WO2005122971A1 - Device for producing a hardenable mass - Google Patents
Device for producing a hardenable mass Download PDFInfo
- Publication number
- WO2005122971A1 WO2005122971A1 PCT/SE2005/000932 SE2005000932W WO2005122971A1 WO 2005122971 A1 WO2005122971 A1 WO 2005122971A1 SE 2005000932 W SE2005000932 W SE 2005000932W WO 2005122971 A1 WO2005122971 A1 WO 2005122971A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mixing
- container
- mass
- space
- piston means
- Prior art date
Links
- 238000002156 mixing Methods 0.000 claims abstract description 218
- 239000007788 liquid Substances 0.000 claims abstract description 39
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000002639 bone cement Substances 0.000 claims abstract description 13
- 239000000316 bone substitute Substances 0.000 claims abstract description 12
- 239000012779 reinforcing material Substances 0.000 claims abstract description 12
- 230000008878 coupling Effects 0.000 claims description 19
- 238000010168 coupling process Methods 0.000 claims description 19
- 238000005859 coupling reaction Methods 0.000 claims description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 12
- 239000000919 ceramic Substances 0.000 claims description 8
- 230000000717 retained effect Effects 0.000 claims description 7
- 206010017076 Fracture Diseases 0.000 claims description 6
- 239000001506 calcium phosphate Substances 0.000 claims description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 6
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 6
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 6
- 229910010293 ceramic material Inorganic materials 0.000 claims description 5
- 239000002872 contrast media Substances 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- RHISTIGVAKTTCM-UHFFFAOYSA-N 5-[[3-[3,5-bis(1,3-dihydroxypropan-2-ylcarbamoyl)-n-(2-hydroxyethyl)-2,4,6-triiodoanilino]-3-oxopropanoyl]-(2-hydroxyethyl)amino]-1-n,3-n-bis(1,3-dihydroxypropan-2-yl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound IC=1C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C(I)C=1N(CCO)C(=O)CC(=O)N(CCO)C1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I RHISTIGVAKTTCM-UHFFFAOYSA-N 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 229910052586 apatite Inorganic materials 0.000 claims description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 4
- -1 ioglucamide Chemical compound 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 4
- 208000010392 Bone Fractures Diseases 0.000 claims description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 3
- XFWJKVMFIVXPKK-UHFFFAOYSA-N calcium;oxido(oxo)alumane Chemical compound [Ca+2].[O-][Al]=O.[O-][Al]=O XFWJKVMFIVXPKK-UHFFFAOYSA-N 0.000 claims description 3
- 239000007943 implant Substances 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- KZYHGCLDUQBASN-UHFFFAOYSA-N 1-n,1-n,3-n,3-n,5-n,5-n-hexakis(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3,5-tricarboxamide Chemical compound OCCN(CCO)C(=O)C1=C(I)C(C(=O)N(CCO)CCO)=C(I)C(C(=O)N(CCO)CCO)=C1I KZYHGCLDUQBASN-UHFFFAOYSA-N 0.000 claims description 2
- DFDJVFYYDGMDTB-BIYVAJLZSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[[(3s,4r,5s)-3,4,5,6-tetrahydroxy-2-oxohexanoyl]amino]benzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(NC(=O)C(=O)[C@@H](O)[C@H](O)[C@@H](O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I DFDJVFYYDGMDTB-BIYVAJLZSA-N 0.000 claims description 2
- IWLIBARWYNRYQO-OCPVLIPCSA-N 3,5-diacetamido-2,4,6-triiodo-n-methyl-n-[2-[methyl-[(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]amino]-2-oxoethyl]benzamide Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CN(C)C(=O)CN(C)C(=O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I IWLIBARWYNRYQO-OCPVLIPCSA-N 0.000 claims description 2
- MKMHLTWTZQIVCH-SFNQMWQSSA-N 3-[acetyl(2-hydroxyethyl)amino]-2,4,6-triiodo-n-methyl-5-[[(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoyl]amino]benzamide Chemical compound CNC(=O)C1=C(I)C(NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C(I)C(N(CCO)C(C)=O)=C1I MKMHLTWTZQIVCH-SFNQMWQSSA-N 0.000 claims description 2
- ODYPLCHSCOJEIZ-GMYJMXFCSA-N 3-[acetyl(methyl)amino]-n-(2-hydroxyethyl)-2,4,6-triiodo-5-[[(2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoyl]amino]benzamide Chemical compound CC(=O)N(C)C1=C(I)C(NC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=C(I)C(C(=O)NCCO)=C1I ODYPLCHSCOJEIZ-GMYJMXFCSA-N 0.000 claims description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 2
- XUHXFSYUBXNTHU-UHFFFAOYSA-N Iotrolan Chemical compound IC=1C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C=1N(C)C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I XUHXFSYUBXNTHU-UHFFFAOYSA-N 0.000 claims description 2
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 2
- BAQCROVBDNBEEB-UBYUBLNFSA-N Metrizamide Chemical compound CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C(=O)N[C@@H]2[C@H]([C@H](O)[C@@H](CO)OC2O)O)=C1I BAQCROVBDNBEEB-UBYUBLNFSA-N 0.000 claims description 2
- 208000001164 Osteoporotic Fractures Diseases 0.000 claims description 2
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims description 2
- ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 claims description 2
- 125000005587 carbonate group Chemical group 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 2
- 229950002407 iodecimol Drugs 0.000 claims description 2
- 229950008828 ioglucol Drugs 0.000 claims description 2
- 229950006335 ioglunide Drugs 0.000 claims description 2
- 229960001025 iohexol Drugs 0.000 claims description 2
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 2
- 229960000780 iomeprol Drugs 0.000 claims description 2
- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical compound OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 claims description 2
- 229960004647 iopamidol Drugs 0.000 claims description 2
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 2
- 229960000824 iopentol Drugs 0.000 claims description 2
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960002603 iopromide Drugs 0.000 claims description 2
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims description 2
- 229950007842 iosarcol Drugs 0.000 claims description 2
- 229950011065 iosimide Drugs 0.000 claims description 2
- 229960003182 iotrolan Drugs 0.000 claims description 2
- 229960004537 ioversol Drugs 0.000 claims description 2
- 229960002611 ioxilan Drugs 0.000 claims description 2
- UUMLTINZBQPNGF-UHFFFAOYSA-N ioxilan Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCCO)=C(I)C(C(=O)NCC(O)CO)=C1I UUMLTINZBQPNGF-UHFFFAOYSA-N 0.000 claims description 2
- 210000003127 knee Anatomy 0.000 claims description 2
- 229960000554 metrizamide Drugs 0.000 claims description 2
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 2
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 2
- 239000004848 polyfunctional curative Substances 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims description 2
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 2
- 210000001694 thigh bone Anatomy 0.000 claims description 2
- 239000000306 component Substances 0.000 description 25
- 208000028659 discharge Diseases 0.000 description 19
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 239000004568 cement Substances 0.000 description 7
- 230000036407 pain Effects 0.000 description 7
- 238000007789 sealing Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 238000002594 fluoroscopy Methods 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002341 toxic gas Substances 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010010214 Compression fracture Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010041541 Spinal compression fracture Diseases 0.000 description 1
- 208000005250 Spontaneous Fractures Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
- B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8816—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8827—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it with filtering, degassing, venting or pressure relief means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
- B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
- B01F35/754251—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/002—Methods
- B29B7/005—Methods for mixing in batches
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B7/00—Mixing; Kneading
- B29B7/02—Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
- B29B7/22—Component parts, details or accessories; Auxiliary operations
- B29B7/26—Component parts, details or accessories; Auxiliary operations for discharging, e.g. doors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4685—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by means of vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/20—Mixing of ingredients for bone cement
Definitions
- the present invention relates to a device for producing a hardenable mass, preferably a bone substitute and/or bone reinforcing material or bone cement or a similar material, wherein a mixing container has a mixing space in which at least one powder and at least one liquid component are mixed to provide the hardenable mass.
- a piston means is provided in the mixing space of the mixing container, which piston means can be retained relative to the mixing container and be released such that it can move in relation thereto in a direction towards at least one opening through which mixed mass can pass out of the mixing container, wherein at least one means which is rotatable relative to the mixing container cooperates with the piston means for, in a retaining position, retaining said piston means relative to the mixing container and, by rotation to a release position, releasing the piston means such that said piston means can move towards the opening.
- Osteoporosis is rapidly increasing, particularly in the industrialized countries. One reckons that about 50% of all women will suffer from fractures due to osteoporosis.
- Vertebroplasty is a percutaneous injection of bone cement into a vertebra in order to alleviate pain in a compression fracture caused by osteoporosis. Vertebroplasty was performed for the first time in France in 1984 and ten years later in the USA. Kyphoplasty means balloon expansion in a collapsed vertebra for, if possible, reducing the risk for further collapse of the vertebra and provide a cavity which is filled with bone cement. Kyphoplasty is regarded as experimental in Europe, but has recently been approved by the FDA for treatment of pathological fractures together with polymeric bone cements. The drawback with kyphoplasty is that this method requires general anaesthesia.
- Vertebroplasty however, can be performed in a surgery in fluoroscopy while administering sedatives and analgesics. Both methods give satisfactory pain relief in more than 75% of the cases. Early treatment of verte- bra compression with vertebroplasty is still discussed even if satisfactory pain relief can be provided. It is recommended to wait at least six weeks before vertebroplasty is performed. While waiting, pain killing treatment is tested. Early treatment with vertebroplasty however, can be considered if there is a risk for complications causing immobilization or if the pain is severe. A principal object with vertebroplasty is except pain relief to prevent further col- lapse of vertebra.
- MR can be used besides common X-ray, said MR also showing oedema in the bone marrow and fracture gaps in the vertebra.
- Vertebroplasty is performed with the patient lying on his or her stomach or on the side during intraveneous sedation and pain relief and under control by a physician.
- a needle is inserted into a mandrine in the vertebra during fluoro- scopy via a transpedicular or posteolateral inlet.
- the needle shall be positioned in the centre line, preferably in the fore or anterior part of the vertebra.
- injection of cement is carried through. Another needle is often necessary for symmetric filling of the vertebra.
- the injection of cement is carefully supervised via TV-fluoroscopy and if leakage occurs outside the limits of the vertebra, the injection is interrupted.
- the required volume for adequate pain relief is small, about 2-3 ml. If larger volumes are used, the risk increases that cement will leak out, as is the risk that bone marrow will spread into the circulation system during injection.
- the injection requires technical knowledge and training. Almost all substantial complications depend on leakage of cement to the spinal canal or through the injection site. In more than 20% there is an asymptomatic leakage of cement into paraspinal soft parts or the lumbar venous system.
- fig. 1 is a longitudinal section through the device according to the invention during a mixing step
- fig. 2 is an enlarged sectional view of a part of the device of fig. 1 and shows a mixing means interconnected with a discharge means
- fig. 3 is a section through the device of fig. 1 during a discharge step
- fig. 4 is a perspective view of a bracket forming part of the device of fig. 1
- fig. 5 is a perspective view of a discharge piston forming part of the device of fig. 1
- fig. 6 is a perspective view of a rotary-movement preventing member forming part of the device of fig. 1 ; fig.
- FIG. 7 is a perspective view of a rotatable means forming part of the device of fig. 1 ;
- fig. 8 is a side view of a screw mechanism for use at the device of fig. 1 ;
- fig. 9 illustrates a part of the device of fig. 1 containing a powder component and during injection of a liquid component;
- fig. 10 illustrates a part of the device of fig. 1 connected to a distributor device;
- fig. 11 is a perspective view of the distributor device of fig. 10;
- fig. 12 illustrates the device of fig. 1 during use in connection with vertebroplasty.
- the device 1 illustrated in the drawings is adapted for producing a hardenable mass 2 such as bone substitute and/or bone reinforcing material or bone cement or similar material.
- This mass 2 shall be fed and/or sucked out of the device 1 and comprises a mixing container 3 of e.g. cylindrical shape.
- the mixing container 3 defines a mixing space 4 in which at least one powder component 5 and at least one liquid component 6 are mixed to produce the hardenable mass 2.
- a piston means 7 which is adapted to be retained relative to the mixing container 3 during a mixing step and thereafter released such that it can move in the mixing space 4 relative to the mixing container 3.
- a rotatable means 8 which in a retaining position P1 retains the piston means 7 relative to the mixing container 3 and which by rotation from the retaining position P1 to a release position P2 can be released relative to the mixing contai- ner 3, whereby the piston means 7 can move in the mixing space 4.
- the piston means 7 and the rotatable means 8 are preferably directly or indirectly interconnected.
- the device 1 preferably but not necessarily comprises a mixing means 9 which is provided for mixing the powder and liquid components 5, 6 with each other until the hardenable mass 2 has been produced. Then, the mass 2 can be stirred with the mixing means 9 if this is appropriate or necessary.
- the mixing means 9 may comprise an elongated member 10, e.g.
- the elongated member 10 is provided with an operating handle 13 for operating the mixing means 9.
- the mixing/stirring can be carried through in a known manner by moving the mixing means 9 back and forth in the mixing space 4 and preferably also rotating it relative to said mixing space 4.
- the piston means 7 preferably has an axial hole 14 extending therethrough and by means of which the elongated member 10 of the mixing means 9 extends into the mixing space 4.
- the elongated member 10 cooperates with the piston means 7 through one or more sealing rings 15 or similar, such that a sealing is provided between said members.
- the elongated member 10 and the hole 14 of the piston means 7 are adapted to each other such that said elongated member 10 can be moved and rotated relative to the piston means 7.
- At least one outer sealing 16 or similar is provided on the piston means 7 for cooperation with the inner side of the mixing container 3 such that a sealing is defined between the piston means 7 and said inner side.
- the outer sealing ring 16 is preferably designed such that it removes mass 2 which deposits on the inner side of the mixing container 3 when it moves in the mixing space 4.
- the piston means 7 may also have an opening 17 with at least one filter 18. The opening 17 is adapted to let out gases from the mixing space 4 and the filter 18 is adapted to prevent the components 5 and/or 6 and the mixed mass 2 from forcing its way out of the mixing space 4 through the opening 17.
- a rotary-movement preventing member 19 is provided on the piston means 7.
- This mem- ber 19 is annular and includes two axially provided hook portions 20, 21 which can be inserted into grooves 22, 23 in the piston means 7 and hooked onto two shoulders 7a, 7b thereon in a radial direction. By means of this positioning, the rotary-movement preventing member 19 is attached to the piston means 7 and can not rotate relative to said means.
- the rotary-movement preventing member 19 further includes an axially provided flange 24 which is adapted to cooperate with a bracket 25 in order to prevent rotation of the rotary- -movement preventing member 19 and thus, the piston means 7, relative to the bracket 25 5 such that the mixing means 9 is rotated relative to the piston means 7 for mixing of the powder and liquid components 5, 6.
- the bracket 25 has a cylindrical member 27 with a hole 28 into which the rotatable means 8 can be inserted and through which said rotatable means can move when it is set in a release position P2.
- the cylindrical member 27 of the bracket 25 may have an annular snap-in portion 29 which can be threaded into one or more locking 10 portions 30 which are located at the inner side of the mixing container 3 and which allow the bracket 25 to be attached to the mixing container 3 by a snap-in closure.
- the bracket 25 may have a number of radially projecting members 33, 34 which can be attached to a radially outwards directed flange 35 on the mixing container 3 by a snap-in closure such that the bracket 25 can not rotate relative
- the rotatable means 8 has a through hole 8a through which the elongated member 10 of the mixing means 9 extends such that said elongated member 10 is movable relative to the rotatable means 8 and vice versa.
- the rotatable means 8 has a first flange 36 or a corresponding member which in relation
- the first flange 36 surrounds a part of the periphery of the rotatable means 8.
- the hole 28 of the bracket 25 has a second flange 31a or a corresponding second member which relative to the direction U is directed radially into the hole 28. This second flange
- a section 31b or a corresponding third part of the hole 28 lacks said flange 31a and is designed such that the first flange 36 of the rotatable means 8 can pass therethrough, whereby the entire rotatable means 8 can be brought to pass through the hole 28 when the first flange 36 and the section 31b cooperate.
- the rotatable means 8 When the rotatable means 8 is set in the retaining position P1 (fig. 1 ), then the first and second flanges 36 and 31a cooperate and prevent the rotatable means 8 from moving relative to the bracket 25 in direction U, while the mixing means 9 can move and be brought to perform mixing movements for mixing the powder and liquid components in the mixing space 4.
- the rotatable means 8 can be brought to its release position P2 (fig. 2) by rotating it 180" relative to the bracket 25 from its retaining position P1 and this rotary movement can be li- mited by bringing the first flange 36 thereof to engage or abut a rotary stop 32.
- the first flange 36 of the rotary means 8 will be disengaged from the cooperation with the second flange 31a of the bracket 25 and it can instead cooperate with the section 31b of the bracket 25 such that the rotatable means 8 and thus, the piston means 7, can move and be displaced in direction U in relation thereto and thus, relative to the mixing container 3.
- the piston means 7 is prevented from rotating relative to the bracket 25 by the flange 24 of the rotary-movement preventing member 19 engaging or gripping preferably into the section 31 b of the bracket 25 when the rotatable means 8 retains the piston means 7 at the bracket 25.
- the rotatable means 8 cooperates preferably with a coupling device 37 which is provided to interconnect the piston means 7 and the elongated member 10 of the mixing means 9 such that the piston means 7 (and the rotatable means 8 provided thereby) can be displaced in axial direction U relative to the mixing container 3 by means of the mixing means 9 for discharge of mixed mass 2 from the mixing space 4.
- the coupling device 37 is located between the rotatable means 8 and the piston means 7 and it is preferably provided to be operated by the rotatable means 8 such that it connects the piston means 7 to the elongated member 10 while simultaneously the rotatable means 8 is rotated from its retaining position P1 to its release position P2.
- the coupling device 37 may comprise a coupling means 38, e.g. a washer, which is threaded onto the elongated member 10 and which is located between the piston means 7 and the rotatable means 8.
- the piston means 7 has a support member 39 which is axially directed towards the rotatable means 8 and located on one side of the elongated member 10, while there is a free space 40 on the other side of the elongated member 10.
- the rotatable means 8 has an axially directed bore 41 , the rear parts of which are provided with a helical spring 42 or a similar resilient element and the fore parts with a pin 43 which projects out of the bore 41.
- the bore 41 with the helical spring 42 is located on the same side of the elongated member 10 and the helical spring thereby presses the coupling means 38 against the support member 39 such that said coup- ling means 38 is held in a neutral position P3 in which it is held against the support member 39 and permits displacement of the elongated member 10 of the mixing means 9 in opposite axial mixing directions B, whereby the powder and liquid components 5, 6 can be mixed in the mixing space 4 with the mixing means 9 while the piston means 7 is retained relative to the mixing container 3.
- the bore 41 and the helical spring 42 will also move 180° relative to the support member 39 and the helical spring 42 will thereby press or push the coupling means 38 into the space 40, which means that the coupling means 38 is tilted relative to the elongated member 10 and is brought to a coupling position P4 in which the coupling means 38 is fastened to the elongated member 10.
- the piston means 7 is connected to the mixing means 9 such that the piston means 7 can be displaced in the direction U by said mixing means 9.
- the coupling device 37 is designed such that it, after said interconnection of the mixing means 9 and the piston means 7, permits release of the mixing means 9 relative to the piston means 7 if said mixing means 9 is pulled in the return direction R relative to the piston means 7.
- it is prevented that said rotation of the mixing means 9 is transferred to the rotatable means 8.
- the bracket 25 is preferably provided to prevent the piston means 7 and the mixing means 9 from being pulled apart from the mixing container 3. Since the rotatable means 8 can move together with the piston means 7 in the mixing space 4 of the mixing container 3, it is ensured that the device 1 will be simple and that it provides for a simple and quick handling when mixing of the powder and liquid components 5, 6 has been performed and the mixed mass 2 shall be discharged. To this end, it is only necessary to rotate the rotatable means 8 from its retaining position P1 to the release posi- tion P2, whereafter it is possible to displace the piston means 7 by means of the mixing means 9 in the direction U for discharge of the mass 2 from the mixing space 4.
- At least one opening 47 can be provided in the side of the mixing container 3 adjacent the piston means 7 when said piston means is retained by the bracket 25. Since the opening 47 is located adjacent the piston means 7, it is closed when the piston means 7 starts to move in the direction U and after further movement of the piston means 7, it will be located behind said piston means, which means that only gas and no mass 2 can be pressed out through the opening 47.
- the opening 48 may be closable when neces- sary.
- the abovementioned opening 17 or openings 47 or 48 permit gas to be pressed out of the mixing space 4 when e.g. the liquid component 6 is injected into said space. Since gas hereby can be pressed out, injection of the liquid component 6 is facilitated. Due to its location, the opening 48 permits gas which is entrapped in the mass 2 to be pressed out of or escape from said mass during discharge thereof.
- At least one vacuum generating device can be provided to generate a vacuum in the mixing space 4 for various purposes, preferably for facilitating quick suction of the liquid component 6 to and distribution thereof in the powder component 5 and/or e.g. for sucking out toxic gases therefrom, which are generated during mixing of the powder and liquid compo- nents 5, 6.
- first vacuum generating device 50 which at a suitable location can be connected to the mixing container 3.
- a first vacuum generating device 50 is schematically il- lustrated in fig. 1.
- the mixing means 9 can be subjected to linear forces such that said mixing means 9 and the piston means 7 are displaced linearly relative to the mixing container 3.
- the mixing means 9 can be displaced linearly by influence from a screw device 51.
- the screw device 51 e.g.
- a nut-like member 52 which has a laterally open fork- -like member 52a with laterally open grooves 53 permitting sideways threading of the nut- -like member 52 onto the flange 35 of the mixing container 3 such that said member 52 is stuck on the mixing container 3.
- the nut-like member 52 is provided with a tapped hole 54 for a screw-like member 55 with outer threads 56 which mesh with the threads in the tapped hole 54 of the nut-like member 52.
- the screw-like member 55 may be a pipe member with a multi-side nut 58 and the pipe member may have a longitudinal slit 57 which is open in a lateral direction and the nut may have an open side 60 such that the screw-like member 55 and the nut 58 can be threaded onto the elongated member 10 of the mixing means 9.
- the nut 58 is adapted to fit into a corresponding multi-side hole 59 in the outer member 45 or any other member on or of the operating handle 13.
- said device can be non- -rotatably located on the mixing container 3 and since the nut 58 can be inserted into the hole 59, the screw-like member 55 may, by means of the operating handle 13, be screwed into the nut-like member 52 via e.g. the outer member 45, whereby the end portion 61 of the screw-like member 55 is brought in contact with the rotatable means 8 and can impart dis- charge forces in the direction U to the rotatable means 8 and through said rotatable means to the piston means 7.
- the piston means 7 can be moved in the direction U either by manually pressing the operating handle 13 or rotating it and transfer the rotary movement by means of the screw device 51.
- a gun-like discharge device 62 or a similar device as is schematically indicated in fig. 1.
- the mixi ⁇ g container 3 is positioned therein such that a pressure means 63 can cooperate with the mixing means 9 or directly with the piston means 7 if there is no mixing means.
- the pressure means 63 is operated by a manually depressable trigger which can move the pressure means 63 stepwise such that said pressure means with force press the mixing means 9 and/or the piston means 7 forward in the direction U.
- the mixing space 4 of the mixing container 3 may carry the powder component 5 when the device 1 is delivered.
- the discharge opening 49 is hereby closed by a closing device 64 which prevents the powder component 5 from falling out of the mixing space 4.
- the liquid component 6 can be provided in a liquid container 65 and can be fed into the mixing space 4 for mixing therein with the powder component 5.
- the liquid container 65 has a discharge end 66 and the closing device 64 can be designed such that the discharge end 66 can open the closing device 64 when it is inserted into said device for injecting the liquid component 6 into the mixing space 4 and the powder component 5 therein.
- the closing device 64 may comprise a valve body 64a which is normally closed and which is opened by the discharge end 66 when said end is inserted into the closing device 64 and automatically returned to closed position when the discharge end 66 is removed or withdrawn from the closing device 64.
- a valve 67 can be provided to cooperate with the closing device 64 to permit gas to escape from the mixing space 4 when the liquid component 6 is injected into said space from the liquid container 65.
- This valve 67 can be closed and may be opened when required.
- the mixing container 3 or parts thereof may be brought in contact with a vibrating device 68 schematically illustrated in fig. 9.
- the mixing container 3 can be connected to a distributor device 69 or vice versa.
- Several containers 70 can be connected thereto or vice versa, such that mass 2 mixed in the mixing space 4 can be fed out or discharged from said mixing space and into the distributor device 69.
- the distributor device 69 distributes the mass 2 to the various containers 70 such that portions of the mass 2 are fed into inner spaces 71 in the containers 70.
- the inner space 71 in each container 70 is substantially smaller than the mixing space 4 of the mixing container 3, which means that one can fill the spaces 71 of a plurality of containers 70, e.g. the spaces 71 of eight containers 70, with a part volume 2a of the mass 2 from the mixing space 4.
- each container 70 can be removed from the distributor device 69 or vice versa and the part volume 2a of mass 2 in the container 70 can be fed and/or sucked out of the container 70.
- the distributor device 69 preferably comprises a distributor body 72 with an axial inlet pipe 73 which can be located close to such an outlet or discharge end 74 of the mixing container 3 having the discharge opening 49.
- the inlet pipe 73 can be located at the discharge end 74 by screwing on or in any other suitable manner such that inner passages in the dist- ributor body 72 communicate with the discharge opening 49.
- the mixing container may instead be located on the inlet pipe 73.
- the distributor device 69 may also comprise a number of discharge pipes 75-82, at least two and e.g. eight pipes, which extend radially in a star-like manner from the distributor body 72 and which communicate with inner members of the distributor body 72.
- Each container 70 has a front part 84 through which it can be mounted, e.g. screwed on to one of the discharge pipes 75-82 of the distributor device 69 or vice versa, such that a 5 part volume 2a of mass 2 can be fed into the space 71.
- a piston 86 forming part of the container 70 is preferably located in a rear part 85 of the container 70.
- a cannula or needle 83 can be located on the front part 84. The part volume 2a of mass 2 is fed or sucked out of the space 71 of the container 70 through said cannula 83.
- Each container 70 may eventually have an opening 87 which preferably is found in the rear part 85 and immediately in front of the piston 86 when said piston is situated in the rear part 85.
- This opening 87 allows gas in the space 71 of the container 70 to be pressed out of the space when said part volume 2a of mass 2 is fed into said space 71.
- gas in the space 71 resists entrance of the part volume 2a of mass 2 into said
- the opening 87 has e.g. a diameter of 0,2-1 ,0 mm, preferably about 0,6 mm.
- the opening 87 may alternatively be a groove (not shown) provided axially in the inner side of the container 70 and extending beyond the piston 86 when said piston is situated in the rear part 85 of the container 70.
- one container 70 at the time is removed from the distributor device 69 and a cannula or needle 83 is mounted preferably on the front part 84 of the container 70 such that the part volume 2a of mass 2 can be fed or sucked out through the cannula 83 with or without support from the piston 86 until the space 71 is empty.
- a container 70 is connected to the spongy bone 89 by inserting the cannula 83 thereof, or a member (not shown) to which the cannula 83 can be connected, into the inner parts 89a such that the space 71 of the container 70 communi- cates therewith.
- At least one vacuum source 90 through a connection line 92 for generating a vacuum in the inner parts 89a and in the space 71 of the container 70 connected thereto such that the part volume 2a of mass 2 is sucked out of said space 71 and through the cannula 83 into the inner parts 89a of the spongy bone 89.
- the piston 86 may eventually be displaced in the direction U for supporting the suction of the part volume 2a of the mass 2 out of the space 71.
- Inner parts 89a of the spongy bone 89 can be provided with mass 2 from the mixing container 3.
- the mixing container 3 can be provided with a cannula or needle (not shown) or similar and this cannula is inserted into the inner parts 89a.
- the mass 2 can thereby be sucked out of the mixing space 4 of the mixing container 3 and into the inner parts 89a by means of the vacuum source 90.
- this suction of mass 2 from the mixing space 4 may be supported by a displacement of the piston means 7 in the direction U.
- the spongy bone 89 may e.g. be a spongy vertebra or an osteoporosis fracture in the form of a thighbone (femoral) or knee (patellar) fracture.
- Mixed mass 2 in the mixing container 3 can be used for fixation of implants, whereby one can provide the container with a discharge pipe or similar (not shown), through which the mass 2 is discharged by means of the piston means 7 into cavities in the bone in which the implant shall be fixed.
- the mass 2 may consist of bone substitute and/or bone reinforcing material which primarily consist of calcium base material or ceramics which can be mixed with a hardener, e.g. water.
- These substances may be selected from the group comprising calcium sulphate- ⁇ - hemihydrate, calcium sulphate- ⁇ -hemihydrate, calcium sulphate-dihydrate, calcium carbonate, ⁇ -tricalcium phosphate, hydroxyapatite, dicalcium phosphate-dihydrate, anhydrous dicalcium phosphate, tetracalcium phosphate, ⁇ -tricalcium phosphate, calcium deficient hydroxyapatite, monocalcium phosphate-monohydrate, monocalcium phosphate, calcium- pyurophosphate, precipitated hydroxyapatite, carbonaceous apatite (dahlite), octacalcium phosphate, amorphous calcium phosphate, oxyapatite, carbonato apatite and calcium alu- minate.
- a ceramic material may be calcium aluminate, which forms part of the product Doxa T from the company Doxa (www.doxa.se/pdf/nyhet__1.pdf).
- X-ray contrast agents can be added to said ceramic bone substitute and/or bone reinfor- cing material, e.g.
- the mass 2 can be a hardenable bone cement comprising polymer and monomer components.
- the polymer may be polymethylmethacrylate (PMMA) and the monomer methyl methacrylate (MMA).
- a polymer base material can be the product CortossTM from the company Orthovita in the U.S.A.. For composition see www.orthovita.com/pro- ducts/cortoss/oustechspecs.html.
- Another polymer base material can be the product SECOUR® Acrylic Resin PMMA from parallax medical inc. (www.parallax-medical.com/go/ 91 -92b550-5642_1157-a432-d7a2b9831 Ofe).
- the mass 2 can be a bone substitute and/or bone reinforcing material and consist of a mineral and/or a ceramic in combination with polymer material.
- the screw device 51 may be a device which can be connected to a mixing container 3 which is designed in another way than what is illustrated in the drawings and where the piston means 7 is located and operated in another way than what is shown in the drawings.
- the distributor device 69 can be connected to a mixing container 3 or vice versa which is designed in another way than what is shown in the drawings and where the piston means 7 is mounted in another way than what is shown in the drawings.
- the invention is not limited to the embodiments described above and illustrated in the drawings.
- the mass 2 may be another type of mass than bone substitute and/or bone reinforcing material or bone cement or similar.
- the rotatable means 8 may cooperate with the piston means with other means than those shown and described; mixing may be carried through in another way than with a mixing means 9 and if there is such a means, this may be designed otherwise; the mixing container 3 may be designed in another way than what is described and illustrated; when using a screw device 51 , this may be of another type than the one described and illustrated and this also refers to the distributor device 69.
- the piston means 7 may either be moved in the direction U by the mixing means 9 or be sucked in the same direction by the vacuum source 90, but it is also possible to move the piston means 7 by using the mixing means 9 and the vacuum source 90 simultaneously.
- the device 1 may be of the disposable type or used repeatedly.
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- Health & Medical Sciences (AREA)
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- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Prostheses (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Developing Agents For Electrophotography (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Discharge Heating (AREA)
- External Artificial Organs (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Insulated Conductors (AREA)
- Materials For Medical Uses (AREA)
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Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09158716.2A EP2108324B1 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
KR1020067027102A KR101247172B1 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
AT05752716T ATE459311T1 (en) | 2004-06-22 | 2005-06-17 | DEVICE FOR PRODUCING A CURDABLE MASS |
DE602005019731T DE602005019731D1 (en) | 2004-06-22 | 2005-06-17 | DEVICE FOR PRODUCING A HARDENABLE MASS |
JP2007517998A JP4891900B2 (en) | 2004-06-22 | 2005-06-17 | Curing substance manufacturing equipment |
US11/587,313 US7938572B2 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
AU2005253916A AU2005253916B2 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
CA2569702A CA2569702C (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
CN200580020615XA CN1972648B (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
PL05752716T PL1758526T3 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
EP05752716A EP1758526B1 (en) | 2004-06-22 | 2005-06-17 | Device for producing a hardenable mass |
HK07112683.0A HK1106995A1 (en) | 2004-06-22 | 2007-11-21 | Device for producing a hardenable mass |
US12/585,194 US8297831B2 (en) | 2004-06-22 | 2009-09-08 | Device for producing a hardenable mass |
US13/613,563 US8662737B2 (en) | 2004-06-22 | 2012-09-13 | Device for producing a hardenable mass |
US14/157,304 US20140198601A1 (en) | 2004-06-22 | 2014-01-16 | Device for Producing A Hardenable Mass |
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SE0401604A SE527528C2 (en) | 2004-06-22 | 2004-06-22 | Apparatus for the preparation of curable pulp and use of the apparatus |
SE0401604-4 | 2004-06-22 |
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US12/585,194 Division US8297831B2 (en) | 2004-06-22 | 2009-09-08 | Device for producing a hardenable mass |
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US (4) | US7938572B2 (en) |
EP (4) | EP1758526B1 (en) |
JP (1) | JP4891900B2 (en) |
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AT (3) | ATE460894T1 (en) |
AU (1) | AU2005253916B2 (en) |
CA (2) | CA2569702C (en) |
DE (3) | DE602005020073D1 (en) |
ES (3) | ES2341464T3 (en) |
HK (3) | HK1106995A1 (en) |
PL (3) | PL1920738T3 (en) |
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SE (1) | SE527528C2 (en) |
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