WO2006053555A3 - Pyrraz0l-3-on- und/oder pyridazin-3-onderivate als inhibitoren der lysyloxidase - Google Patents

Pyrraz0l-3-on- und/oder pyridazin-3-onderivate als inhibitoren der lysyloxidase Download PDF

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Publication number
WO2006053555A3
WO2006053555A3 PCT/DE2005/002086 DE2005002086W WO2006053555A3 WO 2006053555 A3 WO2006053555 A3 WO 2006053555A3 DE 2005002086 W DE2005002086 W DE 2005002086W WO 2006053555 A3 WO2006053555 A3 WO 2006053555A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazol
pyridazin
inhibitors
lysyl oxidase
derivatives used
Prior art date
Application number
PCT/DE2005/002086
Other languages
English (en)
French (fr)
Other versions
WO2006053555A2 (de
Inventor
Elmar Reinhold Burchardt
Original Assignee
Elmar Reinhold Burchardt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elmar Reinhold Burchardt filed Critical Elmar Reinhold Burchardt
Priority to EP05818002A priority Critical patent/EP2089366A2/de
Priority to DE112005003431T priority patent/DE112005003431A5/de
Publication of WO2006053555A2 publication Critical patent/WO2006053555A2/de
Publication of WO2006053555A3 publication Critical patent/WO2006053555A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Supercharger (AREA)

Abstract

Die vorliegende Erfindung betrifft neue Pyridanzin-3-on- und Pyrazol-3-on-Derivate, Verfahren zu Ihrer Herstellung, ein pharmazeutisches Mittel, enthaltend die Pyridanzin-3-on- und/oder Pyrazol-3-on-Derivate sowie die Verwendung der Verbindungen zur Prophylaxe und/oder zur Behandlung von fibrotischen Erkrankungen und/oder pathologischem Remodelling und die Verwendung der Verbindungen zur Expansion von Stammzellen.
PCT/DE2005/002086 2004-11-22 2005-11-20 Pyrraz0l-3-on- und/oder pyridazin-3-onderivate als inhibitoren der lysyloxidase WO2006053555A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05818002A EP2089366A2 (de) 2004-11-22 2005-11-20 Pyrrazol-3-on- und/oder pyridazin-3-onderivate als inhibitoren der lysyloxidase
DE112005003431T DE112005003431A5 (de) 2004-11-22 2005-11-20 Neuartige Inhibitoren der Lysyloxidase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004056226.1 2004-11-22
DE102004056226A DE102004056226A1 (de) 2004-11-22 2004-11-22 Neuartige Inhibitoren der Lysyloxidase

Publications (2)

Publication Number Publication Date
WO2006053555A2 WO2006053555A2 (de) 2006-05-26
WO2006053555A3 true WO2006053555A3 (de) 2006-07-27

Family

ID=36177758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/002086 WO2006053555A2 (de) 2004-11-22 2005-11-20 Pyrraz0l-3-on- und/oder pyridazin-3-onderivate als inhibitoren der lysyloxidase

Country Status (3)

Country Link
EP (1) EP2089366A2 (de)
DE (2) DE102004056226A1 (de)
WO (1) WO2006053555A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016144702A1 (en) 2015-03-06 2016-09-15 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
EA034891B1 (ru) * 2015-03-06 2020-04-02 Фармакеа, Инк. Фторированные ингибиторы лизилоксидазоподобного фермента-2 и их применение
WO2017003862A1 (en) * 2015-07-01 2017-01-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
US10588900B2 (en) 2016-02-09 2020-03-17 Pharmakea, Inc. Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
JP7097874B2 (ja) 2016-09-07 2022-07-08 ファーマケア，インク． リシルオキシダーゼ様２阻害剤の使用
US10774069B2 (en) 2016-09-07 2020-09-15 Pharmakea, Inc. Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
KR20210045984A (ko) 2018-08-03 2021-04-27 파맥시스 엘티디 라이실 옥시다제의 할로알릴아민 설폰 유도체 저해제 및 이의 용도
GB201818750D0 (en) 2018-11-16 2019-01-02 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328913A (en) * 1992-12-11 1994-07-12 Duke University Minoxidil analogs as inhibitors of cell proliferation and lysyl hydroxylase
EP1130015A1 (de) * 1998-08-14 2001-09-05 Nihon Nohyaku Co., Ltd. Pyridazinon-derivate
WO2003097612A1 (de) * 2002-04-12 2003-11-27 Bayer Healthcare Ag Substituierte 2-phenyl-3(2h)-pyridazinone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328913A (en) * 1992-12-11 1994-07-12 Duke University Minoxidil analogs as inhibitors of cell proliferation and lysyl hydroxylase
EP1130015A1 (de) * 1998-08-14 2001-09-05 Nihon Nohyaku Co., Ltd. Pyridazinon-derivate
WO2003097612A1 (de) * 2002-04-12 2003-11-27 Bayer Healthcare Ag Substituierte 2-phenyl-3(2h)-pyridazinone

Also Published As

Publication number Publication date
WO2006053555A2 (de) 2006-05-26
EP2089366A2 (de) 2009-08-19
DE102004056226A1 (de) 2006-05-24
DE112005003431A5 (de) 2007-10-31

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