WO2005091884A2 - Wound packing material for use with suction - Google Patents

Wound packing material for use with suction Download PDF

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Publication number
WO2005091884A2
WO2005091884A2 PCT/US2005/006157 US2005006157W WO2005091884A2 WO 2005091884 A2 WO2005091884 A2 WO 2005091884A2 US 2005006157 W US2005006157 W US 2005006157W WO 2005091884 A2 WO2005091884 A2 WO 2005091884A2
Authority
WO
WIPO (PCT)
Prior art keywords
wound
wound packing
packing
nonabsorbent
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/006157
Other languages
English (en)
French (fr)
Other versions
WO2005091884A3 (en
Inventor
John R. Boehringer
John Karpowicz
Amitabha Mitra
Christopher L. Radl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Laboratories Inc
Original Assignee
Boehringer Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34987320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005091884(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2005227185A priority Critical patent/AU2005227185B2/en
Priority to EP05714089A priority patent/EP1763378B1/en
Priority to AT05714089T priority patent/ATE538766T1/de
Priority to PL05714089T priority patent/PL1763378T3/pl
Priority to CA002560068A priority patent/CA2560068A1/en
Application filed by Boehringer Laboratories Inc filed Critical Boehringer Laboratories Inc
Priority to ES05714089T priority patent/ES2379672T3/es
Priority to JP2007503916A priority patent/JP5069097B2/ja
Publication of WO2005091884A2 publication Critical patent/WO2005091884A2/en
Anticipated expiration legal-status Critical
Publication of WO2005091884A3 publication Critical patent/WO2005091884A3/en
Priority to AU2011200526A priority patent/AU2011200526A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/36—Surgical swabs, e.g. for absorbency or packing body cavities during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/91—Suction aspects of the dressing
    • A61M1/915—Constructional details of the pressure distribution manifold
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/91—Suction aspects of the dressing
    • A61M1/916—Suction aspects of the dressing specially adapted for deep wounds

Definitions

  • the invention relates to a device and method for treating wounds. More specifically, the present invention relates to a therapeutic wound packing material for use with suction and a method of treatment employing the same.
  • BACKGROUND OF THE INVENTION Large open chronic wounds typically secrete exudates during the healing process. It is generally desirable to remove these wound exudates from the wound vicinity to minimize bacterial growth which can ca use infection and delay healing. Excessive exposure to wound exudates can result in maceration of the skin surrounding the wound.
  • Wound exudates are known to contain tissue degrading enzymes that can impede wound healing. It is generally known to cope with exudates of large open chronic wounds by packing them with an absorbent packing such as gauze. Gauze packing fills dead space in the wound and absorbs exudates released by the tissue over time. Disadvantageously, the absorbent gauze must be replaced periodically as it absorbs a larger volume of exudates and becomes saturated. Alternatively, removal of wound exudates can be accomplished with suction. The wound is sealed generally by the application of a cover and suction is applied to the wound to draw out exudates. Often the suction is applied continuously for days or weeks. When suction is used it can be beneficial to also use wound packing.
  • an absorbent packing such as gauze. Gauze packing fills dead space in the wound and absorbs exudates released by the tissue over time. Disadvantageously, the absorbent gauze must be replaced periodically as it absorbs a larger volume of exudates and becomes saturated.
  • the wound packing provides passages from the areas where it contacts the wound to communicate the exudates from the wound surface towards the source of suction.
  • wound packing When wound packing is used in conjunction with suction it is generally found that wounds heal more quickly and wound packing may be replaced less frequently because exudates are continuously removed.
  • absorbent wound packings such as gauze are used with suction their highly absorbent characteristics are not required.
  • Cotton gauze typically absorbs from ten to twenty five times its weight in aqueous liquid. This absorbent quality can be detrimental because absorbent packings tend to retain volumes of exudates within the wound cavity and adjacent the wound surface supporting bacterial growth and enzymatic breakdown of tissue.
  • suction has been applied to the wound, it is generally desirable to permit the wound to contract.
  • Wound contraction is a normal part of wound healing, therefore using a packing that encourages contraction, as opposed to inhibiting it, is desirable.
  • a noncompressible wound packing such as gauze
  • gauze An alternative to gauze as a wound packing is foam.
  • Foams have the disadvantage that they are not readily modified by many traditional methods, such as heat stamping, to produce a surface texture after they are formed. Foam formation methods do not readily lend themselves to the construction of composites. This limits the extent to which multiple materials can be integrated into the foam structure during the manufacturing process. Foam materials are isotropic in that they exhibit uniform properties such as absorbency, pore size etc. in all directions.
  • the present invention is a wound packing material, a method for making the wound packing material, and a method of treating a wound employing the wound packing material.
  • a wound packing for stimulating the healing of a wound in a mammal comprises a plurality of polymeric nonabsorbent fibers coupled together to form a nonabsorbent material suitable for placement within a wound of a mammal.
  • a further embodiment of the present invention is an anisotropic packing.
  • a wound packing for stimulating the healing of a wound comprising a plurality of polymeric nonabsorbent fibers randomly coupled together to form a sheet of nonabsorbent material suitable for placement within a wound of a mammal. Further aspects of the sheet embodiment of the present invention are provided that comprise a corrugated three-dimensional structure and methods of manufacturing the same.
  • a method for treating a wound of a mammal comprising the steps of placing a fibrous nonabsorbent wound packing material in contact with at least one surface of a wound and applying suction to the wound and wound packing material.
  • Figure 1 is an illustration of an exemplary embodiment of a wound packing material of the present invention
  • Figure 2 is a perspective view of an exemplary wound packing sheet of the present invention
  • Figure 3A is a cross sectional view of a deep tissue wound
  • Figure 3B is a cross sectional view of the deep tissue wound of Figure 3A illustrated in combination with an exemplary embodiment of the present invention
  • Figure 4 is a perspective view of an exemplary corrugated unit of the present wound packing invention
  • Figure 5A is a perspective view of an exemplary pleated wound packing sheet of the present invention
  • Figure 5B is a perspective view of an exemplary contoured wound packing sheet of the present invention
  • Figure 5C is a perspective view of an exemplary embossed wound packing sheet of the present invention
  • Figure 5D is a perspective view of an exemplary looped wound packing sheet of the present invention
  • Figure 5E is a perspective view of an exemplary velvet wound packing sheet of the present invention
  • Figure 6A is a top view of an exemplary spiral corrugated wound packing sheet of the
  • Nonabsorbent wound packing has an advantage because it communicates exudates away from the wound and toward a source of suction more quickly and more completely.
  • a component nonabsorbent fiber material, for the purposes of wound packing, is one that absorbs less than about 20% its weight in aqueous liquid.
  • absorbency of a wound packing material is more appropriately characterized as volume of liquid absorbed by volume of packing (in its uncompressed state).
  • a nonabsorbent wound packing preferably retains less than about one third its volume in aqueous liquid. More preferably, it retains less than about 11% its volume. Most preferably, it retains less than about 5% its volume.
  • the absorbency of a wound packing is a function of a number of physical properties. Among them are density, wettability of the base material, the extent to which the base material swells with absorption, surface characteristics of the individual fibers (if any), and the geometric organization of the base material that forms the wound packing. Compressibility is a measure of a material's ability to reduce its volume under compression.
  • a compressible wound packing permits wound contraction under suction. Generally the wound and wound packing are sealed with a flexible cover. A suction is then applied beneath the cover creating a pressure below atmospheric pressure. The pressure differential between atmospheric pressure and the pressure at the wound packing creates a compressive force on the wound packing.
  • a compressible wound packing also adapts to changes in wound geometry induced by patient movement and wound contraction so that it continues to conform to wound geometry.
  • the compressibility of a wound packing is a function of a number of physical characteristics. Chief among these characteristics is the proportion of void volume. A high void volume permits the wound packing to deform in response to a compression force.
  • a material whose response to a compressive force varies depending upon the direction from which the force is received is described as anisotropic.
  • it may, for example, be preferred to promote contraction of a wound's "width" while maintaining the wound's length as well as the wound's depth.
  • it may be desirable to maintain the relative position of the wound's margins while encouraging healing from the wound bed.
  • Another desirable characteristic of a wound packing is resiliency.
  • a resilient material resumes its shape and volume after exposure to compression.
  • a resilient wound packing expands to fill a wound.
  • wound packing should contact all surfaces of a wound so that wound exudates can be drawn away from all wound surfaces by suction. Dead spaces within a wound where no packing is present can fill with wound exudates that impede wound healing. Further, a resilient wound packing will discourage overpacking in a clinical setting because it expands once it is packed into a cavity wound. A resilient packing also has a beneficial ability to resume its configuration when suction is stopped and resumed or after a patient moves. This is also important when suction is applied to the wound in an intermittent fashion. It is also generally desirable to use wound packing that will maintain its integrity such that it does not easily break apart or degrade and subsequently leave material in a wound.
  • Non shedding materials also have the advantage of being able to be purposely cut to fit an irregular wound without breaking apart. Materials with a high degree of integrity are advantageous in that pieces of such materials are much less likely to break away from the whole and get lodged in the wound bed.
  • Figure 1 illustrates an exemplary embodiment of the present invention.
  • wound packing 100 is a mass of fibers 101 randomly coupled together.
  • the fibrous mass can take the form of a simple batting material having a desirable loft. Alternatively, this batting can be constructed from a single tangled monofilament material.
  • Wound packing 100 is resilient and compressible so that it can easily conform to an irregular wound.
  • wound packing 100 is nonwoven.
  • wound packing 100 is spunbonded or melt blown.
  • Component fibers 101 are comprised of a nonabsorbent synthetic polymer. Examples of suitable biocompatible materials are polyolefins such as polypropylene and polyethylene, polyamides such as nylon and related aramids, and polyester. Additionally, fiber treatments such as hyaluronic acid or antimicrobial silver may be incorporated into wound packing 100. Component fibers with one or more of the following beneficial properties are anticipated. Fibers can be bio-absorbable, they may be bio-erodable for the controlled release of a curative agent, they may be adherent for the selective removal of undesirable tissues, substances or microorganisms or they may be non- adherent for the protection of delicate tissue. More preferably, the fibers further incorporate one or more agents recognized in the art to promote wound healing. For example, calcium alginate fibers can be incorporated into wound packing 100.
  • fiber treatments such as hyaluronic acid or antimicrobial silver may be incorporated into wound packing 100.
  • fiber treatments such as hyaluronic acid or antimicrobial silver may be incorporated into wound packing 100.
  • one or more of the fibers incorporated into wound packing 100 are sufficiently conductive to transmit a therapeutic current to the wound tissue from a suitable source (not shown).
  • one or more of the fibers incorporated into wound packing 100 are sufficiently conductive to transmit a therapeutic current to the wound tissue from a suitable source (not shown). Because it is composed of nonabsorbent fibers, wound packing 100 is itself substantially nonabsorbent. Non-absorbency is desirable to minimize retention of wound exudates within the wound packing 100.
  • wound packing 100 may have some apparent absorbency due to minor liquid retention via entrapment in the fibrous matrix and fiber surface adsorption.
  • a controlled proportion of absorbency can be designed into the packing material 100 to permit a patient care provider to administer a medicated solution to the wound area over time by soaking the packing material 100 in the medicated solution.
  • Figure 2 illustrates another exemplary embodiment of the present invention.
  • wound packing sheet 200 comprises a plurality of nonabsorbent synthetic polymeric fibers 202 randomly coupled together to form a substantially flat sheet 204.
  • FIG. 3A An exemplary deep tissue wound is illustrated in Figure 3A. It comprises a wound cavity 300 suitable for treatment with wound packing in conjunction with suction. A wound packing is placed into the wound cavity 300.
  • Figure 3B depicts wound packing sheet 200 packed into a wound cavity 300.
  • Figure 4 illustrates an exemplary corrugated unit embodiment 450 of the present invention comprising two sheets.
  • a first sheet layer 410 is provided, and a second sheet-like layer 420 having an essentially sinusoidal cross section, for example, is coupled to the surface of the first sheet layer at locations 430.
  • the coupling can be achieved by use of an adhesive or heat sealing.
  • a two part silicone adhesive has been found suitable to provide coupling between sheet 410 and sheet 420.
  • a bead of silicone material 440 may be optionally added to adjust the resiliency of the corrugated unit 450.
  • a suitable sheet material is Hollytex® spunbonded polyester manufactured by Ahlstrom Corp. of Mt. Holly Springs, PA. Hollytex® is a preferable choice because it is not prone to fiber shedding.
  • Polyester fibers are preferred for this sheet because they absorb almost no fluid, transport liquids effectively, and are creep resistant in that they more readily return to their original configuration after having a force applied to them for a period of time. While it is preferable to make a corrugated unit embodiment from spunbond sheets, other base sheets are suitable as well. Such sheets may also be made from other nonwoven processes such as meltblowing or hydroentangling or from regular processes such as knitting or weaving. Although sheet layer 420 is illustrated as having a sinusoidal cross-section, the invention is not so limited. It is also contemplated that other cross-sections, such as pleated, may be used. Corrugated unit 450 can be used as a wound packing without further modification. It can also be used to form more complex three-dimensional structures.
  • Spiral wound packing 500 illustrated in Figures 6A and 6B is formed by rolling corrugated unit 450 to expose a portion of the first flat sheet 410 along the circumference.
  • More elaborate structures can also be formed from a plurality of corrugated units.
  • individual corrugated units may be coupled to each other by adhesive or heat sealing means to form multi-corrugated wound packing 550.
  • One or more beads of silicone material 552 can serve dual purposes of coupling the corrugated units 450, as shown in Figure 7, and improving the resiliency of the structure. It should be noted that, while Figure 7 illustrates this embodiment with the peaks of each adjacent corrugation unit in alignment, a staggered configuration is also contemplated.
  • Multi-corrugated wound packing 550 can also be sliced along a cross section at a suitable thickness to produce cut corrugated wound packing. Alternatively, wound packing 550 can be sliced at a bias to produce biased-cut corrugated wound packing.
  • Spiral wound packing 500, cut corrugated wound packing, and biased-cut corrugated wound packing have the benefit of being highly compressible and highly resilient.
  • these wound packing structures are sufficiently compressible to reduce to less than 50% of their original volume when subjected to the approximately 2 psi (pounds per square inch) compression force commonly encountered with the application of suction. More preferably, the wound packing is sufficiently compressible to reduce to less than 25% of its original volume. Most preferably, the wound packing is sufficiently compressible to reduce to less than 10% of its original volume.
  • wound packing structures it is desirable for these wound packing structures to be sufficiently resilient to resume more than 50% of their original volume after exposure to compressive forces common in a clinical setting. Such forces can be as high as 20 psi but are more routinely on the order of 1- 2 psi. More preferably, these wound packing structures are sufficiently resilient to resume more than 80% of their original volume.
  • the structure of spiral wound packing 500, cut corrugated wound packing, and biased-cut corrugated wound packing may also be varied to more easily compress along one axis than the remaining two. This may be achieved by varying the angles at which the corrugated materials are cut or varying the amount and orientation of the adhesive used during manufacture of the corrugated unit.
  • multi-corrugated wound packing 550 is generally anisotropic, having a different composite modulus of elasticity for each axis. This results in a packing that compresses preferentially in certain axes when vacuum is applied. This attribute is valuable when it is desirable to encourage the wound to close preferentially in one direction over another.
  • One version of multi-corrugated wound packing 550 has a modulus of elasticity of 0.9 psi in the x axis, 3.7 psi in the y axis, and 1.0 psi in the z axis.
  • Figure 14A illustrates a wound 1400 that would benefit from an anisotropic wound packing 1410.
  • Figure 14B illustrates wound 1400 with an anisotropic packing 1410 prior to application of suction and
  • Figure 14C illustrates the wound with a contracted perimeter during application of suction with anisotropic packing 1410 in a compressed state.
  • FIG 8 illustrates an exemplary corkscrew wound packing 600 of the present invention.
  • the corkscrew wound packing can be formed simply by winding a single continuous sheet if desired.
  • the spiraling structure of corkscrew wound packing 600 provides a substantially three dimensional structure with minimal manufacturing complexity.
  • the spiraling corkscrew structure may be used as a packing as is or it can be configured with additional spiraling corkscrew structu res to make a more elaborate three dimensional packing.
  • Figure 9 illustrates an exemplary hollow tubular wound packing 700 of the present invention.
  • Tubular structure 700 can be formed by a variety of means known in the textile arts. In particular, it can be formed by braiding component fibers directly into the desired structure.
  • Figure 10 illustrates another exemplary embodiment of the present invention.
  • wound packing material 1000 has a generally spiral shape exhibiting open areas 1020 along the longitudinal axis of the fiber spiral and open areas 1040 between adjacent segments of a particular spiral.
  • Wound packing material 1000 is generally constructed from polymer fibers 1060, such as spandex.
  • fibers 1060 are wrapped around mandrels, such as a steel tube (not shown).
  • the steel tubes with the spandex wrap are stacked in rows and a polyurethane film (not shown) is placed between each row.
  • the polyurethane film is about 0.003 inch thick.
  • the stack of tubes is then clamped together and heated to about 320 degrees F.
  • the polyurethane film melts and adheres to the spandex fibers, thus coupling the adjacent spirals to one another. After cooling, the steel tubes are removed.
  • Wound packing material 1000 as illustrated in
  • Wound packing 1000 benefits from a number of valuable properties. It is generally nonabsorbent, it is compressible and resilient such that it rebounds after compression and can be configured in an anisotropic fashion. Additional embodiments are anticipated.
  • a suitable wound packing can be made by spraying molten filaments on a conveyor with a waffled surface. A biocompatible binding agent is sprayed onto a three dimensional form, subsequently a chopper gun is used to spray chopped fibers with the desired properties onto the form. The binding agent serves to couple the fibers together forming an appropriate wound packing. While preferred embodiments of the invention have been shown and described herein, it will be understood that such embodiments are provided by way of example only. Numerous variations, changes and substitutions will occur to those skilled in the art without departing from the spirit of the invention. Accordingly, it is intended that the appended claims cover all such variations as fall within the spirit and scope of the invention.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Materials For Medical Uses (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Load-Engaging Elements For Cranes (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
PCT/US2005/006157 2004-03-18 2005-02-25 Wound packing material for use with suction Ceased WO2005091884A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2007503916A JP5069097B2 (ja) 2004-03-18 2005-02-25 吸引と共に使用するための創傷充填材
EP05714089A EP1763378B1 (en) 2004-03-18 2005-02-25 Wound packing material for use with suction
AT05714089T ATE538766T1 (de) 2004-03-18 2005-02-25 Wundwickelmaterial für den einsatz mit absaugung
PL05714089T PL1763378T3 (pl) 2004-03-18 2005-02-25 Materiał wypełniający ranę do użycia z odsysaniem
CA002560068A CA2560068A1 (en) 2004-03-18 2005-02-25 Wound packing material for use with suction
AU2005227185A AU2005227185B2 (en) 2004-03-18 2005-02-25 Wound packing material for use with suction
ES05714089T ES2379672T3 (es) 2004-03-18 2005-02-25 Material terapéutico de empaquetadura de heridas para uso con succión
AU2011200526A AU2011200526A1 (en) 2004-03-18 2011-02-09 Wound packaging material for use with suction

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55415804P 2004-03-18 2004-03-18
US60/554,158 2004-03-18
US10/981,119 US7754937B2 (en) 2004-03-18 2004-11-04 Wound packing material for use with suction
US10/981,119 2004-11-04

Publications (2)

Publication Number Publication Date
WO2005091884A2 true WO2005091884A2 (en) 2005-10-06
WO2005091884A3 WO2005091884A3 (en) 2007-11-08

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ID=34987320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006157 Ceased WO2005091884A2 (en) 2004-03-18 2005-02-25 Wound packing material for use with suction

Country Status (9)

Country Link
US (3) US7754937B2 (https=)
EP (2) EP1763378B1 (https=)
JP (2) JP5069097B2 (https=)
AT (1) ATE538766T1 (https=)
AU (2) AU2005227185B2 (https=)
CA (1) CA2560068A1 (https=)
ES (1) ES2379672T3 (https=)
PL (1) PL1763378T3 (https=)
WO (1) WO2005091884A2 (https=)

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EP2285432B1 (en) 2008-05-30 2016-03-23 KCI Licensing, Inc. Reduced-pressure dressing assemblies for use in applying a closing force
CN106563153A (zh) * 2015-10-10 2017-04-19 如皋市启润运动用品有限公司 一种医用功能性生物敷料片
US10080689B2 (en) 2007-12-06 2018-09-25 Smith & Nephew Plc Wound filling apparatuses and methods
US10154928B2 (en) 2012-08-08 2018-12-18 Smith & Nephew Plc Bespoke wound treatment apparatuses and methods for use in negative pressure wound therapy
US10265071B2 (en) 2008-05-30 2019-04-23 Kci Licensing, Inc. Reduced-pressure, linear wound closing bolsters and systems
EP3187209B1 (en) 2010-04-30 2019-06-05 KCI Licensing, Inc. System for sealing an incisional wound
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
WO2022234444A1 (en) * 2021-05-06 2022-11-10 Kci Manufacturing Unlimited Company Bio-absorbable dispersible rapidly deployable wound interface

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DE102005007016A1 (de) 2005-02-15 2006-08-24 Fleischmann, Wilhelm, Dr.med. Vorrichtung zur Behandlung von Wunden
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CA2560068A1 (en) 2005-10-06
ATE538766T1 (de) 2012-01-15
EP1763378A4 (en) 2010-07-07
AU2011200526A1 (en) 2011-03-03
US20050209574A1 (en) 2005-09-22
PL1763378T3 (pl) 2013-03-29
US20100318046A1 (en) 2010-12-16
US7754937B2 (en) 2010-07-13
WO2005091884A3 (en) 2007-11-08
US8500704B2 (en) 2013-08-06
JP5069097B2 (ja) 2012-11-07
EP2415426A1 (en) 2012-02-08
EP1763378B1 (en) 2011-12-28
ES2379672T3 (es) 2012-04-30
JP2012024613A (ja) 2012-02-09
AU2005227185B2 (en) 2010-12-09
AU2005227185A1 (en) 2005-10-06
JP2007531567A (ja) 2007-11-08
US20130296815A1 (en) 2013-11-07
EP1763378A2 (en) 2007-03-21

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