh) * 2007-06-20 2014-01-15 巴斯夫欧洲公司 使用固氮弧菌属物种(Azoarcus Sp)EBN1脱氢酶产生光学活性醇的方法

Also Published As

Publication number Publication date
JP2008538076A (ja) 2008-10-09
EP1863918A2 (de) 2007-12-12
DE102005010804A1 (de) 2006-09-14
WO2006094945A2 (de) 2006-09-14
CN101171339A (zh) 2008-04-30

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