WO2006066459A1 - Source de lumiere standard pour un compteur a photon unique - Google Patents

Source de lumiere standard pour un compteur a photon unique Download PDF

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Publication number
WO2006066459A1
WO2006066459A1 PCT/CN2004/001507 CN2004001507W WO2006066459A1 WO 2006066459 A1 WO2006066459 A1 WO 2006066459A1 CN 2004001507 W CN2004001507 W CN 2004001507W WO 2006066459 A1 WO2006066459 A1 WO 2006066459A1
Authority
WO
WIPO (PCT)
Prior art keywords
emitting diode
light
light source
light emitting
standard
Prior art date
Application number
PCT/CN2004/001507
Other languages
English (en)
French (fr)
Inventor
Jinsheng Yu
Jiang Lan
Xiaolin Yang
Xiaodong Wu
Original Assignee
Beijing Yuande Bio-Medical Engineering Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Yuande Bio-Medical Engineering Co., Ltd. filed Critical Beijing Yuande Bio-Medical Engineering Co., Ltd.
Priority to PCT/CN2004/001507 priority Critical patent/WO2006066459A1/zh
Priority to US11/040,610 priority patent/US20060139630A1/en
Publication of WO2006066459A1 publication Critical patent/WO2006066459A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0407—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings
    • G01J1/0418—Optical elements not provided otherwise, e.g. manifolds, windows, holograms, gratings using attenuators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/08—Arrangements of light sources specially adapted for photometry standard sources, also using luminescent or radioactive material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G01N21/278—Constitution of standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/0271—Housings; Attachments or accessories for photometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Definitions

  • the present invention relates to a single photon counter, and in particular to a standard source for a single photon counter. Background technique
  • the single photon counter is a device that is matched with the corresponding detection reagent and detected by chemiluminescence. It uses a single photon counting method to quantitatively detect the very weak luminescence intensity of the treated sample.
  • single-photon counters are used in hospitals for the determination of various hormones, drugs, vitamins, tumors and infection-related substances, with higher sensitivity, easier, faster and safer.
  • the standard light source should be capable of emitting visible light of intensity and wavelength adapted to the detection range of the single photon counter, and its luminous intensity should be stable over a certain temperature range and for a long period of time. Since the detected light intensity is extremely weak (the lowest value of 1 second is less than 100), the luminous intensity of the conventional standard light source is much higher than its value and cannot be directly adopted.
  • the light source obtained by the standard sample method can only be stable in a short period of time, and can not meet the requirements of the standard light source for mass production of single photon counters.
  • a standard light source for a single photon counter includes: a housing;
  • a light shielding plate disposed above the light emitting diode for reducing the intensity of light emitted by the light emitting diode
  • a light-shielding filler for preventing light emitted by the light-emitting diode from propagating downward, and the light-shielding filler, the light shielding plate and the light emitting diode are sealed together in the casing.
  • the light emitting diode is a blue light emitting diode.
  • the light emitting diode is a green light emitting diode.
  • the visor is a black sheet having a small hole in the center.
  • the visor is a transparent plate with a light-shielding coating.
  • the standard light source further includes a voltage stabilizing circuit for stabilizing the luminous intensity of the light emitting diode.
  • the standard light source further includes a current stabilizing circuit for stabilizing the luminous intensity of the light emitting diode.
  • the standard light source further includes a power stabilizing circuit for stabilizing the luminous intensity of the light emitting diode.
  • the illumination mechanism and the spectral range are consistent with the object detected by the counter, the range of light intensity, stability, etc. can meet the needs, and has small volume, light weight and low energy consumption. And the advantages of low cost.
  • Figure 1 shows the structural arrangement of a standard light source for a single photon counter in accordance with the present invention. detailed description
  • Fig. 1 shows an embodiment of a standard light source according to the invention, in which light emitted by the light-emitting diode 1 is used to calibrate a single photon counter.
  • the light-emitting diode 1 can be a blue light-emitting diode or a green light-emitting diode.
  • the visor 5 is placed above the light emitting diode for reducing the intensity of light emitted by the light emitting diode and for making the illuminating intensity uniform.
  • the visor may be a black sheet having a small hole 7 in the center, or a transparent plate coated with a light-shielding coating of a suitable thickness.
  • a light-shielding filler 6 is filled in the lower portion of the light-emitting diode for preventing the light emitted from the light-emitting diode from propagating downward, and reducing stray light of the system.
  • the light-emitting diode 1, the light-shielding plate 5 and the light-shielding filler 6 are sealed in the casings 2, 3, and 4.
  • the standard light source of the present invention may further comprise a voltage stabilizing circuit, a current stabilizing circuit or a power stabilizing circuit, or three (not shown) for stabilizing the luminous intensity of the light emitting diode.

Description

用于单光子计数仪的标准光源 技术领域
本发明涉及单光子计数仪， 具体涉及用于单光子计数仪的标 准光源。 背景技术
各类激素、 药物、 维生素、 肿瘤及感染相关物质的测定已成 为各医院常规检验工作之一。 但以往采用的放射免疫检测技术存 在半衰期短， 不利于储存， 易对人员及环境造成危害， 检测灵敏 度不足等问题。 20世纪 90年代， 出现了一种以化学发光为代表 的光生物学标记及检测技术， 不仅具有简便、 快速、 安全的特点， 而且具有更高的灵敏度， 因而被迅速应用于临床诊断等方面。
单光子计数仪就是与相应的检测试剂配套， 用化学发光法进 行检测的设备。 它用单光子计数的方法对处理后的样本所发出的 极微弱的发光强度进行定量检测。
与以往采用的放射免疫检测技术相比， 单光子计数仪用于医 院对各类激素、 药物、 维生素、 肿瘤及感染相关物质的测定， 具 有更高的灵敏度， 更加简便、 快速和安全的优点。
为了保证所生产的单光子计数仪输出数据稳定一致， 需用标 准光源对其进行校准。 标准光源要能够发出适应单光子计数仪检 测范围的强度和波长的可见光， 且其发光强度在一定的温度范围 和较长的时间内应保持稳定。 由于检测的光强极弱 （1 秒钟计数 最低值小于 100 ) ， 常规标准光源的发光强度远高于其值， 不能 直接采用。 而采用标准样本方式获得的光源其发光强度仅能在很 短的时间内保持稳定， 不能适应单光子计数仪批量生产对标准光 源的要求。 针对此， 有人采用含碳 14的闪烁晶体制作标准光源。 这种光源虽然发光强度和稳定性能够满足需要，但其制作成本高， 发光机理属于量子理论中的多光子发光事件， 与计数仪检测对象 (单光子发光事件） 不一致， 而且其发光强度分布极不均 ， 故 其使用仍有许多不便。 更由于其含放射性物质， 对人身和环境安 全有潜在的影响。 发明内容
本发明的目的是提供一种用于调试单光子计数仪的专用标准 光源。
根据本发明的一个方面，用于单光子计数仪的标准光源包括： 壳体；
发光二极管；
遮光板， 放在发光二极管的上方， 用于降低所述发光二极管 发出的光的强度， ； 及
遮光填充物， 用于阻止所述发光二极管发出的光向下传播， 所述遮光填充物、 所述遮光板和所述发光二极管一起密封于所述 壳体中。
根据本发明的第二方面，所述发光二极管是蓝光发光二极管。 根据本发明的第三方面，所述发光二极管是绿光发光二极管。 根据本发明的第四方面， 所述遮光板是中心带有小孔的黑色 薄板。
根据本发明的第五方面， 所述遮光板是带有遮光涂层的透明 板。
根据本发明的第六方面， 所迷标准光源还包括稳压电路， 用 于稳定所述发光二极管的发光强度。
根据本发明的第七方面， 所述标准光源还包括稳流电路， 用 于稳定所述发光二极管的发光强度。 根据本发明的第八方面，所述标准光源还包括功率稳定电路， 用于稳定所述发光二极管的发光强度。
根据本发明的用于单光子计数仪的标准光源， 其发光机理、 光谱范围均与计数仪检测对象一致， 光强范围、 稳定性等能满足 需要， 且具有体积小、 重量轻、 能耗低且成本低廉等优点。 附图说明
结合附图和下面实施例的详细说明， 本发明的目的和内容会体 现的更清楚，
图 1示出根据本发明的用于单光子计数仪的标准光源的结构 安排。 具体实施方式
图 1示出了才艮据本发明的标准光源的一个实施例， 在该实施例 中， 发光二极管 1发出的光用于校准单光子计数仪。 发光二极管 1 可以用蓝光发光二极管， 也可以用绿光发光二极管。 遮光板 5 放在发光二极管的上方， 用于降低所述发光二极管发出的光的强 度， 并且使发光强度均 。 所述遮光板可以采用中心打有小孔 7 的黑色薄板， 或涂有适当厚度遮光涂层的透明板等。 遮光填充物 6, 填充在发光二极管的下部， 用于阻止所述发光二极管发出的光 向下传播， 减小系统的杂散光。 发光二极管 1、 遮光板 5和遮光 填充物 6—起被密封于壳体 2、 3、 4中。 此外， 本发明的标准光 源还可以包括一个稳压电路、一个稳流电路或一个功率稳定电路， 或者这三者 （图中未示出） ， 用于稳定所述发光二极管的发光强 度。
以上描述了本发明的一个实施例，提供了用于单光子计数仪的 标准光源的结构安排。 但本领域中的技术人员知道， 可以根据本发 明的基本思想做出不同的变型， 而不受所公开的实施例的限制， 这 些变型都没有超出本发明的权利要求书请求保护的范围。

Claims

1. 一种用于单光子计数仪的标准光源， 包括：
壳体；
发光二极管；
遮光板， 放在发光二极管的上方， 用于降低所述发光二极管 发出的光的强度； 及
遮光填充物， 用于阻止所述发光二极管发出的光向下传播， 所述遮光填充物、 所述遮光板和所述发光二极管一起密封于所述 壳体中。
2. 根据权利要求 1 的标准光源， 其中所述发光二极管是蓝 光发光二极管。
3. 根据权利要求 1 的标准光源， 其中所述发光二极管是绿 光发光二极管。
4. 根据权利要求 1 的标准光源， 其中所述遮光板是中心带 有小孔的黑色薄板。
5. 根据权利要求 1 的标准光源， 其中所述遮光板是带有遮 光涂层的透明板。
6. 根据权利要求 1 的标准光源， 还包括稳压电路， 用于稳 定所述发光二极管的发光强度。
7. 根据权利要求 1 的标准光源， 还包括稳流电路， 用于稳 定所述发光二极管的发光强度。
8. 根据权利要求 1 的标准光源， 还包括功率稳定电路， 用 于稳定所述发光二极管的发光强度。
9. 根据权利要求 1 的标准光源， 还包括稳压电路、 稳流电 路和功率稳定电路， 用于稳定所述发光二极管的发光强度。
PCT/CN2004/001507 2004-12-23 2004-12-23 Source de lumiere standard pour un compteur a photon unique WO2006066459A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2004/001507 WO2006066459A1 (fr) 2004-12-23 2004-12-23 Source de lumiere standard pour un compteur a photon unique
US11/040,610 US20060139630A1 (en) 2004-12-23 2005-01-19 Standard light source for single photo count apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2004/001507 WO2006066459A1 (fr) 2004-12-23 2004-12-23 Source de lumiere standard pour un compteur a photon unique

Related Child Applications (1)

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US11/040,610 Continuation US20060139630A1 (en) 2004-12-23 2005-01-19 Standard light source for single photo count apparatus

Publications (1)

Publication Number Publication Date
WO2006066459A1 true WO2006066459A1 (fr) 2006-06-29

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WO (1) WO2006066459A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009022611B4 (de) * 2009-05-26 2012-03-08 Instrument Systems Optische Messtechnik Gmbh Kalibrierstrahlungsquelle

Citations (6)

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GB2167261A (en) * 1984-11-16 1986-05-21 Stc Plc Optical fibres
CN2233591Y (zh) * 1995-01-19 1996-08-21 连云港市对外贸易公司 一种暗室安全灯
JPH11176220A (ja) * 1997-12-11 1999-07-02 Kikuchi Shokai:Kk 発光装置
US6033087A (en) * 1996-12-26 2000-03-07 Patlite Corporation LED illuminating device for providing a uniform light spot
US20030002281A1 (en) * 2001-06-27 2003-01-02 Yoshinobu Suehiro Shielded reflective light-emitting diode
WO2004090499A1 (en) * 2003-04-10 2004-10-21 Luciol Instruments Sa High resolution otdr for loss measurements

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Publication number Priority date Publication date Assignee Title
JPS5967061A (ja) * 1982-10-07 1984-04-16 Fuji Xerox Co Ltd インクジェットのインク粒子位置検出装置
DE3502634A1 (de) * 1985-01-26 1985-06-20 Deutsche Forschungs- und Versuchsanstalt für Luft- und Raumfahrt e.V., 5000 Köln Optisch-elektronischer entfernungsmesser
DE19618601C2 (de) * 1996-05-09 2000-04-13 Stratec Elektronik Gmbh Verfahren und Anordnung zur Lichtdetektion

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2167261A (en) * 1984-11-16 1986-05-21 Stc Plc Optical fibres
CN2233591Y (zh) * 1995-01-19 1996-08-21 连云港市对外贸易公司 一种暗室安全灯
US6033087A (en) * 1996-12-26 2000-03-07 Patlite Corporation LED illuminating device for providing a uniform light spot
JPH11176220A (ja) * 1997-12-11 1999-07-02 Kikuchi Shokai:Kk 発光装置
US20030002281A1 (en) * 2001-06-27 2003-01-02 Yoshinobu Suehiro Shielded reflective light-emitting diode
WO2004090499A1 (en) * 2003-04-10 2004-10-21 Luciol Instruments Sa High resolution otdr for loss measurements

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