EP1848720A1 - Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel - Google Patents

Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Info

Publication number
EP1848720A1
EP1848720A1 EP05747156A EP05747156A EP1848720A1 EP 1848720 A1 EP1848720 A1 EP 1848720A1 EP 05747156 A EP05747156 A EP 05747156A EP 05747156 A EP05747156 A EP 05747156A EP 1848720 A1 EP1848720 A1 EP 1848720A1
Authority
EP
European Patent Office
Prior art keywords
clopidogrel
base
methyl
ether
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05747156A
Other languages
German (de)
English (en)
Inventor
Venkatasubramanian Radhakrishnan Tarur
Dhananjay Govind Sathe
Kamlesh Digambar Sawant
Harish Kashinath Mondkar
Manoj Madhukarrao Indrayani Niwas Deshpande
Tushar Anil Naik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pvt Ltd
Original Assignee
USV Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pvt Ltd filed Critical USV Pvt Ltd
Publication of EP1848720A1 publication Critical patent/EP1848720A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de résolution rapide de base clopidogrel racémique suivi par la conversion de l'isomère résolu (S) en la forme I cristalline de l'hydrogénosulfate de clopidogrel. L'invention concerne également un procédé de racémisation de l'isomère non souhaité (R) de la base de clopidogrel. L'invention concerne également un procédé amélioré de préparation de sels d'addition acides de clopidogrel.
EP05747156A 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel Withdrawn EP1848720A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000048 WO2006087729A1 (fr) 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Publications (1)

Publication Number Publication Date
EP1848720A1 true EP1848720A1 (fr) 2007-10-31

Family

ID=36644897

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05747156A Withdrawn EP1848720A1 (fr) 2005-02-15 2005-02-15 Procede de resolution rapide destine a une base de clopidogrel et procede de preparation de la forme i polymorphique de l'hydrogenosulfate de clopidogrel

Country Status (4)

Country Link
EP (1) EP1848720A1 (fr)
AU (1) AU2005327776A1 (fr)
CA (1) CA2567806C (fr)
WO (1) WO2006087729A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
WO2008146249A1 (fr) * 2007-05-30 2008-12-04 Wockhardt Research Centre Procédé d'élaboration de clopidogrel
EP2107061A1 (fr) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation de clopidogrel enrichi optiquement
WO2011042804A2 (fr) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited Procédé perfectionné pour la préparation de la forme i d'hydrogénosulfate de clopidogrel
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107383055A (zh) * 2017-08-03 2017-11-24 江苏汉斯通药业有限公司 硫酸氢氯吡格雷的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
EP1606231A1 (fr) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Procede de preparation de clopidogrel, ses sels et compositions pharmaceutiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006087729A1 *

Also Published As

Publication number Publication date
CA2567806A1 (fr) 2006-08-24
CA2567806C (fr) 2011-04-26
WO2006087729A1 (fr) 2006-08-24
AU2005327776A1 (en) 2006-08-24
WO2006087729B1 (fr) 2006-11-09

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