WO2005113765A3 - Procedes d'activation de sulfatases, methodes et compositions d'utilisation associees - Google Patents

Procedes d'activation de sulfatases, methodes et compositions d'utilisation associees Download PDF

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Publication number
WO2005113765A3
WO2005113765A3 PCT/US2005/014097 US2005014097W WO2005113765A3 WO 2005113765 A3 WO2005113765 A3 WO 2005113765A3 US 2005014097 W US2005014097 W US 2005014097W WO 2005113765 A3 WO2005113765 A3 WO 2005113765A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
sulfatases
activation
same
Prior art date
Application number
PCT/US2005/014097
Other languages
English (en)
Other versions
WO2005113765A2 (fr
Inventor
Todd Zankel
Gary Nicholas Zecherle
Christopher M Starr
Teresa Margaret Christianson
Original Assignee
Biomarin Pharm Inc
Todd Zankel
Gary Nicholas Zecherle
Christopher M Starr
Teresa Margaret Christianson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc, Todd Zankel, Gary Nicholas Zecherle, Christopher M Starr, Teresa Margaret Christianson filed Critical Biomarin Pharm Inc
Publication of WO2005113765A2 publication Critical patent/WO2005113765A2/fr
Publication of WO2005113765A3 publication Critical patent/WO2005113765A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des procédés de production de protéines de sulfatases activées. L'invention concerne également des méthodes et des compositions d'utilisation de ces protéines activées dans le traitement de divers troubles.
PCT/US2005/014097 2004-05-06 2005-04-25 Procedes d'activation de sulfatases, methodes et compositions d'utilisation associees WO2005113765A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56854404P 2004-05-06 2004-05-06
US60/568,544 2004-05-06

Publications (2)

Publication Number Publication Date
WO2005113765A2 WO2005113765A2 (fr) 2005-12-01
WO2005113765A3 true WO2005113765A3 (fr) 2006-01-12

Family

ID=35428930

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/014097 WO2005113765A2 (fr) 2004-05-06 2005-04-25 Procedes d'activation de sulfatases, methodes et compositions d'utilisation associees

Country Status (1)

Country Link
WO (1) WO2005113765A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104540517A (zh) * 2012-06-29 2015-04-22 夏尔人类遗传性治疗公司 用于产生重组艾杜糖-2-硫酸酯酶的细胞

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985783B2 (en) * 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
US7722865B2 (en) 2008-01-18 2010-05-25 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
PE20140841A1 (es) 2008-01-18 2014-08-03 Biomarin Pharm Inc Elaboracion de enzimas lisosomales sulfatasa humanas activas y altamente fosforiladas y sus usos
WO2009120611A2 (fr) 2008-03-27 2009-10-01 The Regents Of The University Of California Marqueurs aldéhydiques et leurs utilisations dans le cadre d’une modification de protéines spécifiques d’un site
US20120180148A1 (en) * 2011-01-07 2012-07-12 Jin Thong-Gyu Transgenic mouse model for developing enzyme replacement therapy for iduronate-2-sulfatase deficiency syndrome
KR101158673B1 (ko) 2011-06-24 2012-07-03 주식회사 지씨바이오 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
EP2830642B1 (fr) * 2012-03-30 2019-08-28 Shire Human Genetic Therapies, Inc. Administration sous-cutanée d'iduronate 2-sulfatase
WO2013148323A1 (fr) * 2012-03-30 2013-10-03 Shire Human Genetic Therapies Procédés d'analyse et de préparation de compositions protéiques
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US20140004097A1 (en) * 2012-06-29 2014-01-02 Shire Human Genetic Therapies, Inc. Method of producing recombinant iduronate-2-sulfatase
CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRISTIANSON T. ET AL.: "Overexpression of inactive arysulphatase mutants and in vitro activation by light-dependent oxidation with vanadate.", BIOCHEM. J., vol. 382, September 2004 (2004-09-01), pages 581 - 587, XP002992392 *
ZALK P. ET AL.: "ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase.", BIOCHEM J., vol. 374, May 2003 (2003-05-01), pages 473 - 480, XP002992393 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104540517A (zh) * 2012-06-29 2015-04-22 夏尔人类遗传性治疗公司 用于产生重组艾杜糖-2-硫酸酯酶的细胞

Also Published As

Publication number Publication date
WO2005113765A2 (fr) 2005-12-01

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