WO2006089494A1 - Dispositivo osmótico que contiene amantadina y una sal osmótica - Google Patents
Dispositivo osmótico que contiene amantadina y una sal osmótica Download PDFInfo
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- WO2006089494A1 WO2006089494A1 PCT/CR2005/000005 CR2005000005W WO2006089494A1 WO 2006089494 A1 WO2006089494 A1 WO 2006089494A1 CR 2005000005 W CR2005000005 W CR 2005000005W WO 2006089494 A1 WO2006089494 A1 WO 2006089494A1
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- osmotic
- salt
- amantadine
- osmotic device
- cellulose acetate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Definitions
- the present invention pertains to an osmotic device containing an active drug and an osmotic salt in the nucleus, where the release rate of the active drug is reduced and the release profile of the active drug is modified by increasing the amount of Osmotic salt in the nucleus.
- the osmotic device contains amantadine hydrochloride and sodium chloride in the nucleus. Depending on the amount of sodium chloride present in the nucleus, the osmotic device is capable of providing a sigmoid, pseudo zero order or zero order release of amantadine hydrochloride.
- Osmotic devices have proven useful in releasing active agents such as medicines, nutrients, food products, pesticides, herbicides, germicides, algaecides, chemical reagents, and others known to those with common knowledge, to the environment of use in a controlled manner by prolonged periods of time
- active agents such as medicines, nutrients, food products, pesticides, herbicides, germicides, algaecides, chemical reagents, and others known to those with common knowledge, to the environment of use in a controlled manner by prolonged periods of time
- Known devices include tablets, pills, pills or capsules and others that use osmotic pressure to control the release of the active agent contained in the core of the osmotic device.
- Some osmotic devices may also include layers that comprise one or more materials that are subject to erosion or that slowly dissolve in the environment of use, thereby gradually dispensing the active agent.
- Osmotic salts that show a gradient osmotic pressure against an external fluid through the semipermeable wall of osmotic devices have been used in the nucleus of osmotic devices for a long time.
- US Patents No. 3,977,404, No. 4,008,719, No. 4,014,334, No. 4,034,758, and No. 4,077,407 granted to Theeuwes et al., No. 4,036,227 and No.
- osmotic salts are used mixed with an agent that has limited solubility in the external fluid where the osmotic salt forms a saturated solution that Contains the agent that is osmotically released from the device.
- Osmotic salts are used homogeneously or heterogeneously by mixing the osmotic salt or a mixture thereof with the active agent, either before they are loaded into the reservoir or by mixing after they are loaded into the reservoir.
- the osmotic salt attracts the fluid inside the device producing a solution of the osmotic salt that is released from the device concomitantly transporting undissolved and dissolved agent outside the device.
- salts of highly soluble drugs are difficult to formulate in osmotic devices. The more soluble they are, generally the more difficult to formulate in osmotic devices. This is because drug salts tend to dissolve too quickly thus allowing premature release of the drug, discharge of the drug or a rapid rather than controlled release of the drug. According to McClelland et al. (Pharm. Res. (1991), 8 (1), 88-92), drugs with a water solubility ⁇ 50 mg / ml should be released by an osmotic device in a controlled manner so that ⁇ 95% of the load of drug is released according to zero order kinetics.
- McClelland et al. they propose a modulation of the solubility of the drug in an attempt to change the release profile of the drug from a first order to a zero order.
- McClelland et al. They specifically indicate that ClNa must be in the form of controlled release as ClNa crystals coated with cellulose acetate butyrate to form small osmotic pumps.
- the use of sodium chloride as an osmoagent in an osmotic device is widely known.
- the art generally shows that the increase in the amount of osmoagent results in an increase in osmotic pressure and therefore an increase in the rate of release of the drug from the nucleus of the osmotic device.
- the prior art reveals osmotic devices that have a bilayer or multilayer core, where at least one of the layers is "push" or "motion” comprising sodium chloride in combination with an osmopolymer or a water-swellable polymer.
- Sodium chloride allows water to enter the polymer matrix, thus moistening and swelling the polymer.
- An osmotic device which has a unit core comprising a pharmaceutically acceptable salt of a drug in combination with sodium chloride and other excipients.
- the art reveals osmotic devices that possess a unit nucleus comprising drugs such as pseudoephedrine hydrochloride (Johnson et al. in US Patent No. 6,537,573; Faour et al. in US Patent No. 6,004,582; Hamel et al. in US Patent No. 4,801,461; Chen et al. in U.S. Patent Nos. 5,458,887, No. 5,654,005, and No. 5,558,879), venlafaxine hydrochloride (Faour et al. in U.S.
- Patent No. 6,352,721 reboxetine methanesulfonate (Seroff et al. in U.S. Patent No. 6,387,403 ), carbamazepine (Puthli et al. in U.S. Patent No. 6,534,090), rofecoxib (Faour et al. in U.S. Patent No. 6,491,949), cisapride monohydrate (Faour et al. in U.S. Patent No. 6,004,582), nifedipine (Kettelhoit et al. In US Patent No. 6,294,201); and other drugs (Chen et al. in US Patent Nos.
- 6,352,721 issued to Faour, which describes about three osmotic devices containing a layer of nucleus comprising venlafaxine hydrochloride and sodium chloride, cisapride and sodium chloride and nifedipine and sodium chloride, respectively;
- the osmotic salt is revealed as an osmoagent that increases the osmotic pressure of the nucleus attracting fluid inside the device, and therefore producing a solution or suspension of the active drug that is then released from the device at an increased rate. None of the patents mentioned above reveal that the release rate of the active drug is reduced and that the release profile of the active drug is modified by increasing the amount of osmotic salt in the nucleus.
- the weight percentages of sodium chloride and the drug, as revealed in the prior art, are very variable.
- Amantadine is commercially available in the United States in the form of immediate-release and syrup tablets under the SYMMETREL TM brand of Endo Pharmaceutical Co.
- the administration of amantadine for the treatment of Parkinson's disease, Alzheimer's disease and some Other types of dementias is well known.
- depression among other behavioral disorders, is a known adverse reaction of amantadine therapy.
- amantadine is subject to unwanted interactions with other drugs.
- US Patents No. 6,217,905, No. 5,221,536 and No. 5,190,763 issued to Yesterday et al., And No. 5,192,550 and No. 5,057,321 granted to Edgren et al. from Alza Corporation reveal formulations of bilayer osmotic devices that contain an antiparkinsonian drug such as amantadine.
- the core is bilayer and comprises a drug composition and a push composition.
- An osmotic salt such as sodium chloride, potassium chloride or magnesium chloride can be included in the thrust composition.
- the core is bilayer and comprises a drug composition and a push composition.
- An osmotic salt like chloride Sodium, potassium chloride and magnesium chloride can be included in the push composition.
- US Patent No. 6,284,276 issued to Rudnic et al. discloses an osmotic release pharmaceutical system composed of a semipermeable wall that maintains its integrity during pharmaceutical release and that has a passage through it, and a composition within the semipermeable wall, wherein the composition comprises a pharmaceutical agent of limited solubility , a non-inflatable agent that improves the solubility of the pharmaceutical agent, and a non-inflatable osmotic agent.
- the '276 Patent mentions amantadine as a convenient drug for use in the osmotic device.
- Osmotic devices prepared with two or more layers to provide a desired release profile may be difficult to produce and require specialized manufacturing machinery. Therefore, it would be an improvement in the art to provide a controlled release dosage form that is easy to prepare and that produces the desired release rate or desired release profile for a soluble or insoluble hydrochloride salt of an active agent at modify the amount of sodium chloride in the core of the osmotic device.
- the invention provides an osmotic device that releases amantadine in a controlled manner.
- the release rate of amantadine decreases with the increase in the amount of osmotic salt, such as sodium chloride, added in the nucleus.
- Amantadine salt and osmotic salt have an ion in common.
- the osmotic salt is not per se coated with a release rate control cover.
- the osmotic salt is present in crystalline form or in powder form and is included in the nucleus of the Osmotic device mixed with amantadine and other excipients.
- the core is a unit core where the ingredients are homogeneously or heterogeneously mixed.
- One aspect of the invention provides an osmotic device that has a unitary core surrounded by a semipermeable membrane that has at least one passage therein, where: a.
- the unit core comprises a mixture of amantadine salt, osmotic salt and at least one other pharmaceutically acceptable excipient; b. the osmotic salt is not coated with a cover that controls the release rate; C. the permeability of the semipermeable membrane is adapted to cooperate with the osmotic salt in controlling the release profile of the amantadine salt of the osmotic device; d. amantadine salt and osmotic salt have a common ion; and e.
- the amantadine salt is released according to a first order, zero order or pseudo zero order, or sigmoid controlled release profile, optionally where the release of the amantadine salt is delayed for a period of time, when the osmotic device is exposed to an environment of aqueous use.
- amantadine salt is amantadine hydrochloride; an inorganic salt, or an acidic mineral salt.
- the osmotic salt is a halide metal, an alkali metal halide, or sodium chloride.
- the common ion may be chloride ion, for example, among other ions.
- the weight ratio of amantadine salt with osmotic salt ranges from 3: 1 to 70: 1, from 4: 1 to 30: 1, from 2: 1 to 30: 1, or from 2: 1 to 600: 1.
- the osmotic device may provide a zero order or pseudo zero order release of amantadine salt for a period of at least 4 hours, at least 8 hours, or at least 12 hours;
- the semipermeable membrane may have a permeability adapted to cooperate with the chloride of sodium in the nucleus such that the osmotic device provides a sigmoid release profile for amantadine;
- the semipermeable membrane may have permeability adapted to cooperate with the sodium chloride in the core such that the osmotic device provides a zero order or pseudo zero order release profile for amantadine;
- the semipermeable membrane may have permeability adapted to cooperate with the sodium chloride in the core such that the osmotic device provides a first order release profile for amantadine;
- the osmotic device can provide a sigmoid release profile of amantadine salt; or a combination thereof.
- the semipermeable membrane may comprise a high viscosity cellulose acetate and a low viscosity cellulose acetate;
- the semipermeable membrane comprises a weight ratio of cellulose acetate acetate of 7-10% by weight of hydroxyl groups and a viscosity of 200-280 seconds, to the total amount of cellulose acetate, from 0: 1 to 0.2: 1 , such that the osmotic device provides a zero order or pseudo zero order release profile of amantadine salt for a period of at least 4 hours;
- the semipermeable membrane comprises a weight ratio of cellulose acetate of 7-10% by weight of hydroxyl groups and a viscosity of 200-280 seconds, to the total amount of cellulose acetate, from 0.2: 1 to 1: 1, and the osmotic device provides a first order release profile of amantadine salt; or the semipermeable membrane comprises
- the osmotic device comprises an outer shell comprising a second active agent for immediate release of the drug.
- the outer cover can be a quick release cover.
- the second active drug in the fast-release outer shell can be selected from the group consisting of an antidepressant and an anxiolytic agent.
- An example includes citalopram.
- An example of anxiolytic agent is buspirone.
- some embodiments of the osmotic device further comprise a second active drug in the nucleus.
- the second active drug in the nucleus may be a different antiparkinsonian drug, for example a drug antiparkinsoniana different from aman ⁇ adina.
- the nucleus will comprise at least amantadine and the second different antiparkinsonian drug.
- the second antiparkinsonian drug in the nucleus may be ropinirole, selegiline, levodopa, carbidopa, a combination of levodopa and carbidopa, or a combination thereof. Combinations of various embodiments of the invention described herein are considered within the scope of the invention.
- FIG. 1 shows the in vitro release profiles of amantadine released from the exemplary formulations of Example 1.
- FIG. 2 and 3 show an in vitro release profile of amantadine released from the exemplary formulations of Example 2.
- FIGS. 4, 5 and 6 show other exemplary profiles for the release of amantadine in vitro.
- FIG. 7 shows the regions that correspond to the first order, zero order and sigmoid release profiles according to the limits of the amantadine hydrochloride / CINa ratio (weight / weight) and the cellulose acetate ratio of 7-10 % of hydroxyl groups and viscosity of 200-280 seconds to the total amount of cellulose acetate of the formulations of Example 2.
- FIG. 8 shows an in vitro release profile of amantadine released from the exemplary formulations Ti, T 2 and T 3 of Example 7.
- immediate release is understood as a release of an active agent into an environment for a period of seconds to no more than about 30 minutes. Once the release began and the release begins within a second to no more than about 15 minutes after administration.
- Quadick release means the release of an active agent into an environment for a period of 1 to 59 minutes or 1 minute to 3 hours once the release began and the release can begin within a few minutes after the administration or after the end of a delay period after administration.
- Controlled release means the release of an active agent into an environment for a period of approximately eight hours to approximately 12 hours, 16 hours, 18 hours, 20 hours, one day or more than one day. Controlled release may begin within a few minutes after administration or after the end of a delay period after administration.
- sustained release means the controlled release of an active agent to maintain a constant level of drug in the blood or white tissue of a subject to whom the device is administered.
- Extended release means the controlled release of an active agent from a dosage form into an environment for an extended period of time.
- extended release profile assumes the definition deeply recognized in the art of pharmaceutical sciences.
- An extended release dosage form will release drug at a substantially constant rate for an extended period of time or a substantially constant amount of drug will be released increasing for an extended period of time.
- extended release related to drug release, includes the terms “controlled release,” “prolonged release,” “sustained release,” or “slow release,” as these terms are used in the pharmaceutical sciences.
- a delayed and controlled release dosage form is one that provides a delayed release of a drug followed by a controlled release of the drug.
- Delayed release is understood as any formulation technique where the release of the active substance from the dosage form is modified to occur some time after a conventional immediate release product would. In other words, the beginning of the controlled release of the drug is delayed for an initial period of time. The delay period is usually about 5 minutes to 10 hours, or 30 minutes to 10 hours, or 1 hour to 10 hours.
- a zero order release profile characterizes the release profile of a dosage form that releases a constant amount of drug per unit of time.
- a pseudo-zero order release profile is one that approximates a zero order release profile.
- a dissolution curve shows a release profile of zero or pseudo zero order if its release rate remains constant (or relatively constant within ⁇ 10% of the average value) in the time interval 0 ⁇ a ⁇ t ⁇ b. Any profile that follows the equation:
- a sigmoid release profile characterizes the release profile of a dosage form that releases a drug in a controlled but very slow way during a first period of release, then more quickly during a second period of release and finally very slowly during a third period of release such that the release profile represents a sigmoid.
- a dissolution curve shows a sigmoid release profile within a certain time interval 0 ⁇ a ⁇ t ⁇ b if its release rate reaches a simple maximum within the range (a, b) excluding the extremes.
- a first order release profile characterizes the release profile of a dosage form that releases a percentage of a drug load per unit of time.
- a pseudo-first order release profile is one that approximates a first order release profile.
- the core ingredients may be presented as a heterogeneous mixture or a homogeneous mixture.
- a homogeneous mixture is one in which all the ingredients have been completely mixed such that the composition of the formulation is substantially the same across different portions of the core.
- the combined mixing and direct compression step of the core ingredients generally provides a homogeneous mixture.
- a heterogeneous mixture is one in which the core ingredients are divided into two or more groups that are processed separately to form two or more mixtures, at least one that contains drugs and at least one that contains osmotic salt. Mixtures are then intermingled and compressed to form the unit core.
- a heterogeneous mixture can be obtained by wet granulation, dry granulation, pelleting or combinations thereof.
- Amantadine hydrochloride is commercially available from companies such as Northeast General Pharmaceutical Factory (Shenyang, China). As used herein, the term amantadine refers to the free base or saline form of amantadine.
- Amantadine salt can be presented as an inorganic acid addition salt.
- the inorganic amantadine salt is generally a salt of mineral acid.
- the salts of hydrochloride, hydrobromide, iodhydrate, nitrate, sulfate, bisulfate or phosphate are useful.
- the hydrochloric salt of amantadine is particularly suitable for use according to the invention.
- Osmotic salt is an organic or inorganic salt, where osmotic salt and amantadine salt have a common ion.
- “Common ion” is understood to mean that amantadine salt and osmotic salt each have an ion of the same identity. It does not mean that amantadine salt and osmotic salt actually share the same ion.
- the inorganic osmotic salt is typically a halide metal, in particular an alkali metal halide or an earth halide metal, or more particularly sodium chloride.
- amantadine hydrochloride and sodium chloride have in common the chloride ion.
- the release profiles of the osmotic device in tablets of the invention will vary according to the amount of sodium chloride present in the core.
- FIG. 1 shows in vitro dissolution profiles of amantadine for the osmotic tablet device described in Example 1.
- the in vitro test was performed in a USP Type II dissolution apparatus (paddles) in 900 ml of distilled water with a fixed stirring of 50 revolutions per minute, maintained at a temperature of 37 ⁇ 0.5 ° C. Samples were studied by gas chromatography.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 0% sodium chloride in the core coated with coating formulation A are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile approximates a first order release profile.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 10% sodium chloride in the core coated with coating formulation A are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile approximates a zero order or pseudo zero order release profile.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 15% sodium chloride in the core coated with coating formulation A are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile approximates a zero order release profile.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 20% sodium chloride in the core coated with coating formulation A are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile approximates a zero order release profile.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 10% sodium chloride in the core coated with coating formulation B are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile is sigmoid, has a first phase of slow release, a subsequent phase of faster release and a final phase of slow release.
- the release profiles obtained for the six tablets (# 1 - # 6) of the osmotic devices containing 20% sodium chloride in the core coated with coating formulation B are described in The table below, which details the amount of amantadine released at the indicated time points, once the osmotic device was exposed to the liquid release medium.
- the release profile approximates that of Bl except that it has a slower initial phase of drug release that causes a delay in the second phase of drug release.
- Increasing the amount of sodium chloride in the core coated with the coating formulation A of the osmotic device in tablets of Example 1 reduces the rate of amantadine release and modifies the amantadine release profile from a first release profile. order to a zero order release profile as shown in Figure 1 (release profiles Al ClNa 0%, A2 ClNa 10%, A3 ClNa 15%, and A4 ClNa 20%).
- Increasing the amount of sodium chloride in the core coated with the coating formulation B of Example 1 reduces the rate of amantadine release and modifies the amantadine release profile by extending the delay in the beginning of the controlled release of amantadine as shows Figure 1 (release profiles Bl ClNa 10%, and B2 ClNa 20%).
- the permeability of the semipermeable membrane can be adapted to cooperate with the osmotic salt to control the release profile of the amantadine salt of the osmotic device.
- the permeability is different for the semipermeable membranes A and B.
- the composition of the semipermeable membrane B is such that the cooperation between the semipermeable membrane B and the osmotic salt initially provides a very slow controlled release of the drug for a first period of release of approximately one to three hours, followed by a faster controlled release of the drug for a second release period of approximately four to five hours, and finally another slow controlled release of the drug for a third period of eight to sixteen hours.
- membrane B influences a sigmoid release of the drug.
- composition of the semipermeable membrane A is such that the cooperation between the semipermeable membrane A and the osmotic salt provides a zero order release or release of pseudo zero order of drug for a period of approximately eight to ten hours such that substantially the entire drug It is released within approximately ten hours.
- the semipermeable membrane composition can be adapted to provide membranes that differ in permeability.
- the exemplary formulation of membrane A (Example 1) comprises about 85.7% to 98.3% of a grade 1 cellulose ester, and about 1.7% to 15.0% of a plasticizer.
- the exemplary formulation of membrane B (Example 1) comprises about 33.3% to 61.2% of a first grade 1 cellulose ester, about 33.3% to 61.2% of a second grade 2 cellulose ester, and about 1.7 % to 15.0% of a plasticizer, expressed as a percentage by weight of the coating membrane.
- the osmotic device in 300 mg amantadine hydrochloride tablets (Example 2) prepared with different amounts of sodium chloride in the core, and different amounts of two different polymers of cellulose acetate in the semipermeable membrane, provides a spectrum of profiles of release covering first order release profiles, zero order release profiles, and sigmoid release profiles (Figs. 2 and 3, the release profiles run from A to J).
- the dissolution curves from A to J were related to composition parameters using a non-linear mixing effect model of which three regions (Fig. 7) corresponding respectively to profiles of zero or pseudo zero order, first or pseudo first order and Sigmoid were defined.
- the weight ratio of the cellulose acetates in the semipermeable membrane is defined as the weight ratios of grade 1 cellulose acetate to the total weight of the cellulose acetate polymer (s) present in the membrane semipermeable, where the semipermeable membrane comprises a defined amount of cellulose acetate grade 1, plasticizer and a defined amount of cellulose acetate grade 2.
- a cellulose acetate ratio of 0.2 to 1 defines a semipermeable membrane comprising 20% by weight of cellulose acetate grade 1 and 80% by weight of cellulose acetate grade 2, based on the total weight of cellulose acetates present in the semipermeable membrane.
- a cellulose acetate weight ratio of 0: 1 defines a semipermeable membrane that comprises grade 2 cellulose acetate and plasticizer, but does not contain grade 1 cellulose acetate, this means that grade 1 cellulose acetate is excluded from the membrane , or means that 100% by weight of cellulose acetate of the membrane is grade 2.
- a weight ratio of 1: 1 defines a membrane semipermeable comprising 100% by weight of grade 1 cellulose acetate based on the total weight of cellulose acetates present in the membrane, where the membrane comprises grade 1 cellulose acetate, plasticizer and excludes grade 2 cellulose acetate. It must be highlighted that the weight of the plasticizer is not included in the calculation for the determination of the weight ratio of cellulose acetates.
- the semipermeable membrane comprises the three different grades of cellulose acetates in addition to the plasticizer.
- Combination I these provide a first order or pseudo-first order amantadine release profile for a period of at least 4 hours, at least 8 hours, or at least 12 hours.
- An osmotic device prepared with Combination I comprises a weight ratio of amantadine hydrochloride to ClNa of a range of 600: 1 to 30: 1 and a weight ratio of cellulose acetate in a range of 0.2: 1 to 1: 1 .
- the weight percentage of grade 1 cellulose acetate can vary from 20% to 100% by weight, and the weight percentage of grade 2 cellulose acetate can vary from 80% to 0% by weight, respectively, based on The total amount of cellulose acetate present in the semipermeable membrane, that is, is not based on the weight of the semipermeable membrane itself which may include other components described herein.
- An osmotic Combination II device comprises a weight ratio of amantadine hydrochloride to ClNa in a range of 600: 1 to 30: 1 and a weight ratio of cellulose acetate in a range of 0: 1 to 0.2: 1.
- the weight percentage of grade 1 cellulose acetate can vary from 0% to 20% by weight, and the weight percentage of grade 2 cellulose acetate can vary from 100% to 80% by weight, respectively, based on the total amount of cellulose acetate present in the semipermeable membrane.
- An osmotic Combination III device comprises a weight ratio of amantadine hydrochloride to ClNa ranging from 30: 1 to 2: 1 and a weight ratio of Cellulose acetate with a range of 0: 1 to 1: 1. That is, the weight percentage of grade 1 cellulose acetate can vary from 0% to 100% by weight, and the weight percentage of grade 2 cellulose acetate can vary from 100% to 0% by weight, respectively, based on the total amount of cellulose acetate present in the semipermeable membrane.
- the osmotic device has a weight ratio of amantadine hydrochloride to ClNa of 4: 1 to 30: 1
- the semipermeable membrane comprises a weight ratio of grade 1 cellulose acetate to the total amount of acetate Cellulose from 0.3: 1 to 0.7: 1
- the osmotic device provides a release profile of sigmoid amantadine hydrochloride.
- the dosage forms prepared according to certain embodiments of the present invention preferably show the following dissolution profiles when tested in a USP Type II dissolution apparatus (vanes) in 900 ml of distilled water with a fixed stirring of 50 revolutions per minute , maintained at a temperature of 37 ⁇ 0.5 ° C.
- the osmotic device of the invention may comprise a water soluble and / or erodible coating, which is inert or drug-containing.
- This coating may cover and surround the semipermeable membrane and block any preformed passage in the membrane if the passage has been formed before the coating is added.
- the water soluble and / or erodible coating will generally comprise an inert and non-toxic material that is at least partially, and optionally, substantially and completely soluble or erodible in the environment of use. The selection of appropriate materials for inert or drug-containing water soluble coatings will depend on the desired release rate of the drug from the drug-containing coating and the desired separation of drug release from the core versus the drug-containing coating. .
- a fast-dissolving coating will be soluble in the oral cavity and / or in the upper part of the GI tract, such as the stomach, duodenum, jejunum or the upper part of the small intestine.
- Example materials are disclosed in US Patent Nos. 4,576,604 issued to Guittard et al. and No. 4,673,405 granted to Guittard et al., and No. 6,004,582 granted to Faour et al. and in the text Pharmaceutical Dosage Forms: Tablets Volunte I, 2 " d Edition. (A. Lieberman. ed. 1989, Marcel Dekker, Inc.), whose relevant descriptions are incorporated herein by reference.
- the solution coating Quick will be soluble in saliva, gastric juices and acidic fluids.
- Materials that are suitable for manufacturing the water soluble and / or erodible coatings of the invention include, by way of example and without limitation, water soluble polysaccharide gums such as carrageenan, fucoidane, ghatti gum, tragacanth, arabinogalactan, pectin, and xanthan; salts of water-soluble polysaccharide gums such as sodium alginate, sodium tragacanth, and sodium gum gum; water-soluble hydroxyalkylcellulose where the alkyl group is linear or branched from 1 to 7 carbons such as hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl cellulose; Water soluble synthetic celluloses forming foils such as methylcellulose and its hydroxyalkyl methylcellulose derivatives such as methylcellulose and its hydroxyalkyl methylcellulose cellulose derivatives such as a member selected from the group consisting of hydroxyethyl methylcellulose, hydroxypropyl methylcellulose, and hydroxybut
- sheet forming materials that can be used for this purpose include polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide, a mixture of gelatin and polyvinylpyrrolidone, gelatin, glucose, saccharides, povidone, copovidone, polyvinylpyrrolidone-polyvinyl acetate copolymer.
- the water soluble coating may comprise other pharmaceutical excipients that may or may not alter the way the water soluble coating behaves. The artisan with common knowledge in the art will recognize that the aforementioned materials include film-forming polymers.
- hydroxypropyl cellulose microcrystalline cellulose (MCC, Avicel TM from FMC Corp.), polyethylene-vinyl acetate copolymer (60:40) (EVAC from Aldrich Chemical Co .), 2-hydroxyethyl methacrylate (HEMA), MMA, terpolymers of HEMA: MMA: MA synthesized in the presence of N, N'-bis (methacryloxyethoxycarbonylamino) -azobenzene, azopolymers, system Enteric time-release coating (Time Clock® from Pharmaceuticals Profiles, Ltd., UK) and calcium pectinate can be included in the water-soluble coating.
- MCC microcrystalline cellulose
- EVAC polyethylene-vinyl acetate copolymer
- HEMA 2-hydroxyethyl methacrylate
- MMA terpolymers of HEMA: MMA: MA synthesized in the presence of N, N'-bis (methacryloxyethoxycarbonylamino) -azobenzene
- the inert water-soluble and / or erodible coating that covers the semipermeable wall and blocks the passage is made of synthetic or natural materials, which through selective dissolution or erosion, will allow the passage to be unlocked allowing, in this way, that Start the osmotic release process.
- This slow or fast dissolving water soluble coating can be impermeable to a first external fluid, while soluble to a second external fluid. This property can help achieve a controlled and selective release of the active core compound.
- the water soluble and / or erodible inert coating will be insoluble in the fluid of a first use environment, such as gastric juices, acidic fluids or polar liquids, and will be soluble or erodible in the second environment fluid of use, such as intestinal juices, substantially neutral pH fluids or basic fluids, or apolar fluids.
- a first use environment such as gastric juices, acidic fluids or polar liquids
- the second environment fluid of use such as intestinal juices, substantially neutral pH fluids or basic fluids, or apolar fluids.
- a wide variety of other polymeric materials are known to possess these different solubility properties and can be included in the water soluble coating.
- polymeric materials include, by way of example and without limitation, cellulose acetate phthalate (CAP), cellulose acetate trimelllet (CAT), polyvinyl acetate phthalate (PVAP), hydroxypropyl methylcellulose phthalate (HP), polymethyl acrylate ethylacrylate copolymer ( 1: 1) (MA-EA), polymethacrylate methyl methacrylate copolymer (1: 1) (MA-MMA), polymethacrylate methyl methacrylate copolymer (1: 2), Eudragit TM L-30-D (MA-EA, 1: 1 ), Eudragit TM L- 100-55 (MA-EA, 1: 1), hydroxypropylmethylcellulose acetate succinate (HPMCAS), Coateric TM (PVAP), Aquateric TM (CAP), AQOAT TM (HPMCAS) and combinations thereof.
- the water soluble coating may also comprise dissolution aids, stability modifiers and bioabsorption improvers.
- An optional polymeric material for use in the water soluble and / or erodible inert coating includes enteric materials that resist the action of gastric fluids preventing permeation through the semipermeable wall while one or more of the materials in the core are solubilized in the intestinal tract thereby allowing the release of the drug from the nucleus by osmotic pumping.
- enteric materials that resist the action of gastric fluids preventing permeation through the semipermeable wall while one or more of the materials in the core are solubilized in the intestinal tract thereby allowing the release of the drug from the nucleus by osmotic pumping.
- a material that easily adapts to this type of requirements is the polyvinylpyrrolidone-vinyl acetate copolymer, like the material provided by BASF under its brand Registered Kollidon VA64, mixed with magnesium stearate and other similar excipients.
- the water soluble and / or erodible coating may also comprise povidone, provided by BASF under its trademark Kollidon K 30, and hydroxypropyl methylcellulose, provided by Dow under its trademark Methocel E-15.
- the materials can be prepared in solutions with different concentrations of polymers according to the desired viscosity of the solution. For example, 10% P / V of Kollidon TM K 30 aqueous solution has a viscosity of approximately 5.5-8.5 cps at 2O 0 C, and 2% P / V of Methocel TM E- aqueous solution 15 has a viscosity of approximately 13-18 cps at 2O 0 C.
- the inert water soluble and / or erodible coating may also comprise other suitable materials that are substantially resistant to gastric juices and which will promote enteric or colonic release.
- the water-soluble and / or erodible inert coating may comprise one or more materials that do not dissolve, disintegrate or change their structure in the stomach and during the period of time that the osmotic device resides in the stomach.
- Some representative materials that maintain their integrity in the stomach may comprise a member selected from the group consisting of (a) keratin, keratin sandarac-tolu, salol (phenyl salicylate), salol beta-naphthylbenzoate and acetotanin, salol with balsam from Peru, salol with tolu, salol with chewing gum, salol and stearic acid and lacquered salol; (b) a member selected from the group consisting of formolated protein, formolated gelatin and crosslinked formolated gelatin and exchange resins; (c) a member selected from the group consisting of myristic acid - hydrogenated castor oil - cholesterol, stearic acid - sheep fat, stearic acid - tolu balm, and stearic acid - castor oil; (d) a member selected from the group consisting of lacquer, ammonia lacquer, ammonia lacquer - salo
- the semipermeable membrane of the osmotic device is formed by a material that is substantially permeable to the passage of fluid from the environment of use to the core and substantially impermeable to the passage of the active agent from the nucleus.
- Many common materials are used for this purpose, capable of forming a semipermeable membrane, known to those with common knowledge in the art of pharmaceutical sciences. Some examples of such materials are cellulose esters, cellulose ethers and cellulose ether esters.
- a semipermeable membrane comprising cellulose acetate (AC) and polyethylene glycol (PEG), in particular PEG 400, works well in combination with the other materials required in the present osmotic device.
- This particular combination of AC and PEG provides a semipermeable membrane that gives the osmotic device a good controlled release profile for the active core agent and that retains its chemical and physical integrity in the environment of use.
- the speed of AC: PEG is generally between about 50 and 99% by weight of AC and about between 50 and 1% by weight of PEG, and about 95% by weight of AC and about 5% by weight of PEG This relationship can be modified to alter the permeability and consequently the release profile of the osmotic device.
- Other suitable materials may include a member selected from the group of acylated celluloses such as cellulose acetate, cellulose diacetate, cellulose triacetate and combinations thereof. Many suitable polymers include those described in Argentine Patent No. 199,301, US Patent No.
- Representative materials include a member of the group consisting of cellulose acylate, cellulose diacylate, cellulose triaclate, cellulose acetate, cellulose diacetate, cellulose triacetate, mono, di and tricellulose alkalinates, mono, di and aroylates tricelluloses, and the like.
- polymers include cellulose acetates with a degree of substitution (GS) of up to 1 and an acetyl content of up to 21%; cellulose acetate with an acetyl content of 32 to 39.8%; cellulose diacetate with a GS between 1 and 2 and an acetyl content of 21 to 35%; cellulose triacetate with a GS of between 2 and 3 and an acetyl content of 35 to 44.8%; and the like
- the most specific cellulosic polymers include cellulose propionate with a GS of 1.8 and a propionyl content of between 39.2 and 45% and a hydroxyl content of between 2.8 and 5.4%; cellulose acetate butyrate with a GS of 1.8, an acetyl content between 13 and 15% and a butyryl content between 34 and 39%, cellulose acetate butyrate with an acetyl content between 2 and 29%, a butyryl content of between 17 and 53% and a hydroxy
- Some additional semipermeable polymers are acetaldehyde dimethylacetate, ethyl cellulose acetate, cellulose acetate phthalate for use in low pH environments, methylcarbamate cellulose acetate, dimethylaminoacetate cellulose acetate, semipermeable polyamides, semipermeable polyurethanes, semi-permeable sulfonated semi-permeable polystyrenes semipermeable formed by coprecipitation of a polyanion and a polycation as described in US Patents No. 3,173,876, No. 3,276,586, No. 3,541,005, No. 3,541,006 and No.
- Cellulose esters differ in the length of the cellulose chain and in the type and quantity of the ester groups attached to the chain.
- the permeability decreases.
- Grade 1 cellulose acetate comprises 7-10% by weight of hydroxyl groups and has a viscosity of 200 to 280 seconds determined by ASTM method D1343 (American Society for Testing and Materials).
- Grade 2 cellulose acetate comprises 3-5% by weight of hydroxyl groups and has a viscosity of 6.0 to 45.0 seconds.
- cellulose acetate grades that are suitable for use in the preparation of the semipermeable membrane are described in the following table, which is included by way of example.
- Cellulose acetates of different grades are available from Eastman Chemical Company (Kingston, TN, USA).
- Plasticizers can also be included in the present device to modify the properties and characteristics of the polymers used in the layers or core of the device.
- the term "plasticizer” includes all compounds capable of plasticizing or softening a polymer or binder used in the invention.
- the plasticizer should be able to lower the mixing temperature or the glass transition temperature (softening point temperature) of the polymer or binder.
- Plasticizers such as low molecular weight PEG, generally extend the average molecular weight of the polymer in which they have been included, thus lowering their glass transition temperature or softening point temperature. Plasticizers also generally reduce the viscosity of a polymer. It is possible that the plasticizer endows the osmotic device of the invention with certain advantageous physical properties.
- Plasticizers useful in the invention may include, by way of example and without limitation, low molecular weight polymers, oligomers, copolymers, oils, small organic molecules, low molecular weight polyols with aliphatic hydroxyls, ester plasticizers, glycol ethers , polypropylene glycol, multiple block polymers, single block polymers, low molecular weight polyethylene glycol, citrate ester plasticizers, triacetin, propylene glycol and glycerin.
- plasticizers may also include ethylene glycol, 1,2-butylene glycol, 2,3-butylene glycol, styrenglycol, diethylene glycol, triethylene glycol, tetraethylene glycol and other polyethylene glycol compounds, monopropylene glycol monoisopropyl ether, diethylene glycol monoethylene glycol ether, ethylene glycol monoethylene glycol ether, monoethyl, sorbitol lactate, ethyl lactate, butyl lactate, ethyl glycolate, dibutyl sebacate, acetyltributyl citrate, triethyl citrate, acetyl triethyl citrate, tributyl citrate and allyl glycolate.
- plasticizers are commercially available from suppliers such as Aldrich or Sigma Chemical Co. It has also been contemplated and it is within the scope of the invention that a combination of plasticizers be used in the present formulation.
- PEG-based plasticizers are commercially available or can be obtained through a variety of methods, such as those described in Poly (ethylene glycol) Chemistry: Biotechnical and Biomedical Applications (JM Harris, Ed .; Plenum Press, NY), whose content It is incorporated here as a reference.
- An alternative embodiment of the invention includes wall pore formers to form additional passages over time.
- the release of an active agent from the core can be delayed so that the release profile of the active agent will show a delayed and then controlled release.
- Such a device would be referred to as a delayed controlled release device.
- the osmotic device of the invention comprises at least one passage (pore, hole or opening) that communicates the exterior of the semipermeable wall with the core of the device.
- the passage can be made according to any of the known methods of forming passages in a semipermeable membrane. Such methods include, for example, 1) drilling a hole through the semipermeable membrane with a wick or laser, 2) including a water soluble material within the composition that forms the semipermeable membrane such that when the osmotic device in an aqueous environment a pore is formed, 3) pierce the semipermeable membrane with a punch, or 4) pierce the semipermeable sheet with a tablet punch with a needle tip.
- the passage can pass through the semipermeable wall and one or more of the other sheets that cover the semipermeable membrane or be located between the semipermeable membrane and the core.
- the passage or the passages can be given the desired shape.
- the passage is laser drilled and oval, elliptical, grooved, grooved, cross or circle.
- the preformed passage in the wall is generally performed by mechanical means, such as laser drilling or drilling, or any other similar method known to those with common knowledge in the art.
- the passage is usually formed by controlled laser drilling, using an apparatus similar to that described in Theeuwes et al. '864, whose entire description is incorporated herein by reference. Specific embodiments of the controlled laser drilling method will vary according to the equipment used.
- Theeuwes et al. '864 can be modified as described herein to prepare osmotic devices according to the invention. Other appropriate laser equipment, and methods of use thereof, are described in Emerton et al.
- a preformed passage can be made to substantially maintain its size during the use of the device or it can be made to increase its size during use of the dosage form.
- Pre-urinated passages of different sizes, shapes and functions can be used.
- the preformed passage in the wall may dissolve or tear in a predetermined or random manner, and the shape of the preformed passage after enlargement may be such that it resembles a predetermined or random form.
- the limit to which The passage increases in size may be related to the viscosity, molecular weight or degree of substitution of at least one excipient. Generally, increasing the viscosity, molecular weight or degree of substitution of at least one excipient will increase the limit to which the passage may increase in size.
- a device according to the present invention may comprise one or more preformed passages including two, three, four, five, six, seven, eight, nine, ten or more preformed passages. It is only necessary that the preformed passages together be adapted to allow controlled release of the ingredients from the core during use.
- the membrane comprises a preformed passage whose diameter is between 0.2 and 0.8 mm. In other embodiments, the total area of the preformed passage (s) present in the membrane is between 0.12 mm 2 and 2.1 mm 2 .
- the core of the osmotic device of the present invention will comprise an active agent and an osmotic agent and may also comprise many other materials described herein.
- the amount of active agent present may vary as described above for the external coating. Generally, the active agent will be present in an amount that is in the range of 0.1-99.9% by weight of the uncoated core. The specific ranges will vary depending on the active agent used and the intention to use the osmotic device.
- the osmotic device of the invention may comprise effectively osmotic solutes or osmotic agents, that is osmoagents, which are capable of being totally or partially solubilized in the fluid. These osmoagents will help in the dissolution or suspension of amantadine from the nucleus.
- Osmoagents include, for example, organic and inorganic compounds such as salts, acids, bases, chelating agents, sodium chloride, lithium chloride, magnesium chloride, magnesium sulfate, lithium sulfate, potassium chloride, sodium sulphite.
- One or more osmopolymers can also be incorporated into the core of the device to aid in the release of the active agent.
- Osmopolymers are well known to those with common knowledge in the art of osmotic devices and are well described in patents and scientific literature. Examples of osmopolymers include hydrophilic polymers that swell in contact with water. The osmopolymers can be of vegetable or animal origin, or synthetic.
- osmopolymers include: poly (hydroxy-alkyl) methacrylates with molecular weight of 30,000 to 5,000,000, polyvinylpyrrolidone with molecular weight of 10,000 to 360,000, ammonium and cationic hydrogels, polyelectrolyte complexes, polyvinyl alcohol with low acetate residue, optionally cross-linked with glyoxal, formaldehyde or glutaraldehyde with a degree of polymerization of 200 to 30,000, a mixture of methylcellulose, cross agar and carboxymethylcellulose, a mixture of hydroxypropylmethylcellulose and sodium carboxymethylcellulose, polymers of N-vinu lactams, polyoxyethylene-polyoxypropylene gels polyoxybutylene-polyethylene block copolymers, carob rubber, polyacrylic gels, polyester gels, polyurea gels, polyether gels, polyamide gels, polypeptide gels, polyamino acid gels, polycellulosic acid
- Osmopolymers generally swell or expand to a very large extent, generally showing an increase in volume from 2 to 60 times. Osmopolymers can be non-crossed or crossed.
- the swellable hydrophilic polymers are, in one embodiment, slightly crossed, like the crusaders formed by covalent or ionic bonds.
- the osmotic device of the invention may also comprise an adsorbent, antioxidant, buffering agent, coloring agent, flavoring agent, sweetening, non-sticking agent, binding agent, diluent, excipient for direct compression, disintegrating, sliding, lubricating, opaque and / or polishing agent.
- the term "adsorbent” refers to those agents capable of maintaining other molecules on their surface by physical or chemical means (chemo-absorption). Such compounds include, by way of example and without limitation, powdered carbon and activated carbon and other materials known to those with common knowledge in the art.
- antioxidant refers to those agents that inhibit oxidation and serve to prevent the deterioration of preparations by oxidative process.
- Such compounds include, by way of example and without limitation, ascorbic acid, ascorbyl palmitate, hydroxybutyl anisole, hydroxybutyl toluene, hypophosphorous acid, monothioglycerol, propylgalate, sodium ascorbate, sodium bisulfite, sodium formaldehyde sulfoxylate, sodium metabisulfite and others Materials known to those with common knowledge in art.
- buffer agent refers to a compound used to resist pH change when there is dilution or addition of acids or alkali.
- Such compounds include, by way of example and without limitation, potassium metaphosphate, potassium phosphate, monobasic sodium acetate and anhydrous sodium dihydrate and dihydrate and other materials known to those of ordinary skill in the art.
- sweetening agent refers to a compound used to impart sweet taste to a preparation.
- Such compounds include, by way of example and without limitation, aspartame, dextrose, glycerin, mannitol, sodium saccharin, sorbitol and sucrose and other materials known to those with common knowledge in the art.
- non-stick refers to an agent that prevents the adhesion of the ingredients of the formulation to the punches and molds in a tablet manufacturing machine during the production process.
- Such compounds include, by way of example and without limitation, magnesium stearate, talc, calcium stearate, glycerylbehenate, PEG, hydrogenated vegetable oil, mineral oil, stearic acid and other materials known to those with common knowledge in the art.
- binder refers to a substance used to cause adhesion of the dust particles in the granulation of the tablet.
- Such compounds include, by way of example and without limitation, acacia, alginic acid, sodium carboxymethylcellulose, polyvinyl pyrrolidone, compressible sugar (for example NuTab TM), ethyl cellulose, gelatin, liquid glucose, methylcellulose, povidone and pregelatinized starch and other materials known to those with common knowledge in art.
- a binder can also be included in this device.
- binders include acacia, tragacanth, gelatin, starch, cellulose materials such as methylcellulose and sodium carboxymethylcellulose, alginic acids and salts thereof, polyethylene glycol, guar gum, polysaccharides, bentonites, sugars, invert sugars, poloxamers TM (PLURONIC TM 68) , PLURONIC TM F127), collagen, albumin, gelatin, non-aqueous cellulosic solvents, combinations thereof and others known to those with knowledge.
- Other binders include, for example, polypropylene glycol, polyoxyethylene-polypropylene copolymer, polyethylene ester, polyethylene sorbitan ester, polyethylene oxide, combinations thereof and other materials known to those with common knowledge in the art.
- the term "diluent” or “filler” refers to an inert substance used as a filler material to create the desired filler mass, fluidity properties and compression characteristics in the preparation of tablets and capsules.
- Such compounds include, by way of example and without limitation, calcium dibasic phosphate, kaolin, lactose, sucrose, mannitol, microcrystalline cellulose, powdered cellulose, precipitated calcium carbonate, sorbitol, and starch and other materials known to those with knowledge common in art.
- direct compression excipient refers to a compound used in the direct compression of tablet formulations.
- Such compounds include, by way of example and without limitation, calcium dibasic phosphate (for example Ditab) and other materials known to those with common knowledge in the art.
- sliding refers to agents used in capsule and tablet formulations to promote the fluidity of granulation. These compounds include, by way of example and without limitation, colloidal silica, corn starch, talcum, calcium silicate, magnesium silicate, colloidal silicon, silicon hydrogel and other materials known to those with common knowledge in the art.
- lubricant designates substances that are used in tablet formulations to reduce friction during tablet compression. These compounds include, by way of example and without limitation, calcium stearate, magnesium stearate, mineral oil, stearic acid, and zinc stearate and other materials known to those with common knowledge in the art.
- the term "opaquent” refers to a compound used to coat a tablet or capsule with an opaque coating. It can be used in isolation or in combination with a dye. These compounds include, by way of example and without limitation, titanium dioxide and other materials known to those with common knowledge in the art.
- polishing agent refers to a compound used to provide coated tablets with an attractive gloss. These compounds include, by way of example and without being limiting, carnauba wax, white wax, and other materials known to those with common knowledge in the art.
- disintegrant refers to a compound used in solid dosage forms to promote the disintegration of the solid mass into small particles that are more easily dispersible or dissolved.
- disintegrants include, by way of example and without limitation, starches such as corn starch, potato starch, and pre-gelatinized and modified starches thereof, sweeteners, clays, such as bentonite, microcrystalline cellulose (e.g. .
- ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
- These compounds include, by way of example and without limitation, FD&C Red N ° 3, FD&C Red N 0 20, FD&C Yellow N ° 6, FD&C Blue N 0 2, D&C Green N 0 5, D&C Orange N 0 5, D&C Red N 0 8, caramel, ferric oxide, red, other FD&C dyes and other natural dyes such as grapefruit extract, red beet powder, beta carotene, bijol, carmine, turmeric, paprika, and other materials known to those with common knowledge in art
- the amount of coloring agent used may vary as desired.
- the term "flavoring” refers to a compound used to give a flavor and, sometimes, a pleasant aroma, to a pharmaceutical preparation.
- flavoring agents include synthetic flavoring and aromatic flavoring oils and / or natural oils, plant extracts, leaves, flowers, fruits and other combinations thereof. These may also include cinnamon oil, pyrol oil, peppermint oil, clove oil, bay oil, aniseed oil, eucalyptus, thyme oil, cedar leaf oil, nutmeg oil, sage oil, oil of bitter almonds and cassia oil.
- Other useful flavors include vanilla, citrus oils, including lemon, orange, grape, lime and grapefruit, and fruit essences, including apple, pear, peach, strawberry, raspberry, cherry, plum, pineapple, damask, and so on. Flavors that have proven to be particularly useful include commercially available orange, grape, cherry and chewing gum and mixtures thereof. The amount of flavoring may depend on a number of factors, including the desired organoleptic effect. The flavors will be present in the amount desired by those with common knowledge in art. Particularly preferred flavors are grape and cherry and citrus flavors such as orange.
- the present device may also employ one or more known active surfactants or cosolvents that improve wetting or disintegration of the core or layers of the osmotic device.
- the osmotic device of the invention may also include oils, for example, non-volatile oils such as peanut oil, sesame oil, cottonseed oil, corn oil and olive oil; fatty acids such as oleic acid, stearic acid and isostearic acid; and esters of fatty acids such as ethyl oleate, isopropyl myristate, fatty acid glycerides and fatty acid glycerides acetylated They can also be mixed with alcohols such as ethanol, isopropanol, hexadecyl alcohol, glycerol and propylene glycol; with glycerol ketals such as 2,2-dimethyl-l, 3-dioxolane-4-methanol; with ethers such as polyethylene glycol 450, with petroleum hydrocarbons such as mineral oil and petrolatum; with water or mixtures thereof; with or without the addition of an appropriate pharmaceutical surfactant, a suspending agent or an oil.
- Soaps and synthetic detergents can be used as surfactants and as vehicles for detergent preparations.
- Suitable soaps include alkali metal fatty acids, ammonia and triethanolamine salts.
- Suitable detergents include cationic detergents, for example dimethyl dialkyl ammonium halides, alkyl pyridinium halides and alkylamine acetates; anionic detergents, for example alkyl, aryl and olefin sulfonates, alkyl sulfates, olefins, ethers and monoglycerides and sulfosuccinates; non-ionic detergents, for example, oxides of aminated fats, alkanolamide fatty acids and polyoxyethylene-block-polypropylene copolymer; amphoteric detergents, for example beta-aminopropionate alkyl and quaternary ammonium salts of 2- alkylamidazoline; and their mixtures.
- glyceryl monostearate nylon, cellulose acetate butyrate, d, acid 1-polylactic, 1,6-hexanediamine, diethylenetriamine, starches, derived starches, acetylated monoglycerides, gelatin coacervate, polystyrene-maleic acid copolymer, glycerol, castor wax, stearyl alcohol, glyceryl palmostearate, polyethylene, polyvinyl acetate polyvinyl chloride, 1,3-butylene glycol methacrylate, ethylene glycol dimethacrylate and methacrylate hydrogels.
- phrases "pharmaceutically acceptable” is used herein to refer to those compounds, materials, compositions, and / or dosage forms that, within the scope of medical judgment, are suitable for use in contact with the tissues of the Humans and animals without causing excessive toxicity, irritation, allergic response, or other problem or complication, commensurable in a reasonable risk / benefit ratio.
- the amount of therapeutic compound incorporated in each device will be at least one or more dose units and can be selected according to the known pharmacy principles.
- An effective amount of the therapeutic compound is specifically contemplated. With the term "effective amount”, it is understood that, with respect to, for example, pharmaceutical drugs, a pharmaceutically effective amount is contemplated.
- a pharmaceutically effective amount is the amount of drug or pharmaceutically active substance that is sufficient to elicit the required or desired therapeutic response, in other words, the amount that is sufficient to elicit an appreciable biological response when administered to a patient.
- unit of the dosage form is used herein to mean a device that contains an amount of the therapeutic compound, such that said amount is such that one or more predetermined units may be provided as a single therapeutic administration.
- the device of the invention can be prepared according to the methods described herein or according to methods known in the art.
- the active agent and the excipients that form the core can be mixed in solid, semi-solid or gelatinous form, then moistened and sieved through specific meshes to obtain a granulate.
- the granulate is then dried in a dryer and compressed, for example, with punches to form the uncoated cores.
- Compressed and uncoated cores are then coated with a solution of appropriate materials that will form the wall.
- the wall surrounding each core is perforated with, for example, a laser device to form the preformed passage in the manner previously described.
- an external drug container cover When an external drug container cover is needed, it can be applied to cover the wall as a sprayed coating or a compression coating.
- the device of the invention can be coated with a final coating as is generally done in the art to provide the desired brightness, color, taste and other aesthetic characteristics. Appropriate materials for the preparation of the final coating are well known in the art and are found in the descriptions of many of the references cited and incorporated herein by reference.
- the dosage form of the invention is used in various methods to treat diseases, disorders and / or symptoms that respond to amantadine therapy.
- Symptoms, disorders and / or diseases that respond to amantadine therapy include, but are not limited to, Parkinson's disease, drug-induced extrapyramidal reactions, and signs and symptoms of infections caused by several strains of influenza A virus, especially in high-risk patients such as those in critical public service positions, immunosuppressed patients, nursery staff, in contact with high-risk patients, and those with severe influenza A virus infection.
- the dosage form of the invention is also used in various methods of treating diseases, disorders and / or symptoms that respond to a combination of amantadine and a second drug.
- the invention includes an osmotic device for the combined administration of amantadine in a controlled release manner and an antidepressant in an immediate or rapid release manner, for example, the combination of amantadine and citalopram (Example 3), or fmoxetine, paroxetine, sertraline , fluvoxamine or escitalopram.
- the invention also includes an osmotic device for the combined administration of amantadine in the form of controlled release and an anxiolytic agent in the form of rapid or immediate release, for example, amantadine and buspirone (Example 4) or trazodone, for the reduction of tremor, akinesia.
- the invention also includes an osmotic device for the combined administration of amantadine and a second antiparkinsonian drug in the form of controlled release from the nucleus, for example, amantadine and ropinirole, or selegiline, or levodopa-carbidopa.
- antiparkinsonian drug refers to a drug known in the art for use in the treatment of Parkinson's disease.
- amantadine osmotic device will provide a method for the treatment or prevention of a disorder, disease or symptom that responds to amantadine therapy, where there will be a lower incidence of adverse events compared to a form of immediate release dosage of amantadine.
- Example 5 Three osmotic controlled release formulations of amantadine (T 1 , T 2 and
- the osmotic formulation T 1 controlled release of amantadine contains less than 6% of NaCl w / w, based on the weight of the uncoated core, and more than 25% w / w grade 1 cellulose acetate having 7-10 % of hydroxyl groups and viscosity of 200-280 seconds, based on the weight of the membrane.
- the osmotic formulation T 2 controlled release of amantadine contains more than 6% ClNa w / w, based on the weight of the uncoated core, and more than 25% grade 1 cellulose acetate that has 7-10% groups hydroxyls and viscosity of 200 - 280 seconds, based on the weight of the membrane.
- the osmotic formulation T 3 controlled release of amantadine contains more than 6% ClNa w / w, based on the weight of the uncoated core, and less of 25% grade 1 cellulose acetate having 7-10% hydroxyl groups and viscosity of 200-280 seconds, based on the weight of the membrane.
- the randomized 4-way cross design revealed in Example 8 was used to compare the relative bioavailability (degree of absorption) of three osmotic formulations of amantadine T 1 , T 2 and T 3 and a conventional immediate release tablet (Symmetrel® by Endo Pharmceuticals Inc.) under fasting conditions as the reference.
- the average values of amantadine pharmacokinetic parameters are shown in the following table.
- the bioavailability of amantadine released from the osmotic device formulations Ti, T 2 and T 3 vary according to the composition of the formulation. Bioavailability decreases in the following order: Ti> T 2 > T 3 . On the other hand, T 2 and T 3 resulted in an average of bioavailability below the required minimum of 80% compared to the reference. Ti provided a bioavailability of approximately 87%, compared to the reference.
- the invention also provides a method for varying the bioavailability of amantadine released from an osmotic device comprising a core comprising the amantadine salt and a salt having a common ion and a semipermeable membrane surrounding the core and having a preformed opening, the The method comprises varying the weight ratio of amantadine salt to the osmotic salt in the core and varying the percentage of the weight of grade 1 cellulose acetate to the total weight of cellulose acetates present in the semipermeable membrane, in wherein the semipermeable membrane comprises grade 1 cellulose acetate, grade 2 cellulose acetate, and plasticizer.
- EXAMPLE 1 The osmotic device in 200 mg amantadine hydrochloride tablets comprising coating A, and 0, 10, 15 and 20% sodium chloride in the core, and the osmotic device in 200 mg amantadine hydrochloride tablets which Coating B and 10 and 20% sodium chloride in the core were manufactured using the following general method.
- Amantadine hydrochloride 200 mg
- a diluent 70 - 200 mg
- a binder 18 - 30 mg
- Amantadine hydrochloride 200 mg
- a diluent 70 - 200 mg
- a binder 18 - 30 mg
- Amantadine hydrochloride 200 mg
- a diluent 70 - 200 mg
- a binder 18 - 30 mg
- the wet granulate was screened in a Quadro Cornil at a speed below 1000 rpm, and then dried in a static bed at 50 ° C for moisture reduction. The dried granules were then ground using a Quadro Cornil with a R991 ⁇ mesh at less than 2000 rpm for size reduction. Then, a mixture of slider (0.2-5 mg) and a lubricant (1-7 mg), previously screened through a 100 mesh, was added and mixed for approximately 15 minutes. Mix The resulting was compressed in a compressor with punches 8.0 mm in diameter to form the uncoated cores. The average weight of the uncoated cores was approximately 300 to 500 mg.
- coating composition A containing a cellulose ester (18.0-29.0 mg) and a low molecular weight plasticizer (0.5-3 mg) in a mixture of acetone and purified water
- coating composition B It contains a mixture of two different cellulose esters (9.0 - 15.0 mg of each cellulose ester) and a low molecular weight plasticizer (0.5 - 3 mg) in a mixture of acetone and purified water.
- Part of the resulting uncoated cores containing 0, 5, 10 and 20% sodium chloride were coated with the coating composition A, and the rest of the cores containing 10 and 20% sodium chloride were coated with the coating composition B.
- the coating membrane weighed approximately between 9.5 and 32.0 mg.
- the coating membrane of each core was then perforated with a laser device to form at least a 0.2-0.8 mm passage through the semipermeable coating.
- the binder is selected from the group consisting of polyvinylpyrrolidone, povidone, sodium carboxymethylcellulose, alginic acid, polyethylene glycol, guar gum, polysaccharides, bentonite clay, sugar, poloxamer, collagen, albumin, gelatin, polypropylene glycol;
- the cellulose ester is selected from the group consisting of cellulose acetate, cellulose acylate, cellulose fatty acid ester, and cellulose acetate phthalate;
- the plasticizer is selected from the group consisting of polyethylene glycol, low molecular weight polymer, citrate ester, triacetin, propylene glycol, glycerin, sorbitol lactate, ethyl lactate, butyl lactate, ethyl glycolate, and dibutyl seb;
- the lubricant is selected from the group consisting of calcium stearate, magnesium stearate, mineral oil, stearic acid, and zinc stearate
- Osmotic devices in 300 mg amantadine hydrochloride tablets were manufactured as described herein.
- Osmotic tablets contain the following ingredients in the amounts indicated:
- Amantadine hydrochloride 300 mg
- diluent 1 (20 - 110 mg
- diluent 2 (20 - 60 mg
- a binder (15 - 30 mg)
- an osmopolymer (0 - 45 mg) were first individually screened to unify the size using a Quadro Cornil at less than 500 rpm, and then mixed with sodium chloride (0 - 150 mg) previously ground using a Fitz Mili mill with a mesh of 0020 - 0069 at less than 8000 rpm, in a granulation mixer for up to 5 minutes to form a homogeneous powder mixture.
- the granulation process is initiated by gradually adding purified water to the powder mixture, with continuous mixing, to change the consistency of the dry powder ingredients to granules.
- the wet granulate was screened in a Quadro Cornil at a speed below 500 rpm, and then dried in a static bed at 50 ° C for moisture reduction.
- the dried granules were then ground using a Quadro Cornil with a R991 ⁇ mesh at less than 2000 rpm for size reduction.
- a mixture of slider (0.2-5 mg) and a lubricant (1-7 mg) previously screened through a 60 mesh, was added and mixed for approximately 5 minutes.
- the resulting mixture was compressed in a compressor with punches 10-12 mm in diameter to form the uncoated cores.
- the average weight of the uncoated cores was approximately 300 to 500 mg.
- a coating composition was prepared as follows: cellulose ester 1 (O-50 mg), cellulose ester 2 (0-50 mg) and a low molecular weight plasticizer (0.5-3 mg) were mixed in acetone and purified water. The mixture was sprayed on the uncoated cores to obtain coated cores. The membrane coating weighed approximately between 2.5 and 80.0 mg. The coating membrane of each core was then perforated with laser equipment to form at least a 0.2-0.8 mm passage through the semipermeable coating.
- the binder is selected from the group consisting of polyvinylpyrrolidone, povidone, copolividone, sodium carboxymethylcellulose, alginic acid, polyethylene glycol, guar gum, polysaccharides, bentonite clay, sugar, poloxamer, collagen, albumin, gelatin, polypropylene oxide and polypropylene oxide of polyethylene;
- the cellulose ester is selected from the group consisting of cellulose acetate, cellulose acylate, cellulose fatty acid ester, and cellulose acetate phthalate;
- the plasticizer is selected from the group consisting of polyethylene glycol, low molecular weight polymer, citrate ester, triacetin, propylene glycol, glycerin, sorbitol lactate, ethyl lactate, butyl lactate, ethyl glycolate, and dibutyl sebacate;
- the lubricant is selected from the group consisting of calcium stearate, magnesium stearate, mineral
- the osmotic devices in tablets of Examples 1 and 2 containing amantadine hydrochloride in the core are coated with a coating containing citalopram HBr (5, 10 and 20 mg) by the general procedure.
- Citalopram hydrobromide, a sheet-forming polymer, a disintegrant and a plasticizer are added to the purified water to form the coating suspension. This suspension is sprayed on the tablets in a perforated pail to obtain the drug tablets in the coating.
- a final coating comprising Opadry in purified water is applied to the coated tablets to obtain osmotic devices in amantadine controlled-release tablets and immediate release of citalopram.
- Buspirone hydrochloride a sheet-forming polymer, a disintegrant and a plasticizer are added to acetone to form the coating suspension. This suspension is sprayed on the tablets in a perforated pail to obtain the drug tablets in the coating.
- a final coating comprising Opadry in purified water is applied to the coated tablets to obtain osmotic devices in amantadine controlled-release tablets and immediate buspirone release.
- a randomized, double-blind, pharmacokinetic-pharmacodynamic, double-blind, placebo-controlled, cross-dose, pharmacokinetic study was conducted in patients with Parkinson's disease with fluctuations related to levodopa treatment. (L-Dopa).
- the objective of the study is to correlate the pharmacokinetic profiles of amantadine of each formulation at steady state and the clinical response to levodopa in patients experiencing motor fluctuations.
- Amantadine IR, CR (100, 150, 200, 250 or 300 mg) or placebo is given daily in a morning dose, for a period of at least 7 days where steady state levels are reached. No changes are made to the individual doses of levodopa / dopa decarboxylase inhibitor in patients and it is administered daily at the same time. Plasma concentrations of levodopa, its metabolites, and amantadine are measured at steady state and motor responses are quantified at periodic intervals using the motor test of the Parkinson's Unified Assessment Scale (UPDRS) and the Abnormal Movement Scale. Involuntary (AIMS).
- UPDS Parkinson's Unified Assessment Scale
- AIMS Abnormal Movement Scale. Involuntary
- a pharmacokinetic-pharmacodynamic population model is used to relate plasma concentrations of amantadine and levodopa with the clinical response.
- a dose-proportional relationship between pharmacokinetic parameters of steady state amantadine (AUC, Cmax, Cmin or% fluctuation), and any of the following predictors: UPDR scale, AIMS, pharmacokinetic parameters of levodopa and its metabolites, or incidence or severity of Adverse events are indicative of a systemic concentration-response relationship of amantadine IR or CR in patients with Parkinson's disease and significant evidence of effectiveness in improving motor fluctuations in a dose-related model or improvement in the profile of product safety
- Osmotic tablets contain the following ingredients in the amounts indicated:
- Amantadine hydrochloride, diluent 1, diluent 2 and a binder, were first individually screened to unify the size using a Quadro Cornil at less than 500 rpm, and then mixed with previously ground sodium chloride using a Fitz Mili mill with a 0020 - 0069 mesh at less than 8000 rpm, in a granulation mixer for up to 5 minutes to form a homogeneous powder mixture.
- the granulation process is initiated by gradually adding purified water to the powder mixture, with continuous mixing, to change the consistency of the dry powder ingredients to granules.
- the wet granulate was screened in a Quadro Cornil at a speed below 500 rpm, and then dried in a static bed at 50 ° C for moisture reduction. The dried granules were then ground using a Quadro Cornil with a R991 ⁇ mesh at less than 2000 rpm for size reduction. Then, a mixture of slider and a lubricant, previously screened through a 60 mesh, was added and mixed for approximately 5 minutes. The resulting mixture was compressed in a compressor with punches 7-10 mm in diameter to form the uncoated cores.
- the average weight of the nuclei of the osmotic devices in amantadine hydrochloride tablets of 100, 150 and 300 mg is 150, 225 and 450 mg respectively.
- a coating composition was prepared as follows: cellulose ester 1, cellulose ester 2 and a low molecular weight plasticizer were mixed in acetone and purified water. The mixture was sprayed on the uncoated cores to obtain coated cores. The membrane coating weighed approximately between 8 and 20 mg. The coating membrane of each core was then drilled with laser equipment to form at least a 0.2-0.8 mm passage through the semipermeable coating.
- the binder is selected from the group consisting of polyvinylpyrrolidone, povidone, copolividone, sodium carboxymethylcellulose, alginic acid, polyethylene glycol, guar gum, polysaccharides, bentonite clay, sugar, poloxamer, collagen, albumin, gelatin, polypropylene oxide and polypropylene oxide of polyethylene;
- the cellulose ester is selected from the group consisting of cellulose acetate, cellulose acylate, cellulose fatty acid ester, and cellulose acetate phthalate;
- the plasticizer is selected from the group consisting of polyethylene glycol, low molecular weight polymer, citrate ester, triacetin, propylene glycol, glycerin, sorbitol lactate, ethyl lactate, butyl lactate, ethyl glycolate, and dibutyl sebacate;
- the lubricant is selected from the group consisting of calcium stearate, magnesium stearate, mineral
- the osmotic formulation of controlled release of amantadine hydrochloride Ti contains less than 6% ClNa w / w, based on the weight of the uncoated core. , and more than 25% w / w grade 1 cellulose acetate having 7-10% hydroxyl groups and viscosity of 200-280 seconds, based on the weight of the semipermeable membrane.
- the osmotic controlled release formulation of amantadine T 2 hydrochloride contains more than 6% ClNa w / w, based on the weight of the uncoated core, and more than 25% w / w grade 1 cellulose acetate that has 7 - 10% of hydroxyl groups and viscosity of 200-280 seconds, based on the weight of the semipermeable membrane.
- the osmotic controlled release formulation of amantadine T 3 hydrochloride contains more than 6% ClNa w / w, based on the weight of the uncoated core, and less than 25% w / w grade 1 cellulose acetate that has 7 - 10% of hydroxyl groups and viscosity of 200-280 seconds, based on the weight of the semipermeable membrane.
- the average in vitro release profile obtained for 12 tablets for the Ti formulation is shown in the following table, and in Fig. 8.
- the minimum and maximum functionality represent the release profiles of the approximate upper and lower limits, respectively. , of the release of amantadine hydrochloride from a wider range of Tl formulations.
- the average in vitro release profile obtained for 12 tablets for the T 2 formulation is disclosed in the following table, and in Fig. 8.
- the minimum and maximum functionality represent the release profiles of the approximate upper and lower limits, respectively, of the release of amantadine hydrochloride from a wider range of T2 formulations.
- a randomized four-way cross design was used to compare the relative bioavailability (absorption limit) of three osmotic controlled release formulations of amantadine hydrochloride (Ti, T 2 and T 3 , 300 mg once daily) prepared according to Example 7, and a conventional immediate release tablet (Symmetrel 100 mg, tid) under fasting conditions as the reference. Twenty healthy subjects were recruited and randomly assigned to any of the 4 sequences according to the following scheme.
- Blood samples were obtained before the dose and after administration at 0.5, 1, 1.5, 2, 3, 5, 8, 8.5, 9, 9.5, 10, 11, 13, 16, 16.5, 17, 17.5 , 18, 19, 21, 24, 30, 36, 48 and 72 hours for drug content analysis. Samples from 17 of the 20 subjects (1748 samples) that completed the four periods were analyzed by GC-MS for amantadine.
- the pharmacokinetic parameters were estimated concentration-time data using WinNonlin TM Professional software, version 4.0.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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CA2589479A CA2589479C (en) | 2004-12-03 | 2005-12-02 | Osmotic device containing amantadine and an osmotic salt |
AU2005328058A AU2005328058B2 (en) | 2004-12-03 | 2005-12-02 | Osmotic device containing amantadine and an osmotic salt |
MX2007006472A MX2007006472A (es) | 2004-12-03 | 2005-12-02 | Dispositivo osmotico que contiene amantadina y una sal osmotica. |
ES05857295.9T ES2549581T3 (es) | 2004-12-03 | 2005-12-02 | Dispositivo osmótico que contiene amantadina y una sal osmótica |
JP2007543685A JP5325421B2 (ja) | 2004-12-03 | 2005-12-02 | アマンタジンおよび浸透塩を含有する浸透デバイス |
EP05857295.9A EP1834638B1 (en) | 2004-12-03 | 2005-12-02 | Osmotic device containing amantadine and an osmotic salt |
BRPI0515761-7A BRPI0515761B1 (pt) | 2004-12-03 | 2005-12-02 | dispositivo osmótico contendo amantadina e um sal osmótico |
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US63331904P | 2004-12-03 | 2004-12-03 | |
US60/633,319 | 2004-12-03 |
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WO2006089494A1 true WO2006089494A1 (es) | 2006-08-31 |
WO2006089494A9 WO2006089494A9 (es) | 2006-12-07 |
Family
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PCT/CR2005/000005 WO2006089494A1 (es) | 2004-12-03 | 2005-12-02 | Dispositivo osmótico que contiene amantadina y una sal osmótica |
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EP (2) | EP2965753A1 (es) |
JP (1) | JP5325421B2 (es) |
AR (1) | AR053986A1 (es) |
AU (1) | AU2005328058B2 (es) |
BR (1) | BRPI0515761B1 (es) |
CA (1) | CA2589479C (es) |
ES (1) | ES2549581T3 (es) |
MX (1) | MX2007006472A (es) |
WO (1) | WO2006089494A1 (es) |
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US10213394B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
US10213393B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Feleõsségû Társaság | Composition and method for treating neurological disease |
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-
2005
- 2005-12-01 AR ARP050105025A patent/AR053986A1/es not_active Application Discontinuation
- 2005-12-02 CA CA2589479A patent/CA2589479C/en active Active
- 2005-12-02 JP JP2007543685A patent/JP5325421B2/ja not_active Expired - Fee Related
- 2005-12-02 ES ES05857295.9T patent/ES2549581T3/es active Active
- 2005-12-02 WO PCT/CR2005/000005 patent/WO2006089494A1/es active Application Filing
- 2005-12-02 BR BRPI0515761-7A patent/BRPI0515761B1/pt active IP Right Grant
- 2005-12-02 EP EP15180567.8A patent/EP2965753A1/en not_active Withdrawn
- 2005-12-02 EP EP05857295.9A patent/EP1834638B1/en active Active
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Also Published As
Publication number | Publication date |
---|---|
BRPI0515761A (pt) | 2008-07-29 |
AR053986A1 (es) | 2007-05-30 |
WO2006089494A9 (es) | 2006-12-07 |
EP2965753A1 (en) | 2016-01-13 |
EP1834638B1 (en) | 2015-08-12 |
EP1834638A1 (en) | 2007-09-19 |
MX2007006472A (es) | 2007-07-13 |
BRPI0515761B1 (pt) | 2021-06-08 |
ES2549581T3 (es) | 2015-10-29 |
AU2005328058A1 (en) | 2006-08-31 |
CA2589479C (en) | 2013-01-15 |
AU2005328058B2 (en) | 2012-02-02 |
CA2589479A1 (en) | 2006-08-31 |
JP5325421B2 (ja) | 2013-10-23 |
JP2009517332A (ja) | 2009-04-30 |
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