WO2005086948A2 - Procedes, systemes et dispositifs de distribution de fluides - Google Patents

Procedes, systemes et dispositifs de distribution de fluides Download PDF

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Publication number
WO2005086948A2
WO2005086948A2 PCT/US2005/008133 US2005008133W WO2005086948A2 WO 2005086948 A2 WO2005086948 A2 WO 2005086948A2 US 2005008133 W US2005008133 W US 2005008133W WO 2005086948 A2 WO2005086948 A2 WO 2005086948A2
Authority
WO
WIPO (PCT)
Prior art keywords
collection point
fluid
dam
reservoir
flexible lamina
Prior art date
Application number
PCT/US2005/008133
Other languages
English (en)
Other versions
WO2005086948A3 (fr
Inventor
Dean Schiller
Stephen Kuhn
Timothy Convington
Frank Beninsig
Original Assignee
Dean Schiller
Stephen Kuhn
Timothy Convington
Frank Beninsig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dean Schiller, Stephen Kuhn, Timothy Convington, Frank Beninsig filed Critical Dean Schiller
Publication of WO2005086948A2 publication Critical patent/WO2005086948A2/fr
Publication of WO2005086948A3 publication Critical patent/WO2005086948A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3294—Thermoformed trays or the like with a plurality of recesses for different materials located in different recesses

Definitions

  • the present invention relates generally to product packaging. More specifically, embodiments of the present invention relates to methods, systems and devices for packaging, mixing and or dispensing components such as: aqueous solutions; dry or semi-dry reagents; medical products; drugs; cosmetics; nutrients; biological and chemical agents; and combinations or derivatives thereof.
  • aqueous based products commonly promote their products by providing samples to consumers.
  • One common method for distributing samples is to hand them directly to consumers in a store or other public place.
  • these samples are packaged in smaller versions of the same packaging used for the actual product.
  • Such packaging can be flexible, rigid or semi-rigid.
  • Some notable means for packaging and dispensing liquid solutions in small volumes include: small capped tubes made of metal, plastics and other polymeric materials; jars and small vials; flexible bags. While suitable for hand delivery of samples, the packages are relatively expensive and often require a detachable cap as a second part which further increases the cost and complexity of manufacture.
  • the aqueous contents of such packaging require excess content due to inefficiencies in dispensing. Further, dispensing liquid solutions from such packaging can be imprecise, resulting in unintended dispensing of the aqueous contents.
  • Blister packs are another type of packaging often used to distribute aqueous samples.
  • Blister packs are essentially pouches made of metal foil or plastic that can be torn at the edge to dispense the aqueous contents.
  • blister packs are often used in direct mail and media inserts that are delivered to consumers via the United States Postal Service (USPS).
  • USPS United States Postal Service
  • blister packs are susceptible to incidental bursting when substantial pressure is applied to the blister pack. For example, if a number of magazines are stacked together that include blister packs, the blister packs in some of the magazines may burst due to the external pressure applied by the stack of magazines.
  • the solutions delivered to the patient often comprises a mixed combination of at least one diluent and at least one medicament.
  • the medicaments must be maintained separately from the diluent until immediately before use to prevent degradation.
  • Common packaging of the diluent and medicaments is often further complicated by the character of the medicament which may be a powder sensitive to moisture contamination, or a powder or liquid sensitive to degradation under light or oxygen exposure.
  • Containers such as that disclosed in U.S. Patent Nos.4,458,81 1 to Wilkinson and 4,608,043 to Larkin are representative of prior art multiple compartment flexible containers allowing separate storage of medicaments and diluents which may be mixed immediately prior to use.
  • a second type of prior art devices provide a flexible diluent container with an attachment means for a second container containing a medicament and integral systems for engagement of the containers to maintain sterility while mixing the components.
  • Alternate systems in the prior art include combined containers wherein an inner container is physically manipulated from the exterior of a flexible covering container to release a medicament for mixing with a diluent in the flexible container.
  • a vial contained within the flexible container having a plug or lid which may be extracted from the vial by manipulating the vial through the flexible walls of the container is exemplified in U.S. Patent No. 4,610,684 to Knox et al.
  • An additional alternative is provided in the prior art by pre-mixing the medicament and diluent and freezing the container until ready for use to extend shelf life by preventing degradation of the pre-mixed solution.
  • the complexities and disadvantages are self evident of numerous and complicated parts for the containers or the added requirement for refrigeration support devices of these prior art approaches.
  • an in vitro container having multiple compartments for storage of diluent and medicaments in a single package having simple operative valves, frangible seals or controlled pathways dividing the compartments which may be opened for the combination and mixing of the contents. It is further desirable that the container arrangement precludes the inadvertent delivery of any of the components prior to mixing and allows visual verification of condition of the components prior to mixing and after mixing is complete, before dispensing. It is also desirable that the contents of the container be completely deliverable to the patient without the requirement for the presence of a significant quantity of air in the container.
  • One example is a nutritional perinatal solution made by combining amino acid and dextrose. If there is a delay of many weeks or months between mixture of the ingredients and administration to the patient, a reaction between the ingredients results in unacceptable discoloration of fluid.
  • Another example is the combination of heparin and dextrose. Dextrose has a relatively low pH compared to heparin. With the passage of time after mixing, the more acidic dextrose reduces the effectiveness of the heparin.
  • the present invention discloses methods, systems and devices for mixing or dispensing dry, semi-dry or aqueous components using rigid, semi-rigid or flexible containers, bags, or compartmental apparatus.
  • a planar surface also includes a narrow channel connected to the reservoir and separated from a second recessed area, or collection point, by a dam.
  • the planar surface is overlaid with a flexible lamina, adhered to the planar surface, forming a sealed reservoir between the recessed area of the planar surface and flexible lamina.
  • an essentially planar surface includes at least two reservoirs, each with a corresponding narrow channel.
  • each channel leads to a common collection point in the planar surface.
  • the common collection point is separated from each narrow channel by a dam. This embodiment allows a user to combine the dry, semi-dry, or aqueous materials from each of the at least two reservoirs in the common collection point.
  • the common collection point is covered by a flexible lamina upon which a user may direct or apply a force or action in order to mix the two fluid materials without allowing the fluids to leak or otherwise escape from the common collection point.
  • the common collection point is a successive reservoir that dispenses the mixed fluid to yet another common collection point when pressure is applied to the flexible lamina covering the successive reservoir.
  • contemplated rigid, semi-rigid or flexible containers, bags, or compartmental apparatus are constructed with and or coated with materials selected from the group consisting of but not limited to: silicone; silicone derivatives; rubber; rubber derivatives; neoprene; neoprene derivatives; elastomers; elastomer derivatives; urethane; urethane derivatives; shape memory materials; condutive films, PET film, conductive inks, conductive polymers, conductive coatings; polymer coatings; doped conductive coatings, doped conductive polymer coatings and combinations or derivatives thereof.
  • dry, semi-dry, aqueous or semi-aqueous components or solutions to be mixed or dispensed contemplated by various embodiments are selected from the group consisting of but not limited to: medicaments; medical drugs; vaccines; biochemical agents; gases and gaseous agents; in vitro solutions, cosmetics; nutraceuticals; chemiluminescent reagents; detergents; solvents; aqueous foods; inks; dyes; photographic reagents; bioreactive polymers; gels; liposomes; microspheres; microbeads; reactive chemicals; hemostatic agents; antibiotics; and combinations or derivatives thereof.
  • contemplated flexible lamina is constructed with and or coated with materials selected from the group consisting of but not limited to: silicone; silicone derivatives; rubber; rubber derivatives; neoprene; neoprene derivatives; elastomers; elastomer derivatives; urethane; urethane derivatives; shape memory materials; condutive films, PET film, conductive inks, conductive polymers, conductive coatings; polymer coatings; doped conductive coatings, doped conductive polymer coatings and combinations or derivatives thereof.
  • Figure 1 is a top view of a fluid dispenser according to one embodiment of the present invention.
  • Figure 2A is a cross sectional view of a fluid dispenser according to one embodiment of the present invention.
  • Figure 2B is a cross sectional view of a fluid dispenser illustrating how fluid is dispensed when pressure is applied to a flexible lamina according to one embodiment of the invention
  • Figure 3A is a top view of a multiple reservoir fluid dispenser according to one embodiment of the present invention
  • Figure 3AA is a sectional view of the dispenser of Figure 3A taken along line A-A;
  • Figure 3B is a top view of a multiple reservoir fluid mixer according to one embodiment of the present invention.
  • Figure 3BB is a sectional view of the dispenser of Figure 3B taken along line B-B;
  • Figure 4 is a top view of a multiple reservoir fluid dispenser according to one embodiment of the present invention.
  • Figure 4A is a sectional view of the dispenser of Figure 4 taken along line A-A.
  • FIGS 1 , 2A and 2B are a top view and a cross-sectional views, respectively, of a fluid dispensing device or dispenser 20 according to one embodiment of the present invention.
  • a planar surface 22 includes a recessed area 21 outlined by dashed lines.
  • planar surface 22 is overlaid with a flexible lamina 23 that is adhered to planar surface 22 using a glue substance thus forming a sealed reservoir 24 (best seen in Figure 2B) between the recessed area 21 of planar surface 22 and flexible lamina 23.
  • Figures 1 and 2A also illustrate a recessed collection point 26 which is formed by a second depression in planar surface 22.
  • An un-recessed dam 28 separates collection point 26 from a narrow outlet 29 formed in as a narrow channel in planar surface 22. Narrow outlet 29 may be part of reservoir 24.
  • a fluid is sealed in reservoir 24 between the recessed portion of planar surface 22 and flexible lamina 23.
  • flexible lamina 23 When pressure is applied to flexible lamina 23, for example by pressure from an individual's finger, as illustrated in Figure 2B, the fluid in reservoir 24 flows through narrow outlet 29 towards dam 28.
  • Dam 28 is a thin portion of planar surface 22 which separates narrow outlet 29 from collection point 26. Due to the thin nature of dam 28, the seal between flexible lamina 23 and dam 28 is not strong at this location, thus creating a point of least resistance at dam 28. A pressure buildup at the point of least resistance by continued finger pressure causes lamina 23 to pull away from dam 28, thus allowing fluid in the reservoir 24 to flow over dam 28 into collection point 26.
  • Planar surface 22 may be made from plastic, molded or otherwise formed to include reservoir 24, narrow outlet 29 and collection point 26.
  • planar surface 22 is not limited to plastic nor is surface 22 limited to being planar as it may be curved.
  • Planar surface 22 can be formed from any material, including flexible materials such as rubber that may be formed or molded to include collection point 26, narrow outlet 29 and reservoir 24.
  • Flexible lamina 23 is typically constructed using a material that prevents moisture and vapor transmission, while providing a flexible barrier.
  • flexible lamina is metal foil.
  • a transparent laminate, such as clear plastic may be used as flexible lamina 23.
  • glues, resins, epoxies and/or mechanical fasteners there are a number of ways to adhere flexible lamina 23 to planar surface 22, including, for example glues, resins, epoxies and/or mechanical fasteners.
  • planar surface 22 may vary depending on the intended use and the amount of fluid that is to be held in reservoir 24.
  • the thickness of planar surface 22 may be kept small so that the invention may be placed un-obtrusively between pages in a magazine or other carrier media without substantially altering the look or thickness of the media.
  • limiting the thickness of the planar surface to a range of approximately 15-35 mm may provide a sufficiently thin package to place within a magazine or other carrier media.
  • the length and width of planar surface dimensions may be adjusted accordingly to ensure that reservoir 24 holds sufficient volume to provide a user with an acceptable sample of the fluid product.
  • Substantial uniform pressure may be applied to the top surface of planar surface 22 without causing unwanted release of the fluid stored in reservoir 24.
  • heavy loads such as a stack of magazines or other heavy flat objects can be placed on top of planar surface 22 without resulting in unwanted fluid release.
  • the pressure of these objects rests on the face of planar surface 22. Since the pressure in not directed on flexible lamina 23 covering reservoir 24, unwanted release of the fluid would not occur.
  • the pressure of a large number of magazines or other heavy objects may cause these devices to burst resulting in unwanted release of the fluid inside them.
  • Flexible lamina 23 may be imprinted with marketing information, including product advertisements and/or product information about the sampled fluid.
  • the portion of flexible lamina 23 covering reservoir 24 is transparent, allowing the fluid material held in reservoir 24 to be viewed prior to dispensing.
  • planar surface 22 could be shaped in the form of a star, a triangle, or any other simple or complex shape desired for a particular marketing idea or plan.
  • FIG. 3A illustrates an alternate embodiment of the present invention.
  • planar surface 32 includes two reservoirs 24A and 24B.
  • narrow outlets 29A and 29B of reservoirs 24A and 24B lead to a common collection point 30, which is separated from narrow outlets 29A and 29B by dams 28A and 28B.
  • common collection point 30 is not covered by flexile lamina 23.
  • Figure 3AA shows a sectional view of planar surface 32 along line AA-AA of Figure 3A and having flexible lamina 23 attached thereto.
  • reservoirs 24A and 24B may contain two fluids that can be mixed in common collection point 30 to create a liquid bandage that may be applied to a cut or other wound using an applicator.
  • planar surface 32B includes common collection point 33 covered by flexible lamina 23.
  • fluid from reservoirs 24A and 24B may be released into common collection point 33 when pressure is applied to the flexible lamina 23 covering the respective reservoirs 24A and 24B.
  • Pressure may be applied to the flexible lamina covering common collection point 33 to mix the two fluids located in common collection point 33. There is no release mechanism to allow the mixed fluid material to escape from collection point 33.
  • Figure 3BB shows a sectional view of planar surface 32B along line BB-BB of Figure 3B and having flexible lamina 23 attached thereto.
  • reservoirs 24A and 24B may contain fluids that when mixed create a chemical reaction that releases heat.
  • the packaging may be stored for longer periods of time with the two fluid materials separated from one another and may be mixed when the desired reaction of the two fluids is desirable.
  • planar surface 40 includes a third reservoir 24C and the common collection point is third reservoir 24C.
  • the fluid from reservoirs 24A and 24B flows into reservoir 24C when pressure is applied to the flexible 23, by for example an individual's finger, to mix the fluids from reservoirs 24A and 24B.
  • additional pressure may be applied to flexible lamina 23 causing the fluid in reservoir 24C to flow through narrow outlet 29C.
  • the buildup of pressure at dam 28C results in the separation of flexible lamina 23 from dam 28C.
  • the combined fluid in reservoir 24C then flows into collection point 44.
  • collection point 44 may or may not be covered by flexible lamina 23 depending upon the intended application.
  • Figure 4A shows a sectional view of planar surface 40 along line A-A of Figure 4 and having flexible lamina 23 attached thereto.
  • a further embodiment of the present invention discloses a method to provide an essentially planar component dispensing system comprising the steps of: incorporating at least two component containing reservoirs on at least one support substrate;
  • component dispensing systems of the present invention used in medical arenas are sterilized before, during and or after manufacture.
  • Another embodiment of the present invention provides an essentially planar component dispensing system method comprising the steps of: incorporating at least two component containing reservoirs on at least one support substrate;
  • It is contemplated at an embodiment of the present invention has the method of the removal of mixed components from said at least one collection point selected from the group consisting of: scooping; adhering; pressure release; suction; injection; spatial displacement; pouring; dropping; and combinations or derivatives thereof.
  • a chemiluminescent example of an embodiment of the present invention has one non-light radiating solution housed in one reservoir (Component A). Another non-light radiating chemical solution is housed in the second reservoir of the at least two reservoir system (Component B). When Component A and Component B are mixed together in the at least one collection point, the mixture radiates visible light. In this embodiment, the supplied system remains sealed.
  • Another embodiment of the present invention provides an essentially planar and sealed component mixing system comprising the steps of: incorporating at least two component containing reservoirs on at least one support substrate;
  • Various mixed component reactions contemplated by an embodiment of the present invention include but are not limited to: temperature change reactions; pressure change reactions; explosions (such as a bomb); binding or fusing reactions; splitting reactions; light generation reactions; odor reactions; timing reactions; chemical reactions; biological reactions; gas producing reactions; and combinations or derivatives thereof.
  • the invention may also be used on curved surfaces. Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the embodiments appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
  • the embodiments of the present invention can be used in research, product manufacturing, and data access systems or used in calibration systems as in accordance with the appropriate research, clinical trial, manufacturing or treatment protocols or procedures approved by the appropriate governing institutions having authority to recommend, approve, evaluate or regulate such protocols or procedures.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Jet Pumps And Other Pumps (AREA)

Abstract

La présente invention a trait à la distribution de fluides au moyen d'une surface présentant un passage étroit relié à un réservoir encastré et séparé d'un point de recueil encastré par une barrière. La surface est recouverte d'un laminé flexible et lors de l'application de pression au laminé, la barrière est rompue et le fluide s'écoule depuis le réservoir par le passage étroit jusqu'à la barrière.
PCT/US2005/008133 2004-03-10 2005-03-10 Procedes, systemes et dispositifs de distribution de fluides WO2005086948A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55198404P 2004-03-10 2004-03-10
US60/551,984 2004-03-10

Publications (2)

Publication Number Publication Date
WO2005086948A2 true WO2005086948A2 (fr) 2005-09-22
WO2005086948A3 WO2005086948A3 (fr) 2007-02-08

Family

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Family Applications (1)

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PCT/US2005/008133 WO2005086948A2 (fr) 2004-03-10 2005-03-10 Procedes, systemes et dispositifs de distribution de fluides

Country Status (2)

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US (1) US20050199648A1 (fr)
WO (1) WO2005086948A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMO20110169A1 (it) * 2011-07-07 2013-01-08 Coopbox Group S P A Contenitore
US10638830B2 (en) 2015-05-29 2020-05-05 Colgate-Palmolive Company Neat hand-washing system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635376A (en) * 1970-06-05 1972-01-18 Hellstrom Harold R Quick-open flexible package
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
US5254479A (en) * 1991-12-19 1993-10-19 Eastman Kodak Company Methods for preventing air injection into a detection chamber supplied with injected liquid
US5290518A (en) * 1992-08-17 1994-03-01 Eastman Kodak Company Flexible extraction device with burstable sidewall

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635376A (en) * 1970-06-05 1972-01-18 Hellstrom Harold R Quick-open flexible package
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
US5254479A (en) * 1991-12-19 1993-10-19 Eastman Kodak Company Methods for preventing air injection into a detection chamber supplied with injected liquid
US5290518A (en) * 1992-08-17 1994-03-01 Eastman Kodak Company Flexible extraction device with burstable sidewall

Also Published As

Publication number Publication date
WO2005086948A3 (fr) 2007-02-08
US20050199648A1 (en) 2005-09-15

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