WO2005058926A1 - Nouveau procede de preparation de diisopropyl((1-((2-amino-6-chloro-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonate - Google Patents

Nouveau procede de preparation de diisopropyl((1-((2-amino-6-chloro-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonate Download PDF

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Publication number
WO2005058926A1
WO2005058926A1 PCT/KR2004/003258 KR2004003258W WO2005058926A1 WO 2005058926 A1 WO2005058926 A1 WO 2005058926A1 KR 2004003258 W KR2004003258 W KR 2004003258W WO 2005058926 A1 WO2005058926 A1 WO 2005058926A1
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WO
WIPO (PCT)
Prior art keywords
formula
compound
folbwing
reaction
methyl
Prior art date
Application number
PCT/KR2004/003258
Other languages
English (en)
Inventor
Suk-Kyoon Yoon
Cheol-Min Kim
Byung-Ran So
Ki-Kon Lee
Kun-Hye Nam
Man-Young Yoon
Sang-Chul Choi
Original Assignee
Lg Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd. filed Critical Lg Life Sciences Ltd.
Publication of WO2005058926A1 publication Critical patent/WO2005058926A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un nouveau procédé de préparation d'un composé de formule (1) qui s'avère être un intermédiaire important dans la préparation d'un analogue de nucléoside du composé de formule (2) efficace en tant qu'agent antiviral, en particulier en tant qu'agent antiviral contre l'hépatite B.
PCT/KR2004/003258 2003-12-19 2004-12-10 Nouveau procede de preparation de diisopropyl((1-((2-amino-6-chloro-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonate WO2005058926A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2003-0093946 2003-12-19
KR1020030093946A KR20050062944A (ko) 2003-12-19 2003-12-19 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법

Publications (1)

Publication Number Publication Date
WO2005058926A1 true WO2005058926A1 (fr) 2005-06-30

Family

ID=36603149

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2004/003258 WO2005058926A1 (fr) 2003-12-19 2004-12-10 Nouveau procede de preparation de diisopropyl((1-((2-amino-6-chloro-9h-purin-9-yl)methyl)cyclopropyl)oxy)methylphosphonate

Country Status (4)

Country Link
KR (1) KR20050062944A (fr)
AR (1) AR047055A1 (fr)
TW (1) TWI244392B (fr)
WO (1) WO2005058926A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093229B2 (en) 2005-03-30 2012-01-10 Conforma Therapeutics Corporation Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors
CN106432330A (zh) * 2015-08-11 2017-02-22 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
US5977089A (en) * 1996-07-26 1999-11-02 Gilead Sciences, Inc. Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability
EP0967213A1 (fr) * 1998-06-23 1999-12-29 SUMIKA FINE CHEMICALS Co., Ltd. Procédé pour la préparation des sels de tetraalkyle-ammonium des dérivés 6-halogénopurine
WO2002057288A1 (fr) * 2001-01-19 2002-07-25 Lg Life Sciences Ltd. Nouveaux derives de phosphonate nucleosidique acyclique, sels de ces derniers et procede de preparation de ces derniers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
US5977089A (en) * 1996-07-26 1999-11-02 Gilead Sciences, Inc. Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability
EP0967213A1 (fr) * 1998-06-23 1999-12-29 SUMIKA FINE CHEMICALS Co., Ltd. Procédé pour la préparation des sels de tetraalkyle-ammonium des dérivés 6-halogénopurine
WO2002057288A1 (fr) * 2001-01-19 2002-07-25 Lg Life Sciences Ltd. Nouveaux derives de phosphonate nucleosidique acyclique, sels de ces derniers et procede de preparation de ces derniers

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093229B2 (en) 2005-03-30 2012-01-10 Conforma Therapeutics Corporation Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors
CN106432330A (zh) * 2015-08-11 2017-02-22 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途

Also Published As

Publication number Publication date
KR20050062944A (ko) 2005-06-28
TWI244392B (en) 2005-12-01
AR047055A1 (es) 2006-01-04
TW200522961A (en) 2005-07-16

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