WO2006014466A3 - Nouvelle epo carbamylee et procede permettant de la fabriquer - Google Patents

Nouvelle epo carbamylee et procede permettant de la fabriquer Download PDF

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Publication number
WO2006014466A3
WO2006014466A3 PCT/US2005/023910 US2005023910W WO2006014466A3 WO 2006014466 A3 WO2006014466 A3 WO 2006014466A3 US 2005023910 W US2005023910 W US 2005023910W WO 2006014466 A3 WO2006014466 A3 WO 2006014466A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
carbamylated epo
novel
epo
novel carbamylated
Prior art date
Application number
PCT/US2005/023910
Other languages
English (en)
Other versions
WO2006014466A2 (fr
Inventor
Michael Brines
Anthony Cerami
Carla Cerami Hand
Qiao-Wen Xie
Soren Christensen
J Foldager
M H Vlabjorn
A H Theusen
M Pedersen
M Munk
Original Assignee
Kenneth S Warren Inst Inc
Lundbeck H As
Michael Brines
Anthony Cerami
Carla Cerami Hand
Qiao-Wen Xie
Soren Christensen
J Foldager
M H Vlabjorn
A H Theusen
M Pedersen
M Munk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth S Warren Inst Inc, Lundbeck H As, Michael Brines, Anthony Cerami, Carla Cerami Hand, Qiao-Wen Xie, Soren Christensen, J Foldager, M H Vlabjorn, A H Theusen, M Pedersen, M Munk filed Critical Kenneth S Warren Inst Inc
Publication of WO2006014466A2 publication Critical patent/WO2006014466A2/fr
Publication of WO2006014466A3 publication Critical patent/WO2006014466A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne un procédé optimal permettant d'obtenir par carbamylation un produit présentant un degré faible de polymérisation et d'agrégation. Un tel procédé permet d'obtenir une érythropoiétine totalement carbamylée avec l'ensemble des restes N-terminal et lysine. Cette invention concerne également l'EPO pure totalement carbamylée obtenue grâce au procédé susmentionné, ainsi que des compositions pharmaceutiques contenant un tel composé.
PCT/US2005/023910 2004-07-02 2005-07-01 Nouvelle epo carbamylee et procede permettant de la fabriquer WO2006014466A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US58526204P 2004-07-02 2004-07-02
US58495104P 2004-07-02 2004-07-02
US60/584,951 2004-07-02
US60/585,262 2004-07-02
US58637004P 2004-07-07 2004-07-07
US60/586,370 2004-07-07
DKPA2004/01075 2004-07-07
DKPA200401075 2004-07-07

Publications (2)

Publication Number Publication Date
WO2006014466A2 WO2006014466A2 (fr) 2006-02-09
WO2006014466A3 true WO2006014466A3 (fr) 2006-06-29

Family

ID=35787614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/023910 WO2006014466A2 (fr) 2004-07-02 2005-07-01 Nouvelle epo carbamylee et procede permettant de la fabriquer

Country Status (1)

Country Link
WO (1) WO2006014466A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
ES2420581T3 (es) 2003-03-14 2013-08-26 Biogenerix Gmbh Polímeros solubles en agua ramificados y sus conjugados
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
EP1615945B1 (fr) 2003-04-09 2011-09-28 BioGeneriX AG Methode de glycopegylation et proteines/peptides produits au moyen de ces methodes
US7718363B2 (en) 2003-04-25 2010-05-18 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
WO2004103275A2 (fr) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions et procedes pour preparer des mutants de glycosylation de l'hormone de croissance humaine
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
JP5743368B2 (ja) 2004-01-08 2015-07-01 ラショファーム ゲーエムベーハー ペプチドのｏ結合型グリコシル化
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1799249A2 (fr) 2004-09-10 2007-06-27 Neose Technologies, Inc. Interferon alpha glycopegyle
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006127910A2 (fr) 2005-05-25 2006-11-30 Neose Technologies, Inc. Formulations d'erythropoietine glycopegylees
JP5216580B2 (ja) 2005-05-25 2013-06-19 ノヴォ ノルディスク アー／エス グリコペグ化第ｉｘ因子
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
PL1961821T3 (pl) 2007-02-22 2010-01-29 Polymun Scient Immunbiologische Forschung Gmbh Erytropoetynowe białko fuzyjne
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US20130189239A1 (en) 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEIST M. ET AL.: "Derivatives of Erythropoietin that are tissue protective but not erythropoietic", SCIENCE, vol. 305, July 2004 (2004-07-01), pages 239 - 242, XP002346906 *
MUN K.C. ET AL.: "Impaired biological activity of erythropoietin by cyanate carbamylation", BLOOD PURIF., vol. 18, 2000, pages 13 - 17, XP008068868 *
SATAKE R. ET AL.: "Chemical modification of erythropoietin: an increase in in vitro activity by guanidination", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1038, March 1990 (1990-03-01), pages 125 - 129, XP002999952 *

Also Published As

Publication number Publication date
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