AR052263A1 - DERIVATIVE OF DIAZABICICLONONE - Google Patents

DERIVATIVE OF DIAZABICICLONONE

Info

Publication number
AR052263A1
AR052263A1 ARP050105127A ARP050105127A AR052263A1 AR 052263 A1 AR052263 A1 AR 052263A1 AR P050105127 A ARP050105127 A AR P050105127A AR P050105127 A ARP050105127 A AR P050105127A AR 052263 A1 AR052263 A1 AR 052263A1
Authority
AR
Argentina
Prior art keywords
enantiomers
diazabiciclonone
derivative
difluorophenoxy
dichlorobenzyl
Prior art date
Application number
ARP050105127A
Other languages
Spanish (es)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36332872&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR052263(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR052263A1 publication Critical patent/AR052263A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Composiciones farmacéuticas que lo contienen y su uso como inhibidores de la renina. Reivindicacion 1: Un compuesto de formula (1) designado como ciclopropil-(2,3-diclorobencil)amida de ácido (1R*, 5S*)-7-{4[3-(2- cloro-3,6-difluorofenoxi)- propil]fenil}-3,9-diazabiciclo[3.3.1]non-6-ene-6-carbocíclico, y enantiomeros opticamente puros o una mezcla de enantiomeros, como por ejemplo un racemato; así como también sales farmacéuticamente aceptables, complejos solventes y formas morfologicas de los mismos.Pharmaceutical compositions that contain it and their use as renin inhibitors. Claim 1: A compound of formula (1) designated as cyclopropyl- (2,3-dichlorobenzyl) acid amide (1R *, 5S *) - 7- {4 [3- (2- chloro-3,6-difluorophenoxy) - propyl] phenyl} -3,9-diazabicyclo [3.3.1] non-6-ene-6-carbocyclic, and optically pure enantiomers or a mixture of enantiomers, such as a racemate; as well as pharmaceutically acceptable salts, solvent complexes and morphological forms thereof.

ARP050105127A 2004-12-08 2005-12-07 DERIVATIVE OF DIAZABICICLONONE AR052263A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2004013949 2004-12-08

Publications (1)

Publication Number Publication Date
AR052263A1 true AR052263A1 (en) 2007-03-07

Family

ID=36332872

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050105127A AR052263A1 (en) 2004-12-08 2005-12-07 DERIVATIVE OF DIAZABICICLONONE

Country Status (15)

Country Link
EP (1) EP1824851A2 (en)
JP (1) JP2008522967A (en)
KR (1) KR20070086977A (en)
CN (1) CN101072776A (en)
AR (1) AR052263A1 (en)
AU (1) AU2005313002A1 (en)
BR (1) BRPI0518610A2 (en)
CA (1) CA2589966A1 (en)
IL (1) IL183754A0 (en)
MX (1) MX2007006745A (en)
NO (1) NO20073058L (en)
RU (1) RU2007125724A (en)
TW (1) TW200634014A (en)
WO (1) WO2006061791A2 (en)
ZA (1) ZA200705557B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8138340B2 (en) 2004-08-25 2012-03-20 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
AU2008253519A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd Novel case of renin inhibitors
EP2190811B1 (en) 2007-08-20 2013-08-07 Merck Canada Inc. Renin inhibitors
WO2009135299A1 (en) 2008-05-05 2009-11-12 Merck Frosst Canada Ltd. 3, 4 - substituted piperidine derivatives as renin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL372141A1 (en) * 2002-04-29 2005-07-11 Actelion Pharmaceuticals Ltd. 7-aryl-3,9-diazabicyclo[3.3.1]non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Also Published As

Publication number Publication date
WO2006061791A3 (en) 2006-08-10
NO20073058L (en) 2007-07-04
CA2589966A1 (en) 2006-06-15
CN101072776A (en) 2007-11-14
IL183754A0 (en) 2007-09-20
RU2007125724A (en) 2009-01-20
JP2008522967A (en) 2008-07-03
EP1824851A2 (en) 2007-08-29
AU2005313002A1 (en) 2006-06-15
WO2006061791A2 (en) 2006-06-15
BRPI0518610A2 (en) 2008-11-25
KR20070086977A (en) 2007-08-27
TW200634014A (en) 2006-10-01
MX2007006745A (en) 2007-07-09
ZA200705557B (en) 2008-09-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal