WO2005056689A2 - Cyanine dye compounds - Google Patents

Cyanine dye compounds Download PDF

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Publication number
WO2005056689A2
WO2005056689A2 PCT/US2004/040875 US2004040875W WO2005056689A2 WO 2005056689 A2 WO2005056689 A2 WO 2005056689A2 US 2004040875 W US2004040875 W US 2004040875W WO 2005056689 A2 WO2005056689 A2 WO 2005056689A2
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
unsubstituted
alkyl
nucleic acid
compound
Prior art date
Application number
PCT/US2004/040875
Other languages
English (en)
French (fr)
Other versions
WO2005056689A3 (en
Inventor
Jason Dalwig
David Hagen
Timothy Huang
Jerry Thomas
Stephen Yue
Original Assignee
Molecular Probes, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34681527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005056689(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Molecular Probes, Inc. filed Critical Molecular Probes, Inc.
Priority to EP04813220.3A priority Critical patent/EP1720944B1/en
Publication of WO2005056689A2 publication Critical patent/WO2005056689A2/en
Publication of WO2005056689A3 publication Critical patent/WO2005056689A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
PCT/US2004/040875 2003-12-05 2004-12-06 Cyanine dye compounds WO2005056689A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04813220.3A EP1720944B1 (en) 2003-12-05 2004-12-06 Cyanine dye compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52723403P 2003-12-05 2003-12-05
US60/527,234 2003-12-05
US55447204P 2004-03-18 2004-03-18
US60/554,472 2004-03-18

Publications (2)

Publication Number Publication Date
WO2005056689A2 true WO2005056689A2 (en) 2005-06-23
WO2005056689A3 WO2005056689A3 (en) 2005-10-13

Family

ID=34681527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/040875 WO2005056689A2 (en) 2003-12-05 2004-12-06 Cyanine dye compounds

Country Status (3)

Country Link
US (3) US7446202B2 (US07446202-20081104-C00042.png)
EP (2) EP2607431B1 (US07446202-20081104-C00042.png)
WO (1) WO2005056689A2 (US07446202-20081104-C00042.png)

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WO2014089421A1 (en) * 2012-12-07 2014-06-12 Life Technologies Corporation Detection of rna molecules using substituted unsymmetrical cyanine dyes
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
EP3056548A1 (en) * 2012-03-30 2016-08-17 Life Technologies Corporation Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species
US9441270B2 (en) 2010-08-25 2016-09-13 Pacific Biosciences Of California, Inc. Cyanine dyes
US10557851B2 (en) 2012-03-27 2020-02-11 Ventana Medical Systems, Inc. Signaling conjugates and methods of use

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US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
US7598390B2 (en) 2005-05-11 2009-10-06 Life Technologies Corporation Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use
US7737281B2 (en) 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US8357801B2 (en) * 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US8092784B2 (en) 2005-11-30 2012-01-10 Biotium, Inc. Enzyme substrate comprising a functional dye and associated technology and methods
US8551408B2 (en) 2006-01-24 2013-10-08 Life Technologies Corporation Device and methods for quantifying analytes
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
WO2008092041A2 (en) 2007-01-24 2008-07-31 Carnegie Mellon University Optical biosensors
US20100041045A1 (en) * 2007-11-15 2010-02-18 Sigma-Aldrich Co. Nucleic acid fluorescent stains
US20090131279A1 (en) * 2007-11-15 2009-05-21 Sigma Aldrich Company Nucleic acid fluorescent stains
WO2009079212A2 (en) 2007-12-03 2009-06-25 Carnegie Mellon University Linked peptide fluorogenic biosensors
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
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US9127317B2 (en) 2012-03-02 2015-09-08 Winthrop-University Hospital Method for using probe based PCR detection to measure the levels of circulating demethylated β cell derived DNA as a measure of β cell loss in diabetes
US20150037787A1 (en) * 2013-07-31 2015-02-05 International Business Machines Corporation Polynucleotide configuration for reliable electrical and optical sensing
US10011570B2 (en) 2013-10-03 2018-07-03 Biotium, Inc. Nucleic acid binding dyes with improved safety
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CN115803333A (zh) 2020-07-02 2023-03-14 生命技术公司 三核苷酸帽类似物、其制备和用途
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WO2023056460A1 (en) 2021-09-30 2023-04-06 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
WO2023086103A1 (en) 2021-11-12 2023-05-19 Beckman Coulter, Inc. Novel formulation for drying of polymer dye conjugated antibodies
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