WO2006084642A3 - Microorganisms with a disruption of the respiratory chain gene rcs26 for the production of vitamin c - Google Patents
Microorganisms with a disruption of the respiratory chain gene rcs26 for the production of vitamin c Download PDFInfo
- Publication number
- WO2006084642A3 WO2006084642A3 PCT/EP2006/001008 EP2006001008W WO2006084642A3 WO 2006084642 A3 WO2006084642 A3 WO 2006084642A3 EP 2006001008 W EP2006001008 W EP 2006001008W WO 2006084642 A3 WO2006084642 A3 WO 2006084642A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- production
- vitamin
- microorganisms
- polynucleotides
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05405138.8 | 2005-02-11 | ||
EP05405138 | 2005-02-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006084642A2 WO2006084642A2 (en) | 2006-08-17 |
WO2006084642A3 true WO2006084642A3 (en) | 2007-04-19 |
Family
ID=36202156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/001008 WO2006084642A2 (en) | 2005-02-11 | 2006-02-06 | Microorganisms with a disruption of the respiratory chain gene rcs26 for the production of vitamin c |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006084642A2 (en) |
-
2006
- 2006-02-06 WO PCT/EP2006/001008 patent/WO2006084642A2/en not_active Application Discontinuation
Non-Patent Citations (5)
Title |
---|
DATABASE EMBL [online] 24 January 2005 (2005-01-24), "Gluconobacter oxydans 621H, complete genome.", XP002379245, retrieved from EBI accession no. EM_PRO:CP000009 Database accession no. CP000009 * |
DEPPENMEIER U ET AL: "Biochemistry and biotechnological applications of Gluconobacter strains", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 60, no. 3, November 2002 (2002-11-01), pages 233 - 242, XP002334995, ISSN: 0175-7598 * |
MACAULEY S ET AL: "THE GENUS GLUCONOBACTER AND ITS APPLICATIONS IN BIOTECHNOLOGY", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, CRC PRESS, BOCA RATON, FL, US, vol. 21, no. 1, 2001, pages 1 - 25, XP008026977, ISSN: 0738-8551 * |
PRUST C ET AL: "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 23, no. 2, 23 January 2005 (2005-01-23), pages 195 - 200, XP002334906, ISSN: 1087-0156 * |
SUGISAWA T ET AL: "ISOLATION AND CHARACTERIZATION OF A NEW VITAMIN C PRODUCING ENZYME (L-GULONO-GAMMA-LACTONE DEHYDROGENASE) OF BACTERIAL ORIGIN", BIOSCIENCE, BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 59, no. 2, February 1995 (1995-02-01), pages 190 - 196, XP001084987, ISSN: 0916-8451 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006084642A2 (en) | 2006-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008064837A3 (en) | Novel genes for the fermentative production of hydroxytyrosol | |
BRPI0612411A8 (en) | polynucleotides encoding isoprenoid modification enzymes and methods of employing these | |
WO2005069762A8 (en) | Bacillus licheniformis chromosome | |
WO2008066931A3 (en) | Bacillus licheniformis chromosome | |
EP2336309A3 (en) | Polypeptides having endoglucanase activity and polynucleotides encoding same | |
WO2006032724A3 (en) | Novel laccase enzymes and their uses | |
WO2007063133A3 (en) | Genes useful for the industrial production of citric acid | |
EA200701694A1 (en) | Enzymatic Vitamin C Preparation | |
ATE458812T1 (en) | NEW GENE SMS 37 | |
WO2017051437A3 (en) | A nucleotide sequence encoding 7-dehydrocholesterol reductase, recombinant constructs and recombinant organisms comprising said sequence | |
WO2006084646A3 (en) | Sms 22 gene and gene product that plays a role in the synthesis of vitamin c | |
WO2006084709A3 (en) | Novel gene sms 04 | |
WO2006084703A3 (en) | Novel gene sts 24 | |
WO2006084642A3 (en) | Microorganisms with a disruption of the respiratory chain gene rcs26 for the production of vitamin c | |
HK1090663A1 (en) | Chicken rna polymerase i promoter and the use thereof | |
WO2007031493A3 (en) | A new selection system for wheat | |
WO2006084644A3 (en) | Gene rcs 33 | |
WO2006084643A3 (en) | Novel gene vcs 07 | |
WO2006084732A3 (en) | Novel gene rcs 07 | |
WO2006084728A3 (en) | Novel gene rcs 06 | |
WO2006084712A3 (en) | Novel gene rcs 27 | |
WO2006084702A3 (en) | Novel gene sts 23 | |
WO2006084722A3 (en) | Gene sts 15 | |
WO2006084705A3 (en) | Novel gene sts 06 | |
WO2006084704A3 (en) | Novel gene sts 01 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 06706663 Country of ref document: EP Kind code of ref document: A2 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 6706663 Country of ref document: EP |