WO2006084712A3 - Novel gene rcs 27 - Google Patents

Novel gene rcs 27 Download PDF

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Publication number
WO2006084712A3
WO2006084712A3 PCT/EP2006/001207 EP2006001207W WO2006084712A3 WO 2006084712 A3 WO2006084712 A3 WO 2006084712A3 EP 2006001207 W EP2006001207 W EP 2006001207W WO 2006084712 A3 WO2006084712 A3 WO 2006084712A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
production
vitamin
relates
polypeptides
Prior art date
Application number
PCT/EP2006/001207
Other languages
French (fr)
Other versions
WO2006084712A2 (en
Inventor
Bastien Chevreux
Anne Francoise Mayer
Anja Meury
Nigel John Mouncey
Masako Shinjoh
Original Assignee
Dsm Ip Assets Bv
Bastien Chevreux
Anne Francoise Mayer
Anja Meury
Nigel John Mouncey
Masako Shinjoh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Bastien Chevreux, Anne Francoise Mayer, Anja Meury, Nigel John Mouncey, Masako Shinjoh filed Critical Dsm Ip Assets Bv
Publication of WO2006084712A2 publication Critical patent/WO2006084712A2/en
Publication of WO2006084712A3 publication Critical patent/WO2006084712A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
PCT/EP2006/001207 2005-02-11 2006-02-10 Novel gene rcs 27 WO2006084712A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05405066 2005-02-11
EP05405139.6 2005-02-11
EP05405139 2005-02-11
EP05405066.1 2005-02-11

Publications (2)

Publication Number Publication Date
WO2006084712A2 WO2006084712A2 (en) 2006-08-17
WO2006084712A3 true WO2006084712A3 (en) 2006-11-02

Family

ID=36688139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001207 WO2006084712A2 (en) 2005-02-11 2006-02-10 Novel gene rcs 27

Country Status (1)

Country Link
WO (1) WO2006084712A2 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PRUST CHRISTINA ET AL: "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 2, 23 January 2005 (2005-01-23), pages 195 - 200, XP002334994, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
WO2006084712A2 (en) 2006-08-17

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