WO2006056607A8 - Substituierte pteridine zur behandlung von entzündlichen erkrankungen - Google Patents
Substituierte pteridine zur behandlung von entzündlichen erkrankungenInfo
- Publication number
- WO2006056607A8 WO2006056607A8 PCT/EP2005/056247 EP2005056247W WO2006056607A8 WO 2006056607 A8 WO2006056607 A8 WO 2006056607A8 EP 2005056247 W EP2005056247 W EP 2005056247W WO 2006056607 A8 WO2006056607 A8 WO 2006056607A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inflammatory diseases
- treating inflammatory
- diseases
- substituted pteridines
- pteridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007006357A MX2007006357A (es) | 2004-11-29 | 2005-11-25 | Pteridinas sustituidas para el tratamiento de enfermedades inflamatorias. |
BRPI0516626-8A BRPI0516626A (pt) | 2004-11-29 | 2005-11-25 | pteridinas substituìdas e uso das mesmas |
EP05813409A EP1828189A1 (de) | 2004-11-29 | 2005-11-25 | Substituierte pteridine zur behandlung von entz]ndlichen erkrankungen |
AU2005308785A AU2005308785A1 (en) | 2004-11-29 | 2005-11-25 | Substituted pteridines for treating inflammatory diseases |
CA002589209A CA2589209A1 (en) | 2004-11-29 | 2005-11-25 | Substituted pteridines for treating inflammatory diseases |
JP2007541996A JP2008521775A (ja) | 2004-11-29 | 2005-11-25 | 炎症性疾患治療用の置換プテリジン |
NZ556152A NZ556152A (en) | 2004-11-29 | 2005-11-25 | Substituted pteridines for treating inflammatory diseases |
IL183447A IL183447A0 (en) | 2004-11-29 | 2007-05-28 | Substituted pteridines for treating inflammatory diseases |
IL209879A IL209879A0 (en) | 2004-11-29 | 2010-12-09 | Substituted pteridines ,pharmaceutical compositions containing them and their use in the manufacture of medicaments for treating inflammatory diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004057618A DE102004057618A1 (de) | 2004-11-29 | 2004-11-29 | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
DE102004057618.1 | 2004-11-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006056607A1 WO2006056607A1 (de) | 2006-06-01 |
WO2006056607A8 true WO2006056607A8 (de) | 2007-01-18 |
Family
ID=35789067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/056247 WO2006056607A1 (de) | 2004-11-29 | 2005-11-25 | Substituierte pteridine zur behandlung von entzündlichen erkrankungen |
Country Status (17)
Country | Link |
---|---|
US (1) | US7550472B2 (de) |
EP (1) | EP1828189A1 (de) |
JP (1) | JP2008521775A (de) |
KR (1) | KR20070090975A (de) |
CN (1) | CN101065382A (de) |
AR (1) | AR054992A1 (de) |
AU (1) | AU2005308785A1 (de) |
BR (1) | BRPI0516626A (de) |
CA (1) | CA2589209A1 (de) |
DE (1) | DE102004057618A1 (de) |
IL (2) | IL183447A0 (de) |
MX (1) | MX2007006357A (de) |
NZ (1) | NZ556152A (de) |
RU (1) | RU2007124328A (de) |
TW (1) | TW200633711A (de) |
WO (1) | WO2006056607A1 (de) |
ZA (1) | ZA200703125B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004057595A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
DE102004057645A1 (de) * | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
DE102004057594A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
CA2652840C (en) | 2006-05-24 | 2014-09-09 | Boehringer Ingelheim International Gmbh | 2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases |
JP5352452B2 (ja) * | 2006-06-06 | 2013-11-27 | メディシノバ, インコーポレイテッド | 置換ピラゾロ[1,5−a]ピリジン化合物およびその使用方法 |
EP3102939A4 (de) * | 2014-02-05 | 2018-02-28 | Dana-Farber Cancer Institute, Inc. | Mittel zur modulierung der rgmb-neogenin-bmp-signalisierung und verfahren zur verwendung davon |
MA50441A (fr) | 2017-10-23 | 2020-09-02 | Boehringer Ingelheim Int | Nouvelle association d'agents actifs pour le traitement de pneumopathies interstitielles fibrosantes progressives (pf-ild) |
CN113876761B (zh) * | 2020-07-01 | 2022-12-20 | 广州华真医药科技有限公司 | 磷酸二酯酶4抑制剂ZL-n-91在制备抗骨肉瘤药物中的应用 |
US20230181590A1 (en) | 2021-12-09 | 2023-06-15 | Boehringer Ingelheim International Gmbh | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases |
CA3236757A1 (en) | 2021-12-09 | 2023-06-15 | Boehringer Ingelheim International Gmbh | New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases |
WO2024068386A1 (en) | 2022-09-28 | 2024-04-04 | Boehringer Ingelheim International Gmbh | Use of biomarkers in the treatment of fibrotic conditions with a pde4b-inhibitor |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2940972A (en) * | 1957-06-27 | 1960-06-14 | Thomae Gmbh Dr K | Tri-and tetra-substituted pteridine derivatives |
DE3323932A1 (de) | 1983-07-02 | 1985-01-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel |
US4560685A (en) * | 1984-06-18 | 1985-12-24 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | 2-Piperazino-pteridines useful as antithrombotics and antimetastatics |
DE3445298A1 (de) | 1984-12-12 | 1986-06-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
DE3540952C2 (de) | 1985-11-19 | 1997-08-14 | Thomae Gmbh Dr K | 2-Piperazino-pteridine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
JP2002533464A (ja) | 1998-12-28 | 2002-10-08 | カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント | プテリジン誘導体の免疫抑制作用 |
GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
DE10202468A1 (de) * | 2002-01-23 | 2004-09-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung |
DE102004057595A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
DE102004057645A1 (de) * | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
DE102004057594A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
-
2004
- 2004-11-29 DE DE102004057618A patent/DE102004057618A1/de not_active Withdrawn
-
2005
- 2005-11-18 US US11/282,535 patent/US7550472B2/en active Active
- 2005-11-25 JP JP2007541996A patent/JP2008521775A/ja active Pending
- 2005-11-25 RU RU2007124328/04A patent/RU2007124328A/ru not_active Application Discontinuation
- 2005-11-25 CN CNA2005800408289A patent/CN101065382A/zh active Pending
- 2005-11-25 NZ NZ556152A patent/NZ556152A/en not_active IP Right Cessation
- 2005-11-25 WO PCT/EP2005/056247 patent/WO2006056607A1/de active Application Filing
- 2005-11-25 KR KR1020077014857A patent/KR20070090975A/ko not_active Application Discontinuation
- 2005-11-25 BR BRPI0516626-8A patent/BRPI0516626A/pt not_active IP Right Cessation
- 2005-11-25 CA CA002589209A patent/CA2589209A1/en not_active Abandoned
- 2005-11-25 MX MX2007006357A patent/MX2007006357A/es active IP Right Grant
- 2005-11-25 AR ARP050104923A patent/AR054992A1/es unknown
- 2005-11-25 AU AU2005308785A patent/AU2005308785A1/en not_active Abandoned
- 2005-11-25 EP EP05813409A patent/EP1828189A1/de not_active Withdrawn
- 2005-11-28 TW TW094141780A patent/TW200633711A/zh unknown
-
2007
- 2007-04-13 ZA ZA200703125A patent/ZA200703125B/xx unknown
- 2007-05-28 IL IL183447A patent/IL183447A0/en unknown
-
2010
- 2010-12-09 IL IL209879A patent/IL209879A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20070090975A (ko) | 2007-09-06 |
WO2006056607A1 (de) | 2006-06-01 |
IL183447A0 (en) | 2007-09-20 |
CA2589209A1 (en) | 2006-06-01 |
RU2007124328A (ru) | 2009-02-20 |
IL209879A0 (en) | 2011-02-28 |
BRPI0516626A (pt) | 2008-09-16 |
EP1828189A1 (de) | 2007-09-05 |
MX2007006357A (es) | 2007-06-20 |
AU2005308785A1 (en) | 2006-06-01 |
US7550472B2 (en) | 2009-06-23 |
JP2008521775A (ja) | 2008-06-26 |
NZ556152A (en) | 2009-06-26 |
TW200633711A (en) | 2006-10-01 |
AR054992A1 (es) | 2007-08-01 |
DE102004057618A1 (de) | 2006-06-01 |
US20060116372A1 (en) | 2006-06-01 |
ZA200703125B (en) | 2008-09-25 |
CN101065382A (zh) | 2007-10-31 |
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