WO2006061791A3 - Novel diazabicyclononene derivative - Google Patents

Novel diazabicyclononene derivative Download PDF

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Publication number
WO2006061791A3
WO2006061791A3 PCT/IB2005/054113 IB2005054113W WO2006061791A3 WO 2006061791 A3 WO2006061791 A3 WO 2006061791A3 IB 2005054113 W IB2005054113 W IB 2005054113W WO 2006061791 A3 WO2006061791 A3 WO 2006061791A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
derivative
preparation
pharmaceutical compositions
diazabicyclononene
Prior art date
Application number
PCT/IB2005/054113
Other languages
French (fr)
Other versions
WO2006061791A2 (en
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Hans-Peter Weber
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Hans-Peter Weber
Thomas Weller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36332872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006061791(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to US11/792,728 priority Critical patent/US20080103152A1/en
Priority to AU2005313002A priority patent/AU2005313002A1/en
Priority to EP05824541A priority patent/EP1824851A2/en
Priority to JP2007543997A priority patent/JP2008522967A/en
Priority to CA002589966A priority patent/CA2589966A1/en
Application filed by Actelion Pharmaceuticals Ltd, Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Hans-Peter Weber, Thomas Weller filed Critical Actelion Pharmaceuticals Ltd
Priority to MX2007006745A priority patent/MX2007006745A/en
Priority to BRPI0518610-2A priority patent/BRPI0518610A2/en
Publication of WO2006061791A2 publication Critical patent/WO2006061791A2/en
Publication of WO2006061791A3 publication Critical patent/WO2006061791A3/en
Priority to IL183754A priority patent/IL183754A0/en
Priority to NO20073058A priority patent/NO20073058L/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I) or (I’) and especially their use as inhibitors of renin.
PCT/IB2005/054113 2004-12-08 2005-12-08 Novel diazabicyclononene derivative WO2006061791A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0518610-2A BRPI0518610A2 (en) 2004-12-08 2005-12-08 compound, compound enantiomer, pharmaceutical composition, and use of a compound
AU2005313002A AU2005313002A1 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative
EP05824541A EP1824851A2 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative
JP2007543997A JP2008522967A (en) 2004-12-08 2005-12-08 New diazabicyclononene derivatives
CA002589966A CA2589966A1 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative
US11/792,728 US20080103152A1 (en) 2004-12-08 2005-12-08 Novel Diazabicyclononene Derivative
MX2007006745A MX2007006745A (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative.
IL183754A IL183754A0 (en) 2004-12-08 2007-06-07 Novel diazabicyclononene derivative
NO20073058A NO20073058L (en) 2004-12-08 2007-06-15 NOVEL DIAZABICYCLONONES DERIVATIVE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP2004/013949 2004-12-08
EP2004013949 2004-12-08

Publications (2)

Publication Number Publication Date
WO2006061791A2 WO2006061791A2 (en) 2006-06-15
WO2006061791A3 true WO2006061791A3 (en) 2006-08-10

Family

ID=36332872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/054113 WO2006061791A2 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative

Country Status (15)

Country Link
EP (1) EP1824851A2 (en)
JP (1) JP2008522967A (en)
KR (1) KR20070086977A (en)
CN (1) CN101072776A (en)
AR (1) AR052263A1 (en)
AU (1) AU2005313002A1 (en)
BR (1) BRPI0518610A2 (en)
CA (1) CA2589966A1 (en)
IL (1) IL183754A0 (en)
MX (1) MX2007006745A (en)
NO (1) NO20073058L (en)
RU (1) RU2007125724A (en)
TW (1) TW200634014A (en)
WO (1) WO2006061791A2 (en)
ZA (1) ZA200705557B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462703T1 (en) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd BICYCLONONE DERIVATIVES AS RENIN INHIBITORS
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
AU2008253519A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd Novel case of renin inhibitors
WO2009023964A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
ES2548134T3 (en) 2008-05-05 2015-10-14 Actelion Pharmaceuticals Ltd. 3,4-substituted piperidine derivatives as renin inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Also Published As

Publication number Publication date
AU2005313002A1 (en) 2006-06-15
EP1824851A2 (en) 2007-08-29
TW200634014A (en) 2006-10-01
KR20070086977A (en) 2007-08-27
MX2007006745A (en) 2007-07-09
BRPI0518610A2 (en) 2008-11-25
IL183754A0 (en) 2007-09-20
CA2589966A1 (en) 2006-06-15
AR052263A1 (en) 2007-03-07
RU2007125724A (en) 2009-01-20
JP2008522967A (en) 2008-07-03
NO20073058L (en) 2007-07-04
ZA200705557B (en) 2008-09-25
WO2006061791A2 (en) 2006-06-15
CN101072776A (en) 2007-11-14

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