WO2005075976A3 - Vorrichtung und verfahren zur kopplung von kapillaren trennverfahren und massenspektrometrie - Google Patents

Vorrichtung und verfahren zur kopplung von kapillaren trennverfahren und massenspektrometrie Download PDF

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Publication number
WO2005075976A3
WO2005075976A3 PCT/EP2005/000712 EP2005000712W WO2005075976A3 WO 2005075976 A3 WO2005075976 A3 WO 2005075976A3 EP 2005000712 W EP2005000712 W EP 2005000712W WO 2005075976 A3 WO2005075976 A3 WO 2005075976A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
separation methods
coupling
capillary separation
capillary
Prior art date
Application number
PCT/EP2005/000712
Other languages
English (en)
French (fr)
Other versions
WO2005075976A2 (de
Inventor
Dieter Lubda
Ulrich Tallarek
Erdmann Rapp
Original Assignee
Merck Patent Gmbh
Dieter Lubda
Ulrich Tallarek
Erdmann Rapp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Dieter Lubda, Ulrich Tallarek, Erdmann Rapp filed Critical Merck Patent Gmbh
Priority to US10/588,457 priority Critical patent/US20080315083A1/en
Priority to JP2006551770A priority patent/JP2007520711A/ja
Priority to EP05701173A priority patent/EP1711807A2/de
Publication of WO2005075976A2 publication Critical patent/WO2005075976A2/de
Publication of WO2005075976A3 publication Critical patent/WO2005075976A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6073—Construction of the column body in open tubular form
    • G01N30/6078—Capillaries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Die vorliegende Erfindung betrifft Kapillaren, die zumindest teilweise mit Metallfolie ummantelt sind sowie deren Einsatz bei der Kopplung von Verfahren wie HPLC, CE (Kapillarelektrophorese), CEC (Kapillarelektrochromatographie) oder pCEC (pressurized CEC) mit MS (Massenspektrometrie). Durch die erfindungsgemässe Ummantelung mit Metallfolie ist eine direkte Kopplung der Kapillaren an ein Massenspektrometer ohne Verwendung weiterer Übergangsstücke, wie Spraynadeln oder Leerkapillarstücken, möglich.
PCT/EP2005/000712 2004-02-05 2005-01-25 Vorrichtung und verfahren zur kopplung von kapillaren trennverfahren und massenspektrometrie WO2005075976A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/588,457 US20080315083A1 (en) 2004-02-05 2005-01-25 Device and Method for Coupling Capillary Separation Methods and Mass Spectrometry
JP2006551770A JP2007520711A (ja) 2004-02-05 2005-01-25 キャピラリー分離法および定量分析計を連結させるためのデバイスおよび方法
EP05701173A EP1711807A2 (de) 2004-02-05 2005-01-25 Vorrichtung und verfahren zur kopplung von kapillaren trennverfahren und massenspektrometrie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004005888A DE102004005888A1 (de) 2004-02-05 2004-02-05 Vorrichtung und Verfahren zur Kopplung von kapillaren Trennverfahren und Massenspektrometrie
DE102004005888.1 2004-02-05

Publications (2)

Publication Number Publication Date
WO2005075976A2 WO2005075976A2 (de) 2005-08-18
WO2005075976A3 true WO2005075976A3 (de) 2005-12-15

Family

ID=34801672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000712 WO2005075976A2 (de) 2004-02-05 2005-01-25 Vorrichtung und verfahren zur kopplung von kapillaren trennverfahren und massenspektrometrie

Country Status (5)

Country Link
US (1) US20080315083A1 (de)
EP (1) EP1711807A2 (de)
JP (1) JP2007520711A (de)
DE (1) DE102004005888A1 (de)
WO (1) WO2005075976A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008206353B2 (en) * 2007-01-12 2013-09-12 Board Of Regents, The University Of Texas System Interfacing low-flow separation techniques
WO2008087715A1 (ja) * 2007-01-17 2008-07-24 Shimadzu Corporation イオン化用エミッタ、イオン化装置及びイオン化用エミッタの製造方法
US8895918B2 (en) * 2011-06-03 2014-11-25 Purdue Research Foundation Ion generation using modified wetted porous materials
CN102522311A (zh) * 2011-10-20 2012-06-27 中国科学院上海有机化学研究所 一种纳喷雾电极及其制作方法和应用
US9196468B2 (en) * 2012-05-18 2015-11-24 Dh Technologies Development Pte. Ltd. Method and system for introducing make-up flow in an electrospray ion source system
BE1021813B1 (fr) * 2014-02-13 2016-01-19 Analis Sa Interface ce-ms
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
JP6948266B2 (ja) 2015-02-06 2021-10-13 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ プローブ、システム、カートリッジ、およびその使用方法
US20190019662A1 (en) * 2017-07-14 2019-01-17 Purdue Research Foundation Electrophoretic mass spectrometry probes and systems and uses thereof
CN107702949A (zh) * 2017-08-15 2018-02-16 杭州臻盛科技有限公司 顶空取样针以及取样方法
JP6717438B2 (ja) * 2017-09-14 2020-07-01 株式会社島津製作所 Ｅｓｉスプレイヤー及びイオン化装置
WO2019053850A1 (ja) * 2017-09-14 2019-03-21 株式会社島津製作所 液体クロマトグラフ
DE102018000650A1 (de) 2018-01-27 2019-08-01 Friedrich-Schiller-Universität Jena Verfahren zur Bestimmung von Verunreinigungen in Polyalkylenethern oder Polyalkylenaminen und dessen Verwendung
DE102018103609B4 (de) * 2018-02-19 2021-06-02 Bruker Daltonik Gmbh Flüssigkeitsanschluss-Einrichtung für die Ionisierung durch Elektrosprühen
CN113075114B (zh) * 2019-12-17 2022-07-01 北京大学 一种用于单细胞分析的有机质谱流式分析方法
GB202211210D0 (en) * 2022-08-01 2022-09-14 Micromass Ltd Electrospray device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926271A (en) * 1975-02-03 1975-12-16 Rupprecht Georg Microbalance
WO1982001578A1 (en) * 1980-11-03 1982-05-13 Aircraft Co Hughes Metallic clad capillary tubing
US4726822A (en) * 1984-10-22 1988-02-23 Honeywell Inc. Fast response thermochromatographic capillary columns

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5922112U (ja) * 1982-08-03 1984-02-10 丹野　直弘 芯管入同軸型ガラス毛細管電極
US6297499B1 (en) * 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
JP2001074697A (ja) * 1999-09-07 2001-03-23 Jeol Ltd エレクトロスプレー・イオン源
DE10028447A1 (de) * 2000-06-14 2001-12-20 Merck Patent Gmbh Verfahren zur Herstellung von monolithischen Chromatographiesäulen
US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
AU1189702A (en) * 2000-10-13 2002-04-22 Fluidigm Corp Microfluidic device based sample injection system for analytical devices
EP1363714B1 (de) * 2001-02-20 2012-10-10 Advion BioSystems, Inc. Mikrochip-elektrosprayvorrichtung und säule mit affinitätsadsorptionsmitteln und ihre verwendung
JP2003331776A (ja) * 2002-05-10 2003-11-21 Hitachi Ltd イオン源および質量分析装置および質量分析方法
JP4613002B2 (ja) * 2003-10-29 2011-01-12 株式会社日立ハイテクノロジーズ エレクトロスプレイ用カラム一体型チップの製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926271A (en) * 1975-02-03 1975-12-16 Rupprecht Georg Microbalance
WO1982001578A1 (en) * 1980-11-03 1982-05-13 Aircraft Co Hughes Metallic clad capillary tubing
US4726822A (en) * 1984-10-22 1988-02-23 Honeywell Inc. Fast response thermochromatographic capillary columns

Also Published As

Publication number Publication date
EP1711807A2 (de) 2006-10-18
DE102004005888A1 (de) 2005-08-25
JP2007520711A (ja) 2007-07-26
WO2005075976A2 (de) 2005-08-18
US20080315083A1 (en) 2008-12-25

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