WO2006016574A1 - Agent anticancéreux utilisant l'arn interférence - Google Patents

Agent anticancéreux utilisant l'arn interférence Download PDF

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Publication number
WO2006016574A1
WO2006016574A1 PCT/JP2005/014566 JP2005014566W WO2006016574A1 WO 2006016574 A1 WO2006016574 A1 WO 2006016574A1 JP 2005014566 W JP2005014566 W JP 2005014566W WO 2006016574 A1 WO2006016574 A1 WO 2006016574A1
Authority
WO
WIPO (PCT)
Prior art keywords
hsp105
sirna
expression
cancer
rnai
Prior art date
Application number
PCT/JP2005/014566
Other languages
English (en)
Japanese (ja)
Inventor
Yasuharu Nishimura
Tetsuya Nakatsura
Seiji Hosaka
Original Assignee
Kumamoto University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kumamoto University filed Critical Kumamoto University
Priority to JP2006531647A priority Critical patent/JPWO2006016574A1/ja
Publication of WO2006016574A1 publication Critical patent/WO2006016574A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention révèle un nouvel agent anticancéreux utilisant le phénomène de l'ARN interférence. L'invention révèle spécifiquement un agent anticancéreux contenant un facteur qui est capable de supprimer l'expression du HSP105 à travers l'ARN interférence.
PCT/JP2005/014566 2004-08-12 2005-08-09 Agent anticancéreux utilisant l'arn interférence WO2006016574A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006531647A JPWO2006016574A1 (ja) 2004-08-12 2005-08-09 ＲＮＡｉを利用した抗腫瘍剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004235087 2004-08-12
JP2004-235087 2004-08-12

Publications (1)

Publication Number Publication Date
WO2006016574A1 true WO2006016574A1 (fr) 2006-02-16

Family

ID=35839343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/014566 WO2006016574A1 (fr) 2004-08-12 2005-08-09 Agent anticancéreux utilisant l'arn interférence

Country Status (2)

Country Link
JP (1) JPWO2006016574A1 (fr)
WO (1) WO2006016574A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9381208B2 (en) 2006-08-08 2016-07-05 Rheinische Friedrich-Wilhelms-Universität Structure and use of 5′ phosphate oligonucleotides
US9399658B2 (en) 2011-03-28 2016-07-26 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
US10059943B2 (en) 2012-09-27 2018-08-28 Rheinische Friedrich-Wilhelms-Universität Bonn RIG-I ligands and methods for producing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ISHIHARA K. ET AL: "Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105", BIOCHIM.BIOPHYS.ACTA., vol. 1444, no. 1, 1999, pages 138 - 142, XP001024442 *
NISHIMURA Y.: "Hito T-saibo ga Ninshiki suru Shuyo Tokui Kogen no Dotei", HEISEI 15 NENDO GAN KENKYU NI KAKAWARU TOKUTEI RYOIKI KENKYU (GAN TOKUTEI) KENKYU HOKOKUSHO SHU ROKU, HEISEI 16 NEN, MARCH, pages 348 - 351, XP002999841 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9381208B2 (en) 2006-08-08 2016-07-05 Rheinische Friedrich-Wilhelms-Universität Structure and use of 5′ phosphate oligonucleotides
US10238682B2 (en) 2006-08-08 2019-03-26 Rheinische Friedrich-Wilhelms-Universität Bonn Structure and use of 5′ phosphate oligonucleotides
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
US10036021B2 (en) 2008-05-21 2018-07-31 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
US10196638B2 (en) 2008-05-21 2019-02-05 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
US9399658B2 (en) 2011-03-28 2016-07-26 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US9896689B2 (en) 2011-03-28 2018-02-20 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US10059943B2 (en) 2012-09-27 2018-08-28 Rheinische Friedrich-Wilhelms-Universität Bonn RIG-I ligands and methods for producing them
US10072262B2 (en) 2012-09-27 2018-09-11 Rheinische Friedrich-Wilhelms-Universität Bonn RIG-I ligands and methods for producing them
US11142763B2 (en) 2012-09-27 2021-10-12 Rheinische Friedrich-Wilhelms-Universität Bonn RIG-I ligands and methods for producing them

Also Published As

Publication number Publication date
JPWO2006016574A1 (ja) 2008-05-01

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