WO2005094769A1 - Preparations cosmetiques ou dermatologiques contenant un melange de filtre uva, de filtre uvb et d'un oxyde metallique - Google Patents

Preparations cosmetiques ou dermatologiques contenant un melange de filtre uva, de filtre uvb et d'un oxyde metallique Download PDF

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Publication number
WO2005094769A1
WO2005094769A1 PCT/EP2005/001499 EP2005001499W WO2005094769A1 WO 2005094769 A1 WO2005094769 A1 WO 2005094769A1 EP 2005001499 W EP2005001499 W EP 2005001499W WO 2005094769 A1 WO2005094769 A1 WO 2005094769A1
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic
weight
dermatological preparations
filter
uvinul
Prior art date
Application number
PCT/EP2005/001499
Other languages
German (de)
English (en)
Inventor
Valerie Andre
Thomas Wünsch
Michael Schaper
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of WO2005094769A1 publication Critical patent/WO2005094769A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966—Triazines or their condensed derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • Cosmetic or dermatological preparations containing a mixture of a UV-A filter, a UV-B filter and a metal oxide.
  • the invention relates to cosmetic or dermatological preparations containing a mixture of a UV-A filter, a UV-B filter and a metal oxide.
  • the light stabilizers used in cosmetic and dermatological preparations have the task of preventing harmful effects of sunlight on human skin or at least reducing their effects. In addition, these light stabilizers also serve to protect other ingredients from destruction or degradation by UV radiation. In hair cosmetic formulations, damage to the keratin fiber by UV rays is to be reduced.
  • UV-B 280 to 320 ⁇ m
  • UV-A radiation > 320 nm
  • the influence on human skin is particularly noticeable with UV-B radiation due to sunburn. Accordingly, the industry offers a larger number of substances that absorb UV-B radiation and thus prevent sunburn.
  • UV-B filter is 2, 4, 6-trianilino-p- (carbo-2 '-ethyl-hexyl-1 x -oxi) -1, 3, 5-triazine, which is from BASF Aktiengesellschaft under the trade name Uvmul T150 is being marketed.
  • Uvinul ® T150 is characterized by good UV absorption properties with an exceptionally high extinction coefficient> 1500 at 314 nm.
  • N, N-Diethylamino-hydroxybenzoyl-n-hexylbenzoate of the formula II is a UV-A filter which is marketed by BASF Aktiengesellschaft under the trade name Uvinul A Plus.
  • the metal oxides zinc oxide and / or titanium dioxide used as component c) are preferably used as micropigments with a primary particle size of 5 to 200 nm, particularly preferably 10 to 60 nm. It may also be advantageous if the metalloxides are in hydrophobicized form, i.e. that they are treated to be water-repellent on the surface. Examples of surface-treated pigments include in DE-A-33 14 742, EP-A-0 518 772 and in EP-A-0 518 773.
  • Examples of commercially available zinc oxide or titanium dioxide are Uvinul ® Ti0 2 and Z-Cote ® , both of which are marketed by BASF Aktiengesellschaft.
  • Cosmetic or dermatological preparations containing are preferred
  • Cosmetic or dermatological preparations containing are particularly preferred
  • the cosmetic and dermatological preparations containing light stabilizers are generally based on a carrier which contains at least one oil phase. Accordingly, oils, oil-in-water and water-in-oil emulsions, creams and pastes, lip protection stick compositions or grease-free gels are suitable.
  • sun protection preparations of this type can be in liquid, pasty or solid form, for example as water-in-oil creams, oil-in-water creams and lotions, aerosol foam creams, gels, oils, grease pencils, powders, sprays or alcoholic water lotions.
  • Customary oil components in cosmetics are, for example, paraffin oil, glyceryl stearate, isopropyl yristate, diisopropyl adipate, 2-ethylhexanoic acid cetyl stearyl ester, hydrogenated polyisobutene, petroleum jelly, caprylic acid / capric acid triglycerides, microcrystalline wax, lanolin and stearic acid and silicone oil.
  • Suitable silicone oils are e.g. linear polydimethylsiloxanes, poly (methylphenylsiloxanes), cyclic siloxanes and mixtures thereof.
  • the number average molecular weight of the polydimethylsiloxanes and poly (methylphenylsiloxanes) is preferably in a range from about 1000 to 150,000 g / mol.
  • Preferred cyclic siloxanes have 4- to 8-membered rings.
  • Suitable cyclic siloxanes are e.g. commercially available under the name cyclomethicone.
  • Typical cosmetic auxiliaries which can be considered as additives are, for example, co-emulsifiers, fats and waxes, stabilizers, thickeners, biogenic active substances, film formers, fragrances, dyes, pearlescent agents, preservatives, pigments, electrolytes (for example magnesium sulfate) and pH -Regulatoren.
  • co-emulsifiers for example, co-emulsifiers, fats and waxes, stabilizers, thickeners, biogenic active substances, film formers, fragrances, dyes, pearlescent agents, preservatives, pigments, electrolytes (for example magnesium sulfate) and pH -Regulatoren.
  • Known W / O and, in addition, O / W emulsifiers such as polyglycerol esters, sorbitan esters or partially esterified glycerides are preferred as co-emulsifiers.
  • Typical examples of fats are glycerides; as waxes include beeswax, paraffin wax or microwaxes, optionally in combination with hydrophilic waxes.
  • Metal salts of fatty acids such as magnesium, aluminum and / or zinc stearate can be used as stabilizers.
  • Suitable thickeners are, for example, crosslinked polyacrylic acids and their derivatives, polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl cellulose, furthermore fatty alcohols, monoglycerides and fatty acids, polyacrylates, Polyvinyl alcohol and polyvinyl pyrrolidone.
  • Biogenic active ingredients are understood to mean, for example, plant extracts, protein hydrolyzates and vitamin complexes.
  • Common film Formers are, for example, hydrocolloids such as chitosan, microcrystalline chitosan or quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives and similar compounds.
  • Suitable preservatives are, for example, formaldehyde solution, parabens such as methyl paraben, 1, 2-dibromo-2, 4-di-cyanobutane, p-hydroxybenzoate or sorbic acid.
  • Suitable pearlizing agents are, for example, glycol distearic acid esters such as ethylene glycol distearate, but also fatty acids and fatty acid monoglycol esters.
  • the dyes which can be used are the substances which are suitable and approved for cosmetic purposes, as compiled, for example, in the publication "Cosmetic Dyes” by the Dye Commission of the German Research Foundation, published by Verlag Chemie, Weinheim, 1984. These dyes are usually used in a concentration of 0.001 to 1% by weight, based on the mixture as a whole.
  • the total proportion of auxiliaries and additives can be 1 to 80, preferably 6 to 40% by weight and the non-aqueous proportion ("active substance") 20 to 80, preferably 30 to 70% by weight, based on the composition. be.
  • the preparation of the agents can be carried out in a manner known per se, i.e. for example by hot, cold, hot / cold or PIT emulsification. This is a purely mechanical process, there is no chemical reaction.
  • UV filter substances Any UV-A and UV-B filter substances are suitable as UV filter substances which can be used with the combination of Uvinul T150, Uvinul A Plus together with zinc oxide and / or titanium dioxide. Examples include:
  • the light protection preparations according to the invention can be used as shampoos, lotions, gels, hair sprays, aerosol foam creams or emulsions, inter alia, for washing, dyeing and styling the hair.
  • UV filter action of the preparations according to the invention can also be used to stabilize active ingredients and auxiliaries in cosmetic and dermatological formulations.
  • the preparations according to the invention are distinguished by a particularly high absorption capacity in the area of UV-B radiation with a sharp band structure and high sun protection factors.
  • the high sun protection factor of the preparations which was measured even at low concentrations of UV-absorbing active ingredients, was surprising.
  • the sun protection factor of the cosmetic or dermatological formulations is in the range greater than 14, preferably in the range greater than 25.
  • Corresponding values can be achieved, for example, by means of a light protection emulsion with a Uvinul T150 content of 3% by weight, Uvinul® A Plus of 2% by weight. % and a concentration of zinc oxide and / or titanium dioxide of 4% by weight.
  • Uvinul T 150 0.1 to 10% by weight, preferably 1 to 6% by weight, particularly preferably 2 to 6% by weight , very particularly preferably 2 to 4 wt .-%), Uvinul A Plus ® (0.1 to 10 wt .-%, preferably 1 to 6 wt .-%, particularly preferably 1 to 5 wt .-%, most preferably 1 to 3% by weight) and zinc oxide or titanium dioxide (0.1 to 15% by weight, preferably 1 to 8% by weight, particularly preferably 2 to 6% by weight) already satisfactory sun protection values can be obtained.
  • Uvinul T 150 0.1 to 10% by weight, preferably 1 to 6% by weight, particularly preferably 2 to 6% by weight , very particularly preferably 2 to 4 wt .-%)
  • Uvinul A Plus ® 0.1 to 10 wt .-%, preferably 1 to 6 wt .-%, particularly preferably 1 to 5 wt .-%, most preferably 1 to 3% by weight
  • phase A and C were heated separately to approx. 85 ° C.
  • Phase C and the metal oxide were then stirred into phase A with homogenization.
  • the emulsion was cooled to room temperature with stirring and bottled. All quantities are based on the total weight of the preparations.
  • Emulsion A containing 3% by weight Uvinul ® T150, 2% by weight Uvinul ® A Plus and 4% by weight zinc oxide (sun protection factor 29)
  • Emulsion B containing 3% by weight Uvinul ® T150 and 2% by weight Uvinul 0 A Plus (sun protection factor 17)
  • Emulsion C containing 3% by weight of Uvinul ® T150 and 4% by weight of zinc oxide (sun protection factor 23)
  • Emulsion D containing 3% by weight of Uvinul ® T150 and 4% by weight of Uvinul ® Ti0 2 (sun protection factor 23)
  • Emulsion E containing 3% by weight Uvinul ® T150 (sun protection factor 9)
  • Emulsion F containing 4% by weight zinc oxide (sun protection factor 4)
  • Emulsion G containing 4% by weight Uvinul ® Ti0 (sun protection factor 6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques contenant a) 0,1 à 10 % en poids de 2,4,6-trianilino-p-(carbo-2`-éthyle-hexyle-1`-oxy)-1,3,5-triazine de formule I (I), b) 0,1 à 10 % en poids de N,N-diéthylamino-hydroxybenzoyle-n-benzoate d'hexyle de formule II (II), et c) 0,1 à 15 % en poids d'oxyde de zinc et/ou de titane.
PCT/EP2005/001499 2004-02-17 2005-02-15 Preparations cosmetiques ou dermatologiques contenant un melange de filtre uva, de filtre uvb et d'un oxyde metallique WO2005094769A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004007885.8 2004-02-17
DE200410007885 DE102004007885A1 (de) 2004-02-17 2004-02-17 Kosmetische und dermatologische Zubereitungen, enthaltend ein Gemisch aus einem UV-A-Filter, einem UV-B-Filter und einem Metalloxid

Publications (1)

Publication Number Publication Date
WO2005094769A1 true WO2005094769A1 (fr) 2005-10-13

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PCT/EP2005/001499 WO2005094769A1 (fr) 2004-02-17 2005-02-15 Preparations cosmetiques ou dermatologiques contenant un melange de filtre uva, de filtre uvb et d'un oxyde metallique

Country Status (2)

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DE (1) DE102004007885A1 (fr)
WO (1) WO2005094769A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008028665A1 (de) * 2008-06-09 2009-12-17 Beiersdorf Ag Kosmetische Zubereitung mit Titandioxid in multimodaler Partikelgrößenverteilung
CN107157789A (zh) * 2016-02-29 2017-09-15 爱茉莉太平洋股份有限公司 隔离有害射线用化妆组合物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310237A2 (fr) * 2001-11-09 2003-05-14 Beiersdorf AG Formulations cosmétiques et dermatologiques antisolaires contenant des hydroxybenzophénones et des polymères d'acrylamide
WO2003039506A2 (fr) * 2001-11-09 2003-05-15 Beiersdorf Ag Preparations cosmetiques et dermatologiques a protection solaire contenant des hydroxybenzophenones et des alkyle naphtalates
WO2003053395A1 (fr) * 2001-12-20 2003-07-03 Beiersdorf Ag Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole
DE10214054A1 (de) * 2002-03-28 2003-10-09 Beiersdorf Ag Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Alpha Olefin/Maleinsäureanhydrid-Copolymeren
WO2003082221A1 (fr) * 2002-03-28 2003-10-09 Beiersdorf Ag Formulations cosmetiques et dermatologiques de protection solaire resistantes a l'eau contenant des polymeres sequences de polyoxyethylene-polydodecylglycol
WO2003082237A2 (fr) * 2002-03-28 2003-10-09 Beiersdorf Ag Formulations de protection solaire cosmetiques et dermatologiques hydroresistantes contenant une quantite d'esters acetyles de l'acide stearique
EP1388338A1 (fr) * 2002-08-07 2004-02-11 Beiersdorf AG Composition solaire moussante
WO2005025521A2 (fr) * 2003-09-15 2005-03-24 Basf Aktiengesellschaft Preparations pulverulentes contenant un melange de 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine et de diethylamino-hydroxybenzoyl-hexyl-benzoate

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310237A2 (fr) * 2001-11-09 2003-05-14 Beiersdorf AG Formulations cosmétiques et dermatologiques antisolaires contenant des hydroxybenzophénones et des polymères d'acrylamide
WO2003039506A2 (fr) * 2001-11-09 2003-05-15 Beiersdorf Ag Preparations cosmetiques et dermatologiques a protection solaire contenant des hydroxybenzophenones et des alkyle naphtalates
WO2003053395A1 (fr) * 2001-12-20 2003-07-03 Beiersdorf Ag Formulations cosmetiques et dermatologiques a effet de protection solaire, contenant des substances filtrant les u.v., solubles dans l'eau et des derives de benzoxazole
DE10214054A1 (de) * 2002-03-28 2003-10-09 Beiersdorf Ag Wasserfeste kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Alpha Olefin/Maleinsäureanhydrid-Copolymeren
WO2003082221A1 (fr) * 2002-03-28 2003-10-09 Beiersdorf Ag Formulations cosmetiques et dermatologiques de protection solaire resistantes a l'eau contenant des polymeres sequences de polyoxyethylene-polydodecylglycol
WO2003082237A2 (fr) * 2002-03-28 2003-10-09 Beiersdorf Ag Formulations de protection solaire cosmetiques et dermatologiques hydroresistantes contenant une quantite d'esters acetyles de l'acide stearique
EP1388338A1 (fr) * 2002-08-07 2004-02-11 Beiersdorf AG Composition solaire moussante
WO2005025521A2 (fr) * 2003-09-15 2005-03-24 Basf Aktiengesellschaft Preparations pulverulentes contenant un melange de 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine et de diethylamino-hydroxybenzoyl-hexyl-benzoate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008028665A1 (de) * 2008-06-09 2009-12-17 Beiersdorf Ag Kosmetische Zubereitung mit Titandioxid in multimodaler Partikelgrößenverteilung
CN107157789A (zh) * 2016-02-29 2017-09-15 爱茉莉太平洋股份有限公司 隔离有害射线用化妆组合物

Also Published As

Publication number Publication date
DE102004007885A1 (de) 2005-09-08

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