WO2006089150A3 - Agents anti-angiogeniques comportant de l'aldesleukine - Google Patents

Agents anti-angiogeniques comportant de l'aldesleukine Download PDF

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Publication number
WO2006089150A3
WO2006089150A3 PCT/US2006/005720 US2006005720W WO2006089150A3 WO 2006089150 A3 WO2006089150 A3 WO 2006089150A3 US 2006005720 W US2006005720 W US 2006005720W WO 2006089150 A3 WO2006089150 A3 WO 2006089150A3
Authority
WO
WIPO (PCT)
Prior art keywords
aldesleukin
antiangiogenic agents
compositions
antiangiogenic
agents
Prior art date
Application number
PCT/US2006/005720
Other languages
English (en)
Other versions
WO2006089150A2 (fr
Inventor
Sharon Lea Aukerman
Kimberly Denis-Mize
Laurence Elias
Bahija Jallal
Daniel Menezes
Gary W Witherell
Original Assignee
Chiron Corp
Sharon Lea Aukerman
Kimberly Denis-Mize
Laurence Elias
Bahija Jallal
Daniel Menezes
Gary W Witherell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Sharon Lea Aukerman, Kimberly Denis-Mize, Laurence Elias, Bahija Jallal, Daniel Menezes, Gary W Witherell filed Critical Chiron Corp
Priority to CA002598448A priority Critical patent/CA2598448A1/fr
Priority to BRPI0608880-5A priority patent/BRPI0608880A2/pt
Priority to JP2007556337A priority patent/JP2008530239A/ja
Priority to AU2006214138A priority patent/AU2006214138A1/en
Priority to MX2007010037A priority patent/MX2007010037A/es
Priority to EP06735400A priority patent/EP1853302A2/fr
Publication of WO2006089150A2 publication Critical patent/WO2006089150A2/fr
Publication of WO2006089150A3 publication Critical patent/WO2006089150A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

L'invention concerne une polythérapie faisant appel à des compositions IL-2 et à des agents anti-angiogéniques pour traiter le cancer. En outre, l'invention concerne des méthodes de réduction de toxicités et d'augmentation d'efficacité associées à l'administration de compositions de IL-2 ou de compositions anti-angiogéniques.
PCT/US2006/005720 2005-02-18 2006-02-17 Agents anti-angiogeniques comportant de l'aldesleukine WO2006089150A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002598448A CA2598448A1 (fr) 2005-02-18 2006-02-17 Agents anti-angiogeniques comportant de l'aldesleukine
BRPI0608880-5A BRPI0608880A2 (pt) 2005-02-18 2006-02-17 agentes anti-angiogênicos com aldesleucina
JP2007556337A JP2008530239A (ja) 2005-02-18 2006-02-17 アルデスロイキンを含む抗血管形成性剤
AU2006214138A AU2006214138A1 (en) 2005-02-18 2006-02-17 Antiangiogenic agents with aldesleukin
MX2007010037A MX2007010037A (es) 2005-02-18 2006-02-17 Agentes antiangiogenicos con aldesleucina.
EP06735400A EP1853302A2 (fr) 2005-02-18 2006-02-17 Agents anti-angiogeniques comportant de l'aldesleukine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65434105P 2005-02-18 2005-02-18
US60/654,341 2005-02-18

Publications (2)

Publication Number Publication Date
WO2006089150A2 WO2006089150A2 (fr) 2006-08-24
WO2006089150A3 true WO2006089150A3 (fr) 2006-11-02

Family

ID=36569884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/005720 WO2006089150A2 (fr) 2005-02-18 2006-02-17 Agents anti-angiogeniques comportant de l'aldesleukine

Country Status (10)

Country Link
EP (1) EP1853302A2 (fr)
JP (1) JP2008530239A (fr)
KR (1) KR20070108909A (fr)
CN (1) CN101146549A (fr)
AU (1) AU2006214138A1 (fr)
BR (1) BRPI0608880A2 (fr)
CA (1) CA2598448A1 (fr)
MX (1) MX2007010037A (fr)
RU (1) RU2007134570A (fr)
WO (1) WO2006089150A2 (fr)

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EP2149565A1 (fr) * 2008-07-24 2010-02-03 Bayer Schering Pharma AG Dérivés de chinazoline substitués par du sulfonamide en tant que modulateurs d'immunité pour le traitement de inflammations et allergies
US9045453B2 (en) 2008-11-14 2015-06-02 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
EA020117B1 (ru) * 2008-11-14 2014-08-29 Консерт Фармасьютикалс Инк. Замещенные диоксопиперидинилфталимидные производные
PL2473487T3 (pl) 2009-09-03 2017-07-31 Bristol-Myers Squibb Company Chinazoliny jako inhibitory kanałów jonowych potasowych
WO2012079075A1 (fr) 2010-12-10 2012-06-14 Concert Pharmaceuticals, Inc. Dérivés de phtalimide deutérés
WO2013130849A1 (fr) 2012-02-29 2013-09-06 Concert Pharmaceuticals, Inc. Dérivés de phthalimide dioxopipéridinyle substitués
EP2838879A1 (fr) 2012-04-20 2015-02-25 Concert Pharmaceuticals Inc. Rigosertib deutéré
US9145411B2 (en) 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
EP2922838B1 (fr) 2012-10-22 2018-03-14 Concert Pharmaceuticals Inc. Formes solides de {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidin-3,4,4,5,5-d5)-2,6-dion}
WO2014110322A2 (fr) 2013-01-11 2014-07-17 Concert Pharmaceuticals, Inc. Dérivés substitués de dioxopipéridinyl phtalimide
WO2014127214A1 (fr) 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Composés thérapeutiques et utilisations de ceux-ci
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
AU2014219024B2 (en) 2013-02-20 2018-04-05 KALA BIO, Inc. Therapeutic compounds and uses thereof
WO2014170910A1 (fr) 2013-04-04 2014-10-23 Natco Pharma Limited Procédé de préparation du lapatinib
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
KR101478925B1 (ko) 2013-12-31 2015-01-08 아주대학교산학협력단 프로테아좀 저해제와 로페라마이드를 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물
CA3036336A1 (fr) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Formes cristallines de composes therapeutiques et leurs utilisations
BR112019004463A2 (pt) 2016-09-08 2019-05-28 Kala Pharmaceuticals Inc formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso
US10392399B2 (en) 2016-09-08 2019-08-27 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN108069913B (zh) * 2016-11-18 2022-03-01 陕西师范大学 双(吗啉基烷氧基)喹唑啉衍生物及其在抗肿瘤方面的用途
WO2020102195A1 (fr) 2018-11-13 2020-05-22 Biotheryx, Inc. Isoindolinones substituées
CN114920704B (zh) * 2019-07-26 2023-11-03 暨南大学 一种苯基哌嗪喹唑啉类化合物或其药学上可接受的盐、制法与用途
CN111499583B (zh) * 2020-05-22 2022-02-15 沈阳工业大学 喹唑啉衍生物及其作为抗肿瘤药物的应用
CN112538071A (zh) * 2020-11-30 2021-03-23 新乡医学院第一附属医院 用作raf-1抑制剂的化合物、制备方法和用途

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Also Published As

Publication number Publication date
RU2007134570A (ru) 2009-03-27
EP1853302A2 (fr) 2007-11-14
JP2008530239A (ja) 2008-08-07
KR20070108909A (ko) 2007-11-13
BRPI0608880A2 (pt) 2010-02-02
MX2007010037A (es) 2008-02-15
WO2006089150A2 (fr) 2006-08-24
CA2598448A1 (fr) 2006-08-24
CN101146549A (zh) 2008-03-19
AU2006214138A1 (en) 2006-08-24

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