WO2005057224A1 - 自動分析装置用反応ディスク及び分離用セル - Google Patents
自動分析装置用反応ディスク及び分離用セル Download PDFInfo
- Publication number
- WO2005057224A1 WO2005057224A1 PCT/JP2004/018209 JP2004018209W WO2005057224A1 WO 2005057224 A1 WO2005057224 A1 WO 2005057224A1 JP 2004018209 W JP2004018209 W JP 2004018209W WO 2005057224 A1 WO2005057224 A1 WO 2005057224A1
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- WO
- WIPO (PCT)
- Prior art keywords
- cell
- separation
- supernatant
- suspension
- insoluble matter
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00495—Centrifuges
- G01N2035/00504—Centrifuges combined with carousels
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/111666—Utilizing a centrifuge or compartmented rotor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Definitions
- the present invention relates to a reaction disk for an automatic analyzer for analyzing (measuring) a predetermined component contained in a supernatant such as plasma obtained by removing a blood cell or the like which is a suspension force of blood or the like. More particularly, the present invention relates to a reaction disk and a separation cell for reducing the size of an automatic analyzer for measuring the concentration of a target substance in plasma or the like.
- This type of conventional apparatus separates plasma and the like from whole blood by a separate centrifugation treatment or filtration treatment as a pretreatment, and analyzes the separated plasma and the like as a sample liquid.
- the separation cell when performing a centrifugal separation process, the separation cell is usually placed obliquely. Therefore, when adding the function of performing centrifugation processing to the automatic analyzer, the separation cell is installed at an angle or a swing type in which the cell is inclined during the centrifugation is adopted.
- the separation cell and the reaction cell were provided on one disk, the structure became complicated or the device had to be enlarged to mount the disk.
- the separation disk was installed separately from the reaction disk, and in that case, the size of the device could not be reduced and the cost could be increased.
- the invention according to claim 1 of the present invention is directed to blood collected from a patient in a hospital room or the like. It is an object of the present invention to provide an inexpensive and miniaturized reaction disk for an automatic analyzer so that components in a suspension can be quantitatively analyzed immediately.
- Another object of the present invention is to provide a separation cell capable of reducing the size of a reaction disk at low cost.
- the separation cell employs a diagonally installed force and a method of being tilted during rotation.
- the cost is increased due to the large size of the device and the inability to integrally mold the disk. For such a reason, it has not been customary to arrange a separation cell and a measurement cell on the same disk in such a way that separation and measurement are completely independent of each other.
- the present inventors have made intensive studies and as a result, the separation cell was centrifuged in the same upright state as the rotating shaft, and even when centrifuged in the upright state, the suspension of blood or the like was easily obtained.
- the present inventors have found out that water can be prevented from flowing out, and have reached the present invention in which a separation cell and a measurement cell are provided on the same reaction disk.
- the separation cell and the measurement cell are provided on the same reaction disk so that they can maintain an upright state while both are rotating.
- the cell is formed so that the suspension does not flow out during centrifugation.
- the supernatant obtained by placing the suspension in the separation cell and separating by centrifugation is dispensed into the measurement cell, and the target substance in the supernatant is removed. It is characterized by analyzing.
- the rotation speed of a single motor is adjusted so that the motor rotates at high speed when rotating the separation cell, and rotates at low speed (for positioning) when rotating the measurement cell. It is preferable to be able to convert or switch to a separation and measurement motor
- An insoluble matter collecting part is provided in the separation cell, and a lid body is provided on the upper part of the separating cell above the insoluble matter collecting part so that the suspension does not flow out during the centrifugation. (Claim 3).
- the reaction disk is provided so as to be able to maintain an upright state during the rotation of the dilution cell, in addition to the separation cell and the measurement cell, and the dilution cell is a diluent during centrifugation.
- the diluent in the dilution cell may be dispensed into the measurement cell to dilute the supernatant (claim 4).
- a shelf is provided in the cell, and the lower part of the shelf is used as an insoluble matter collecting part and the upper part is used as a supernatant separating part.
- the upper part of the cell above the insoluble matter collecting part is partially covered with a centrifugal separator so that suspension does not flow out. It is covered with a lid and used in an upright state during the centrifugation process (claim 9).
- the insoluble matter collection section having a small cross section and the supernatant separation section having a large cross section are connected up and down so that they communicate with each other at one side to form a separation cell, and the other side of the connection section is formed.
- the shelf needs to be provided on the separation cell in the direction of the center of rotation (claim 11).
- the invention's effect is to be provided on the separation cell in the direction of the center of rotation (claim 11).
- the separation cell and the measurement cell are provided on the same reaction disk so that they can maintain an upright state during rotation. Since an automatic analyzer equipped with this can be miniaturized and manufactured at low cost, the supernatant such as plasma is immediately separated from a suspension such as blood collected from a patient in a hospital room or the like, and the components in the supernatant are analyzed. It is extremely suitable as a soot device.
- the suspension can be easily prevented from flowing out during the centrifugation, and the supernatant can be separated without mixing insoluble matter even with a small amount of sample.
- the separation cell can be formed small and inexpensively.
- the present invention can be applied to suspensions containing insolubles.
- suspensions include, for example, body fluids such as blood, for example, excreta (feces, etc.), biological samples (sputum, pus, skin-derived materials, lymphocytes, blood cells, cell-derived materials, tissue-derived materials, etc.).
- the present invention provides a method for preparing, from a suspension as described above, blood cells, blood coagulation factors (for example, fibrinogen, prothrombin, factor V, factor VIII, etc.), platelets, undigested substances, cells, tissues, bacteria, It is useful for removing insoluble substances such as viruses and their crushed products and separating and collecting supernatants such as plasma, serum, various extracts, and culture supernatants. Above all, it is useful for separating and fractionating plasma by removing insoluble substances such as blood cells from blood and removing and separating insoluble substances such as blood cells and some blood coagulation factors from blood. This is particularly useful when separating and fractionating plasma.
- blood coagulation factors for example, fibrinogen, prothrombin, factor V, factor VIII, etc.
- plasma When plasma is separated from blood according to the present invention, it is preferable to remove not only blood cells but also platelets as an insoluble substance. However, platelets are completely removed to the extent that they do not hinder subsequent analysis. You don't have to remove it! /.
- FIGS. 1 and 2 show one embodiment of the present invention, in which a disk-shaped reaction disk 1 is rotatably formed by a rotating shaft 2 erected in the center, and has a peripheral edge portion.
- the separation cells 4 and 4 'facing each other and a large number of reaction cells (measurement cells) 3 are provided independently in an upright state (vertically or almost vertically)! /
- the reaction cell 3 is provided vertically, as shown in FIG. 1 (B). When installed obliquely, it is extremely difficult to keep the optical path length of the reaction cell 3 constant. This is because the length of the optical path of the reaction cell needs to be kept constant in order to accurately perform the analysis after the reaction.
- Separation cells 4, 4 ' are also provided vertically as shown in Fig. 2 (A). If the separation cell is installed at an angle, it will be difficult to aspirate the supernatant after centrifugation, and extra space will be required in the device, which will make the device larger. In addition, the efficiency of maintaining the reaction cell 3 at a constant temperature becomes poor, the positioning of the measuring lamp and the light-receiving part becomes complicated, and the molding of the counter-application cell and the separation cell becomes difficult, leading to an increase in cost. Disadvantage of Occurs.
- a lid 6 that partially covers the opening 5 is provided.
- the reason why the entire opening 5 is not covered is that a probe for dispensing the suspension and collecting the supernatant is introduced (since a space for inserting the probe is required). Therefore, the lid 6 that partially covers the opening 5 may have an opening through which a probe can be inserted into the lid 6.
- the separation cells 4 and 4 are configured such that a large-section supernatant separation section 8 is connected to a small-section insoluble matter collection section 7 so as to communicate therewith.
- the step of the connecting portion is a shelf 9.
- the surface of the insoluble matter collecting section 7 facing the center of the disk 1 is formed in the step portion, and the surface facing the outside on the opposite side is formed flat.
- the lid 6 is preferably large enough to cover at least the opening of the insoluble matter collecting section 7.
- the opening 5 not covered by the lid 6 is preferably a force that is opposed to the shelf 9. This is preferable because the substance is easily prevented from flowing out during centrifugation.
- an opening through which a probe can be inserted is formed in the lid 6, it is preferable that the opening face the shelf 9.
- the separation cells 4 and 4 are formed in a sectoral or trapezoidal cross section. This is not necessarily required, but it is preferable that the shape be such that it becomes tapered toward the inside of the disk 1. The reason for this is that the size of the insolubles collecting section 7 is set to a certain size, and the structure in which only the supernatant is accumulated in the supernatant separating section 8 facilitates the separation of the supernatant.
- the blood collection tube For example, conventionally, collected blood is centrifuged together with the blood collection tube. At this time, since the blood volume is at least 5 mL or more, it is not so difficult to collect the supernatant (eg, plasma) in units of / zL after separation. Further, some recent blood collection tubes have a function of preventing a blood cell from dancing and rising due to a separating agent entering between blood cells and plasma. In the present invention, in order to realize the overall miniaturization, it is intended to form the sample so as to be able to carry out a sample of about 400 L without any trouble. About 200 ⁇ L of plasma, etc., obtained from a sample of about 400 ⁇ L by separation is about 200 ⁇ L, so it is extremely difficult to separate plasma, etc., without raising blood cells with a conventional separation cell. .
- the inside of the separation cells 4 and 4 ′ blood cells (insoluble matter) are not pressed during centrifugation).
- the sample collected on the shelf 9 after centrifugation is only plasma (supernatant), so that when collecting, it is possible to prevent blood cells (insoluble matter) from rising. Can be achieved.
- the lid 6 does not necessarily need to be provided at the upper end of the separation cell, but the amount of the suspension that can be separated is determined by the position of the lid 6 and the sum of the spaces of the insolubles collecting sections 7 and 8. Therefore, in order to maximize the capacity, the position of the lid 6 is preferably located at the upper end in consideration of the ease of forming the cell, which is preferred at the upper end.
- the volume of the insoluble matter collecting section 7 is determined by the amount of the insoluble matter in the target suspension, and a volume that does not allow the insoluble matter to enter the space of the supernatant separating section 8 is required.
- the height of the shelf 9 is determined by the amount of the target suspension and the amount of insolubles in the suspension.
- the difference in the hematocrit of the blood also determines the capacity of the blood cell (insoluble matter) collection unit 7, so even if the blood has a high hematocrit, the blood cells (insoluble matter) are stored in the insoluble matter collection unit 7. This capacity needs to be determined to fit.
- a predetermined amount of a suspension eg, blood
- a suspension eg, blood
- a dispensing probe through an opening 5 not covered by the lid 6 of the separation cells 4 and 4 ′ shown in FIGS. 1 and 2.
- rotate the motor rotate the rotating shaft 2 at high speed, and centrifuge.
- shelf 9 contains the supernatant (e.g., Must be configured so that it is above (at most coincident with) the interface between plasma and insolubles (e.g. blood cells)
- a dispensing probe is inserted through the opening 5 in FIG. 3, and a supernatant (eg, plasma) portion is collected and dispensed into the reaction cell 3. Since the supernatant (eg, plasma) is located above the shelf 9, insolubles (eg, blood cells) could be prevented from rising.
- a supernatant eg, plasma
- the triangles indicate that a reagent disk (not shown) is provided adjacent to the reaction disk 1, and the dispensing probe 10 (see note: FIG. 4) is located between the reagent disk and the reaction disk 1. Reciprocate to supply the reagent into the reaction cell 3. At this time, the reaction cell 3 is moved to a position where the reaction cell 3 can be dispensed by the dispensing probe 10 by rotating the motor!
- the motor is configured to rotate at a high speed when the separation cell is rotated, and to perform a positioning rotation when rotating the measurement cell. This can be achieved by switching between a single motor for converting the rotational speed, and a motor for separation and measurement.
- the motor for high-speed rotation (for separation) and the motor for positioning (for measurement) are rotated by a clutch so that either the rotation axis of the separation cell or the rotation axis of the measurement cell is rotated. , To switch. For example, when the clutch is engaged, the high-speed rotation motor rotates the rotation axis of the separation cell, and when the clutch is released, the rotation of the positioning motor rotates the rotation axis of the measurement cell. Just do it.
- the motor when converting the rotation speed of a single motor, the motor can rotate at high speed when rotating the separation cell, and when rotating the measurement cell, the motor rotates for positioning.
- the rotation speed of the motor itself is converted so that the motor can rotate at low speed, or the rotation speed of the reaction disk can be converted by combining appropriate gears and belts without changing the rotation speed of the motor itself. It is performed according to the usual law in this field.
- Supplying the reagent causes a reaction between the supernatant (eg, plasma) and the reagent.
- the optical density changed by the reaction is measured with the photometer shown in Fig. 4 as before.
- reaction cell 3 of the reaction disk 1 is accommodated in a reaction block (constant temperature bath) 11 so as to maintain the reaction cell 3 at a predetermined constant temperature.
- the light from the lamp 12 passes through the lens 13, irradiates the reaction cell 3 from the light irradiation window 14 of the reaction block 11, passes through the reaction cell 3, and passes through the mirror 15.
- Spectral section The sample is taken out from the fiber 16 and the absorbance is determined based on the data.
- the concentration of the target substance is measured in accordance with a standard method in this field, such as using a standard or using a calibration curve indicating the relationship between absorbance and the concentration of the target substance.
- FIGS. 5 and 6 show another embodiment of the present invention, in which a dilution cell 18 is independently provided in an upright state (vertically or almost vertically) so as to face the separation cell 4. ing. A predetermined amount of the supernatant separated in the separation cell 4 is put into the reaction cell 3 and, if necessary, diluted with the diluent in the dilution cell 18 and further supplied with the reagent so that the reaction is performed. ing.
- the diluting cell is installed obliquely, the same drawbacks as when the diluting cell is installed obliquely occur, such as difficulty in sucking the diluent.
- the dilution cell 18 is formed in the step 9 as in the separation cell 4.
- the dilution cell 18 does not necessarily need to be installed at a position facing the separation cell 4, but it is easy to balance the rotation of the disk during centrifugation. It is preferred to provide.
- the dilution cell 18 has a weight (weight at the time of centrifugation) when the diluent is retained inside the dilution cell (when the diluent is dispensed), and the suspension (e.g., blood). , Etc.) (the separation cell 4 into which the suspension has been dispensed) and the shape (weight of the separation cell 4 during centrifugation) of the It is preferable to form them taking into account the material and the like.
- the dilution cell 18 when it is not necessary to dilute the supernatant separated in the separation cell 4 with the diluent (i.e., when the diluent cell 18 is not required or the diluent cell 18 holds the diluent). (If there is no need to dispense)], the dilution cell 18 was installed at a position facing the separation cell 4 for the above reason, and the suspension (eg, blood, etc.) was held inside. The diluent is retained inside the diluting cell 18 (dispensed) so that the weight of the diluting cell (separating cell 4 into which the suspension has been dispensed) is about the same as that of the diluting cell, and centrifuged. May be performed.
- diluent examples include water, physiological saline, and buffers commonly used in this field, for example, such as Tris buffer, phosphate buffer, veronal buffer, borate buffer, and good buffer. I can do it.
- a lid 6 partially covering the opening is provided. 'Is provided. The reason why the entire opening is not covered is to insert a probe for collecting the diluent (because a space for inserting the probe is required).
- the lid 6 partially covering the opening, or the lid 6 may be formed with an opening for inserting the probe in the same manner as described above.
- the dilution cell 18 is also formed in a sector or trapezoidal cross section. This need not necessarily be the case, but it is preferable that the shape be such that it becomes tapered toward the inside of the disc 1.
- the end opposite to the opening side of the lid ⁇ is formed as a bent portion 19 that stands upward.
- the bent portion 19 does not necessarily need to be formed in the dilution cell 18.
- at least one end of the disc 1 such as one end of the separation cell lid 6 opposite to the opening side of the lid 6 or one measurement cell. It is good if it is formed in the place.
- the bent portion 19 is for positioning the disk 1 (setting the origin).
- a sensor (not shown) is installed at one location around the disc 1, and when the disc 1 rotates, the sensor detects the bent portion 19 and stops at a predetermined position. Use this stop position as the origin of disk 1!
- analyzing the target substance in the supernatant refers to measuring (quantifying) the amount of the target substance present in the supernatant, roughly measuring the amount of the target substance (determination). Volume) and to detect (qualitatively) the presence or absence of the target substance in the supernatant.
- a biochemical field for example, in a clinical test field, a biochemical field, a biological field such as a chemical assay, an enzymatic assay, an immunoassay, or the like.
- a biological field such as a chemical assay, an enzymatic assay, an immunoassay, or the like.
- the reagents used in the present invention may be those commonly used in the fields and methods described above, and may be appropriately selected depending on the type of the target substance and the analysis method.
- FIG. 1 shows (A) a plan view and (B) a − a sectional view showing one embodiment of the reaction disk of the present invention.
- FIG. 2 (A) is a cross-sectional view taken along line b − b of FIG. 1 (A), and FIG. 2 (B) is a plan view of the reaction disk of only 02 (A).
- FIG. 3 is a cross-sectional view showing one embodiment of the separation cell of the present invention.
- FIG. 4 is a cross-sectional view showing an example of a device for measuring an optical density changed by a reaction between plasma and a reagent.
- FIG. 5 is a perspective view showing another embodiment of the present invention.
- FIG. 6 is a cross-sectional view of FIG.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2004800363423A CN1890569B (zh) | 2003-12-08 | 2004-12-07 | 自动分析装置 |
US10/581,695 US7722812B2 (en) | 2003-12-08 | 2004-12-07 | Reaction disk and separation cell for automatic analyzer |
JP2005516125A JP4055802B2 (ja) | 2003-12-08 | 2004-12-07 | 自動分析装置用反応ディスク |
EP04820205.5A EP1693675A4 (en) | 2003-12-08 | 2004-12-07 | REACTION PLATE AND DISTRIBUTION CELL FOR USE IN AN ANALYSIS AUTOMAT |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003408523 | 2003-12-08 | ||
JP2003-408523 | 2003-12-08 |
Publications (1)
Publication Number | Publication Date |
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WO2005057224A1 true WO2005057224A1 (ja) | 2005-06-23 |
Family
ID=34674877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2004/018209 WO2005057224A1 (ja) | 2003-12-08 | 2004-12-07 | 自動分析装置用反応ディスク及び分離用セル |
Country Status (5)
Country | Link |
---|---|
US (1) | US7722812B2 (ja) |
EP (1) | EP1693675A4 (ja) |
JP (1) | JP4055802B2 (ja) |
CN (1) | CN1890569B (ja) |
WO (1) | WO2005057224A1 (ja) |
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WO2009090991A1 (ja) * | 2008-01-15 | 2009-07-23 | Kyowa Medex Co., Ltd. | 遠心分離装置及び該装置を用いる測定用サンプルの調製方法 |
JP2017187496A (ja) * | 2016-04-08 | 2017-10-12 | アイセンス,インコーポレーテッド | 遠心分離が可能な円形タイプカートリッジおよびこれを用いたモジュール式自動分析装置 |
KR101860744B1 (ko) | 2016-04-08 | 2018-05-24 | 주식회사 아이센스 | 원형타입 카트리지를 갖는 모듈식 자동 분석장치 및 그 확장형 시스템 |
KR20180106756A (ko) * | 2017-03-21 | 2018-10-01 | 주식회사 아이센스 | 원심분리가 가능한 원형타입 카트리지 및 이를 이용한 모듈식 자동 분석장치 |
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US10457975B1 (en) * | 2016-02-10 | 2019-10-29 | William George Pitt | Hollow rotating device for separating particles from blood |
CN107966578B (zh) * | 2017-12-26 | 2024-01-02 | 江苏柯伦迪医疗技术有限公司 | 一种医用快速生化检测系统及检测方法 |
CN107966579A (zh) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | 一种具有生化、酶免及化学发光快速检测系统及方法 |
CN109188007B (zh) * | 2018-09-06 | 2022-04-12 | 桂林优利特医疗电子有限公司 | 一种全自动生化分析仪反应盘及其使用方法 |
US11754576B2 (en) * | 2018-10-08 | 2023-09-12 | Team Conveyer Intellectual Properties, LLC | Coordinated conveyers in an automated system |
CN109444444A (zh) * | 2018-10-10 | 2019-03-08 | 深圳市国赛生物技术有限公司 | 一种检测分析仪及其使用方法 |
AU2020271780B2 (en) | 2019-04-11 | 2023-08-10 | Team Conveyor Intellectual Properties, LLC | Coordinated conveyers in an automated system |
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- 2004-12-07 WO PCT/JP2004/018209 patent/WO2005057224A1/ja active Application Filing
- 2004-12-07 JP JP2005516125A patent/JP4055802B2/ja not_active Expired - Fee Related
- 2004-12-07 CN CN2004800363423A patent/CN1890569B/zh not_active Expired - Fee Related
- 2004-12-07 EP EP04820205.5A patent/EP1693675A4/en not_active Withdrawn
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009090991A1 (ja) * | 2008-01-15 | 2009-07-23 | Kyowa Medex Co., Ltd. | 遠心分離装置及び該装置を用いる測定用サンプルの調製方法 |
JP4944970B2 (ja) * | 2008-01-15 | 2012-06-06 | 協和メデックス株式会社 | 遠心分離装置及び該装置を用いる測定用サンプルの調製方法 |
JP2017187496A (ja) * | 2016-04-08 | 2017-10-12 | アイセンス,インコーポレーテッド | 遠心分離が可能な円形タイプカートリッジおよびこれを用いたモジュール式自動分析装置 |
KR101860744B1 (ko) | 2016-04-08 | 2018-05-24 | 주식회사 아이센스 | 원형타입 카트리지를 갖는 모듈식 자동 분석장치 및 그 확장형 시스템 |
US10371709B2 (en) | 2016-04-08 | 2019-08-06 | I-Sens, Inc. | Circular type cartridge enabling centrifugation and modular automatic analyzer using the same |
KR20180106756A (ko) * | 2017-03-21 | 2018-10-01 | 주식회사 아이센스 | 원심분리가 가능한 원형타입 카트리지 및 이를 이용한 모듈식 자동 분석장치 |
KR101970790B1 (ko) | 2017-03-21 | 2019-04-19 | 주식회사 아이센스 | 원심분리와 자동분석이 가능한 원형카트리지 및 이를 이용한 모듈식 자동분석장치 |
Also Published As
Publication number | Publication date |
---|---|
CN1890569A (zh) | 2007-01-03 |
JP4055802B2 (ja) | 2008-03-05 |
JPWO2005057224A1 (ja) | 2007-07-05 |
EP1693675A1 (en) | 2006-08-23 |
US20070087429A1 (en) | 2007-04-19 |
US7722812B2 (en) | 2010-05-25 |
CN1890569B (zh) | 2011-03-16 |
EP1693675A4 (en) | 2013-09-18 |
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