WO2006084728A3 - Novel gene rcs 06 - Google Patents

Novel gene rcs 06 Download PDF

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Publication number
WO2006084728A3
WO2006084728A3 PCT/EP2006/001223 EP2006001223W WO2006084728A3 WO 2006084728 A3 WO2006084728 A3 WO 2006084728A3 EP 2006001223 W EP2006001223 W EP 2006001223W WO 2006084728 A3 WO2006084728 A3 WO 2006084728A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
production
vitamin
relates
polypeptides
Prior art date
Application number
PCT/EP2006/001223
Other languages
French (fr)
Other versions
WO2006084728A2 (en
Inventor
Bastien Chevreux
Anne Francoise Mayer
Anja Meury
Nigel John Mouncey
Masako Shinjoh
Original Assignee
Dsm Ip Assets Bv
Bastien Chevreux
Anne Francoise Mayer
Anja Meury
Nigel John Mouncey
Masako Shinjoh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Bastien Chevreux, Anne Francoise Mayer, Anja Meury, Nigel John Mouncey, Masako Shinjoh filed Critical Dsm Ip Assets Bv
Priority to EP06706848A priority Critical patent/EP1846552A2/en
Publication of WO2006084728A2 publication Critical patent/WO2006084728A2/en
Publication of WO2006084728A3 publication Critical patent/WO2006084728A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
PCT/EP2006/001223 2005-02-11 2006-02-10 Novel gene rcs 06 WO2006084728A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06706848A EP1846552A2 (en) 2005-02-11 2006-02-10 Novel gene rcs 06

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05405151 2005-02-11
EP05405066 2005-02-11
EP05405066.1 2005-02-11
EP05405151.1 2005-02-11

Publications (2)

Publication Number Publication Date
WO2006084728A2 WO2006084728A2 (en) 2006-08-17
WO2006084728A3 true WO2006084728A3 (en) 2006-11-02

Family

ID=36688109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001223 WO2006084728A2 (en) 2005-02-11 2006-02-10 Novel gene rcs 06

Country Status (2)

Country Link
EP (1) EP1846552A2 (en)
WO (1) WO2006084728A2 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PRUST CHRISTINA ET AL: "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 2, 23 January 2005 (2005-01-23), pages 195 - 200, XP002334994, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
WO2006084728A2 (en) 2006-08-17
EP1846552A2 (en) 2007-10-24

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