WO2004096116A3 - Diazabicyclononene derivatives - Google Patents

Diazabicyclononene derivatives Download PDF

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Publication number
WO2004096116A3
WO2004096116A3 PCT/EP2004/004372 EP2004004372W WO2004096116A3 WO 2004096116 A3 WO2004096116 A3 WO 2004096116A3 EP 2004004372 W EP2004004372 W EP 2004004372W WO 2004096116 A3 WO2004096116 A3 WO 2004096116A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
preparation
pharmaceutical compositions
derivatives
diazabicyclononene
Prior art date
Application number
PCT/EP2004/004372
Other languages
French (fr)
Other versions
WO2004096116A2 (en
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Thierry Sifferlen
Original Assignee
Actelion Pharmaceuticals Ltd
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Thierry Sifferlen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller, Thierry Sifferlen filed Critical Actelion Pharmaceuticals Ltd
Priority to CA002521898A priority Critical patent/CA2521898A1/en
Priority to JP2006505261A priority patent/JP2006525259A/en
Priority to EP04729414A priority patent/EP1622564A2/en
Priority to BRPI0409882-0A priority patent/BRPI0409882A/en
Priority to AU2004233577A priority patent/AU2004233577A1/en
Priority to US10/555,382 priority patent/US20060223795A1/en
Priority to MXPA05011711A priority patent/MXPA05011711A/en
Publication of WO2004096116A2 publication Critical patent/WO2004096116A2/en
Publication of WO2004096116A3 publication Critical patent/WO2004096116A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
PCT/EP2004/004372 2003-05-02 2004-04-26 Diazabicyclononene derivatives WO2004096116A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002521898A CA2521898A1 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives
JP2006505261A JP2006525259A (en) 2003-05-02 2004-04-26 New diazabicyclononene derivatives
EP04729414A EP1622564A2 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives
BRPI0409882-0A BRPI0409882A (en) 2003-05-02 2004-04-26 compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
AU2004233577A AU2004233577A1 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives
US10/555,382 US20060223795A1 (en) 2003-05-02 2004-04-26 Novel diazabicyclononene derivatives
MXPA05011711A MXPA05011711A (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0304622 2003-05-02
EPPCT/EP03/04622 2003-05-02

Publications (2)

Publication Number Publication Date
WO2004096116A2 WO2004096116A2 (en) 2004-11-11
WO2004096116A3 true WO2004096116A3 (en) 2005-03-24

Family

ID=33395698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004372 WO2004096116A2 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives

Country Status (10)

Country Link
EP (1) EP1622564A2 (en)
JP (1) JP2006525259A (en)
KR (1) KR20060015573A (en)
CN (1) CN1780838A (en)
AU (1) AU2004233577A1 (en)
BR (1) BRPI0409882A (en)
CA (1) CA2521898A1 (en)
MX (1) MXPA05011711A (en)
RU (1) RU2005137571A (en)
WO (1) WO2004096116A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508262A (en) * 2003-10-13 2007-04-05 アクテリオン　ファマシューティカルズ　リミテッド Novel diazabicyclononene derivatives and uses thereof
EP1680427A1 (en) * 2003-10-23 2006-07-19 Actelion Pharmaceuticals Ltd. Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
AU2004295092A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd. Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
WO2006021403A1 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
CA2577084A1 (en) 2004-08-25 2006-03-02 Olivier Bezencon Bicyclononene derivatives as renin inhibitors
WO2006058546A1 (en) * 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Novel lactame derivatives as renin inhibitors
WO2006063610A1 (en) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
CN101107248A (en) * 2005-01-28 2008-01-16 埃科特莱茵药品有限公司 7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.31]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide as inhibitors of renin for the treatment of hypertension.
WO2006131884A2 (en) * 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2430139T3 (en) 2005-12-30 2013-11-19 Novartis Ag 3,5-substituted piperidine compounds as renin inhibitors
EP2007725A2 (en) * 2006-03-16 2008-12-31 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
US8343968B2 (en) 2007-05-24 2013-01-01 Merck Canada Inc. Case of renin inhibitors
KR101238479B1 (en) 2007-06-25 2013-03-04 노파르티스 아게 N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
WO2009023964A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
SG192543A1 (en) 2008-05-05 2013-08-30 Merck Canada Inc 3, 4 - substituted piperidine derivatives as renin inhibitors
JPWO2013038936A1 (en) * 2011-09-13 2015-03-26 タカラバイオ株式会社 Method for stopping peroxidase reaction and reaction stopper

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004002957A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Novel tetrahydropyridine derivatives as renin inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004002957A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Novel tetrahydropyridine derivatives as renin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EL-ABBADY S A ET AL: "ENHANCED REACTIVITY OF PYRIDIN-3-OL TOWARDS 4-PHENYL-1,2,4-TRIAZOLINE 3,5-DIONE: FMO TREATMENT OF THE CYCLOADDITION PROCESS BY ASED-MO CALCULATIONS METHOD", ZAGAZIG JOURNAL OF PHARMACEUTICAL SCIENCES, FACULTY OF PHARMACY ZAGAZIG UNIVERSITY, CAIRO, EG, vol. 5, no. 1, June 1996 (1996-06-01), pages 68 - 74, XP001154254, ISSN: 1110-5089 *

Also Published As

Publication number Publication date
CN1780838A (en) 2006-05-31
CA2521898A1 (en) 2004-11-11
MXPA05011711A (en) 2006-01-23
JP2006525259A (en) 2006-11-09
AU2004233577A1 (en) 2004-11-11
RU2005137571A (en) 2006-05-10
WO2004096116A2 (en) 2004-11-11
KR20060015573A (en) 2006-02-17
BRPI0409882A (en) 2006-05-23
EP1622564A2 (en) 2006-02-08

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