WO2005092178A1 - 循環器機能測定装置、循環器機能測定方法 - Google Patents
循環器機能測定装置、循環器機能測定方法 Download PDFInfo
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- WO2005092178A1 WO2005092178A1 PCT/JP2005/003729 JP2005003729W WO2005092178A1 WO 2005092178 A1 WO2005092178 A1 WO 2005092178A1 JP 2005003729 W JP2005003729 W JP 2005003729W WO 2005092178 A1 WO2005092178 A1 WO 2005092178A1
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- pressure
- organ function
- blood pressure
- circulatory organ
- compression pressure
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
Definitions
- Cardiovascular function measuring device cardiovascular function measuring method
- the present invention relates to a circulatory organ function measuring device and a circulatory organ function measuring method for analyzing a state of a living body based on a pulse wave obtained from a living body.
- Patent Document 1 discloses the following technology. That is, after the compression pressure is raised to a predetermined target compression pressure, the amplitude of the pulse wave is sequentially detected in the process of gradually reducing the compression pressure, and the relationship between the compression pressure and the amplitude of the pulse wave is derived.
- the relationship between the compression pressure and the amplitude of the pulse wave draws an envelope that maximizes the amplitude value of the pulse wave when the compression pressure substantially matches the average blood pressure value.
- one inclination angle ⁇ of a straight line connecting a point corresponding to the systolic blood pressure value and a point having an amplitude value of 63.2% of the maximum amplitude value is derived.
- the degree of arterial stiffness of the subject is determined according to the magnitude of the inclination angle ⁇ , and as shown in Fig. 43, the difference (width) W between two compression pressures that takes 90% of the maximum amplitude.
- a technique for determining the degree of arteriosclerosis of a subject in accordance with the ratio to the maximum amplitude value H is disclosed.
- a pulse wave contains various information related to the circulatory function, for example, information indicating a state of a blood vessel or a state of a heart.
- information indicating a state of a blood vessel or a state of a heart.
- it acts on blood vessels.
- the rate of change in the volume of the blood vessel is not constant but changes according to the pressure. .
- the rate of change in volume of a blood vessel differs greatly between a state in which the pressure acting on the blood vessel is small and a state in which the pressure acting on the blood vessel is large.
- the blood vessel has a three-layer structure having different elastic properties of the intima, the media and the adventitia. This is because, in the state where the pressure is large, the extensibility of the blood vessel wall depends on the properties of the adventitia, and the tissues involved in the extensibility differ depending on the pressure acting on the blood vessel.
- the present invention has been made in view of such circumstances, and a cardiovascular function measurement device and a cardiovascular function measurement device capable of measuring cardiovascular functions such as arteriosclerosis with higher accuracy.
- the aim is to provide a method.
- Patent Document 1 Japanese Patent No. 2938238
- a circulatory organ function measuring device includes: a pressure applying unit that presses a predetermined part of a body of a subject; and a pressure applied by the pressure applying unit.
- Pressure detection means for detecting, pressure control means for changing the compression pressure by the pressure application means based on the detected compression pressure, and pressure control means for changing the compression pressure based on the detected compression pressure at the predetermined portion
- Pulse wave detection means for detecting pulse wave information relating to the magnitude of the pulse wave
- pulse wave information storage means for storing the detected pulse wave information in association with the compression pressure information relating to the compression pressure at the time of detection; Dividing an envelope formed based on the correspondence between the pulse wave information stored in the pulse wave information storage means and the compression pressure information into a plurality of regions with a predetermined compression pressure as a boundary, envelope When the entire area is viewed as one area, the entire area and each of the divided areas
- a circulatory organ function determining means for determining a circulatory organ function
- the envelope formed based on the correspondence between the pulse wave information and the compression pressure information is divided into a plurality of regions with a predetermined compression pressure as a boundary, and the entire envelope is From at least two regions of the whole region and each of the divided regions as viewed as one region, a characteristic amount indicating the characteristic of the envelope is extracted, and the circulatory organ function is extracted based on the extracted characteristic amounts. Since the determination is performed, the measurement of the circulatory function including arteriosclerosis can be performed with higher accuracy.
- FIG. 1 is a block diagram showing a configuration of a first embodiment of a circulatory organ function measuring device according to the present invention.
- FIG. 2 is a graph showing a pressure change in a cuff for compressing a brachial artery.
- FIG. 3 is a graph showing a state in which pulse waves sequentially detected in a slow speed decompression process change in a time series according to a pressure change.
- FIG. 4 is a graph showing an outline of an envelope of a pulse wave obtained in a very slow decompression process of a cuff compressing a brachial artery.
- FIG. 5 is a graph showing an example of the shape pattern of the envelope shown in FIG. 4.
- FIG. 6 is a diagram for explaining a feature value adopted in the cardiovascular function measurement method according to the first embodiment.
- FIG. 7 is a diagram for explaining a feature value employed in the cardiovascular function measurement method according to the first embodiment.
- FIG. 8 is a diagram for explaining a feature value employed in the cardiovascular function measurement method according to the first embodiment.
- FIG. 9 is a diagram for explaining the relationship between the compression pressure at which the amplitude value of the pulse wave is maximum and the average blood pressure.
- FIG. 10 is a graph showing a change in volume at a compression site of a blood vessel according to a pressure difference (mean blood pressure compression pressure).
- FIG. 11 is a diagram showing a form in which the arterial stiffness of a certain subject is numerically displayed.
- FIG. 12 is a flowchart showing an example of the operation of the circulatory organ function measuring device of the first embodiment.
- FIG. 13 is a diagram showing another extraction mode for extracting a feature value.
- FIG. 14 is a block diagram illustrating a configuration of a circulatory organ function measuring device according to a second embodiment.
- Fig. 15 is a flowchart showing an example of the operation of the circulatory organ function measuring device of the second embodiment.
- FIG. 16 is a block diagram illustrating a configuration of a circulatory organ function measuring device according to a third embodiment.
- FIG. 17 is a diagram showing an example in which each blood pressure value (systolic blood pressure, diastolic blood pressure, and average blood pressure) calculated by the blood pressure calculating unit is used as a boundary value for dividing an envelope to obtain a feature amount.
- FIG. 18 is a diagram showing an example in which each blood pressure value (systolic blood pressure, average blood pressure) calculated by the blood pressure calculating unit is used as a boundary value for dividing an envelope to obtain a feature amount.
- FIG. 19 is a diagram illustrating an example in which each blood pressure value (systolic blood pressure, diastolic blood pressure) calculated by the blood pressure calculating unit is used as a boundary value for dividing an envelope to obtain a feature amount.
- FIG. 22 is a diagram for explaining a characteristic portion of the fourth embodiment.
- FIG. 26 is a block diagram illustrating a configuration of a circulatory organ function measurement device according to a seventh embodiment.
- FIG. 27 is a flowchart showing an example of the operation of the circulatory organ function measuring device of the seventh embodiment.
- FIG. 28 is a block diagram illustrating a configuration of a circulatory organ function measuring device according to an eighth embodiment.
- FIG. 29 is a flowchart showing an example of the operation of the circulatory organ function measuring device of the eighth embodiment.
- FIG. 30 is a block diagram illustrating a configuration of a circulatory organ function measuring device according to a ninth embodiment.
- FIG. 31 is a flowchart showing an example of the operation of the circulatory organ function measuring device according to the ninth embodiment.
- FIG. 32 is a graph showing another example of a pressure change in the cuff for compressing the brachial artery.
- FIG. 33 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 34 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 35 is a view showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 36 is a view showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 37 is a view showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 38 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 39 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 40 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 41 is a diagram showing a display form of a determination result of a circulatory organ function of a subject.
- FIG. 42 is a view for explaining a conventional technique.
- FIG. 43 is a view for explaining a conventional technique.
- FIG. 44 is a graph showing a change in volume at a compression site of a blood vessel according to a pressure difference (mean blood pressure compression pressure).
- FIG. 1 to FIG. 5 are diagrams for explaining the method of measuring the circulatory function.
- FIG. 2 is a graph showing a change in the compression pressure for compressing the brachial artery.
- the horizontal axis represents the elapsed time of the force for starting the pressurization by the cuff 1
- the vertical axis represents the compression pressure.
- a waveform 201 in FIG. 2 shows a change in the compression pressure until the compression pressure reaches the predetermined pressure value
- a waveform 202 in FIG. 2 shows a change in the compression pressure at the time of the slow depressurization.
- FIG. 3 is a graph showing a state in which the amplitude value of the pulse wave for each heartbeat sequentially detected in the slow speed depressurization process changes in a time series according to a change in the compression pressure.
- the amplitude value of the detected pulse wave also changes, and the amplitude value of the pulse wave shows a characteristic change and draws a mountain-shaped envelope.
- FIG. 4 shows an envelope obtained in a time-series manner (ie, when the maximum amplitude values of pulse waves for each heartbeat obtained in the slow depressurization process of the cuff 1 for compressing the brachial artery are obtained (that is, when arranged in accordance with the compression pressure)).
- FIG. 4 For example, the amplitude of the pressure signal force pulse wave obtained when the pressure is reduced at a constant speed within a predetermined range of the compression pressure including the subject's systolic and diastolic blood pressures is extracted and time-series
- a mountain-shaped envelope 206 as shown in FIG. 4 is obtained, and the amplitude value of the pulse wave changes as the compression pressure changes.
- this envelope 206 has a characteristic shape depending on the individual, and it is known that the shape changes depending on various diseases, and an example is shown in FIG. 5 (a)-(e).
- the change in the amplitude value of the pulse wave (envelope shape) according to the change in the compression pressure is caused by the change in the volume of the blood vessel due to the change in the compression pressure, and hence the actual mechanical characteristics of the blood vessel. This reflects the degree of atherosclerosis (progress) in particular. Therefore, the envelope It is considered that the features of the shape can be quantified, and the circulatory function mainly of arterial stiffness can be measured based on the quantified features.
- FIG. 5 (a) shows an example of a healthy person
- the shape pattern of FIG. 5 (c) shows the volume of a blood vessel when the compression pressure changes from the shape pattern of FIG. 5 (a). Because of little change, it is considered that the four-skin measurer who is undergoing atherosclerosis is older.
- Fig. 5 (b) shows the case of hypotension (low systolic blood pressure, state (for example, 100 or less)) or soft blood vessels! /, (Depending on the external pressure caused by the flexibility of blood vessel wall and internal pressure).
- FIG. 5 (d) shows an example of an envelope in a case where the heart is considered to have some kind of disease.
- FIG. 5 (e) shows an example of the envelope when hypertension is considered and arterial stiffening is considered to be progressing or when the patient is elderly.
- FIG. 8 is a diagram for explaining a feature value used in the cardiovascular function measurement method of the present embodiment.
- the compression pressure at which the amplitude value of the pulse wave is the maximum is defined as a boundary value, and corresponds to a compression pressure band higher than the boundary value (hereinafter, referred to as a high-pressure compression pressure band P1).
- a characteristic value for measuring the circulatory function in each compression pressure band PI and P2 by dividing the envelope into a region and a region corresponding to the low pressure side compression pressure band (hereinafter referred to as the low pressure side compression pressure band P2) I'm trying to get
- FIG. 6 shows the difference (width) W1 between the compression pressure pi that takes the amplitude value rl of a certain pulse wave and the boundary value pa in the region of the high-pressure compression pressure zone P1 in the envelope, and the low-pressure side.
- FIG. 7 is a diagram showing that, in a compression pressure zone P2, a difference (width) W2 between a compression pressure p2 having an amplitude value r2 different from the amplitude value rl and the boundary value pa is extracted as a feature amount.
- FIG. 7 shows the slope ⁇ 1 at the point where the pulse wave amplitude value is r 3 and the compression pressure is p 3 in the region of the high pressure compression pressure band P 1 in the envelope, and the low pressure compression pressure band P 2.
- FIG. 7 is a diagram showing that a pulse wave amplitude value r4 ( ⁇ r3) and a slope ⁇ 2 at a point where the compression pressure is p4 are extracted as feature amounts.
- FIG. 8 shows the pressure difference tl between the compression pressures p5 and p6 taking the amplitude values r5 and r6 of a certain pulse wave in the region of the high pressure side compression pressure band P1 in the envelope, and the low pressure side compression pressure band.
- FIG. 9 is a diagram showing that, in the region of P2, the amplitude values r5 and r6 and the pressure difference t2 between the compression pressures p7 and p8 having different amplitude values r7 and r8 are extracted as feature amounts.
- each of the feature values Wl, W2, ⁇ 1, 02, tl, t2 and the corresponding pulse wave amplitude value rl-r8 is a certain percentage of the maximum amplitude value rmax. Is multiplied by, and this ratio is derived in advance by statistics.
- a boundary value for dividing an envelope for obtaining a feature amount for measuring a circulatory organ function into a plurality of regions is set to a compression pressure at which a pulse wave amplitude value becomes maximum.
- a pressure (internal pressure) from the blood and an external pressure (compression pressure) are applied to the blood vessel wall.
- the compression pressure substantially coincides with the average blood pressure
- the pressure difference between the average internal and external pressures applied to the blood vessel wall is substantially zero, and the state is unloaded.
- the compliance of the blood vessel (the ability of the blood vessel wall to follow the pulsation) is maximized, and the volume change of the blood vessel with respect to a constant pulse pressure is maximized, so that the amplitude value of the pulse wave is maximized.
- the compression pressure at which the amplitude value of the pulse wave is the maximum substantially matches the average blood pressure.
- a region to the left of the average blood pressure is a region where the compression pressure is higher than the average blood pressure, and a region to the right of the average blood pressure is a region where the compression pressure is lower than the average blood pressure.
- FIG. 10 is a graph showing a change in volume at a compression site of a blood vessel according to a pressure difference (mean blood pressure compression pressure).
- the horizontal axis represents the pressure difference between the inside and outside of the blood vessel, and the vertical axis represents the volume of the blood vessel.
- the point at which the pressure difference becomes 0 that is, the point at which the direction of the resultant force acting on the blood vessel wall (the resultant force of the pressure (internal pressure) from blood and the external pressure (compression pressure)) changes.
- the volume change characteristics of blood vessels differ greatly.
- the envelope is divided into a plurality of regions by using the compression pressure at which the amplitude value of the pulse wave is the maximum, that is, the average blood pressure as a boundary, and the feature amount is extracted from each region, whereby the blood vessel
- the state of the wall can be detected according to the direction of the force (combined force) acting on the blood vessel wall. Therefore, the progress of arterial sclerosis can be grasped more accurately than in the case where it is not possible to obtain one feature amount for the entire envelope as in the conventional technique.
- a, b, and c are constants and values set based on statistics.
- the circulatory organ function measuring apparatus 100 of the present embodiment includes a cuff 1, a pressure control section 2, a pressure detection section 3, a pulse wave detection section 4, a control section 5, and a circulatory organ function display. Part 6 is provided.
- the cuff 1 is attached, for example, in a state of being wound around the upper arm of the subject.
- the pressure control unit 2 includes a pressurizing pump for pressurizing the cuff 1 and an exhaust valve for depressurizing the cuff 1.
- the pressure control unit 2 pressurizes and depresses the cuff 1 in response to a control signal from the control unit 5, and performs measurement. The purpose is to adjust the pressure applied to the upper arm of a regular person.
- the pressure detector 3 includes, for example, a pressure sensor (not shown) and an AZD converter, and outputs a pressure signal indicating the pressure of the cuff 1 as a digital signal to the pulse wave detector 4 and the controller 5.
- the pulse wave detection unit 4 includes, for example, a predetermined filter circuit, and generates a pulse wave signal by removing a predetermined frequency component such as a DC component from the pressure signal output from the pressure detection unit 3, for example. It extracts the amplitude of the pulse wave signal power pulse wave.
- the control unit 5 controls the entire operation of the circulatory organ function measuring apparatus 100, and for example, a control program for controlling the operation of the circulatory organ function measuring apparatus 100 and a state for determining the state of the circulatory organ function.
- ROM Read Only Memory
- RAM Random Access Memory
- CPU Central Processing
- control unit 5 for measuring the circulatory function mainly based on arteriosclerosis as described above Functionally, it includes a pulse wave detection pressure calculation unit 51, a pulse wave data storage unit 52, a feature amount extraction pressure band derivation unit 53, a feature amount extraction unit 54, and a circulatory organ function determination unit 55.
- the pulse wave detection pressure calculation unit 51 associates the compression pressure output from the pressure detection unit 3 and the pulse wave detection unit 4 in a predetermined cycle with the amplitude value of the pulse wave, in other words, the horizontal axis Is the compression pressure, and the vertical axis is the pulse wave amplitude value.
- the maximum amplitude value of the pulse wave for each heartbeat is plotted in a two-dimensional coordinate system, and a mountain-shaped envelope 206 as shown in FIG. 4 is generated. .
- the pulse wave data storage unit 52 stores the compression pressure and the pulse wave amplitude value associated with each other by the pulse wave detection pressure calculation unit 51 in a table format (the envelope).
- the feature amount extraction pressure band deriving section 53 sets a plurality of compression pressure bands for extracting feature amounts according to a preset program.
- the feature quantity extraction pressure band deriving unit 53 sets the compression pressure taking the maximum amplitude value rmax of the pulse wave as a boundary value, and sets a compression pressure band P1 on the high pressure side and a compression pressure band P2 on the low pressure side from the boundary value. (See Figure 6— Figure 8).
- the feature quantity extraction unit 54 performs the feature quantity (Wl, W2) or ( ⁇ 1, ⁇ 2) or (tl, tl) in each compression pressure band P1, P2 set by the feature quantity extraction pressure band derivation unit 53. It extracts t2).
- the circulatory function determining unit 55 is to statistically investigate in advance the relationship between a state related to circulatory functions such as arteriosclerosis, endothelial cell dysfunction, hypertension, and peripheral vasoconstriction, and the characteristic amount. Based on the statistical data obtained by the above, the determination table data in which the state of the circulatory organ function estimated to correspond statistically to the extracted feature amount and the degree of the state are stored, The circulatory organ function of the subject is determined based on the feature amount (Wl, W2) or ( ⁇ 1, ⁇ 2) or (tl, t2) extracted by the feature amount extraction unit 54.
- the circulatory organ function judging unit 55 extracts, for example, the feature amount extracted using the judgment table data indicating the relationship between the degree of arteriosclerosis and the judgment value Q obtained based on the statistical data for arteriosclerosis.
- Kaura derives the arterial stiffness corresponding to the determination value Q calculated by the above equation (1).
- the arteriosclerosis degree is represented by, for example, a numerical value up to 110, and the larger the numerical value V, the more the arteriosclerosis progresses.
- the circulatory organ function display unit 6 is a display device composed of, for example, a liquid crystal display, etc. It is for displaying the judgment result data output from the function judgment section 55.
- the circulatory organ function measuring apparatus 100 of the present embodiment is configured so that a numerical value up to 1 to 100 indicating the degree of arterial stiffness derived by the circulatory organ function judging unit 55 is displayed on the circulatory organ function display unit 6, for example. ing.
- FIG. 11 shows that the degree of arteriosclerosis of a subject is measured as “65”.
- FIG. 12 is a flowchart showing an example of the operation of the circulatory organ function measuring device 100.
- step ST 1 the pressure control unit 2 Supplies air into cuff 1 in response to a control signal from
- step ST2 when the pressure detector 3 detects that the pressure of the cuff 1 has reached the predetermined pressure, for example, a predetermined pressure higher than the expected systolic blood pressure of the subject, the pressure control unit 2 starts the slow depressurization of the cuff 1.
- the predetermined pressure for example, a predetermined pressure higher than the expected systolic blood pressure of the subject
- step ST3 the pressure detecting section 3 outputs a pressure signal corresponding to the waveform 202 (see FIG. 2) to the pulse wave detecting section 4, and the pulse wave detecting section 4 shown in FIG.
- the pulse wave is detected from the pressure signal, and the amplitude value of the pulse wave is detected from the obtained pulse wave.
- the pulse wave detection time pressure calculation unit 51 associates the compression pressure output from the pressure detection unit 3 and the pulse wave detection unit 4 at a predetermined cycle with the amplitude value of the pulse wave.
- the pulse wave data storage unit 52 stores the compression pressure and the pulse wave amplitude value associated with each other by the pulse wave detection time pressure calculation unit 51 in a table format.
- the maximum amplitude value of the pulse wave for each heartbeat is plotted on a two-dimensional coordinate system in which the horizontal axis represents the compression pressure of the cuff 1 and the vertical axis represents the amplitude value of the pulse wave.
- step ST5 the feature amount extraction pressure band deriving unit 53 sets the compression pressure that takes the maximum amplitude value rmax of the pulse wave as a boundary value according to a preset program, and sets the boundary value as the boundary value.
- a compression pressure band P1 on the higher pressure side and a compression pressure band P2 on the lower pressure side are set.
- step ST6 the feature amount extraction unit 54 sets the feature amount extraction pressure band derivation unit 53
- the feature quantity (Wl, W2) or ( ⁇ 1, ⁇ 2) or (tl, t2) in the compression pressure band PI, P2 set in the above is extracted, respectively.
- step ST7 the circulatory organ function determining unit 53 calculates a determination value Q from the above-described equation (1), and based on the determination table data stored in the ROM, determines the value of Q Is read out as the determination result.
- step ST8 the pressure control unit 2 rapidly exhausts the air in the cuff 1 in response to the control signal from the control unit 5, the compression pressure is reduced, and the pressure on the upper arm of the subject is reduced. Surge is released.
- step ST9 the circulatory organ function judging section 55 outputs the read judgment result data on the state of the circulatory organ function to the circulatory organ function display section 6, and the circulatory organ function displaying section 6 displays the state of the circulatory organ function. (For example, the above-mentioned quantified arteriosclerosis degree) is displayed.
- the compression pressure set as the boundary value is not limited to the compression pressure at which the amplitude value of the pulse wave becomes maximum.
- the arterial stiffness of the subject is determined according to the ratio of the difference between the two compression pressures that take an amplitude value of 90% of the maximum amplitude value and the maximum amplitude value.
- the maximum amplitude value is the thickness of the muscle of the subject, regardless of the hardness of the blood vessel.
- the measurement accuracy of the degree of arteriosclerosis is limited, but in the extraction form shown in FIG. 6 of the present embodiment, only the widths Wl and W2 are used as characteristic quantities for measuring the circulatory function. As a result, it is possible to measure the circulatory function more accurately than the background technology
- the compression pressure taking the amplitude value r9 of a certain pulse wave is obtained in the region of the high-pressure side compression pressure zone P1 in the envelope.
- the area of the high-pressure side compression pressure zone P1 and the entire area of the envelope correspond to “at least two areas” in claim 1 of the claims.
- the circulatory organ function measuring apparatus 100 of the present embodiment includes, in addition to the configuration of the first embodiment (the configuration shown in FIG. 1), a blood pressure calculating unit 5 that estimates a blood pressure based on the amplitude value of a detected pulse wave. 6 and a blood pressure value display section 7 for displaying each blood pressure value calculated by the blood pressure calculation section 56. Note that the other parts are substantially the same as those of the first embodiment, and therefore only the differences will be described.
- FIG. 14 is a block diagram for explaining the configuration of the circulatory organ function measuring device 100 according to the second embodiment. The same components as those in the first embodiment are denoted by the same reference numerals.
- the blood pressure calculation unit 56 is provided in the control unit 5 and includes the envelope force maximum indicating the relationship between the compression pressure and the amplitude of the pulse wave stored in the pulse wave data storage unit 52. It calculates hypertension, diastolic blood pressure and mean blood pressure. In the process of slowly reducing the compression pressure, the blood pressure calculation unit 56 sets the compression pressure at the time when the amplitude value of the pulse wave suddenly increases (inflection point A in FIG. 6) as the systolic blood pressure, and calculates the peak pressure of the envelope.
- the compression pressure corresponding to the mean pressure is defined as the average blood pressure, and the compression pressure at the time when the amplitude of the pulse wave suddenly decreases (inflection point B in Fig. 6) is defined as the diastolic blood pressure in the process of slowly reducing the compression pressure. .
- the blood pressure value display unit 7 displays each blood pressure value (systolic blood pressure, minimum blood pressure, and average blood pressure) calculated by the blood pressure calculating unit 56.
- the blood pressure value display unit 7 may be configured by the same display device as the circulatory organ function display unit 6.
- FIG. 15 is a flowchart showing an example of the operation of the circulatory organ function measuring device 100. The measurement of the blood pressure value is performed in parallel with the circulatory organ function determination processing described in the first embodiment. In order to avoid duplication of the same description, in this flowchart, the measurement of the blood pressure value is performed. Only processing is shown.
- steps ST11 to ST14 are substantially the same as steps ST11 to ST4 of the first embodiment, and thus description thereof will be omitted.
- step ST15 the blood pressure calculation unit 56 determines the systolic blood pressure by the above-described calculation method based on the envelope indicating the relationship between the compression pressure and the amplitude value of the pulse wave stored in the pulse wave data storage unit 52. , Calculate the diastolic blood pressure and the average blood pressure.
- step ST16 the cuff 1 is rapidly evacuated by the pressure control unit 2 according to the control signal from the control unit 5, the cuff 1 is depressurized, and the pressure on the upper arm of the subject is released. You. Then, in step ST17, data indicating the blood pressure value calculated by the blood pressure calculation unit 56 is output to the blood pressure value display unit 7, and each blood pressure value is displayed on the blood pressure value display unit 7.
- all the blood pressures of the systolic blood pressure, the diastolic blood pressure, and the average blood pressure are calculated (estimated).
- the present invention is not limited to this. At least one of the average blood pressure may be calculated (estimated).
- the circulatory organ function measuring device 100 of the present embodiment calculates the blood pressure value calculated by the blood pressure calculating section 56 in addition to the configuration of the second embodiment (the configuration shown in FIG. 14). This is different from the first embodiment in that the data shown is output to the feature amount extraction pressure band deriving unit 53, and the other points are substantially the same as those in the second embodiment.
- each blood pressure value (systolic blood pressure, diastolic blood pressure, and average blood pressure) calculated by the blood pressure calculating unit 56 is used as a boundary value for dividing the envelope.
- FIG. 17 to FIG. 19 show the respective blood pressure values (systolic blood pressure, diastolic blood pressure and average blood pressure) calculated by the blood pressure calculating unit 56. Is a diagram showing an example in which a feature amount is obtained by using as a boundary value for dividing an envelope.
- FIG. 17 shows that the envelope is divided into a region of the compression pressure band P3 higher than the systolic blood pressure, a region of the compression pressure band P4 between the mean blood pressure and the systolic blood pressure, and a graph of the range between the mean blood pressure and the diastolic blood pressure.
- the difference (width) W5 between the compression pressure pi 2 (mean blood pressure pi 2 and systolic blood pressure) at which the amplitude value of the pulse wave takes rl l and the amplitude value of the pulse wave takes rl2 The difference (width) between the compression pressure pl3 (minimum blood pressure ⁇ p 13 ⁇ mean blood pressure) and the average blood pressure (width)
- the difference between W6 and the compression pressure pl4 (pl4> systolic blood pressure) where the pulse wave amplitude value takes rl 3 and the systolic blood pressure
- the circulatory organ function is determined by using the (width) W7 and the difference (width) W8 between the compression pressure pl5 (pl5 minus diastolic blood pressure) and the diastolic blood pressure at which the amplitude value of the pulse wave takes r14 as a feature value.
- FIG. 18 shows that the envelope is divided into a region of the compression pressure zone P7 higher than the systolic blood pressure, a region of the compression pressure zone P8 between the average blood pressure and the maximum blood pressure, and a region of the compression pressure zone P9 lower than the average blood pressure. It is divided into three compression pressure zones and the compression pressure zones P7-P9, and the difference (width) W9-Wl 1 between the compression pressure and the boundary value, which take different pulse wave amplitude values, is extracted. Show what you did.
- the difference (width) W10 between the compression pressure pl7 (pl7 minus the average blood pressure) and the mean blood pressure, and the difference (width) W11 between the compression pressure pl8 (pl8> systolic blood pressure) and the systolic blood pressure where the pulse wave amplitude value takes rl7 Is used as a feature value to determine a circulatory organ function.
- FIG. 19 shows that the envelope is divided into a region of the compression pressure zone P10 higher than the systolic blood pressure, a region of the compression pressure zone P11 between the systolic blood pressure and the diastolic blood pressure, and a region of the compression pressure zone lower than the diastolic blood pressure.
- the difference (width) W13, W14 between the compression pressure that takes the amplitude value of the wave and the boundary value is shown.
- the difference (width) W12 between two compression pressures pl8 and pl9 (diastolic pressure pl9 ⁇ p18 ⁇ systolic blood pressure) where the pulse wave amplitude value takes rl8, and the pulse wave amplitude value is rl9
- the circulatory function is determined using W14 as a feature value.
- the blood pressure values (systolic blood pressure, diastolic blood pressure, and average blood pressure) calculated by the blood pressure calculating unit 56 are used as boundary values for dividing the envelope, the boundary values are compared. Can be easily obtained.
- the feature quantity to be extracted is not limited to the width W5 to W14 as described above, and takes two amplitude values having different slope values of a certain point in each area on the envelope and amplitude values of pulse waves.
- the pressure difference between the two compression pressures may be used.
- the blood pressure set as the boundary value is the highest blood pressure and the lowest blood pressure. At least one of blood pressure and average blood pressure calculated using the following formula
- the systolic blood pressure, the average blood pressure, and the diastolic blood pressure set as the boundary values are detected from the envelope, but in the present embodiment, the systolic blood pressure and the diastolic blood pressure are detected in the third embodiment.
- the envelope force is detected in the same manner as in the embodiment.
- the average blood pressure is derived by calculation without using the envelope.
- the circulatory organ function measuring apparatus 100 of the present embodiment has substantially the same configuration as that of the third embodiment (Fig. 1).
- the blood pressure calculation unit 56 calculates the average blood pressure using, for example, the following equation.
- the operation expression (2) is a well-known operation expression derived from statistics.
- the reason why the average blood pressure is derived by the calculation in this way is as follows. Particularly in the case of the elderly and those with advanced arteriosclerosis, as shown in Figs. 20 and 21, even if the amplitude of the pulse wave is measured in the same way for the same person, the pulse wave Since the maximum amplitude value of the pulse wave and the amplitude value of the pulse wave near it become unstable, the compression pressure at which the amplitude value of the pulse wave becomes maximum is not constant. As a result, as shown in FIGS.
- the difference (width) W15, W16 between the compression pressure taking a certain amplitude value r21, r22 and the boundary value is not constant due to the change in the boundary value, and There is a possibility that the judgment result of the circulatory function may vary.
- one characteristic amount is extracted from each of the divided compression pressure bands PI and P2. In the present embodiment, however, a plurality of characteristic amounts are extracted from each compression pressure band. It is intended to be issued.
- Fig. 23 extracts widths W17 and W18 in the region of the compression pressure zone P1 on the high pressure side from the boundary value as a characteristic amount, and features widths W19 and W20 in the region of the compression pressure band P2 on the low pressure side below the boundary value. It shows what is extracted as a quantity.
- Fig. 24 shows that the width W21 is extracted as a feature value in the region of the compression pressure zone P1 on the high pressure side from the boundary value, and the width W22-W24 is characterized in the region of the compression pressure zone P2 on the low pressure side of the boundary value. It shows what is extracted as a quantity.
- the measured value of Q measures the circulatory function mainly of atherosclerosis.
- a type of force feature amount a plurality of widths W17-W24 are extracted as feature amounts from the region of each compression pressure band PI, P2, besides, as shown in FIG. It is also possible to use multiple feature values from each region, such as the slope of a certain point in each region and the pressure difference between two compression pressures that take two amplitude values with different pulse wave amplitude values as shown in Fig. 8. You may try to extract ⁇ .
- the same type (same dimension) of the feature amount is extracted from each of the divided compression pressure zones.
- different compression pressure band forces and different types of feature amounts are extracted.
- Fig. 25 shows an example in which different feature quantities are extracted from different compression pressure zones.
- the width W25 starts from the high pressure side compression pressure zone P1. From the region of the low pressure side compression pressure zone P2, the area S1 of the region surrounded by the boundary line and the envelope on the low pressure side is extracted. [0088] According to this, the measurement of the circulatory organ function can be performed with high accuracy.
- the combination of the types of the feature amounts to be extracted is not limited to the combination of the width and the area as described above, but may be the combination of the slope and the width of the envelope, or the combination of the slope and the area. When the envelope is divided into three or more regions, it may be a combination of width, area, and inclination.It is important to extract the features that are considered optimal in each compression pressure band. .
- the circulatory organ function measuring device 100 of the present embodiment inputs physical characteristics such as the age, sex, height, and weight of the subject in addition to the configuration of the first embodiment (the configuration shown in FIG. 1). And a function to set the method of extracting feature values according to the input physical characteristics.
- the other parts are substantially the same as those in the first embodiment, and therefore, only the differences will be described.
- FIG. 26 is a block diagram for explaining a configuration of a circulatory organ function measuring device 100 according to the seventh embodiment.
- the circulatory organ function measuring apparatus 100 according to the seventh embodiment is different from the circulatory organ function measuring apparatus 100 according to the first embodiment in that a personal information input unit 8 and a feature amount An extraction method setting unit 57 is provided.
- the personal information input unit 8 is for inputting physical characteristics such as the age, gender, height, and weight of the subject, and the input physical characteristic information is a feature amount extraction method setting unit. Output to 57.
- the feature value extraction method setting unit 57 is provided in the control unit 5, and sets an appropriate feature value extraction method according to the physical characteristics input by the personal information input unit 8.
- the feature amount extraction method includes a method of setting a boundary value and a method of setting the type of the feature amount to be extracted, and can be set based on statistical data. For example, an elderly person often shows a distorted envelope as shown in FIG. 20 and FIG. 21, and therefore, for example, the feature amount extraction method described in the fourth embodiment is adopted.
- the feature amount extraction pressure band deriving unit 53 sets a plurality of compression pressure bands for extracting feature amounts according to the feature amount extraction method set by the feature amount extraction method setting unit 57.
- FIG. 27 is a flowchart showing an example of the operation of the circulatory organ function measuring device 100.
- step ST21 when the physical information is input by the personal information input unit 8, in step ST22, the feature amount extraction method setting unit 57 determines the input physical characteristics. An appropriate extraction method of the feature amount is selected accordingly. Then, steps ST23 to ST26 perform substantially the same processing as steps ST1 to ST4.
- step ST27 the feature amount extraction pressure band deriving unit 53 sets a plurality of compression pressure bands for calculating a feature amount according to a preset program.
- step ST28 the feature amount extracting unit 54 extracts the feature amount selected by the feature amount extracting method setting unit 57 from the compression pressure band set by the feature amount extracting pressure band deriving unit 53.
- steps ST29 to ST31 substantially the same processing as in steps ST7 to ST9 is performed.
- the function of inputting the physical characteristics of the subject and the function of selecting a method of extracting a characteristic amount according to the input physical characteristics are mounted on the circulatory organ function measuring apparatus 100. Since the feature values are extracted according to the selected feature value extraction method, the circulatory function suitable for the physical characteristics of the subject can be measured.
- the circulatory organ function measuring apparatus 100 stores the physical characteristics of the subject in the form of ID (Identification). ) And memorize them, and input the ID instead of the physical characteristics when measuring the circulatory function.
- the circulatory organ function measuring apparatus 100 of the present embodiment estimates the blood pressure level that should be used to more accurately determine the circulatory organ function.
- the method of extracting the feature amount suitable for each is set.
- FIG. 28 is a block diagram for explaining a configuration of a circulatory organ function measuring device 100 according to the eighth embodiment.
- the circulatory organ function measuring apparatus 100 according to the eighth embodiment is different from the circulatory organ function measuring apparatus 100 according to the first embodiment in that the blood pressure calculating section 56 shown in FIG. And a blood pressure value display unit 7 and a feature amount extraction method setting unit 57 ′.
- the blood pressure calculation unit 56 estimates each blood pressure value of the subject based on the envelope, and the blood pressure value display unit 7 displays each blood pressure value estimated by the blood pressure calculation unit 56. It is.
- the feature amount extraction method setting section 57 ′ sets an appropriate feature amount extraction method according to the blood pressure value calculated by the blood pressure calculation section 56. That is, the feature value extraction method setting unit 57 ′ determines whether the subject has only a high systolic blood pressure and a diastolic blood pressure is normal, only the diastolic blood pressure is high, or both the systolic blood pressure and the diastolic blood pressure are high!
- the blood pressure state such as the blood pressure is estimated by the blood pressure calculating unit 56, and a feature amount extraction method suitable for the estimated blood pressure state is set. Note that the method of extracting the feature amount can be set based on the statistical data, as in the seventh embodiment.
- the feature amount extraction pressure band deriving unit 53 sets a plurality of compression pressure bands for calculating the feature amount according to the feature amount extraction method set by the feature amount extraction method setting unit 57 ′.
- FIG. 29 is a flowchart showing an example of the operation of the circulatory organ function measuring device 100. As shown in FIG. 29, steps ST41 to ST44 are substantially the same as steps ST11 to ST4 of the first embodiment, and thus description thereof will be omitted.
- step ST45 the blood pressure calculation unit 56 estimates the blood pressure value of the subject based on the envelope, and in step ST46, the feature amount extraction method setting unit 57 'estimates the blood pressure by the blood pressure calculation unit 56. An appropriate feature amount extraction method is set according to the obtained blood pressure value.
- step ST47 the feature amount extraction pressure band deriving unit 53 generates a plurality of compression pressure bands for calculating the feature amount according to the feature amount extraction method set by the feature amount extraction method setting unit 57 ′. Set.
- Steps ST48 to ST50 perform substantially the same processing as Steps ST6 to ST8, and in Step ST51, the circulatory organ function display unit 6 displays the state of the circulatory organ function by the circulatory organ function determination unit 55. In addition to displaying the determination result, the blood pressure value display unit 7 displays the blood pressure value estimated by the blood pressure calculation unit 56.
- the circulatory organ function measuring apparatus 100 of the present embodiment has a function of estimating a blood pressure value of a subject from an envelope in addition to the configuration of the first embodiment (the configuration shown in FIG. 1), And a function for correcting the blood pressure value. Note that the other parts are substantially the same as those of the first embodiment, and therefore only the differences will be described.
- FIG. 30 is a block diagram illustrating a configuration of a circulatory organ function measurement device 100 according to the ninth embodiment.
- a circulatory organ function measuring apparatus 100 according to the ninth embodiment is different from the circulatory organ function measuring apparatus 100 according to the first embodiment in that a blood pressure calculating section 56 similar to FIG. And a blood pressure value display unit 7 and an estimated blood pressure correction unit 58.
- the blood pressure calculator 56 estimates the systolic blood pressure, the diastolic blood pressure, and the average blood pressure from the envelope, as in the second embodiment.
- the estimated blood pressure correction unit 58 corrects the blood pressure value estimated by the blood pressure calculation unit 56.
- the estimated blood pressure correction unit 58 performs processing on an envelope specific to each symptom, for example, an envelope specific to hypertension, an envelope specific to arteriosclerosis, an envelope having abnormalities in the intima and media, and an entire blood vessel wall.
- a predetermined correction formula or correction table is stored in correspondence with the envelope having an abnormality and the envelope of a healthy person (an example of which is shown in FIGS. 5 (a) to 5 (e)).
- the blood pressure value calculated by the blood pressure calculation unit 56 is corrected using the correction table.
- the number and types of correction formulas and correction tables used for the correction can be set as appropriate.
- envelopes there are two types of envelopes, namely, an envelope of a healthy person and an envelope of a person with relatively advanced arteriosclerosis. Only the one corresponding to the envelope may be set, or only the one corresponding to Fig. 5 (a)-(c) of Fig. 5 (a)-(e) may be set.
- the blood pressure value display section 7 displays the blood pressure value corrected by the estimated blood pressure correction section 58.
- FIG. 31 is a flowchart showing an example of the operation of the circulatory organ function measuring device 100.
- steps ST61 to ST64 are substantially the same as steps ST11 to ST4 of the first embodiment, and thus description thereof will be omitted.
- step ST65 the characteristic amount extraction pressure band deriving unit 53 sets a plurality of compression pressure bands for calculating the characteristic amount according to a preset program, and sets the blood pressure calculation unit 56 Estimates the blood pressure value from the envelope.
- step ST66 the feature amount extraction unit 54 extracts the feature amount in the compression pressure band set by the feature amount extraction pressure band derivation unit 53, respectively.
- step ST67 the estimated blood pressure correction unit 58 corrects the blood pressure value estimated by the blood pressure calculation unit using the above-described correction formula or correction table.
- step ST68 the cuff 1 is rapidly evacuated by the pressure control unit 2 in response to the control signal from the control unit 5, the cuff 1 is depressurized, and the pressure on the upper arm of the subject is released. .
- step ST69 the circulatory organ function judging section 55 outputs the read judgment result data on the state of the circulatory organ function to the display section 6, and the circulatory organ function display section 6 displays the judgment result of the circulatory organ function state.
- the blood pressure value display unit 7 displays data indicating the blood pressure value estimated by the blood pressure calculation unit 56 as a blood pressure value.
- the blood pressure value of the subject is corrected using the correction formula or the correction table corresponding to various symptoms, so that the blood pressure of the person having various symptoms is corrected.
- the blood pressure value can be estimated with higher accuracy than when the blood pressure is uniformly estimated by the same estimation method.
- the cuff 1 starts the process of depressurizing the cuff 1 slowly.
- the pressure of the cuff 1 may be changed from the predetermined pressure at which the predetermined pressure is lower than the expected minimum blood pressure of the subject.
- a configuration may be adopted in which a pulse wave signal is detected.
- FIG. 32 shows an example of a temporal change in the pressure of the cuff 1 when a pulse wave is detected by applying the pressure of the cuff 1 at a very low speed.
- the location where the pulse wave is detected is not limited to the upper arm, but may be another location such as the wrist.
- it is not limited to the pressure signal of the cuff 1 but limited by means of obtaining a pulse wave signal that can detect similar features using a pulse wave signal obtained by a photoelectric sensor installed in the cuff 1, for example. What is not done.
- the arterial stiffness of the subject is represented by a numerical value up to 1 to 100 based on the magnitude of the value Q calculated by Expression (1), and the numerical value Is displayed on the circulatory function display section 6 Not only this, but also the progress of arteriosclerosis can be seen at a glance. 20, 21—40, 41—60, 61—80, 81
- One hundred levels are divided into five levels, and as shown in Figure 33, the cardiovascular function display section 6 is divided into five vertically divided bar graphs.
- the arterial stiffness of the subject may be indicated by the level.
- FIG. 33 shows that the arterial stiffness of a certain subject was level 3 out of 5 levels.
- the subject's arterial stiffness level should be turned on only for the number of lighting sections corresponding to that level.
- the present invention is not limited to this.
- the arteriosclerosis level of the subject is represented by letters or symbols assigned to the arteriosclerosis level, for example, alphabets A to E,
- the level of arterial stiffness of the subject may be indicated by an alphabet corresponding to the level on the circulatory organ function display section 6 !.
- a lighting portion for example, an LED for displaying a different color according to the level of arteriosclerosis is provided, and the level of arteriosclerosis of the subject is indicated by the display color. It may be. The point is that the form of the display indicating the state of arterial stiffness should be changed according to the state.
- the level of arteriosclerosis is divided into four levels, and a plurality of light emitting units that emit light of different colors, for example, red and yellow, according to the level of progress of the arteriosclerosis.
- a plurality of light emitting units that emit light of different colors, for example, red and yellow
- four types of LEDs, blue and green are associated with each other, indicating that the degree of arterial sclerosis is progressing second out of four stages.
- the number of levels of arterial stiffness is increased, or if the number of levels is determined, the number of LEDs is reduced to reduce the cost. You can plan.
- stage data indicating which stage of the subject's arterial stiffness falls into a plurality of preset stages with respect to the progress of arteriosclerosis is output, and the stage data is output as the stage data.
- the display form in the cardiovascular function display section 6 should be changed accordingly.
- the circulatory function deciding unit 55 includes a circulatory function deciding reference value set according to physical characteristics such as age and gender ( As shown in Fig. 37, the circulatory organ function display section 6 is provided with a display section for displaying age, gender, etc., and a display section for displaying the degree of arteriosclerosis. The difference between the function determination result and the cardiovascular function determination reference value (average value) set according to age and gender may be displayed so as to visually indicate the component. Fig.
- the circulatory organ function judging unit 55 calculates the arteriosclerosis degree of a healthy person derived based on statistics and The relationship with the age is stored, and as shown in FIG. 38, the actual arterial stiffness of the subject is converted into the age of a healthy subject having the arterial stiffness, and the equivalent age and the actual age are calculated. Age may be displayed so that they can be compared. The equivalent age may be calculated, for example, as follows.
- the equivalent age Y is calculated by the following equation (4).
- a and b are constants, and the judgment value X, which is preferably set based on the statistics obtained also from a plurality of healthy persons without disease, is obtained by substituting the judgment value Q described above, for example. Good.
- FIG. 38 shows that the actual age was 40 years old, but the corresponding age was determined to be 55 years old, and arteriosclerosis progressed more than the age.
- FIG. 39 shows that for a given subject, the likelihood of a lifestyle-related disease is at level 3 out of 5 levels.
- aging is also a major factor of arterial stiffness, but when considering only the risk of lifestyle-related diseases, the arteriosclerosis excluding the effects of aging is displayed. Is preferred.
- the effect of aging can be derived from statistics by providing an input device for inputting the age of the subject to be measured, and corresponding to the age of the subject input by the input device. After removing the influence of aging, the risk of lifestyle-related diseases may be displayed.
- the feature amount is extracted in each compression pressure band.
- the state in which the pressure acting on the blood vessel is small the compression pressure as the external pressure is large
- the extensibility of the blood vessel wall depends on the characteristics of the intima and media
- the extensibility of the blood vessel wall depends on the characteristics of the adventitia. Since the tissues related to extensibility differ according to the pressure acting on the blood vessels, the arteriosclerosis degree is derived for each compression pressure zone based on each feature value, and May be displayed.
- Fig. 40 shows the arterial stiffness derived based on the characteristic amount that also extracted the regional force in the high-pressure side compression pressure band (the intra- and extra-vascular pressure difference is on the low-pressure side), and the low-pressure side compression pressure band (intra- and extra-vascular pressure). The difference indicates the area force of the high pressure side)
- the degree of hardening on the high pressure side mainly the degree of hardening of the inner and middle films
- the degree of hardening on the low pressure side mainly the outer degree
- the degree of cure of the film is level 2 out of 5 levels.
- the symptoms of the adventitia and the intima of the blood vessel are displayed by a level meter. You may do it. That is, the circulatory function determining unit 55 determines the state of the tissue constituting the blood vessel of the subject based on the degree of arterial stiffness of the subject, and the circulatory function display unit 6 displays the state of the tissue by the above-described determining means. The status of the determined organization may be displayed. For example, FIG. 41 shows a form in which the symptoms of the adventitia-media and the intima are displayed at three levels (the greater the number of levels, the worse the symptoms).
- the intima is level 3 out of 3 steps
- the media is level 2 in 3 steps
- the adventitia is level 0 in 3 steps.There is no problem with the adventitia, but arteriosclerosis has progressed to the media. Show an example! /
- the degree of arteriosclerosis is derived and displayed in the compression pressure band on the high pressure side and the compression pressure band on the low pressure side, respectively, and the symptoms of blood vessels are displayed separately for the adventitia, media and intima. By doing so, it is possible to determine which compression pressure zone has a problematic force, or which vascular tissue is abnormal, and make diagnosis easier.
- the compression pressure and the amplitude value of the pulse wave associated with each other in the pulse wave detection pressure calculation unit 51 are stored in the pulse wave data storage unit 52 in a table format.
- the number of obtained pulse waves is small, so that the pulse wave amplitude value for obtaining the characteristic amount is stored in a table format in the pulse wave data storage unit 52.
- the amplitude value does not match the amplitude value of any of the pulse waves stored in and becomes an intermediate value.
- the stored amplitude value of the pulse wave which is close to the amplitude value of the pulse wave for obtaining the characteristic amount, and the compression pressure corresponding to the amplitude value are read, and the read amplitude value and compression pressure are read. Therefore, it is preferable that the compression pressure corresponding to the amplitude value of the pulse wave for obtaining the feature amount is derived by interpolation.
- an expression approximating the shape (curve) of a portion around the amplitude value of the read pulse wave in the envelope is derived, and this expression and a pulse for obtaining the characteristic amount are obtained.
- the one that derives the compression pressure corresponding to the amplitude value from the amplitude value of the wave is used.
- the pulse wave detector 4 generates a pulse wave signal indicating the amplitude value of the pulse wave based on the pressure signal output from the pressure detector 3.
- the present invention is not limited to this, and the pulse wave detector 4 generates a pulse wave signal indicating the area value of the pulse wave for each heart beat based on the pressure signal, and replaces the pulse wave amplitude value with the pulse wave amplitude value.
- the feature value may be extracted in the same manner as described above using an envelope indicating the relationship between the area value and the compression pressure.
- the magnitude of the pulse wave in the claims includes not only the amplitude value of the pulse wave but also the area value of the pulse wave.
- the above-mentioned width is used as the type of the feature quantity used for determining the circulatory function using the magnitude of the pulse wave, for example, as shown in FIGS. 6, 17 to 19, and 23 to 25, It is sufficient to include at least one difference between the compression pressure set as the boundary and the compression pressure corresponding to the magnitude of the predetermined pulse wave in the envelope (the widths Wl and W2 in FIG. 6 and the width W1 in FIG. 17). (W5—W8 in FIG. 18, W9—Wll in FIG. 18, W13 and W14 in FIG. 19, W17—W20 in FIG. 23, 21—W24 in FIG. 24, and W25 in FIG. 25).
- a circulatory organ function measuring device may be configured by appropriately combining the functions of the first to tenth embodiments and the other modified embodiments (1) to (10).
- the circulatory organ function measurement device compresses a predetermined part of the body of the subject to be measured.
- Pressure applying means for pressing pressure detecting means for detecting the pressing pressure by the pressure applying means, and pressure control means for changing the pressing pressure by the pressure applying means based on the detected pressing pressure.
- Pulse wave detection means for detecting pulse wave information relating to the magnitude of the pulse wave generated at the predetermined portion in the process of changing the compression pressure based on the compression pressure, and detecting the pulse wave information and the compression pressure at the time of the detection.
- Pulse wave information storage means for storing the compression pressure information in association with the compression pressure information; and an envelope formed based on the correspondence between the pulse wave information stored in the pulse wave information storage means and the compression pressure information.
- the region is divided into a plurality of regions, and when the entire envelope is regarded as one region, at least two regions of the entire region and the divided regions are used. It comprises a feature extraction means for extracting a feature value indicating a feature of the envelope, which is extracted and cardiovascular function determining means for determining cardiovascular function based on each feature quantity.
- the feature amount extracting means includes an envelope formed based on the correspondence between the pulse wave information stored in the pulse wave information storage means and the compression pressure information. Is divided into a plurality of regions with a predetermined compression pressure as a boundary, and at least two regions out of the entire region when the entire envelope is viewed as one region and each of the divided regions is divided into two regions. Any one of the compression pressure difference, the slope, and the area within the range of the region and indicating the characteristic of the shape of the envelope may be extracted as the characteristic amount.
- the extracted feature quantity is at least one difference between a compression pressure set as the boundary and a compression pressure corresponding to a predetermined pulse wave size in the envelope.
- the compression pressure set as the boundary may be configured to be the compression pressure at which the magnitude of the pulse wave is maximized.
- the above-mentioned circulatory organ function measuring apparatus may further include a blood pressure estimating means for estimating a blood pressure using the envelope.
- a blood pressure estimating means for estimating a blood pressure using the envelope.
- the blood pressure estimating means for estimating blood pressure using the envelope is further provided, and the compression pressure set as the boundary is estimated by the blood pressure estimating means. It may be configured to be blood pressure.
- the above-mentioned circulatory organ function measuring device further comprises a blood pressure estimating means for estimating a blood pressure using the envelope, wherein the compression pressure set as the boundary is the compression pressure at which the magnitude of the pulse wave is maximum. It may be configured to include the blood pressure estimated by the blood pressure estimating means. With this configuration, the boundary value can be obtained relatively easily.
- the boundary value is set based on the blood pressure estimated by the blood pressure estimating means, and the feature value including the type of the feature value to be extracted is extracted.
- a first extraction method setting unit for setting a method wherein the feature amount extraction unit is configured to extract the feature amount according to a feature amount extraction method set by the first extraction method setting unit. You may. With this configuration, it is possible to measure the circulatory function including arteriosclerosis with higher accuracy.
- the above-mentioned circulatory organ function measuring device may be configured to include a correction unit that corrects the blood pressure estimated by the blood pressure estimation unit using the extracted feature amount.
- the blood pressure value can be estimated with higher accuracy than when the blood pressure of a person having various symptoms is uniformly estimated by the same estimation method.
- the feature amount extracting means may be configured to extract a plurality of feature amounts from the same area. In these circulatory organ function measuring devices, the feature amount extracting means extracts different types of feature amounts from each region.
- the configuration may be such that With this configuration, it is possible to more accurately measure the circulatory function including arteriosclerosis.
- input means for inputting physical characteristics of the subject, and setting and setting of the boundary value based on the input physical characteristics.
- Second extraction method setting means for setting an extraction method of a feature quantity including a type of the feature quantity to be extracted, wherein the feature quantity extraction means includes a feature quantity extraction means that sets the feature quantity set by the second extraction method setting means.
- the feature quantity may be extracted according to an extraction method! / ⁇ .
- the above-mentioned circulatory organ function measuring device may be configured to include a display means for displaying the judgment result of the circulatory function judgment means! ⁇ .
- the circulatory organ function determining means outputs the progress of arteriosclerosis of the subject as a numerical value
- the display means is output by the circulatory organ function determining means.
- the above numerical values may be displayed. With this configuration, the determination result can be displayed.
- the circulatory organ function determining means sets the degree of arteriosclerosis of the subject in advance according to the progress of arteriosclerosis. It is for outputting stage data indicating which stage among a plurality of stages applies, and the display unit may be configured to display the stage data output by the circulatory organ function determination unit. .
- the display means includes a plurality of light-emitting means which emit light of different colors, each of which is associated with each of the stages, and is output by the circulatory organ function determining means.
- the step data may be displayed by causing a light emitting unit corresponding to the step data to emit light.
- the above-mentioned circulatory organ function measuring device includes input means for inputting the physical characteristics of the person to be measured, and the circulatory organ function determining means is adapted to respond to the physical characteristics.
- Storage means for storing a reference value of the feature amount preset in advance, and the display means Is based on the circulatory organ function determination result determined based on the feature value extracted by the feature value extraction means and the reference value corresponding to the physical characteristics of the subject having the feature value! / It may be configured to display the circulatory organ function determination reference value determined by! With this configuration, the difference between the measured cardiovascular function judgment result and the cardiovascular function judgment reference value set according to age and gender can be visually enhanced. Wear.
- the circulatory organ function determining unit includes a storage unit for storing a relationship between the degree of arteriosclerosis of a healthy subject and its age derived based on statistics, Converting means for converting the degree of arteriosclerosis derived from the characteristic amount extracted by the characteristic amount extracting means into the age of a healthy person corresponding to the degree of arterial stiffness; and the display means converts the degree of arteriosclerosis by the converting means. May be displayed. With this configuration, it is possible to compare the actual age with the equivalent age.
- the circulatory organ function determining means includes a converting means for converting the degree of arterial stiffness of the subject into the number of factors possessing lifestyle-related diseases
- the display means may be configured to display the factor holding number converted by the conversion means. With this configuration, it is possible to know the number of factors possessed.
- the circulatory organ function determining means determines the state of the tissue constituting the blood vessel of the subject based on the degree of arteriosclerosis of the subject.
- the display means may be configured to display the state of the tissue determined by the circulatory function determining means. With this configuration, it is possible to determine which tissue has an abnormality and to make diagnosis easier.
- the circulatory organ function measuring method compresses a predetermined part of the body of the subject, detects the compression pressure, and performs the compression based on the detected compression pressure.
- the compression pressure by the force application means is changed, and based on the detected compression pressure, pulse wave information on the magnitude of the pulse wave generated in the predetermined portion in the process of changing the compression pressure is detected, and the detected pulse wave information and In correspondence with the compression pressure information related to the compression pressure at the time of the detection
- An envelope formed based on the correspondence between the stored and stored pulse wave information and the compression pressure information is divided into a plurality of regions with a predetermined compression pressure as a boundary, and the entire envelope is At least two regions out of the entire region and each of the divided regions when viewed as one region are extracted.
- the characteristic amounts indicating the characteristics of the envelope are extracted, and the circulatory organ function is performed based on the extracted characteristic amounts. Is determined. With this configuration, it is possible to measure the circulatory function including arteriosclerosis with higher accuracy.
- a circulatory organ function measuring apparatus and a circulatory organ function measuring method capable of analyzing the state of a living body more accurately than a background art based on a pulse wave obtained from a living body. Can be.
Abstract
Description
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CN109464137A (zh) * | 2018-11-29 | 2019-03-15 | 东莞市康助医疗科技有限公司 | 一种降压式动脉硬度评价方法、系统及装置 |
CN109464137B (zh) * | 2018-11-29 | 2021-12-10 | 东莞市康助医疗科技有限公司 | 一种降压式动脉硬度评价方法、系统及装置 |
EP3692895A1 (en) * | 2019-02-07 | 2020-08-12 | Samsung Electronics Co., Ltd. | Apparatus and method for estimating bio-information |
CN111528820A (zh) * | 2019-02-07 | 2020-08-14 | 三星电子株式会社 | 用于估计生物信息的设备 |
US11633115B2 (en) | 2019-02-07 | 2023-04-25 | Samsung Electronics Co., Ltd. | Apparatus and method for estimating bio-information |
Also Published As
Publication number | Publication date |
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TWI289051B (en) | 2007-11-01 |
JP3601539B1 (ja) | 2004-12-15 |
TW200533317A (en) | 2005-10-16 |
JP2005278708A (ja) | 2005-10-13 |
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