EP1858597A1 - Preparations cosmetiques et dermatologiques, contenant des particules de dioxyde de titane transparentes a revetement de surface - Google Patents

Preparations cosmetiques et dermatologiques, contenant des particules de dioxyde de titane transparentes a revetement de surface

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Publication number
EP1858597A1
EP1858597A1 EP06708638A EP06708638A EP1858597A1 EP 1858597 A1 EP1858597 A1 EP 1858597A1 EP 06708638 A EP06708638 A EP 06708638A EP 06708638 A EP06708638 A EP 06708638A EP 1858597 A1 EP1858597 A1 EP 1858597A1
Authority
EP
European Patent Office
Prior art keywords
cosmetic
titanium dioxide
dioxide particles
dermatological preparations
coated titanium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP06708638A
Other languages
German (de)
English (en)
Inventor
Valerie Andre
Scott D. Thomson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of EP1858597A1 publication Critical patent/EP1858597A1/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/36—Compounds of titanium
    • C09C1/3607—Titanium dioxide
    • C09C1/3669—Treatment with low-molecular organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/36—Compounds of titanium
    • C09C1/3607—Titanium dioxide
    • C09C1/3653—Treatment with inorganic compounds
    • C09C1/3661—Coating
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/36—Compounds of titanium
    • C09C1/3692—Combinations of treatments provided for in groups C09C1/3615 - C09C1/3684
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/12—Surface area

Definitions

  • Cosmetic and dermatological preparations containing transparent surface-coated titanium dioxide particles containing transparent surface-coated titanium dioxide particles
  • the present invention relates to cosmetic and dermatological preparations for the protection of human skin and hair against UV radiation, comprising in the visible range transparent surface-coated titanium dioxide particles having a crystal size of 10 to 20 nm and a specific surface area of 90 to 110 m 2 / g characterized in that the surface coating of the titanium dioxide particles comprises a multiple coating of a) alumina and b) methicone or a copolymer of methicone and dimethicone or a multiple coating of a) alumina, b) methicone or a copolymer of methicone and dimethicone and c) silica.
  • Metal oxides such as titanium dioxide or zinc oxide are widely used in sunscreens. Their effect is based essentially on reflection, scattering and absorption of harmful UV radiation and depends essentially on the primary particle size of the metal oxides.
  • Microfine titanium dioxide is widely used in cosmetic formulations since it is chemically stable and toxicologically harmless and does not cause any skin irritation or sensitization. It is currently the most commonly used and most important mineral sunscreen.
  • metal oxides such as titanium dioxide or zinc oxide
  • photocatalytic activity which triggers reactions that can lead to the formation of reactive species (e.g., hydroxyl radicals).
  • the prior art attempts to reduce the photocatalytic activity of these metal oxides without reducing the UV screening properties, for example, by surrounding them with a shell of inorganic and / or organic surface components.
  • These surface components may include Al 2 O 3 , SiO 2 and / or siloxanes.
  • EP-A-0 988 853 describes metal oxide particles coated with silicon dioxide, and their preparation and use as a constituent in sunscreens.
  • the disadvantage here is that these coated metal oxide particles have a low surface functionality and a high degree of adhesion of the particles. This makes it difficult on the one hand, the incorporation of the particles in a cosmetic formulation, on the other hand, their stability is limited with respect to sedimentation.
  • EP 0 869 762 B1 describes silicone polymer-coated hydrophobicized metal oxides and their use as sunscreens in cosmetic products.
  • EP 1 284 277 A1 describes silica-coated metal oxide particles having a low structure and sunscreens prepared therewith.
  • Titanium dioxide nanoparticles with particle sizes below about 30 nm are potentially suitable for use as UV absorbers in cosmetic and dermatological preparations.
  • Titanium dioxide nanoparticles with particle sizes below about 5 nm show a blue shift of the absorption edge due to the size quantization effect (L. Brus, J. Phys. Chem. (1986), 90, 2555-2560) and are therefore suitable for use as UV absorbers in UV radiation. A range less suitable.
  • agglomerates are undesirable in cosmetic transparent formulations because they are often already recognizable as particles on the skin with the naked eye, reduce the transparency and the UV protection of a sunscreen and settle on storage. Agglomerates can also lead to instability of the formulation.
  • the object of the present invention to provide cosmetic and dermatological sunscreen preparations which contain titanium dioxide particles with which the disadvantages of the prior art can be eliminated.
  • the titanium dioxide particles should have a low photocatalytic activity and a low scattering behavior.
  • the titanium dioxide particles in the transparent area and can be incorporated well into cosmetic dispersions. An irreversible aggregation of the particles should be avoided if possible, so that a complex dispersion process can be avoided.
  • methicone and dimethicone stands for methyl hydrogen polysiloxane or dimethyl polysiloxane.
  • the crystallite size of the surface-coated titanium dioxide particles present in the cosmetic and dermatological preparations according to the invention is in the range from 10 to 20 nm, preferably 12 to 18 nm, particularly preferably 14 to 16 nm, determined by means of X-ray diffraction spectroscopy.
  • the surface-coated titanium dioxide particles used in the cosmetic and dermatological preparations according to the invention is in a range between 90 and 110 m 2 / g, preferably between 95 and 105 m 2 / g.
  • a preferred form of the cosmetic and dermatological preparation is characterized in that the surface coating of the titanium dioxide particles as additional component c) contains silicon dioxide.
  • an outer layer of a copolymer of methicone and dimethicone (CAS No: 68037-59-2) are enveloped.
  • the thickness of the multiple coating of alumina, silica and methicone or the copolymer of methicone and diemethicone can be between 0.5 and 3 nm can be varied. In this range, the particles show sufficiently high UV absorption, reflection and scattering.
  • the surface-coated titanium dioxide particles used according to the invention are obtainable, for example, by a process described in US Pat. No. 6,660,380 for coated zinc oxide particles.
  • a further preferred embodiment of the cosmetic and dermatological preparations is characterized in that the transparent surface-coated titanium dioxide particles have a titanium dioxide content of from 70 to 92% by weight, preferably from 72 to 90% by weight, particularly preferably from 73 to 83% by weight , wherein the percentages are based on the total weight of the surface-coated titanium dioxide particles contained in the cosmetic and dermatological preparations.
  • a likewise preferred embodiment of the cosmetic and dermatological preparations is characterized in that the transparent surface-coated titanium dioxide particles have a silicon dioxide content of 4 to 10% by weight, preferably 5 to 9% by weight, particularly preferably 6.5 to 8.5% by weight. %, the percentages being based on the total weight of the surface-coated titanium dioxide particles contained in the cosmetic and dermatological preparations.
  • a further preferred embodiment of the cosmetic and dermatological preparations is characterized in that the transparent surface-coated titanium dioxide particles have an aluminum oxide content of 1 to 10% by weight, preferably 1 to 5% by weight, particularly preferably 2.5 to 4.5% by weight. %, the percentages being based on the total weight of the surface-coated titanium dioxide particles contained in the cosmetic and dermatological preparations.
  • a further preferred embodiment of the cosmetic and dermatological preparations is characterized in that the transparent surface-coated titanium dioxide particles have a methicone or methicone / dimethicone copolymer content of 3 to 10% by weight, preferably 4 to 7% by weight, particularly preferably 4.5 to 6.5% by weight, the percentages being based on the total weight of the surface-coated titanium dioxide particles present in the cosmetic and dermatological preparations.
  • a further preferred embodiment of the cosmetic and dermatological preparations is characterized in that the titanium dioxide particles comprise a rutile Proportion of 94 to 100%, preferably 98 to 100%, particularly preferably 98.5 to 99.5%.
  • the content of visibly transparent surface-coated titanium dioxide particles in the cosmetic and dermatological preparations according to the invention is in the range from 0.1 to 25% by weight, preferably 0.1 to 10% by weight, particularly preferably 1 to 7% by weight. %, based on the total weight of the cosmetic and dermatological preparations.
  • the sunscreen-containing cosmetic and pharmaceutical preparations are generally based on a carrier which contains at least one oil phase. But it is also possible preparations on a watery basis. Accordingly, oils, oil-in-water and water-in-oil emulsions, creams and pastes, lipid protection sticks or gels are contemplated.
  • emulsions u.a. also O / W macroemulsions, O / W microemulsions or O / W / O emulsions having dispersed in surface-coated titanium dioxide particles in question, wherein the emulsions by phase inversion technology, according to DE-A-197 26 121 are available.
  • Usual cosmetic adjuncts which may be considered as additives are e.g. Co-emulsifiers, fats and waxes, stabilizers, thickeners, biogenic agents, film formers, perfumes, dyes, pearlescers, preservatives, pigments, electrolytes (e.g., magnesium sulfate) and pH regulators.
  • Co-emulsifiers e.g., Co-emulsifiers, fats and waxes, stabilizers, thickeners, biogenic agents, film formers, perfumes, dyes, pearlescers, preservatives, pigments, electrolytes (e.g., magnesium sulfate) and pH regulators.
  • Suitable coemulsifiers are preferably known W / O and also O / V emulsifiers, such as polyglycerol esters, sorbitan esters or partially esterified glycerides.
  • Typical examples of fats are glycerides; as waxes are u.a. Beeswax, paraffin wax or microwaxes, optionally in combination with hydrophilic waxes.
  • metal salts of fatty acids e.g. Magnesium, aluminum and / or zinc stearate can be used.
  • Suitable thickeners are, for example, crosslinked polyacrylic acids and their derivatives, polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl cellulose, furthermore fatty alcohols, monoglycerides and fatty acids, polyacrylates, polyvinyl alcohol and polyvinylpyrrolidone.
  • Biogenic active ingredients are, for example, plant extracts, protein hydrolysates and vitamin complexes.
  • Typical film formers are, for example, hydrocolloids such as chitosan, microcrystalline chitosan or quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives and similar compounds.
  • Suitable preservatives are, for example, formaldehyde solution, p-hydroxybenzoate or sorbic acid.
  • Suitable pearlescing agents are, for example, glycol distearic acid esters, such as ethylene glycol distearate, but also fatty acids and fatty acid monoglycol esters.
  • Dyes which may be used are those which are suitable and approved for cosmetic purposes, as compiled, for example, in the publication "Kosmetician Anlagenrbesch” of the Farbstoffkommission of the Irish Anlagenscade, published by Verlag Chemie, Weinheim, 1984. These dyes are usually used in concentrations of 0.001 to 0.1 wt .-%, based on the total mixture.
  • antioxidants An additional content of antioxidants is generally preferred. Thus, all antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
  • the antioxidants are selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as DL-carnosine, D-carnosine, L-camosine and theirs Derivatives (eg anserine), carotenoids, carotenes (eg .beta.-carotene, lycopene) and derivatives thereof, chlorogenic acid and its derivatives, lipoic acid and derivatives thereof (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thiorodoxin, glutathione, cysteine , Cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl, and lauryl, palmi
  • the amount of the aforementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30 wt .-%, particularly preferably 0.05 to 20 wt .-%, in particular 1 to 10 wt .-%, based on the total weight of Preparation.
  • vitamin E and / or its derivatives are the antioxidant (s), it is advantageous to choose their respective concentration from the range from 0.001 to 10% by weight, based on the total weight of the formulation.
  • vitamin A and / or its derivatives or carotenoids constitute the antioxidant (s)
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvent:
  • Oils such as triglycerides of capric or capric acid, but preferably castor oil
  • Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with low-C alkanoic acids or with fatty acids;
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and or unbranched alcohols of a chain length of 3 to 30 carbon atoms.
  • ester oils can then advantageously be selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl ether, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate.
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12-18 C-atoms.
  • the fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, for.
  • synthetic oils for example, olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any mixtures of such oil and wax components are also advantageous to use in the context of the present invention. It may also be advantageous, if appropriate, to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, isohexa decane, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 -C 15 -alkyl benzoate, caprylic-capric triglyceride, dicaprylyl ether.
  • Particularly advantageous are mixtures of C 2 -C 15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 12 -C 5 -alkyl benzoate and isotridecyl isononanoate and mixtures of C 12 -C 15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
  • hydrocarbons paraffin oil, squalane and squalene are to be used advantageously in the context of the present invention.
  • Advantageous oil components are also z. Butyloctyl salicylate (for example that available under the trade name Hallbrite BHB from the company CP Hall), hexadecyl Cylbenzoate and Butyloctylbenzoat and mixtures thereof (Hallstar AB) and / or diethyl hexyl naphthalate (Hallbrite TQ).
  • Butyloctyl salicylate for example that available under the trade name Hallbrite BHB from the company CP Hall
  • hexadecyl Cylbenzoate and Butyloctylbenzoat and mixtures thereof Hallstar AB
  • Hallbrite TQ diethyl hexyl naphthalate
  • the oil phase may further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.
  • cyclomethicone octamethylcyclotetrasiloxane
  • silicone oil is used according to the invention.
  • other silicone oils are also advantageous for the purposes of the present invention, for example Hexamethylcyclotrisi- loxan, polydimethylsiloxane, poly (methylphenylsiloxane).
  • mixtures of cyclomethicone and isotridecyl isonanoate, of cyclomethicone and 2-ethylhexyl isostearate are particularly advantageous.
  • Gels used in the present invention usually contain low C number alcohols, e.g. Ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an above-mentioned oil in the presence of a thickener which is preferably silica or an aluminosilicate in oily-alcoholic gels, in aqueous-alcoholic or alcoholic gels, preferably a polyacrylate.
  • a thickener which is preferably silica or an aluminosilicate in oily-alcoholic gels, in aqueous-alcoholic or alcoholic gels, preferably a polyacrylate.
  • Fixed pins contain e.g. natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • lip balms and stick formulations are used for body deodorization.
  • liquid oils for example paraffin oils, castor oil, isopropyl myristate
  • semi-solid constituents eg petrolatum, lanolin
  • solid constituents eg. Beeswax, ceresin and microcrystalline waxes or ozokerite
  • high-melting waxes eg., Carnauba wax, candelilla wax
  • Suitable propellants for cosmetic and / or dermatological preparations which can be sprayed from aerosol containers in the context of the present invention are the customary known highly volatile, liquefied propellants, for example hydrocarbons (propane, butane, isobutane), which can be used alone or mixed with one another , Also, compressed air is advantageous to use.
  • hydrocarbons propane, butane, isobutane
  • Cosmetic preparations according to the present invention may also be present as gels, in addition to an effective content of the active ingredient according to the invention and solvents commonly used for this, preferably water, or organic thickening agents, for. Gum arabic, xanthan gum, sodium alginate, celulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickening agents, e.g. For example, aluminum silicates such as bentonites, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • the thickener is present in the gel e.g. in an amount of between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight.
  • the total proportion of auxiliaries and additives may be 1 to 80, preferably 6 to
  • the preparation of the agents can be carried out in a manner known per se, i. for example, by hot, cold, hot-hot / cold or PIT emulsification. This is a purely mechanical process, a chemical reaction does not take place.
  • the sunscreen preparations according to the invention can accordingly be in liquid, pasty or solid form, for example as water-in-oil creams, oil-in-water creams and lotions, aerosol foam creams, gels, oils, fatty sticks, powders, sprays or alcoholic-aqueous lotions ,
  • the majority of sunscreens in the human epidermis cosmetic and pharmaceutical preparations are composed of compounds which absorb UV light in the UV-B range, i. in the range from 280 to 320 nm.
  • the proportion of the UV-A absorbers to be used according to the invention is from 10 to 90% by weight, preferably from 20 to 50% by weight, based on the total amount of UV-B and UV-A absorbing agent substances.
  • Suitable UV filter substances which are used in combination with the transparent surface-coated titanium dioxide particles to be used according to the invention are any UV-A and UV-B filter substances.
  • any UV-A and UV-B filter substances are any UV-A and UV-B filter substances.
  • Polymeric or polymer-bound filter substances can also be used according to the invention.
  • the cosmetic and dermatological preparations according to the invention may advantageously also contain inorganic pigments based on metal oxides and / or other sparingly soluble or insoluble metal compounds selected from the group of the oxides of zinc (ZnO), iron (eg Fe 2 O 3 ), zirconium (ZrO 2 ), silicon (SiO 2 ), manganese (eg MnO), aluminum (Al 2 O 3 ), cerium (eg Ce 2 O 3 ), mixed oxides of the corresponding metals and mixtures of such oxides.
  • inorganic pigments based on metal oxides and / or other sparingly soluble or insoluble metal compounds selected from the group of the oxides of zinc (ZnO), iron (eg Fe 2 O 3 ), zirconium (ZrO 2 ), silicon (SiO 2 ), manganese (eg MnO), aluminum (Al 2 O 3 ), cerium (eg Ce 2 O 3 ), mixed oxides of the corresponding metals and mixtures of such oxides.
  • pigments based on ZnO Particular preference is given to pigments based on ZnO.
  • the inorganic pigments may be present in coated form, i. that they are superficially treated.
  • This surface treatment can be, for example, that the pigments are provided in a manner known per se, as described in DE-A-33 14 742, with a thin hydrophobic layer.
  • Sunscreen formulations in shampoos, lotions, gels, hair sprays, hair dyes, aerosol foam creams or emulsions in concentrations of 0.1 to 10 wt .-%, preferably 1 to 7 wt .-% are incorporated.
  • the respective formulations can be used, inter alia, for washing, dyeing and hair styling.
  • the formulations to be used according to the invention are generally distinguished by a particularly high absorption capacity in the region of UV-A radiation with a sharp band structure. Furthermore, they are readily soluble in cosmetic oils and can be easily incorporated into cosmetic formulations.
  • the emulsions prepared with the formulations are distinguished by their high stability, and the preparations produced therewith by their pleasant skin feel.
  • UV filter effect of the formulations according to the invention can also be exploited for the stabilization of active ingredients and excipients in cosmetic and pharmaceutical formulations.
  • Phase C Mix phase A / B, homogenize and then allowed to cool to 4O 0 C
  • phase C Mix phase C with phase A / B, homogenize and then cool to 40 0 C.
  • Heat phase A to 80 ° C. and homogenize; Heat phase B to 80 ° C.;
  • phase C Mix phase C with phase A / B, homogenize and then cool to 40 0 C.

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Abstract

La présente invention concerne des préparations cosmétiques et dermatologiques destinées à protéger la peau humaine et les cheveux contre le rayonnement ultraviolet, lesquelles préparations contiennent des particules de dioxyde de titane à revêtement de surface transparentes dans le domaine visible, présentant une taille de cristallite de 10 à 20 nm et une surface spécifique de 90 à 110 m2/g. Cette invention se caractérise en ce que le revêtement de surface des particules de dioxyde de titane comprend un revêtement multicouche constitué a) d'oxyde d'aluminium et b) de méthicone ou d'un copolymère de méthicone et de diméthicone ou bien un revêtement multicouche constitué a) d'oxyde d'aluminium, b) de méthicone ou d'un copolymère de méthicone et de diméthicone et de c) dioxyde de silicium.
EP06708638A 2005-03-07 2006-03-03 Preparations cosmetiques et dermatologiques, contenant des particules de dioxyde de titane transparentes a revetement de surface Ceased EP1858597A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005010803A DE102005010803A1 (de) 2005-03-07 2005-03-07 Kosmetische und dermatologische Zubereitungen, enthaltend transparente oberflächenbeschichtete Titandioxidpartikel
PCT/EP2006/060451 WO2006094944A1 (fr) 2005-03-07 2006-03-03 Preparations cosmetiques et dermatologiques, contenant des particules de dioxyde de titane transparentes a revetement de surface

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EP1858597A1 true EP1858597A1 (fr) 2007-11-28

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US (1) US20080020054A1 (fr)
EP (1) EP1858597A1 (fr)
JP (1) JP2008531744A (fr)
KR (1) KR20070110532A (fr)
CN (1) CN101137415A (fr)
AU (1) AU2006221980A1 (fr)
BR (1) BRPI0608260A2 (fr)
CA (1) CA2599257A1 (fr)
DE (1) DE102005010803A1 (fr)
TW (1) TW200700106A (fr)
WO (1) WO2006094944A1 (fr)

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JP5137503B2 (ja) * 2006-09-15 2013-02-06 株式会社日本触媒 化粧料用紫外線カット剤およびそれを用いた化粧料
DE102007005335A1 (de) * 2007-02-01 2008-08-07 Beiersdorf Ag Lichtschutzzubereitung mit einer Kombination von Mikropigmenten
US20110256076A1 (en) * 2008-10-22 2011-10-20 Fletcher Robert B Sunscreen compositions incorporating methycellulose as an spf booster and methods
CN101785783A (zh) * 2009-01-22 2010-07-28 朱晓颂 金属Ti微粒子在促进或增大皮肤外用抗菌或杀菌药物功效上的用途
WO2011016527A1 (fr) * 2009-08-07 2011-02-10 株式会社モチガセ Générateur de radicaux hydroxyle, matière antivirale utilisant le générateur de radicaux hydroxyle, et procédé de production de radicaux hydroxyle
JP5649051B2 (ja) * 2010-03-31 2015-01-07 株式会社コーセー 微粒子金属酸化物分散組成物
KR102222666B1 (ko) 2020-09-18 2021-03-05 (주)젠텍 저백탁 및 발림성이 향상된 화장료 조성물용 이산화티탄 복합 안료 및 제조 방법, 이산화티탄 복합 안료를 이용한 화장료 조성물
KR20220151058A (ko) 2021-05-04 2022-11-14 주식회사 코스메카코리아 자외선 차단능력을 상승시키는 무기성 복합안료 및 이를 함유하는 화장료 조성물
KR102472647B1 (ko) 2021-12-31 2022-11-30 (주)젠텍 자외선 차단 효과가 향상된 화장료 조성물용 이산화티탄 안료 및 제조 방법, 이산화티탄 복합 안료를 이용한 화장료 조성물
KR102655036B1 (ko) 2022-12-30 2024-04-08 (주)젠텍 백탁 및 자외선 차단 효과가 향상된 화장료 조성물용 하이브리드 이산화티탄 안료의 제조 방법

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JPH04190839A (ja) * 1990-11-24 1992-07-09 Kanebo Ltd 改質粉体

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GB8712752D0 (en) * 1987-05-30 1987-07-01 Tioxide Group Plc Particulate material
FR2744914B1 (fr) * 1996-02-15 1998-03-20 Rhone Poulenc Chimie Dispersion de dioxyde de titane, poudre a base de dioxyde de titane, leur utilisation dans les formulations cosmetiques
EP1112964B1 (fr) * 1999-05-12 2017-02-22 Sakai Chemical Industry Co., Ltd. Particules d'oxyde de zinc a activite de surface supprimee, leur production et leur utilisation
US20010016202A1 (en) * 2000-01-14 2001-08-23 Shiseido Company, Ltd. Silicone-treated powder, process of production thereof and composition containing the same
ATE280203T1 (de) * 2001-08-08 2004-11-15 Degussa Mit siliziumdioxid umhüllte metalloxidpartikel

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See also references of WO2006094944A1 *

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BRPI0608260A2 (pt) 2016-11-08
WO2006094944A1 (fr) 2006-09-14
JP2008531744A (ja) 2008-08-14
TW200700106A (en) 2007-01-01
DE102005010803A1 (de) 2006-09-14
AU2006221980A1 (en) 2006-09-14
US20080020054A1 (en) 2008-01-24
CA2599257A1 (fr) 2006-09-14
CN101137415A (zh) 2008-03-05
KR20070110532A (ko) 2007-11-19

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