WO2005080335A1 - 3-3-di-substituted-oxindoles as inhibitors of translation initiation - Google Patents
3-3-di-substituted-oxindoles as inhibitors of translation initiation Download PDFInfo
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- WO2005080335A1 WO2005080335A1 PCT/US2005/004373 US2005004373W WO2005080335A1 WO 2005080335 A1 WO2005080335 A1 WO 2005080335A1 US 2005004373 W US2005004373 W US 2005004373W WO 2005080335 A1 WO2005080335 A1 WO 2005080335A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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| JP2006553263A JP4989976B2 (ja) | 2004-02-13 | 2005-02-11 | 翻訳開始阻害剤としての３−３−二置換オキシインドール |
| CA002555812A CA2555812A1 (en) | 2004-02-13 | 2005-02-11 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| EP05722960A EP1718611A4 (en) | 2004-02-13 | 2005-02-11 | 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION |
| AU2005214338A AU2005214338B2 (en) | 2004-02-13 | 2005-02-11 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US11/463,421 US7737172B2 (en) | 2004-02-13 | 2006-08-09 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US12/368,588 US7846962B2 (en) | 2004-02-13 | 2009-02-10 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US12/796,787 US8088816B2 (en) | 2004-02-13 | 2010-06-09 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US12/796,831 US8268879B2 (en) | 2004-02-13 | 2010-06-09 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US12/916,956 US8044089B2 (en) | 2004-02-13 | 2010-11-01 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| US13/233,074 US8354440B2 (en) | 2004-02-13 | 2011-09-15 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
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| US54438404P | 2004-02-13 | 2004-02-13 | |
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| US11/463,421 Continuation US7737172B2 (en) | 2004-02-13 | 2006-08-09 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
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| PCT/US2005/004373 WO2005080335A1 (en) | 2004-02-13 | 2005-02-11 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
Country Status (6)
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005097107A3 (en) * | 2004-04-08 | 2006-03-30 | Bioimage As | Diphenyl - indol-2-on compounds and their use in the treatment of cancer |
| WO2008129075A1 (en) * | 2007-04-24 | 2008-10-30 | Topotarget A/S | Substituted 3-(4-hydroxyphenyl)-indolin-2-one-compounds |
| EP2010168A2 (en) * | 2006-02-14 | 2009-01-07 | The President and Fellows of Harvard College | Histone deacetylase inhibitors |
| WO2010109008A1 (en) | 2009-03-26 | 2010-09-30 | Topotarget A/S | Prodrugs of substituted 3-(4-hydroxyphenyl)-indolin-2-ones |
| US7932252B2 (en) | 2004-05-12 | 2011-04-26 | Chemocentryx, Inc. | Aryl sulfonamides |
| US7973069B2 (en) | 2004-07-14 | 2011-07-05 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| CN102127002A (zh) * | 2011-01-20 | 2011-07-20 | 华东师范大学 | 一种制备3,3-二芳基取代和3-烷基-3-芳基取代氧化吲哚衍生物的方法 |
| US8178579B2 (en) | 2001-05-09 | 2012-05-15 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US8304451B2 (en) | 2006-05-03 | 2012-11-06 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| US8329945B2 (en) | 1996-03-26 | 2012-12-11 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US8435780B2 (en) | 2000-03-03 | 2013-05-07 | President And Fellows Of Harvard College | Class II human histone deacetylases, and uses related thereto |
| US8440716B2 (en) | 2008-07-23 | 2013-05-14 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
| US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
| US8754237B2 (en) | 2006-02-14 | 2014-06-17 | President And Fellows Of Harvard College | Bifunctional histone deacetylase inhibitors |
| US8999289B2 (en) | 2005-03-22 | 2015-04-07 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
| CN107072205A (zh) * | 2014-09-10 | 2017-08-18 | Epizyme股份有限公司 | Smyd抑制剂 |
| CN107635996A (zh) * | 2015-06-19 | 2018-01-26 | 安斯泰来制药有限公司 | 咪唑并二氮*化合物 |
| EP3912625A1 (en) * | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| US20220064152A1 (en) * | 2020-08-31 | 2022-03-03 | Trustees Of Boston University | Novel fungal modulators |
| EP4119542A1 (en) * | 2019-11-01 | 2023-01-18 | FMC Corporation | An efficient process for the synthesis of 2-amino-5-chloro-n,3-dimethylbenzamide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2435040A2 (en) * | 2009-05-28 | 2012-04-04 | President and Fellows of Harvard College | N,n-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation |
| WO2014047437A1 (en) * | 2012-09-20 | 2014-03-27 | President And Fellows Of Harvard College | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| EP2945646A4 (en) * | 2013-01-18 | 2016-09-21 | David J Shapiro | ESTROGEN RECEPTOR INHIBITORS |
| WO2014145386A2 (en) | 2013-03-15 | 2014-09-18 | University Of Florida Research Foundation Incorporated | Novel allosteric inhibitors of thymidylate synthase |
| US9718775B2 (en) | 2014-03-14 | 2017-08-01 | Milliken & Company | Oxindole compounds and compositions comprising the same |
| US10076267B2 (en) | 2014-10-03 | 2018-09-18 | General Electric Company | Methods and systems for improved navigation |
| WO2016209688A1 (en) | 2015-06-24 | 2016-12-29 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of cancer and uses thereof |
| CR20210060A (es) * | 2018-07-03 | 2021-04-08 | Univ Illinois | Activadores de la respuesta a proteínas desplegadas |
| CN113548999B (zh) * | 2020-04-24 | 2023-04-28 | 复旦大学 | 消旋和手性3-(2,3-丁二烯基)氧化吲哚酮类化合物及制备方法及应用 |
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| JP2003176269A (ja) * | 2001-12-12 | 2003-06-24 | Mitsubishi Pharma Corp | 環状アミド化合物およびその医薬用途 |
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| ES426436A1 (es) * | 1974-05-18 | 1976-07-01 | Andreu Sa Dr | Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona. |
| JPS55129284A (en) * | 1979-03-27 | 1980-10-06 | Shionogi & Co Ltd | 3-(1-imipazolyl)indolin-2-one |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| SU1823440A1 (ru) | 1990-10-18 | 1996-11-20 | Киевский научно-исследовательский филиал Государственного научно-исследовательского и проектного института хлорной промышленности | N-производные 3,3-бис-(4-оксиарил)индолин-2-она в качестве модификаторов поликарбоната |
| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| JPH07301916A (ja) | 1994-04-28 | 1995-11-14 | Nippon Zeon Co Ltd | ポジ型レジスト組成物 |
| JPH08183853A (ja) | 1994-12-28 | 1996-07-16 | Nippon G Ii Plast Kk | ポリカーボネート、ポリカーボネート組成物およびこれらの製造方法 |
| DE19638888A1 (de) * | 1996-09-23 | 1998-03-26 | Bayer Ag | Cokatalysatoren für die Bisphenolsynthese |
| JP4035287B2 (ja) | 2000-12-11 | 2008-01-16 | 本州化学工業株式会社 | イサチンビス（ｏ−クレゾール）の製造方法 |
| JP4035286B2 (ja) | 2000-12-11 | 2008-01-16 | 本州化学工業株式会社 | イサチンビス（ｏ−クレゾール）の製造方法 |
| DE10202874A1 (de) | 2002-01-25 | 2003-08-07 | Basf Ag | Verfahren zur Herstellung von 3,3-Bis-(4-hydroxyaryl)- oxindolen |
| EP1487792A1 (en) * | 2002-03-15 | 2004-12-22 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
| KR20060130781A (ko) * | 2004-04-08 | 2006-12-19 | 토포타겟 에이/에스 | 다이페닐 인돌-2-온 화합물 및 암 치료에 있어서의 그의용도 |
| US8318699B2 (en) | 2005-01-31 | 2012-11-27 | The Trustees Of The University Of Pennsylvania | Tumor necrosis factor inhibitors |
| US20100029646A1 (en) | 2006-12-11 | 2010-02-04 | Topo Target A/S | Prodrugs of diphenyl ox-indol-2-one compounds |
| WO2008129075A1 (en) | 2007-04-24 | 2008-10-30 | Topotarget A/S | Substituted 3-(4-hydroxyphenyl)-indolin-2-one-compounds |
-
2005
- 2005-02-11 JP JP2006553263A patent/JP4989976B2/ja not_active Expired - Fee Related
- 2005-02-11 AU AU2005214338A patent/AU2005214338B2/en not_active Ceased
- 2005-02-11 CA CA002555812A patent/CA2555812A1/en not_active Abandoned
- 2005-02-11 WO PCT/US2005/004373 patent/WO2005080335A1/en not_active Application Discontinuation
- 2005-02-11 EP EP05722960A patent/EP1718611A4/en not_active Withdrawn
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2006
- 2006-08-09 US US11/463,421 patent/US7737172B2/en not_active Expired - Fee Related
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2009
- 2009-02-10 US US12/368,588 patent/US7846962B2/en not_active Expired - Fee Related
-
2010
- 2010-06-09 US US12/796,787 patent/US8088816B2/en not_active Expired - Fee Related
- 2010-06-09 US US12/796,831 patent/US8268879B2/en not_active Expired - Fee Related
- 2010-11-01 US US12/916,956 patent/US8044089B2/en not_active Expired - Fee Related
-
2011
- 2011-09-15 US US13/233,074 patent/US8354440B2/en not_active Expired - Fee Related
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| See also references of EP1718611A4 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20120077759A1 (en) | 2012-03-29 |
| US20110046367A1 (en) | 2011-02-24 |
| US20090299058A1 (en) | 2009-12-03 |
| US20070099976A1 (en) | 2007-05-03 |
| AU2005214338B2 (en) | 2011-11-10 |
| US8354440B2 (en) | 2013-01-15 |
| US8088816B2 (en) | 2012-01-03 |
| US8268879B2 (en) | 2012-09-18 |
| EP1718611A1 (en) | 2006-11-08 |
| US20100256388A1 (en) | 2010-10-07 |
| JP4989976B2 (ja) | 2012-08-01 |
| JP2007522234A (ja) | 2007-08-09 |
| US7737172B2 (en) | 2010-06-15 |
| US8044089B2 (en) | 2011-10-25 |
| EP1718611A4 (en) | 2009-09-23 |
| US7846962B2 (en) | 2010-12-07 |
| CA2555812A1 (en) | 2005-09-01 |
| US20100249201A1 (en) | 2010-09-30 |
| AU2005214338A1 (en) | 2005-09-01 |
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