BRPI0518610A2 - compound, compound enantiomer, pharmaceutical composition, and use of a compound - Google Patents

compound, compound enantiomer, pharmaceutical composition, and use of a compound

Info

Publication number
BRPI0518610A2
BRPI0518610A2 BRPI0518610-2A BRPI0518610A BRPI0518610A2 BR PI0518610 A2 BRPI0518610 A2 BR PI0518610A2 BR PI0518610 A BRPI0518610 A BR PI0518610A BR PI0518610 A2 BRPI0518610 A2 BR PI0518610A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
enantiomer
preparation
relates
Prior art date
Application number
BRPI0518610-2A
Other languages
Portuguese (pt)
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Hans-Peter Weber
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36332872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0518610(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0518610A2 publication Critical patent/BRPI0518610A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPOSTO, ENANCIâMERO DO COMPOSTO, COMPOSIÇçO FARMACÊUTICA, E, USO DE UM COMPOSTO. A invenção refere-se a um novo derivado de 3,9- diazabiciclol[3.3.1]noneno e aos seus enanejômeros e ao seu uso como ingredientes ativos na preparação de composições farmacêuticas. A invenção também se refere aos aspectos relacionados incluindo processos para a preparação dos compostos, composições farmacêuticas contendo pelo menos um composto de fórmula (I) ou (I') e especialmente seu uso como inibidores de remna.COMPOUND, COMPOUND ENERGY, PHARMACEUTICAL COMPOSITION, AND USE OF A COMPOUND. The invention relates to a novel 3,9-diazabicyclol [3.3.1] nonene derivative and its enaneomers and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also relates to related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I) or (I ') and especially their use as rna inhibitors.

BRPI0518610-2A 2004-12-08 2005-12-08 compound, compound enantiomer, pharmaceutical composition, and use of a compound BRPI0518610A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004013949 2004-12-08
PCT/IB2005/054113 WO2006061791A2 (en) 2004-12-08 2005-12-08 Novel diazabicyclononene derivative

Publications (1)

Publication Number Publication Date
BRPI0518610A2 true BRPI0518610A2 (en) 2008-11-25

Family

ID=36332872

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518610-2A BRPI0518610A2 (en) 2004-12-08 2005-12-08 compound, compound enantiomer, pharmaceutical composition, and use of a compound

Country Status (15)

Country Link
EP (1) EP1824851A2 (en)
JP (1) JP2008522967A (en)
KR (1) KR20070086977A (en)
CN (1) CN101072776A (en)
AR (1) AR052263A1 (en)
AU (1) AU2005313002A1 (en)
BR (1) BRPI0518610A2 (en)
CA (1) CA2589966A1 (en)
IL (1) IL183754A0 (en)
MX (1) MX2007006745A (en)
NO (1) NO20073058L (en)
RU (1) RU2007125724A (en)
TW (1) TW200634014A (en)
WO (1) WO2006061791A2 (en)
ZA (1) ZA200705557B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005020314D1 (en) 2004-08-25 2010-05-12 Actelion Pharmaceuticals Ltd Bicyclophone derivatives as renin inhibitors
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
EP2162436A4 (en) 2007-05-24 2010-08-04 Merck Frosst Canada Ltd Novel case of renin inhibitors
AU2008288648A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
CA2722734C (en) 2008-05-05 2013-11-05 Merck Frosst Canada Ltd. 3,4-substituted piperidine derivatives as renin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL164767A0 (en) * 2002-04-29 2005-12-18 Actelion Pharmaceuticals Ltd 7-Aryl-3,9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertenision, cardiovascular or renal diseases

Also Published As

Publication number Publication date
NO20073058L (en) 2007-07-04
CN101072776A (en) 2007-11-14
KR20070086977A (en) 2007-08-27
ZA200705557B (en) 2008-09-25
JP2008522967A (en) 2008-07-03
CA2589966A1 (en) 2006-06-15
EP1824851A2 (en) 2007-08-29
MX2007006745A (en) 2007-07-09
IL183754A0 (en) 2007-09-20
WO2006061791A2 (en) 2006-06-15
WO2006061791A3 (en) 2006-08-10
TW200634014A (en) 2006-10-01
RU2007125724A (en) 2009-01-20
AR052263A1 (en) 2007-03-07
AU2005313002A1 (en) 2006-06-15

Similar Documents

Publication Publication Date Title
BRPI0508263A (en) 1,2,3,4-tetrahydro-isoquinoline derivatives, pharmaceutical composition and use of 1,2,3,4-tetrahydro-isoquinoline derivative
BR0207715A (en) Compounds, pharmaceutical compositions, and use of one or more compounds
BRPI0508579A (en) compound, pharmaceutical composition, and use of a compound
BRPI0116237B8 (en) "sulfamide compound, pharmaceutical composition containing it and its use as an endothelin receptor antagonist drug".
BRPI0508540A (en) compound, pharmaceutical composition, and use of a compound
BRPI0109200B8 (en) compounds and pharmaceutical compositions
BRPI0213522C1 (en) hydroxypyrimidinone derivative compounds, pharmaceutical composition, and use of a compound
BRPI0709633B8 (en) pyridine and pyrimidine derivatives as mglur2 antagonists, pharmaceutical composition and their use
ECSP045378A (en) NEW DIAZABICICLONONENE DERIVATIVES
BRPI0112986B8 (en) azabicyclic compounds, process for their preparation, as well as pharmaceutical compositions comprising said compounds
BRPI0307267B8 (en) use of beta-lactamase inhibitor compounds and pharmaceutical compositions for antibacterial therapy
BRPI0414514A (en) use of a compound, compound, and pharmaceutical compositions
BRPI0513891B8 (en) substituted propenyl piperazine derivatives, their use as new histone deacetylase inhibitors, pharmaceutical composition, combination and preparation process of these
BRPI0508281A (en) compounds, process for the preparation thereof, fungicidal agent, seed, and process for combating phytopathogenic harmful fungi
WO2007015824A3 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
BRPI0407811A (en) pyrazolopyridine derivatives, process for their preparation, pharmaceutical composition and their use
BRPI0509912A (en) compounds, process for preparing same, pharmaceutical composition, and use of a compound
BR0312633A (en) Compound, use of compound, pharmaceutical composition, process for preparing a compound
BRPI0407306A (en) HIV-inhibiting 1,2,4-triazines
BR0312000A (en) Compounds, pharmaceutical compositions, method for treating or prophylaxis of diseases, and use of the compounds
BRPI0909055A2 (en) pyridin-2-yl derived compound, pharmaceutical composition containing it and use of such compound.
TW200714598A (en) Urea derivatives, methods for their manufacture, and uses therefor
TW200637861A (en) Novel diazabicyclononene derivative
BRPI0518610A2 (en) compound, compound enantiomer, pharmaceutical composition, and use of a compound
ATE462703T1 (en) BICYCLONONE DERIVATIVES AS RENIN INHIBITORS

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]