WO2005044973A3 - 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 - Google Patents

新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 Download PDF

Info

Publication number
WO2005044973A3
WO2005044973A3 PCT/JP2004/016666 JP2004016666W WO2005044973A3 WO 2005044973 A3 WO2005044973 A3 WO 2005044973A3 JP 2004016666 W JP2004016666 W JP 2004016666W WO 2005044973 A3 WO2005044973 A3 WO 2005044973A3
Authority
WO
WIPO (PCT)
Prior art keywords
optically active
coa reductase
novel
acetoacetyl
producing optically
Prior art date
Application number
PCT/JP2004/016666
Other languages
English (en)
French (fr)
Other versions
WO2005044973A2 (ja
WO2005044973A1 (ja
Inventor
Shigeru Kawano
Yoshihiko Yasohara
Original Assignee
Kaneka Corp
Shigeru Kawano
Yoshihiko Yasohara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp, Shigeru Kawano, Yoshihiko Yasohara filed Critical Kaneka Corp
Priority to JP2005515359A priority Critical patent/JPWO2005044973A1/ja
Priority to US10/577,601 priority patent/US20070037263A1/en
Priority to EP04818252A priority patent/EP1688480A4/en
Publication of WO2005044973A2 publication Critical patent/WO2005044973A2/ja
Publication of WO2005044973A1 publication Critical patent/WO2005044973A1/ja
Publication of WO2005044973A3 publication Critical patent/WO2005044973A3/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/008—Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本発明は、（Ｒ）−３−ヒドロキシペンタンニトリル、光学活性３−ヒドロキシブタン酸エステル及び光学活性１−フェニルエタノール誘導体の光学活性アルコールの簡便な製法の提供、並びに、上記光学活性アルコール、特に（Ｒ）−３−ヒドロキシペンタンニトリルの製造に有用な新規酵素の提供を目的とする。 本発明は、３−ケトペンタンニトリルを不斉還元して、光学純度９９％ｅ．ｅ．以上の（Ｒ）−３−ヒドロキシペンタンニトリルを生成しうる新規アセトアセチルＣｏＡ還元酵素；３−ケトペンタンニトリル、アセト酢酸エステル及び１−フェニルエタノン誘導体それぞれに、当該新規酵素もしくは既知のアセトアセチルＣｏＡ還元酵素を作用させ、対応する光学活性アルコールを製造する方法である。
PCT/JP2004/016666 2003-11-11 2004-11-10 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 WO2005044973A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2005515359A JPWO2005044973A1 (ja) 2003-11-11 2004-11-10 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法
US10/577,601 US20070037263A1 (en) 2003-11-11 2004-11-10 Novel acetoacetyl-coa reductase and process for producing optically active alcohol
EP04818252A EP1688480A4 (en) 2003-11-11 2004-11-10 NOVEL ACETOACETYL-COA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003380987 2003-11-11
JP2003-380987 2003-11-11

Publications (3)

Publication Number Publication Date
WO2005044973A2 WO2005044973A2 (ja) 2005-05-19
WO2005044973A1 WO2005044973A1 (ja) 2005-05-19
WO2005044973A3 true WO2005044973A3 (ja) 2005-06-30

Family

ID=

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541759A (ja) * 1998-01-19 2002-12-10 エルジ ケミカル リミテッド アルカリゲネスラタス由来のポリヒドロキシアルカノエート生合成関連遺伝子
WO2003031636A1 (fr) * 2001-10-05 2003-04-17 Kaneka Corporation Procede de production de 3-hydroxy-pentanenitrile optiquement actif

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541759A (ja) * 1998-01-19 2002-12-10 エルジ ケミカル リミテッド アルカリゲネスラタス由来のポリヒドロキシアルカノエート生合成関連遺伝子
WO2003031636A1 (fr) * 2001-10-05 2003-04-17 Kaneka Corporation Procede de production de 3-hydroxy-pentanenitrile optiquement actif

Also Published As

Publication number Publication date
EP1688480A2 (en) 2006-08-09
US20070037263A1 (en) 2007-02-15
JPWO2005044973A1 (ja) 2007-11-29
KR20060113697A (ko) 2006-11-02
EP1688480A4 (en) 2007-07-11
WO2005044973A2 (ja) 2005-05-19

Similar Documents

Publication Publication Date Title
EP1605041A3 (en) Aldolase, and method for producing optically active IHOG and monatin
BR0207287A (pt) Glicosamina e método de fabricação de glicosamina a partir de biomassa microbiana
EP1130043A3 (en) Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
EP1258470A3 (en) Process for producing optically active alcohol
EP1469079B8 (en) Carbonyl reductases, polynucleotides comprising DNA encoding the same, methods for producing the same, and methods for producing optically active alcohol utilizing the same
EP1995314A4 (en) PROCESS FOR PRODUCTION OF ERYTHRO- OR THREO-2-AMINO-3-HYDROXYPROPIONIC ACID ESTER, NOVEL CARBONYL REDUCTASE, REDUCTASE-ENCODING GENE, VECTOR, TRANSFORMANT, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ALCOHOL USING THE SUSDITS
EP0927755A3 (en) Haloaccloacetate reductase, method for producing said enzyme, and method for producing alcohols using said enzyme
WO2006034812A3 (de) Verfahren zur herstellung von optisch aktiven 2-methylalkan-1-ols aus dem entsprechenden 2-methylalk-2-en-1-al, umfassend eine carbonylselektive reduktion, eine enantioselektive hydrierung und eine lipase-katalysierte, stereoselektive acylierung zwecks anreicherung des gewünschten enatiomers
AU2002213634A1 (en) Method for the production of fatty acid esters of lower alcohols
EP1182184A4 (en) METHOD FOR PRODUCING TETRAFLUORO-BENZOL METHANOLS
MY139322A (en) Method for producing 2-azetidinone derivative
NZ514106A (en) Process for the preparation of hydroxy methylthiobutyric acid esters
DK1106679T3 (da) Fremgangsmåde til fremstilling af et fermenteringsprodukt
WO2005044973A1 (ja) 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法
WO2005044973A3 (ja) 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法
EP0955375A3 (en) Method for producing optically active 4-Halo-3-Hydroxybutyric acid ester
WO2006094112A3 (en) Production open-chained sophorolipids
EP1298119A4 (en) CHLOROHYDROXYACETONE DERIVATIVE AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE CHLOROPROPANEDIOL DERIVATIVE FROM CHLOROHYDROXYACETONE DERIVATIVE
AU2002310883A1 (en) Process for the preparation of substituted carboxylic acid estersby enzymatic hydrolysis
AU2003289229A1 (en) Process for producing optically active 3-hydroxypropionic ester derivative
AU2003299300A1 (en) METHOD FOR THE PRODUCTION OF R-Alpha-LIPOIC ACID BY FERMENTATION
WO2003031636A1 (fr) Procede de production de 3-hydroxy-pentanenitrile optiquement actif
PT1266967E (pt) Processo para a producao de pravastatina e lovastatina
AU2001236057A1 (en) Process for the production of optically active beta-amino alcohols
AU2003241747A1 (en) PROCESS FOR PRODUCING OPTICALLY ACTIVE ss-AMINO ALCOHOL

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005515359

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2007037263

Country of ref document: US

Ref document number: 10577601

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2004818252

Country of ref document: EP

Ref document number: 1020067008603

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004818252

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020067008603

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 10577601

Country of ref document: US