WO2006087729B1 - Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel - Google Patents

Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Info

Publication number
WO2006087729B1
WO2006087729B1 PCT/IN2005/000048 IN2005000048W WO2006087729B1 WO 2006087729 B1 WO2006087729 B1 WO 2006087729B1 IN 2005000048 W IN2005000048 W IN 2005000048W WO 2006087729 B1 WO2006087729 B1 WO 2006087729B1
Authority
WO
WIPO (PCT)
Prior art keywords
clopidogrel
aliphatic
ether
methyl
base
Prior art date
Application number
PCT/IN2005/000048
Other languages
English (en)
Other versions
WO2006087729A1 (fr
Inventor
Venkatasubramanian Radha Tarur
Dhananjay Govind Sathe
Kamlesh Digambar Sawant
Harish Kashinath Mondkar
Manoj Madhukarrao Deshpande
Tushar Anil Naik
Original Assignee
Usv Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Ltd filed Critical Usv Ltd
Priority to AU2005327776A priority Critical patent/AU2005327776A1/en
Priority to PCT/IN2005/000048 priority patent/WO2006087729A1/fr
Priority to CA2567806A priority patent/CA2567806C/fr
Priority to EP05747156A priority patent/EP1848720A1/fr
Priority to US11/149,646 priority patent/US7446200B2/en
Publication of WO2006087729A1 publication Critical patent/WO2006087729A1/fr
Publication of WO2006087729B1 publication Critical patent/WO2006087729B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de résolution rapide de base clopidogrel racémique suivi par la conversion de l'isomère résolu (S) en la forme I cristalline de l'hydrogénosulfate de clopidogrel. L'invention concerne également un procédé de racémisation de l'isomère non souhaité (R) de la base de clopidogrel. L'invention concerne également un procédé amélioré de préparation de sels d'addition acides de clopidogrel.
PCT/IN2005/000048 2004-10-04 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel WO2006087729A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2005327776A AU2005327776A1 (en) 2005-02-15 2005-02-15 Rapid resolution process for clopidogrel base and a process for preparation of Clopidogrel bisulfate polymorph - Form I
PCT/IN2005/000048 WO2006087729A1 (fr) 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel
CA2567806A CA2567806C (fr) 2005-02-15 2005-02-15 Procede de resolution rapide du clopidogrel base et un procede de preparation de la forme polymorphique i du bisulfate de clopidogrel
EP05747156A EP1848720A1 (fr) 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel
US11/149,646 US7446200B2 (en) 2004-10-04 2005-06-10 Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000048 WO2006087729A1 (fr) 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Publications (2)

Publication Number Publication Date
WO2006087729A1 WO2006087729A1 (fr) 2006-08-24
WO2006087729B1 true WO2006087729B1 (fr) 2006-11-09

Family

ID=36644897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000048 WO2006087729A1 (fr) 2004-10-04 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Country Status (4)

Country Link
EP (1) EP1848720A1 (fr)
AU (1) AU2005327776A1 (fr)
CA (1) CA2567806C (fr)
WO (1) WO2006087729A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
US7985859B2 (en) 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (fr) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation de clopidogrel enrichi optiquement
WO2011042804A2 (fr) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited Procédé perfectionné pour la préparation de la forme i d'hydrogénosulfate de clopidogrel
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107383055A (zh) * 2017-08-03 2017-11-24 江苏汉斯通药业有限公司 硫酸氢氯吡格雷的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
EP1606231A1 (fr) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Procede de preparation de clopidogrel, ses sels et compositions pharmaceutiques

Also Published As

Publication number Publication date
CA2567806C (fr) 2011-04-26
CA2567806A1 (fr) 2006-08-24
EP1848720A1 (fr) 2007-10-31
WO2006087729A1 (fr) 2006-08-24
AU2005327776A1 (en) 2006-08-24

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